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NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

2'-deoxy-2',2'-difluorouridine

Cas:114248-23-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2',2'-DIFLUORO-2'-DEOXYURIDINE CAS 114248-23-6

Cas:114248-23-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 114248-23-6 with competitive price

Cas:114248-23-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2',2'-DIFLUORO-2'-DEOXYURIDINECAS:114248-23-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig

2',2'-DIFLUORO-2'-DEOXYURIDINECAS:114248-23-6

Cas:114248-23-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Uridine,2'-deoxy-2',2'-difluoro-

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2',2'-DIFLUORO-2'-DEOXYURIDINE

Cas:114248-23-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2'-Deoxy-2',2'-difluorouridine

Cas:114248-23-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

2',2'-Difluorodeoxyuridine

Cas:114248-23-6

Min.Order:100 Gram

Negotiable

Type:Manufacturers

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2',2'-Difluorodeoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2',2'-DIFLUORO-2'-DEOXYURIDINE

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Uridine,2'-deoxy-2',2'-difluoro-

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2'-Deoxy-2',2'-difluorouridine CAS No.114248-23-6

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

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Asure Biochem CO.,LTD.

*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:10G/bottle 1kg/tin 5kg/tin 25kg/carton Application:1. Chemical raw materials 2. Used as an analytical reage

2'-Deoxy-2',2'-difluorouridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

2',2'-DIFLUORO-2'-DEOXYURIDINE

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2',2'-DIFLUORO-2'-DEOXYURIDINE

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

2-Deoxy-2,2-difluoro-D-uridine;2-Deoxy-2,2-difluorouridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2',2'-Difluoro-2'-Deoxyuridine

Cas:114248-23-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

114248-23-6

Cas:114248-23-6

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei youze Biotechnology Co.,Ltd

1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment terms accepted (Btc;MoneyGram;WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery (3-10 DAYS fast deli

2',2'-Difluoro-2'-deoxyuridine CAS:114248-23-6 the cheapest price

Cas:114248-23-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 18.0

Type:Trading Company

inquiry

Shanghai Forever Synthesis Co.,Ltd.

As a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according t

2',2'-Difluoro-2'-Deoxy Uridine

Cas:114248-23-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Chemlin Chemical Co., Ltd.

please contact us to confirm the required quantity and quote, we will provide you with COA,NMR,HPLC and other relevant informationAppearance:White crystals Storage:Store in a cool place. Keep container tightly closed in a dry and well-ventilated plac

Uridine,2'-deoxy-2',2'-difluoro-

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan MoonZY Biological Technology Co.,Ltd

1. Quality: High purity, strict quality control, 10 years experience in chemical industry. 2. Price: Moderate price, more QTY more discount. 3. MOQ: Sample order is welcome to test quality. 4. Shipping time: In Stock, can be shipp

2',2'-Difluoro-2'-deoxyuridine,114248-23-6

Cas:114248-23-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

2’,2’-Difluoro-2’-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 2',2'-Difluoro-2'-deoxyuridine, CAS:114248-23-6 with the most competitive price and t

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changzhou Hopschain Chemical Co.,Ltd

We can customize any of the nucleoside sugars. And the product you find from lookchem,we have stock Package:As your requirement Application:Intermediate Transportation:By Express

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Skyrun Industrial Co.,Ltd

Good Price, Sufficient capacity Application:Medical intermediate; Used in organic synthesis;

2',2'-Difluoro-2'-deoxyuridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Topbatt Chemical Co., Ltd.

Topbatt Chemical Co., Ltd., Established in 2019, located in Shenzhen, Guangdong Province, is a Manufacturer and Trading company which specialized in fine chemicals like Pharmaceutical Reference Standards and Stable Isotopes. Our Stable Isotopes produ

2',2'-Difluoro-2'-Deoxy Uridine

Cas:114248-23-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate
143157-27-1

((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 12h; Temperature;99%
With ammonia In methanol99%
With ammonia In methanol at 20℃; for 15h;95.8%
gemcitabine hydrochloride
122111-03-9

gemcitabine hydrochloride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
With acetic acid; sodium nitrite In water at 20℃; for 48h;95%
Multi-step reaction with 3 steps
1: pyridine / 15 h / 25 °C
2: acetic acid / water / 14 h / Reflux
3: ammonia / methanol / 15 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine / 15 h / 25 °C
2: acetic acid / water / 14 h / Reflux
3: ammonia / methanol / 15 h / 20 °C
View Scheme
2'-deoxy-2',2'-difluorouridine-3',5'-dibenzoate
1201895-94-4

2'-deoxy-2',2'-difluorouridine-3',5'-dibenzoate

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
With ammonia In methanol at 23℃; for 23h;90%
gemcitabine
95058-81-4

gemcitabine

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
With hydrogenchloride; isopentyl nitrite In 1,4-dioxane; water at 70℃; Inert atmosphere;68%
Multi-step reaction with 3 steps
1: dmap; pyridine / 3.5 h / 0 - 20 °C / Inert atmosphere
2: acetic acid / Reflux
3: ammonia / methanol / 20 °C
View Scheme
2’-deoxy-2’,2’-difluoro-cytidine
103882-84-4

2’-deoxy-2’,2’-difluoro-cytidine

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
With water; acetic acid for 24h; Heating;
gemcitabine hydrochloride
122111-03-9

gemcitabine hydrochloride

A

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

B

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

C

1-(2-deoxy-2,2-difluoro-α-D-erythropentofuranosyl)uracil

1-(2-deoxy-2,2-difluoro-α-D-erythropentofuranosyl)uracil

Conditions
ConditionsYield
With sodium hydroxide at 40℃; for 672h; Mechanism; further reagent, temperature, time;
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
1445381-44-1

(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / water / 14 h / Reflux
2: ammonia / methanol / 15 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / Reflux
2: ammonia / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid; water / 12 h / 110 °C
2: ammonia / methanol / 12 h / 20 °C
View Scheme
(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
1334513-02-8

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 20h; Inert atmosphere; diastereoselective reaction;87%
Stage #1: Deoxydifluorouridine With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester In tetrahydrofuran at 0 - 20℃; for 1.5h;
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C15H24F2N2O5Si

C15H24F2N2O5Si

Conditions
ConditionsYield
With pyridine; 1H-imidazole at 25 - 50℃; for 12h; Temperature; Inert atmosphere;85.5%
With pyridine; 1H-imidazole at 20℃;
With 1H-imidazole In pyridine at 20℃;
With 1H-imidazole In N,N-dimethyl-formamide for 8h; Inert atmosphere;
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

1-((2R,4R,5S)-3,3-difluoro-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-((2R,4R,5S)-3,3-difluoro-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With pyridine; 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere;84%
acetic anhydride
108-24-7

acetic anhydride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

1-((2R,4R,5R)-3,3-difluorotetrahydro-4-acetoxy-5-acetoxymethylfuran-2-yl)pyrimidin-2,4(1H,3H)-dione

1-((2R,4R,5R)-3,3-difluorotetrahydro-4-acetoxy-5-acetoxymethylfuran-2-yl)pyrimidin-2,4(1H,3H)-dione

Conditions
ConditionsYield
With pyridine at 0 - 5℃; for 16h;81%
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C30H28F2N2O7

C30H28F2N2O7

Conditions
ConditionsYield
With pyridine at 0 - 25℃; Temperature;77.7%
With pyridine at 0 - 20℃;
With pyridine at 0 - 20℃; for 15h;
With pyridine at 20℃; for 15h;
With pyridine at 20℃; for 15h;
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil
132832-46-3

1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate; iodine; acetic acid at 80℃; for 2h; Inert atmosphere;75%
benzoyl chloride
98-88-4

benzoyl chloride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate
143157-27-1

((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate

Conditions
ConditionsYield
With 4-methyl-morpholine; dmap In tetrahydrofuran at 0 - 5℃; for 8h;72%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C15H24F2N2O5Si

C15H24F2N2O5Si

Conditions
ConditionsYield
Stage #1: Deoxydifluorouridine With pyridine; 4,4'-dimethoxytrityl chloride at 0 - 20℃; for 15h;
Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 20℃; for 12h;
Stage #3: With acetic acid In water at 20℃; for 20h;
70%
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C9H9Cl2F2N2O6P
1233921-78-2

C9H9Cl2F2N2O6P

Conditions
ConditionsYield
With trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate at 20℃; Cooling with ice;57.3%
(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1337529-56-2

(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
Stage #1: Deoxydifluorouridine With tert-butylmagnesium chloride In tetrahydrofuran at -10℃; for 1h; Inert atmosphere;
Stage #2: (S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 0℃; for 5h; Inert atmosphere;
22%
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C15H22F2N2O5Si

C15H22F2N2O5Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C16H26F2N2O6Si

C16H26F2N2O6Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C32H44F2N2O6Si2

C32H44F2N2O6Si2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C32H42F2N2O6Si2

C32H42F2N2O6Si2

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C33H44F2N2O5Si2

C33H44F2N2O5Si2

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C33H46F2N2O5Si2

C33H46F2N2O5Si2

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
7.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 25 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C53H63F2N3O5Si2

C53H63F2N3O5Si2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
7.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 25 °C
8.1: Triphenylsilyl chloride; dmap; triethylamine / acetonitrile / 5 h / 20 °C
8.2: 1 h
8.3: 12 h / 20 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C31H31F2N3O5
1445381-68-9

C31H31F2N3O5

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
7.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 25 °C
8.1: Triphenylsilyl chloride; dmap; triethylamine / acetonitrile / 5 h / 20 °C
8.2: 1 h
8.3: 12 h / 20 °C
9.1: ammonium fluoride / methanol / 15 h / 25 - 70 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C11H15F2N3O4
1445381-71-4

C11H15F2N3O4

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
7.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 25 °C
8.1: Triphenylsilyl chloride; dmap; triethylamine / acetonitrile / 5 h / 20 °C
8.2: 1 h
8.3: 12 h / 20 °C
9.1: ammonium fluoride / methanol / 15 h / 25 - 70 °C
10.1: formic acid / water / 15 h / 25 - 35 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine / 15 h / 20 °C
2: 1H-imidazole / dichloromethane / 14 h / 20 °C
3: acetic acid / water / 15 h / 20 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C11H18F2N3O13P3
1445398-18-4

C11H18F2N3O13P3

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: pyridine; 4,4'-dimethoxytrityl chloride / 15 h / 0 - 20 °C
1.2: 12 h / 20 °C
1.3: 20 h / 20 °C
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux
3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C
3.2: 0.5 h / 20 °C / pH 7
4.1: pyridine; 4,4'-dimethoxytrityl chloride / dichloromethane / 3 h / 0 - 25 °C
4.2: 15 h / 25 °C
4.3: 15 h / 20 °C
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 - 0 °C / Inert atmosphere
6.2: 12 h / 0 - 20 °C / Inert atmosphere
7.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 25 °C
8.1: Triphenylsilyl chloride; dmap; triethylamine / acetonitrile / 5 h / 20 °C
8.2: 1 h
8.3: 12 h / 20 °C
9.1: ammonium fluoride / methanol / 15 h / 25 - 70 °C
10.1: formic acid / water / 15 h / 25 - 35 °C
11.1: pyridine; trichlorophosphate; trimethyl phosphite / 1 h / 4 °C
11.2: 2 h / 20 °C
11.3: 2 h / 20 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C36H42F2N2O7Si

C36H42F2N2O7Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 15 h / 0 - 20 °C
2: 1H-imidazole / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: pyridine / 15 h / 20 °C
2: 1H-imidazole / dichloromethane / 14 h / 20 °C
View Scheme
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

C25H28F2N2O5Si

C25H28F2N2O5Si

Conditions
ConditionsYield
With pyridine
Deoxydifluorouridine
114248-23-6

Deoxydifluorouridine

C45H44F2N2O6Si

C45H44F2N2O6Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: silver nitrate; 2,4,6-trimethyl-pyridine / dichloromethane / 20 °C
View Scheme

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