1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia
Cas:95058-81-4
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryItems Standard Result Appearance White crystal or crystalline powder Conforms HNMR Right
Cas:95058-81-4
Min.Order:1 Gram
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Unique advantages for Gemcitabine Cas 95058-81-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:N/A Package:100g,1kg/foil bag;25kg/drum
Cas:95058-81-4
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inquiryGemcitabine Base[CAS:95058-81-4] White or almost white crystalline powder, odorless IR spectrum shall comply with that of the reference standard HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade,
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:95058-81-4
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inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
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Name:Fludarabine CAS:95058-81-4 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P
Cas:95058-81-4
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inquiryTIANFUCHEM-- 95058-81-4 -- Gemcitabine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationshi
Cas:95058-81-4
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryGemcitabine base CAS: 95058-81-4 Other name: 2'-DEOXY-2',2'-DIFLUOROCYTIDINE Molecular formular: C9H11F2N3O4 Appearance:White crystalline powder Storage:RT. Package:25kg bag Application:Metabolism Drug; Carcino-Chemotherapeutic
Appearance:White to off-white powder Storage:Keep in dark place,Sealed in dry,Store in freezer, under -20°C Package:25kg/drum Application:Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:95058-81-4
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:95058-81-4
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:95058-81-4
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:95058-81-4
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Gemcitabine CAS:95058-81-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:95058-81-4
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio
Cas:95058-81-4
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry(2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-2-((3-fluorobenzoyloxy)methyl)tetrahydrofuran-3-yl 3-fluorobenzoate
gemcitabine
Conditions | Yield |
---|---|
With ammonia; water at 20℃; for 3h; | 100% |
With methanol; ammonia; water at 20℃; for 3h; | 100% |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
gemcitabine
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 3h; | 82.7% |
With sodium t-butanolate In methanol at 20℃; for 2h; |
1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one
gemcitabine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; for 12h; Product distribution / selectivity; | 76.9% |
gemcitabine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; Product distribution / selectivity; | 72.6% |
With ammonia In methanol at 20℃; Product distribution / selectivity; | 72.6% |
With ammonia; water In methanol at 20℃; for 12h; | 71% |
With ammonia In methanol at 20℃; Product distribution / selectivity; |
gemcitabine
Conditions | Yield |
---|---|
With Amberlite IRA 400, OH-form In methanol at 40 - 45℃; for 36h; Product distribution / selectivity; | 71% |
With ammonia In methanol; water at 20℃; for 24h; Product distribution / selectivity; |
gemcitabine
Conditions | Yield |
---|---|
With ammonia In methanol Product distribution / selectivity; | 63% |
With ammonia In methanol for 8h; Product distribution / selectivity; | 63% |
With ammonia In methanol |
2-amino-N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide trifluoroacetic acid
A
C11H14F2N4O5
B
gemcitabine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol | A 51% B n/a |
2'-deoxy-2',2'-difluoro-3',5'-di-O-(triisopropylsilyl)cytidine
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃; stereoselective reaction; | A 42% B 36% |
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃; |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol | A 38% B n/a |
bis(trimethylsilyl)-N-acetylcytosine
3,5-bis-O-(tert-butyldimethylsilyl)-1-O-(methanesulfonyl)-2-deoxy-2,2-difluororibose
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
Multistep reaction; |
1-[2'-deoxy-2',2'-difluoro-3',5'-bis(tert-butyldiphenylsilyloxy)-ribofuranosyl]-cytosine
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With ammonium fluoride In methanol at 65℃; for 3h; |
gemcitabine hydrochloride
gemcitabine
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; dichloromethane at 20℃; | |
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; | |
Multi-step reaction with 4 steps 1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C 2: pyridine / tetrahydrofuran / 1 h / 4 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4 View Scheme | |
Multi-step reaction with 4 steps 1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C 2: pyridine / tetrahydrofuran / 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4 View Scheme | |
Multi-step reaction with 4 steps 1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C 2: pyridine / tetrahydrofuran / 48 h / 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C 4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4 View Scheme |
N4-benzoyl-2'-deoxy-2',2'-difluorocytidine
gemcitabine
Conditions | Yield |
---|---|
With pyridine; ammonium hydroxide In water at 37℃; for 18h; Kinetics; |
C13H15F2N3O6
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With sodium ethanolate In isopropyl alcohol for 1 - 6h; Heating / reflux; |
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
gemcitabine
Conditions | Yield |
---|---|
With water; CD-1 mouse small intestinal homogenate for 6h; pH=7.5; Conversion of starting material; Aqueous acetate buffer; Enzymatic reaction; | |
With water; CD-1 mouse post-mitochondrial liver (S9) homogenate for 6h; pH=8.0; Conversion of starting material; Aqueous phosphate buffer; Enzymatic reaction; | |
With water; beagle dog post-mitochondrial liver (S9) homogenate for 6h; pH=8.0; Conversion of starting material; Aqueous phosphate buffer; Enzymatic reaction; |
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; Product distribution / selectivity; | |
With ammonia In methanol at 20℃; | |
With ammonia In methanol at 20℃; for 10h; Product distribution / selectivity; |
gemcitabine
Conditions | Yield |
---|---|
In water; isopropyl alcohol G-values; Irradiation; |
gemcitabine
Conditions | Yield |
---|---|
In water; isopropyl alcohol G-values; Irradiation; |
gemcitabine
Conditions | Yield |
---|---|
In water; isopropyl alcohol G-values; Irradiation; |
gemcitabine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 15 - 30℃; for 5.33333h; |
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With methanol; ammonia at -5 - 5℃; for 8 - 10h; |
(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride
gemcitabine
Conditions | Yield |
---|---|
With ammonia In methanol Product distribution / selectivity; | |
With methanol; 2,2,2-trifluoroethanol; potassium carbonate Product distribution / selectivity; |
2’-deoxy-2’,2’-difluoro-cytidine
gemcitabine
Conditions | Yield |
---|---|
With ammonia In water Resolution of racemate; |
C23H19F2N3O6
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
With sodium methylate |
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 2.2: Reflux 3.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: methanesulfonyl chloride; triethylamine / dichloromethane 2.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 2.2: Reflux 3.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme |
1-methylsulfonyl-2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose
A
α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
B
gemcitabine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 1.2: Reflux 2.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C 1.2: Reflux 2.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C View Scheme |
Conditions | Yield |
---|---|
at 20℃; under 9.0009E-09 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer; |
Conditions | Yield |
---|---|
at 20℃; under 9.75098E-09 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer; |
Conditions | Yield |
---|---|
at 20℃; under 3.0003E-08 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer; |
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
gemcitabine
4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one
Conditions | Yield |
---|---|
With pyridine at 20℃; for 4h; | 100% |
With pyridine at 20℃; for 48h; | 84% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 82.3% |
tert-butyldimethylsilyl chloride
gemcitabine
4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Cooling with ice; Inert atmosphere; | 99% |
With 1H-imidazole at 20℃; | 97.1% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Solvent; Reagent/catalyst; | 95% |
chloroformic acid ethyl ester
gemcitabine
1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-4-(ethoxycarbonylamino)pyrimidin-2-one
Conditions | Yield |
---|---|
In ethyl acetate; acetonitrile for 3h; Inert atmosphere; Reflux; | 98.31% |
di-tert-butyl dicarbonate
gemcitabine
(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 20℃; for 50h; | 94% |
With sodium carbonate In water at 20℃; for 30h; | 89% |
With sodium carbonate In 1,4-dioxane; water at 20℃; for 72h; | 88% |
1,5-pentanedioic acid
gemcitabine
1-hydroxybenzotriazol-hydrate
Conditions | Yield |
---|---|
With 4-methyl-morpholine | 94% |
gemcitabine
gemcitabine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 20 - 70℃; | 93.4% |
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity; | 91.5% |
With hydrogenchloride In isopropyl alcohol at 0 - 5℃; for 2h; pH=2; | 90% |
di-tert-butyl dicarbonate
gemcitabine
3′,5′-O-bis(tert-butoxycarbonyl)-gemcitabine
Conditions | Yield |
---|---|
Stage #1: gemcitabine With potassium hydroxide In water at 20℃; for 1h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 1h; | 93% |
Stage #1: gemcitabine With potassium hydroxide In water for 1h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 2.67h; | 90% |
With potassium hydroxide In 1,4-dioxane |
benzoyl chloride
gemcitabine
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
Conditions | Yield |
---|---|
With pyridine; dmap at 0 - 20℃; for 3.5h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With triethylamine In pyridine at 20℃; for 6h; Inert atmosphere; Cooling with ice; regioselective reaction; | 91.2% |
Azelaic anhydride
gemcitabine
Conditions | Yield |
---|---|
91% |
benzyl chloroformate
gemcitabine
4-(benzyloxycarbonylamino)-1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2(1H)-one
Conditions | Yield |
---|---|
Stage #1: gemcitabine With pyridine; chloro-trimethyl-silane at 4 - 20℃; for 1.5h; Inert atmosphere; Stage #2: benzyl chloroformate In methanol at 20℃; Inert atmosphere; | 91% |
gemcitabine
4-amino-1-(2-deoxy-2,2’-difluoro-β-D-erythro-pentofuranosyl)-5-iodopyrimidin-2(1H)-one
Conditions | Yield |
---|---|
With hydrogen iodide; iodine In tetrachloromethane; ethanol; water at 45℃; for 16h; | 90% |
gemcitabine
p-toluenesulfonyl chloride
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-4-methylbenzenesulfonamide
Conditions | Yield |
---|---|
With pyridine; chloro-trimethyl-silane; ammonia In methanol Inert atmosphere; | 90% |
With pyridine; chloro-trimethyl-silane at 20℃; for 2h; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With pyridine; lipase B Candida antarctica In hexane at 50℃; for 6h; Enzymatic reaction; | 89% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide | 87% |
di-tert-butyl dicarbonate
gemcitabine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 50℃; for 18h; | 86% |
In N,N-dimethyl-formamide at 50℃; for 18h; | 86% |
gemcitabine
Conditions | Yield |
---|---|
In tetrahydrofuran at 0℃; | 85% |
(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
gemcitabine
Conditions | Yield |
---|---|
With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 22h; Inert atmosphere; diastereoselective reaction; | 83% |
(fluorenylmethoxy)carbonyl chloride
gemcitabine
Conditions | Yield |
---|---|
Stage #1: gemcitabine With pyridine; chloro-trimethyl-silane for 0.333333h; Stage #2: (fluorenylmethoxy)carbonyl chloride In water for 2.5h; | 80.9% |
Stage #1: gemcitabine With 1H-imidazole; dmap; tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; Stage #2: (fluorenylmethoxy)carbonyl chloride With pyridine In dichloromethane at 20℃; Stage #3: With pyridine hydrogenfluoride In tetrahydrofuran at 20℃; for 24h; | 79.4% |
Conditions | Yield |
---|---|
With pyridine at 20℃; for 4h; | 80% |
With pyridine at 0 - 20℃; for 4h; | 64% |
With pyridine at 0 - 20℃; for 4h; | 39% |
gemcitabine
Conditions | Yield |
---|---|
With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 20h; Inert atmosphere; diastereoselective reaction; | 80% |
Conditions | Yield |
---|---|
Stage #1: C18H26O13 With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: gemcitabine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; | 80% |
gemcitabine
Gemcitabine monophosphate
Conditions | Yield |
---|---|
Stage #1: gemcitabine With trichlorophosphate at 20℃; for 0.15h; Flow reactor; Green chemistry; Stage #2: With water at 20℃; Temperature; Flow reactor; Green chemistry; chemoselective reaction; | 78% |
With trimethyl phosphite; trichlorophosphate at -5℃; for 2h; | 53% |
With recombinant deoxyribonucleoside kinase AtdNK from Arabidopsis thaliana (ecotype Columbia); ATP In aq. buffer Kinetics; Concentration; Reagent/catalyst; Enzymatic reaction; | |
Multi-step reaction with 5 steps 1: pyridine / 4 h / 0 - 20 °C 2: pyridine / 2 h / 0 - 20 °C 3: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / 20 °C 5: ammonium hydroxide View Scheme | |
Multi-step reaction with 7 steps 1: pyridine / 4 h / 0 - 20 °C 2: pyridine / 2 h / 0 - 20 °C 3: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane 5: 1H-tetrazole; water / acetonitrile 6: pyridine; iodine; triethylamine; water 7: ammonium hydroxide View Scheme |
Conditions | Yield |
---|---|
With pyridine; lipase B Candida antarctica In hexane at 50℃; for 6h; Enzymatic reaction; | 76.9% |
Conditions | Yield |
---|---|
Stage #1: C30H33N2O8S3(1-) With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: gemcitabine In dimethyl sulfoxide for 15h; | 75% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 60℃; Inert atmosphere; | 75% |
succinic acid
gemcitabine
Conditions | Yield |
---|---|
Stage #1: succinic acid With thionyl chloride; triethylamine In 1,4-dioxane at 110℃; for 4h; Inert atmosphere; Stage #2: gemcitabine With triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 75% |
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