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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

GEMCITABIN

Cas:95058-81-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia

Professional for Gemcitabine cas no 95058-81-4 (Lower price)

Cas:95058-81-4

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystal or crystalline powder Conforms HNMR Right

High purity Various Specifications Gemcitabine CAS:95058-81-4

Cas:95058-81-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Gemcitabine CAS No.95058-81-4

Cas:95058-81-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Gemcitabine Cas 95058-81-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:N/A Package:100g,1kg/foil bag;25kg/drum

High quality and purity 99% Gemcitabine Cas 95058-81-4 with best price

Cas:95058-81-4

Min.Order:100 Gram

FOB Price: $3.0 / 3.5

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Gemcitabine Base[CAS:95058-81-4] White or almost white crystalline powder, odorless IR spectrum shall comply with that of the reference standard HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade,

Gemcitabine Base

Cas:95058-81-4

Min.Order:100 Gram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Gemcitabine

Cas:95058-81-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Gemcitabine 95058-81-4 ISO Producer

Cas:95058-81-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Gemcitabine

Cas:95058-81-4

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Gemcitabine

Cas:95058-81-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Fludarabine CAS:95058-81-4 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

Professional for Gemcitabine cas no 95058-81-4 (Lower price)

Cas:95058-81-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 95058-81-4 -- Gemcitabine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationshi

TIANFUCHEM-- 95058-81-4 -- Gemcitabine in stock

Cas:95058-81-4

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 95058-81-4 with fast shipping

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Gemcitabine/ LIDE PHARMA- Factory supply / Best price

Cas:95058-81-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Gemcitabine base CAS: 95058-81-4 Other name: 2'-DEOXY-2',2'-DIFLUOROCYTIDINE Molecular formular: C9H11F2N3O4 Appearance:White crystalline powder Storage:RT. Package:25kg bag Application:Metabolism Drug; Carcino-Chemotherapeutic

Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:Keep in dark place,Sealed in dry,Store in freezer, under -20°C Package:25kg/drum Application:Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.

Gemcitabine factory price

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

99%min Gemcitabine Manufacturer For Advanced And Metastatic Pancreatic Cancer

Cas:95058-81-4

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

GMP Factory Supply Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Gemcitabine CAS 95058-81-4 For research Use only

Cas:95058-81-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Gemcitabine

Cas:95058-81-4

Min.Order:10 Gram

FOB Price: $4.0 / 5.2

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Gemcitabine CAS:95058-81-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Gemcitabine CAS:95058-81-4

Cas:95058-81-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:95058-81-4

Cas:95058-81-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Gemcitabine

Cas:95058-81-4

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Gemcitabine

Cas:95058-81-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

hot sale 95058-81-4high purity 95058-81-4Gemcitabine manufacturer

Cas:95058-81-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Gemcitabine Hydrochloride high quality

Cas:95058-81-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

(2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-2-((3-fluorobenzoyloxy)methyl)tetrahydrofuran-3-yl 3-fluorobenzoate
942288-40-6

(2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-2-((3-fluorobenzoyloxy)methyl)tetrahydrofuran-3-yl 3-fluorobenzoate

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia; water at 20℃; for 3h;100%
With methanol; ammonia; water at 20℃; for 3h;100%
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
134790-39-9

(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 20℃; for 3h;82.7%
With sodium t-butanolate In methanol at 20℃; for 2h;
1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one
896109-84-5

1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 12h; Product distribution / selectivity;76.9%
1-(5'-O-benzoyl-2'-deoxy-2',2'-difluoro-3-O-(p-phenylbenzoyl)-D-ribofuranosyl)-4-aminopyrimidin-2-one

1-(5'-O-benzoyl-2'-deoxy-2',2'-difluoro-3-O-(p-phenylbenzoyl)-D-ribofuranosyl)-4-aminopyrimidin-2-one

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; Product distribution / selectivity;72.6%
With ammonia In methanol at 20℃; Product distribution / selectivity;72.6%
With ammonia; water In methanol at 20℃; for 12h;71%
With ammonia In methanol at 20℃; Product distribution / selectivity;
(2R,3R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

(2R,3R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With Amberlite IRA 400, OH-form In methanol at 40 - 45℃; for 36h; Product distribution / selectivity;71%
With ammonia In methanol; water at 20℃; for 24h; Product distribution / selectivity;
C31H25F2N3O7

C31H25F2N3O7

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In methanol Product distribution / selectivity;63%
With ammonia In methanol for 8h; Product distribution / selectivity;63%
With ammonia In methanol
2-amino-N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide trifluoroacetic acid
1018907-93-1

2-amino-N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide trifluoroacetic acid

A

C11H14F2N4O5
1018908-06-9

C11H14F2N4O5

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanolA 51%
B n/a
2'-deoxy-2',2'-difluoro-3',5'-di-O-(triisopropylsilyl)cytidine
1260238-57-0

2'-deoxy-2',2'-difluoro-3',5'-di-O-(triisopropylsilyl)cytidine

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃; stereoselective reaction;A 42%
B 36%
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃;
C2HF3O2*C14H18F2N4O5
1018908-14-9

C2HF3O2*C14H18F2N4O5

A

C14H18F2N4O5
1018908-15-0

C14H18F2N4O5

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanolA 38%
B n/a
bis(trimethylsilyl)-N-acetylcytosine
18027-23-1

bis(trimethylsilyl)-N-acetylcytosine

3,5-bis-O-(tert-butyldimethylsilyl)-1-O-(methanesulfonyl)-2-deoxy-2,2-difluororibose
103882-89-9

3,5-bis-O-(tert-butyldimethylsilyl)-1-O-(methanesulfonyl)-2-deoxy-2,2-difluororibose

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
Multistep reaction;
1-[2'-deoxy-2',2'-difluoro-3',5'-bis(tert-butyldiphenylsilyloxy)-ribofuranosyl]-cytosine
952408-92-3

1-[2'-deoxy-2',2'-difluoro-3',5'-bis(tert-butyldiphenylsilyloxy)-ribofuranosyl]-cytosine

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonium fluoride In methanol at 65℃; for 3h;
gemcitabine hydrochloride
122111-03-9

gemcitabine hydrochloride

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With potassium carbonate In ethanol; dichloromethane at 20℃;
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Multi-step reaction with 4 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C
2: pyridine / tetrahydrofuran / 1 h / 4 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4
View Scheme
Multi-step reaction with 4 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C
2: pyridine / tetrahydrofuran / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4
View Scheme
Multi-step reaction with 4 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 20 °C
2: pyridine / tetrahydrofuran / 48 h / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C
4: Pd0-functionalized resin / aq. phosphate buffer / 37 °C / pH 7.4
View Scheme
N4-benzoyl-2'-deoxy-2',2'-difluorocytidine
142816-70-4

N4-benzoyl-2'-deoxy-2',2'-difluorocytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With pyridine; ammonium hydroxide In water at 37℃; for 18h; Kinetics;
C13H15F2N3O6
861445-90-1

C13H15F2N3O6

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With sodium ethanolate In isopropyl alcohol for 1 - 6h; Heating / reflux;
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
892128-60-8

N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With water; CD-1 mouse small intestinal homogenate for 6h; pH=7.5; Conversion of starting material; Aqueous acetate buffer; Enzymatic reaction;
With water; CD-1 mouse post-mitochondrial liver (S9) homogenate for 6h; pH=8.0; Conversion of starting material; Aqueous phosphate buffer; Enzymatic reaction;
With water; beagle dog post-mitochondrial liver (S9) homogenate for 6h; pH=8.0; Conversion of starting material; Aqueous phosphate buffer; Enzymatic reaction;
1-(5'-O-benzoyl-2'-deoxy-2',2'-difluoro-3-O-(p-phenylbenzoyl)-D-ribofuranosyl)-4-aminopyrimidin-2-one

1-(5'-O-benzoyl-2'-deoxy-2',2'-difluoro-3-O-(p-phenylbenzoyl)-D-ribofuranosyl)-4-aminopyrimidin-2-one

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In methanol at 20℃; Product distribution / selectivity;
With ammonia In methanol at 20℃;
With ammonia In methanol at 20℃; for 10h; Product distribution / selectivity;
N4-(1-(5-nitrothien-2-yl)ethyl)oxycarbonyl-2',2'-difluoro-2'-deoxycytidine

N4-(1-(5-nitrothien-2-yl)ethyl)oxycarbonyl-2',2'-difluoro-2'-deoxycytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
In water; isopropyl alcohol G-values; Irradiation;
N4-(2-nitro-1-methylimidazol-5-yl)methoxycarbonyl-2',2'-difluoro-2'-deoxycytidine

N4-(2-nitro-1-methylimidazol-5-yl)methoxycarbonyl-2',2'-difluoro-2'-deoxycytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
In water; isopropyl alcohol G-values; Irradiation;
N4-(5-nitrothien-2-yl)methoxycarbonyl-2',2'-difluoro-2'-deoxycytidine

N4-(5-nitrothien-2-yl)methoxycarbonyl-2',2'-difluoro-2'-deoxycytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
In water; isopropyl alcohol G-values; Irradiation;
3',5'-bis(tert-butyldiphenylsilyloxy)-2',2'-difluoro-2'-deoxycytidine

3',5'-bis(tert-butyldiphenylsilyloxy)-2',2'-difluoro-2'-deoxycytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 15 - 30℃; for 5.33333h;
2',2'-difluoro-2'-deoxy-N-acetylcytidine-3',5'-dibenzoate

2',2'-difluoro-2'-deoxy-N-acetylcytidine-3',5'-dibenzoate

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With methanol; ammonia at -5 - 5℃; for 8 - 10h;
(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride
1147119-18-3

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In methanol Product distribution / selectivity;
With methanol; 2,2,2-trifluoroethanol; potassium carbonate Product distribution / selectivity;
2’-deoxy-2’,2’-difluoro-cytidine
103882-84-4

2’-deoxy-2’,2’-difluoro-cytidine

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With ammonia In water Resolution of racemate;
C23H19F2N3O6
1155863-81-2

C23H19F2N3O6

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
With sodium methylate
2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose

2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C
2.2: Reflux
3.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: methanesulfonyl chloride; triethylamine / dichloromethane
2.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C
2.2: Reflux
3.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C
View Scheme
1-methylsulfonyl-2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose
1173700-36-1

1-methylsulfonyl-2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose

A

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
95058-85-8

α-1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C
1.2: Reflux
2.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.5 h / 20 °C
1.2: Reflux
2.1: tetramethylammonium fluoride; acetic acid / N,N-dimethyl-formamide / 20 °C
View Scheme
C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

A

C4H11N*C72H72N4O12*H(1+)

C4H11N*C72H72N4O12*H(1+)

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
at 20℃; under 9.0009E-09 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer;
C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

A

C4H11N*C72H72N4O12*H(1+)

C4H11N*C72H72N4O12*H(1+)

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
at 20℃; under 9.75098E-09 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer;
C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

C4H11N*C9H11F2N3O4*C72H72N4O12*H(1+)

A

C4H11N*C72H72N4O12*H(1+)

C4H11N*C72H72N4O12*H(1+)

B

gemcitabine
95058-81-4

gemcitabine

Conditions
ConditionsYield
at 20℃; under 3.0003E-08 Torr; Kinetics; Fourier-Transform Ion Cyclotron Resonance mass spectrometer;
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

gemcitabine
95058-81-4

gemcitabine

4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one
1254062-21-9

4-amino-1-((6aR,8R,9aR)-9,9-difluoro-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f] [1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

Conditions
ConditionsYield
With pyridine at 20℃; for 4h;100%
With pyridine at 20℃; for 48h;84%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;82.3%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

gemcitabine
95058-81-4

gemcitabine

4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
688009-09-8

4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Cooling with ice; Inert atmosphere;99%
With 1H-imidazole at 20℃;97.1%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Solvent; Reagent/catalyst;95%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

gemcitabine
95058-81-4

gemcitabine

1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-4-(ethoxycarbonylamino)pyrimidin-2-one
155968-14-2

1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-4-(ethoxycarbonylamino)pyrimidin-2-one

Conditions
ConditionsYield
In ethyl acetate; acetonitrile for 3h; Inert atmosphere; Reflux;98.31%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

gemcitabine
95058-81-4

gemcitabine

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate
250698-51-2

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 20℃; for 50h;94%
With sodium carbonate In water at 20℃; for 30h;89%
With sodium carbonate In 1,4-dioxane; water at 20℃; for 72h;88%
1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

gemcitabine
95058-81-4

gemcitabine

1-hydroxybenzotriazol-hydrate
80029-43-2, 123333-53-9

1-hydroxybenzotriazol-hydrate

5-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl)amino)-5-oxo-pentanoic acid

5-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl)amino)-5-oxo-pentanoic acid

Conditions
ConditionsYield
With 4-methyl-morpholine94%
gemcitabine
95058-81-4

gemcitabine

gemcitabine hydrochloride
122111-03-9

gemcitabine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 20 - 70℃;93.4%
With hydrogenchloride In water; acetone at 20℃; for 2h; Product distribution / selectivity;91.5%
With hydrogenchloride In isopropyl alcohol at 0 - 5℃; for 2h; pH=2;90%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

gemcitabine
95058-81-4

gemcitabine

3′,5′-O-bis(tert-butoxycarbonyl)-gemcitabine
250698-52-3

3′,5′-O-bis(tert-butoxycarbonyl)-gemcitabine

Conditions
ConditionsYield
Stage #1: gemcitabine With potassium hydroxide In water at 20℃; for 1h;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 1h;
93%
Stage #1: gemcitabine With potassium hydroxide In water for 1h;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 2.67h;
90%
With potassium hydroxide In 1,4-dioxane
benzoyl chloride
98-88-4

benzoyl chloride

gemcitabine
95058-81-4

gemcitabine

(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate
1445381-44-1

(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

Conditions
ConditionsYield
With pyridine; dmap at 0 - 20℃; for 3.5h; Inert atmosphere;93%
trityl chloride
76-83-5

trityl chloride

gemcitabine
95058-81-4

gemcitabine

5'-Tr-gemcytabine

5'-Tr-gemcytabine

Conditions
ConditionsYield
With triethylamine In pyridine at 20℃; for 6h; Inert atmosphere; Cooling with ice; regioselective reaction;91.2%
Azelaic anhydride
45289-91-6

Azelaic anhydride

gemcitabine
95058-81-4

gemcitabine

5-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl)amino)-5-oxo-nonanoic acid

5-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl)amino)-5-oxo-nonanoic acid

Conditions
ConditionsYield
91%
benzyl chloroformate
501-53-1

benzyl chloroformate

gemcitabine
95058-81-4

gemcitabine

4-(benzyloxycarbonylamino)-1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2(1H)-one
138685-83-3

4-(benzyloxycarbonylamino)-1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2(1H)-one

Conditions
ConditionsYield
Stage #1: gemcitabine With pyridine; chloro-trimethyl-silane at 4 - 20℃; for 1.5h; Inert atmosphere;
Stage #2: benzyl chloroformate In methanol at 20℃; Inert atmosphere;
91%
gemcitabine
95058-81-4

gemcitabine

4-amino-1-(2-deoxy-2,2’-difluoro-β-D-erythro-pentofuranosyl)-5-iodopyrimidin-2(1H)-one
95058-82-5

4-amino-1-(2-deoxy-2,2’-difluoro-β-D-erythro-pentofuranosyl)-5-iodopyrimidin-2(1H)-one

Conditions
ConditionsYield
With hydrogen iodide; iodine In tetrachloromethane; ethanol; water at 45℃; for 16h;90%
gemcitabine
95058-81-4

gemcitabine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-4-methylbenzenesulfonamide
1519060-68-4

N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-4-methylbenzenesulfonamide

Conditions
ConditionsYield
With pyridine; chloro-trimethyl-silane; ammonia In methanol Inert atmosphere;90%
With pyridine; chloro-trimethyl-silane at 20℃; for 2h; Inert atmosphere;83%
vinyl myristate
5809-91-6

vinyl myristate

gemcitabine
95058-81-4

gemcitabine

O5’-tetradecanoyl-2',2'-difluoro-2'-deoxycytidine

O5’-tetradecanoyl-2',2'-difluoro-2'-deoxycytidine

Conditions
ConditionsYield
With pyridine; lipase B Candida antarctica In hexane at 50℃; for 6h; Enzymatic reaction;89%
N-(pyridin-4-carbonyl)-D-Ala-L-Proline

N-(pyridin-4-carbonyl)-D-Ala-L-Proline

gemcitabine
95058-81-4

gemcitabine

C23H26F2N6O7

C23H26F2N6O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide87%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

gemcitabine
95058-81-4

gemcitabine

tert-butyl [1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamate

tert-butyl [1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 18h;86%
In N,N-dimethyl-formamide at 50℃; for 18h;86%
(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

gemcitabine
95058-81-4

gemcitabine

C21H27F2N4O8P

C21H27F2N4O8P

Conditions
ConditionsYield
In tetrahydrofuran at 0℃;85%
(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
1334513-02-8

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

gemcitabine
95058-81-4

gemcitabine

isopropyl ((S)-(((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((S)-(((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 22h; Inert atmosphere; diastereoselective reaction;83%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

gemcitabine
95058-81-4

gemcitabine

(9H-fluoren-9-yl)methyl (1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

(9H-fluoren-9-yl)methyl (1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Conditions
ConditionsYield
Stage #1: gemcitabine With pyridine; chloro-trimethyl-silane for 0.333333h;
Stage #2: (fluorenylmethoxy)carbonyl chloride In water for 2.5h;
80.9%
Stage #1: gemcitabine With 1H-imidazole; dmap; tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃;
Stage #2: (fluorenylmethoxy)carbonyl chloride With pyridine In dichloromethane at 20℃;
Stage #3: With pyridine hydrogenfluoride In tetrahydrofuran at 20℃; for 24h;
79.4%
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

gemcitabine
95058-81-4

gemcitabine

C30H29F2N3O6
1421929-71-6

C30H29F2N3O6

Conditions
ConditionsYield
With pyridine at 20℃; for 4h;80%
With pyridine at 0 - 20℃; for 4h;64%
With pyridine at 0 - 20℃; for 4h;39%
(2S)-2-[(S)-(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphorylamino]propionic acid benzyl ester

(2S)-2-[(S)-(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphorylamino]propionic acid benzyl ester

gemcitabine
95058-81-4

gemcitabine

benzyl ((S)-(((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

benzyl ((S)-(((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With pyridine; dimethylaluminum chloride In hexane at 0 - 20℃; for 20h; Inert atmosphere; diastereoselective reaction;80%
C18H26O13
807370-86-1

C18H26O13

gemcitabine
95058-81-4

gemcitabine

C27H35F2N3O16

C27H35F2N3O16

Conditions
ConditionsYield
Stage #1: C18H26O13 With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;
Stage #2: gemcitabine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
80%
gemcitabine
95058-81-4

gemcitabine

Gemcitabine monophosphate
116371-67-6

Gemcitabine monophosphate

Conditions
ConditionsYield
Stage #1: gemcitabine With trichlorophosphate at 20℃; for 0.15h; Flow reactor; Green chemistry;
Stage #2: With water at 20℃; Temperature; Flow reactor; Green chemistry; chemoselective reaction;
78%
With trimethyl phosphite; trichlorophosphate at -5℃; for 2h;53%
With recombinant deoxyribonucleoside kinase AtdNK from Arabidopsis thaliana (ecotype Columbia); ATP In aq. buffer Kinetics; Concentration; Reagent/catalyst; Enzymatic reaction;
Multi-step reaction with 5 steps
1: pyridine / 4 h / 0 - 20 °C
2: pyridine / 2 h / 0 - 20 °C
3: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / 20 °C
5: ammonium hydroxide
View Scheme
Multi-step reaction with 7 steps
1: pyridine / 4 h / 0 - 20 °C
2: pyridine / 2 h / 0 - 20 °C
3: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane
5: 1H-tetrazole; water / acetonitrile
6: pyridine; iodine; triethylamine; water
7: ammonium hydroxide
View Scheme
vinyl laurate
2146-71-6

vinyl laurate

gemcitabine
95058-81-4

gemcitabine

O5'-dodecanoyl-2',2'-difluoro-2'-deoxycytidine

O5'-dodecanoyl-2',2'-difluoro-2'-deoxycytidine

Conditions
ConditionsYield
With pyridine; lipase B Candida antarctica In hexane at 50℃; for 6h; Enzymatic reaction;76.9%
C30H33N2O8S3(1-)

C30H33N2O8S3(1-)

gemcitabine
95058-81-4

gemcitabine

C39H42F2N5O11S3(1-)

C39H42F2N5O11S3(1-)

Conditions
ConditionsYield
Stage #1: C30H33N2O8S3(1-) With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; for 0.5h;
Stage #2: gemcitabine In dimethyl sulfoxide for 15h;
75%
succinic acid anhydride
108-30-5

succinic acid anhydride

gemcitabine
95058-81-4

gemcitabine

N4-n-butyryl gemcitabine
1374587-08-2

N4-n-butyryl gemcitabine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 60℃; Inert atmosphere;75%
succinic acid
110-15-6

succinic acid

gemcitabine
95058-81-4

gemcitabine

N-(3-Carboxy-1-oxopropyl)-2'-deoxy-2',2'-difluorocytidine

N-(3-Carboxy-1-oxopropyl)-2'-deoxy-2',2'-difluorocytidine

Conditions
ConditionsYield
Stage #1: succinic acid With thionyl chloride; triethylamine In 1,4-dioxane at 110℃; for 4h; Inert atmosphere;
Stage #2: gemcitabine With triethylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
75%

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