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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryChinese Name: Cidofovir Chinese synonyms: Cidofovir (anhydrous); Cidofovir (cidofovir dihydrate); Cidofovir; [1-(4-amino-2-oxopyrimidine-1-yl) -3-hydroxypropane-2-yl] oxymethylphosphonic acid; (S) - [[2-(4-amino-2-oxo-1 (2H) pyrimidine) -1-(
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inquiryProduct Name: Cidofovir Synonyms: (S)-1-[3-HYDROXY-2-(PHOSPHONYL-METHOXY)PROPYL]-CYTOSINE;(S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE;[1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquiryCidofovir CAS:113852-37-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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inquiryWuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
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(S)-1-<3-Hydroxy-2-<(diethylphosphonyl)methoxy>propyl>cytosine
cidofovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide In acetonitrile for 14h; Ambient temperature; | 95% |
With trimethylsilyl bromide | 80% |
N4-benzoyl-1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine
cidofovir
Conditions | Yield |
---|---|
With ammonium hydroxide at 20℃; for 3h; | 80% |
With ammonium hydroxide for 4h; Ambient temperature; Yield given; |
cidofovir
Conditions | Yield |
---|---|
With ammonium hydroxide at 20℃; for 3h; | 71% |
4-methoxy-2-pyrimidone
(R)-2--3-ytimethylacetyl-1,2,3-propanetriol 1-p-toluenesulfonate
cidofovir
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
Cytosine
(R)-2--3-ytimethylacetyl-1,2,3-propanetriol 1-p-toluenesulfonate
cidofovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide; caesium carbonate 1.) DMFA, 100 deg C, 72 h, 2.) CH3CN, RT, 24 h; Yield given. Multistep reaction; |
bis(2-propyl) N4-benzoyl-1-(S)-(2-phosphonomethoxy-3-triphenylmethoxypropyl)cytosine
cidofovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide; sodium methylate 1.) CH3CN, overnight, 2.) CH3OH, RT, overnight; Yield given. Multistep reaction; |
bis(2-propyl) 1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine
cidofovir
Conditions | Yield |
---|---|
With trimethylsilyl bromide; water; triethylamine 1.) CH3CN, overnight, 2.) 20 min; Multistep reaction; |
(S)-N1-[2-hydroxy-3-(triphenylmethoxy)propyl]-N4-benzoylcytosine
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: NaH / dimethylformamide / 6 h / 0 °C 2: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C 3: TMSBr / CH2Cl2 / 18 h / Ambient temperature 4: conc. NH4OH / 4 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 12 h / 60 °C 2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 3: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 4: ammonium hydroxide / 3 h / 20 °C View Scheme |
diethyl (S)-4-N-benzoyl-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TMSBr / CH2Cl2 / 18 h / Ambient temperature 2: conc. NH4OH / 4 h / Ambient temperature View Scheme |
[(S)-1-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diethyl ester
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C 2: TMSBr / CH2Cl2 / 18 h / Ambient temperature 3: conc. NH4OH / 4 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 2: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 3: ammonium hydroxide / 3 h / 20 °C View Scheme |
(S)-1-<3-(Benzyloxy)-2-<(diethylphosphonyl)methoxy>propyl>cytosine
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / cyclohexene / 20percent Pd(OH)2/C / ethanol / 12 h / Heating 2: 95 percent / Me3SiBr / acetonitrile / 14 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 65 percent / H2 / Pd(OH)2 on carbon / ethanol; cyclohexane / Heating 2: 80 percent / TMS-bromide View Scheme |
Conditions | Yield |
---|---|
With recombinant puromycin-sensitive aminopeptidase; sodium chloride In water at 37℃; pH=7.4; Kinetics; aq. buffer; Enzymatic reaction; |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: methanesulfonamide; C50H56N4O4; potassium carbonate; potassium hexacyanoferrate(III); K2Os2(OH)4 / water; tert-butyl alcohol / 12 h / 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 48 h / 0 °C / Inert atmosphere 3: dmap / dichloromethane 4: potassium carbonate / acetonitrile / 12 h / 60 °C 5: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 6: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 7: ammonium hydroxide / 3 h / 20 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 48 h / 0 °C / Inert atmosphere 2: dmap / dichloromethane 3: potassium carbonate / acetonitrile / 12 h / 60 °C 4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 5: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 6: ammonium hydroxide / 3 h / 20 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dmap / dichloromethane 2: potassium carbonate / acetonitrile / 12 h / 60 °C 3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 4: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 5: ammonium hydroxide / 3 h / 20 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 12 h / 60 °C 2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 3: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 4: ammonium hydroxide / 3 h / 20 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 2: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 3: ammonium hydroxide / 3 h / 20 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 2: ammonium hydroxide / 3 h / 20 °C View Scheme |
(S)-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dmap / dichloromethane 2: potassium carbonate / acetonitrile / 12 h / 60 °C 3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 4: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 5: ammonium hydroxide / 3 h / 20 °C View Scheme |
N-(1-allyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: methanesulfonamide; C50H56N4O4; potassium carbonate; potassium hexacyanoferrate(III); K2Os2(OH)4 / water; tert-butyl alcohol / 12 h / 0 °C 2: dmap / dichloromethane 3: potassium carbonate / acetonitrile / 12 h / 60 °C 4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C 5: trimethylsilyl bromide / dichloromethane / 18 h / 20 °C 6: ammonium hydroxide / 3 h / 20 °C View Scheme |
4,4'-dimethoxytrityl chloride
cidofovir
(S)-1-{3-[4,4'-Dimethoxytrityloxy]-2-(phosphonomethoxy)propyl}cytosine
Conditions | Yield |
---|---|
In dimethyl sulfoxide | 95% |
Stage #1: cidofovir With tributyl-amine In methanol Stage #2: 4,4'-dimethoxytrityl chloride With tributyl-amine In dimethyl sulfoxide at 20℃; | 91% |
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; for 24h; Inert atmosphere; | 65% |
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; for 24h; Inert atmosphere; | 62% |
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; Inert atmosphere; | 61% |
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; Inert atmosphere; | 56% |
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃; Inert atmosphere; | 45% |
cidofovir
Conditions | Yield |
---|---|
Stage #1: cidofovir; N,N-dicyclohexyl-4-morpholine carboxamidine In N,N-dimethyl-formamide Stage #2: With pyridine; dicyclohexyl-carbodiimide at 60 - 100℃; for 16h; | 44% |
Stage #1: cidofovir; N,N-dicyclohexyl-4-morpholine carboxamidine In DMF (N,N-dimethyl-formamide) Stage #2: With pyridine; dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 60 - 100℃; for 16.5h; | 44% |
With dicyclohexyl-carbodiimide In pyridine; N,N-dimethyl-formamide at 20 - 100℃; for 28h; |
N,N'-dicyclohexyl-4-morpholine carboxamidine
cidofovir
cyclic cidofovir DCMC salt
Conditions | Yield |
---|---|
With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; for 16h; | 44% |
Stage #1: N,N'-dicyclohexyl-4-morpholine carboxamidine; cidofovir In N,N-dimethyl-formamide Stage #2: With pyridine; dicyclohexyl-carbodiimide at 60 - 100℃; for 16.5h; | 44% |
cidofovir
Conditions | Yield |
---|---|
With pyrimidine nucleoside monophosphate kinase (EC 2.7.4.14); ATP In phosphate buffer at 37℃; for 15h; pH=7.5; Enzyme kinetics; Further Variations:; Reaction partners; phosphorylation; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 60 - 65℃; for 0.5h; |
Conditions | Yield |
---|---|
With oxalyl dichloride Product distribution; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In water |
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In water |
cidofovir
cyclic cidofovir
Conditions | Yield |
---|---|
With pyridine; N,N'-dicyclohexyl-4-morpholine carboxamidine; dicyclohexyl-carbodiimide at 100℃; | |
Multi-step reaction with 2 steps 1: EDC / H2O 2: PyBOP View Scheme | |
Multi-step reaction with 2 steps 1: dimethylformamide / 0.5 h / 60 - 65 °C 2: 94 percent / NaOH / H2O; dimethylformamide; methanol / pH 3.5 View Scheme | |
With methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 35℃; for 3h; | |
With N,N'-dicyclohexyl-4-morpholine carboxamidine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 100℃; |
cidofovir
Conditions | Yield |
---|---|
With triethylammonium hydrogensulfite; triethylamine In methanol at 20℃; |
(S)-2-hydroxyethyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate
cidofovir
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; |
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-hydroxy-ethyl ester
cidofovir
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; |
(S)-2-hydroxyethyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate
cidofovir
trifluoroacetic acid
Conditions | Yield |
---|---|
Stage #1: (S)-2-hydroxyethyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate; cidofovir With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; Stage #2: trifluoroacetic acid In dichloromethane at 20℃; for 3h; |
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-hydroxy-ethyl ester
cidofovir
trifluoroacetic acid
Conditions | Yield |
---|---|
Stage #1: 2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-hydroxy-ethyl ester; cidofovir With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; Stage #2: trifluoroacetic acid In dichloromethane at 20℃; for 3h; |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylammonium hydrogensulfite; Et3N / aq. methanol / 20 °C 2: 1 g / aq. methanol / 16 h / 70 °C View Scheme |
cidofovir
1-O-hexadecyloxypropyl cyclic cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dicyclohexyl-morpholinocarboxamidine; 1,3-dicyclohexylcarbodiimide; pyridine / 100 °C 2: dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1,3-dicyclohexyl carbodiimide / dimethylformamide; pyridine / 28 h / 20 - 100 °C 2: 31 percent / dimethylformamide / 6 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide 1.2: 16.5 h / 60 - 100 °C 2.1: N,N-dimethyl-formamide / 6 h / 80 °C View Scheme |
cidofovir
1-O-octadecyloxyethyl cyclic cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dicyclohexyl-morpholinocarboxamidine; 1,3-dicyclohexylcarbodiimide; pyridine / 100 °C 2: dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1,3-dicyclohexyl carbodiimide / dimethylformamide; pyridine / 28 h / 20 - 100 °C 2: 33 percent / dimethylformamide / 6 h / 80 °C View Scheme |
cidofovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dicyclohexyl-morpholinocarboxamidine; 1,3-dicyclohexylcarbodiimide; pyridine / 100 °C 2: dimethylformamide / 80 °C 3: aq. NaOH View Scheme | |
Multi-step reaction with 3 steps 1: 1,3-dicyclohexyl carbodiimide / dimethylformamide; pyridine / 28 h / 20 - 100 °C 2: 31 percent / dimethylformamide / 6 h / 80 °C 3: 105 mg / aqueous NaOH / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: N,N-dimethyl-formamide 1.2: 16.5 h / 60 - 100 °C 2.1: N,N-dimethyl-formamide / 6 h / 80 °C 3.1: sodium hydroxide / 1.5 h / 20 °C 3.2: 3 h / 20 °C / pH 3.51 View Scheme |
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