Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
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inquiryFluorocytosine, 2022-85-7 99% in stock Capecitabine Emtricitabine intermediates Customization Our Key Technology: 1. Low Temperature Reactions 2. Coupling Reactions 3. Fluorine Chemistry 4. A
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inquiryProName: Fluorocytosine CasNo: 2022-85-7 Molecular Formula: C4H4FN3O Appearance: detailed see specifications Application: It is an important intermediate used i... DeliveryTime: In stock PackAge: 100g/bag,1kg/
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inquiryItems Standard Result Appearance White or off-white crystalline powder Off-white crystalline powder Cytosine(HPLC)
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inquiryProduct Name: Fluorocytosine CAS No:2022-85-7 Molecular Formula: C4H4FN3O Molecular Weight: 129.09 Purity:99.5%min Appearance:White crystalline powder Standard:Enterprise Specifications: Items
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inquiryProduct description: Product name Fluorocytosine CAS number 2022-85-7 Assay ≥99% Appearance White powder Capacity 200mt/year Application Capecitabine intermediate Mo
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inquiryUnique advantages for Fluorocytosine Cas 2022-85-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:2-8°C Package:1kg/foil bag, 25kg/drum or as you req
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
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inquiryAbout Product Details Fluorocytosine Chemic
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inquiryFluorocytosine Basic information Product Name: Fluorocytosine Synonyms: 4-amino-5-fluoro-2(1h)-pyrimidinon;4-Amino-5-fluoro-2(1H)-pyrmidinone;5-fluorocystosine;5-fluorocytosin;5-fluoro-c
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryEnglish name Fluorocytosine CAS RN 2022-85-7 Molecular formula C4H4FN3O Molecular weight 129.09 EINECS 217-968-7 Appearance: white powder Storage:Store in cool and dry place, away from
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inquiryFluorocytosine Chemical Properties Melting point 298-300 °C (dec.) (lit.) density 1.3990 (estimate) storage temp. 2-8°C solubility Sparingly soluble in water, slightly soluble in ethanol (96 per cent) form Crystalline Powd
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inquiryBeluga chemical professional supply High quality 5-Flucytosine CAS 2022-85-7 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China an
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2,5-difluoro-4-chloro-pyrimidine
Flucytosine
Conditions | Yield |
---|---|
With ammonia In hydrogenchloride; ethanol; water | 98.1% |
Conditions | Yield |
---|---|
Stage #1: Cytosine With hydrogen fluoride at -15 - 0℃; Inert atmosphere; Stage #2: at -20℃; for 4h; Inert atmosphere; Further stages; | 95.7% |
With 1,1,1,3',3',3'-hexafluoro-propanol; fluorine at 20℃; under 1125.11 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere; | 87.4% |
With formic acid for 1.5h; Time; Flow reactor; Autoclave; | 63% |
With formic acid; fluorine at 9℃; for 0.0833333h; Temperature; Concentration; Inert atmosphere; |
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 40 - 60℃; | 95% |
With hydrogenchloride In water at 100℃; for 4h; | 57% |
N-acetyl-5-bromocytosine
Flucytosine
Conditions | Yield |
---|---|
Stage #1: N-acetyl-5-bromocytosine With acetamide; potassium fluoride In N,N-dimethyl-formamide at 130℃; for 5h; Inert atmosphere; Stage #2: With ammonia In methanol at 40℃; for 12h; Reagent/catalyst; Solvent; Temperature; | 93% |
Flucytosine
Conditions | Yield |
---|---|
Stage #1: N-9-fluorenylmethoxycarbonyl-5-bromocytosine With potassium fluoride; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 110℃; for 10h; Inert atmosphere; Stage #2: With sodium hydroxide In 1,4-dioxane at 50℃; for 2h; Inert atmosphere; | 91.1% |
Conditions | Yield |
---|---|
Stage #1: C7H12FNO2; urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; for 1.5h; Large scale; Stage #2: With hydrogenchloride In water at 0 - 25℃; for 2h; pH=6; pH-value; Temperature; Large scale; | 84.2% |
Flucytosine
Conditions | Yield |
---|---|
With sulfuric acid; water; sodium nitrite at 1 - 20℃; for 1.7h; | 83% |
With sulfuric acid; sodium nitrite In water at 0 - 40℃; | 82% |
Conditions | Yield |
---|---|
With formic acid for 1.5h; Time; Flow reactor; Sealed tube; | A 66% B n/a |
With formic acid; fluorine for 1.5h; Flow reactor; Overall yield = 64 %; |
5-fluoro-2-(methylsulfonyl)pyrimidin-4-amine
Flucytosine
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 3h; | 66% |
β-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine
A
(2-furyl)methyl alcohol
B
Flucytosine
Conditions | Yield |
---|---|
With acetic acid at 35 - 40℃; for 1h; pH=3 - 4; Product distribution; Further Variations:; pH-values; Temperatures; | A 58% B n/a |
Flucytosine
Conditions | Yield |
---|---|
With ammonium hydroxide at 70 - 80℃; for 3h; Autoclave; Large scale; | 52% |
5-fluoro-2-(methylsulfanyl)pyrimidin-4-amine
Flucytosine
Conditions | Yield |
---|---|
With water; hydrogen bromide at 126℃; for 4h; | 51% |
Conditions | Yield |
---|---|
With hydrogen bromide | |
With hydrogen bromide |
Conditions | Yield |
---|---|
With fluorine In water at 0℃; for 1h; |
Flucytosine
Conditions | Yield |
---|---|
With ammonia In methanol at 50℃; for 5h; | 26 g |
Flucytosine
Conditions | Yield |
---|---|
With ammonia In methanol at 50℃; for 5h; Solvent; Large scale; | 2.67 kg |
Conditions | Yield |
---|---|
With pyridine at 0 - 20℃; for 16h; Inert atmosphere; | 99% |
Flucytosine
1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-(L)-erythron-pentofuranose
(L)-5’-O-(t-butyldiphenylsilyl)-2’,3-dideoxy-2’-fluoro-5-fluorocytidine
Conditions | Yield |
---|---|
Stage #1: Flucytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 1h; Stage #2: 1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-(L)-erythron-pentofuranose With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; for 4h; Inert atmosphere; | 99% |
Flucytosine
pentyl chloroformate
(5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamic acid amyl ester
Conditions | Yield |
---|---|
With pyridine; tetrabutylammomium bromide In dichloromethane at 20℃; for 1.5h; Reagent/catalyst; | 96% |
With pyridine In dichloromethane at -10 - 20℃; for 2h; Concentration; Inert atmosphere; | 94.3% |
With pyridine | 75% |
With tetra(n-butyl)ammonium hydrogensulfate; triethylamine In chloroform; water at 5 - 10℃; for 1h; | 300 g |
Conditions | Yield |
---|---|
In ammonia for 1h; | 95% |
With triethylamine In water at 100℃; for 0.0833333h; Michael addition; microwave irradiation; | 84% |
Conditions | Yield |
---|---|
In methanol at 45℃; Concentration; Temperature; Solvent; | 95% |
Flucytosine
acrylic acid methyl ester
Conditions | Yield |
---|---|
In ammonia for 1h; | 94% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h; | 93.3% |
Flucytosine
1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 5 - 10℃; for 2h; | 92.7% |
Flucytosine
1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-fluorocytosine
Conditions | Yield |
---|---|
Stage #1: Flucytosine With 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 3h; Heating; Stage #2: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; for 8h; | 91% |
Flucytosine
2-amino-1,9-dihydro-6H-purin-6-one
water
sodium hydroxide
Conditions | Yield |
---|---|
In ethanol; water byproducts: NaNO3; hydrated metal nitrate refluxed for about 10 hs in a mixt. of EtOH and triethyl orthoformate; 5-fluorocytozine and guanine added separately (molar ratio 2:1:1); mixt. refluxed for several hs; vol. reduced; pH adjusted to 7 (aq. NaOH soln.) with stirring; ppt. filtered; washed (EtOH, Et2O); oven-dried at 50-60°C; elem. anal.; | 91% |
Flucytosine
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate With triethylsilane; iodine In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: Flucytosine With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0 - 20℃; for 1h; Reagent/catalyst; Inert atmosphere; stereoselective reaction; | 91% |
Stage #1: Flucytosine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane at 25 - 130℃; Inert atmosphere; Stage #2: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate With zirconium(IV) chloride In dichloromethane at 25 - 30℃; for 6h; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
In ammonia for 4h; | 90% |
Conditions | Yield |
---|---|
With pyridine at 100℃; | 90% |
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane In toluene at 100℃; | 90% |
Flucytosine
2-amino-1,9-dihydro-6H-purin-6-one
water
sodium hydroxide
Conditions | Yield |
---|---|
In ethanol; water byproducts: NaNO3; hydrated metal nitrate refluxed for about 10 hs in a mixt. of EtOH and triethyl orthoformate; 5-fluorocytozine and guanine added separately (molar ratio 2:1:1); mixt. refluxed for several hs; vol. reduced; pH adjusted to 7 (aq. NaOH soln.) with stirring; ppt. filtered; washed (EtOH, Et2O); oven-dried at 50-60°C; elem. anal.; | 89% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 89% |
Flucytosine
1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
Conditions | Yield |
---|---|
With titanium tetrachloride In dichloromethane at 10 - 20℃; for 4h; Solvent; | 88.6% |
Stage #1: Flucytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 3h; Reflux; Stage #2: 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose With tin(IV) chloride In dichloromethane at -5℃; Inert atmosphere; Heating; | 83.6% |
Stage #1: Flucytosine With trifluorormethanesulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile for 2h; Reflux; Stage #2: 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose With trifluorormethanesulfonic acid at 20 - 55℃; | 80% |
Flucytosine
Conditions | Yield |
---|---|
Stage #1: Flucytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 4h; Vorbrueggen Nucleoside Synthesis; Reflux; Stage #2: 1,2,3-tri-O-acetyl-α,β-D-ribofuranose-5-[phenylbis(isoamyl-L-aspartyl)]phosphate With tin(IV) chloride In 1,2-dichloro-ethane at 20℃; for 3h; Reagent/catalyst; Solvent; Vorbrueggen Nucleoside Synthesis; diastereoselective reaction; | 88% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 87% |
Flucytosine
2-amino-1,9-dihydro-6H-purin-6-one
water
sodium hydroxide
Conditions | Yield |
---|---|
In ethanol; water byproducts: NaNO3; hydrated metal nitrate refluxed for about 10 hs in a mixt. of EtOH and triethyl orthoformate; 5-fluorocytozine and guanine added separately (molar ratio 2:1:1); mixt. refluxed for several hs; vol. reduced; pH adjusted to 7 (aq. NaOH soln.) with stirring; ppt. filtered; washed (EtOH, Et2O); oven-dried at 50-60°C; elem. anal.; | 86% |
Flucytosine
C13H9ClF4N4O2
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 86% |
Flucytosine
Conditions | Yield |
---|---|
Stage #1: Flucytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane at 120℃; for 12h; Inert atmosphere; Stage #2: (4-acetoxy-1,3-dioxan-2-yl)methyl benzoate With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0 - 20℃; Inert atmosphere; stereoselective reaction; | 86% |
Flucytosine
2-phenylimidazo[2,1-b][1,3]benzothiazole-3-carbaldehyde
Conditions | Yield |
---|---|
With acetic acid In ethanol for 24h; Reflux; | 85.1% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 85% |
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