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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Cas:161599-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose

Cas:161599-46-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-2-fluoro-5-methyltetrahydrofuran-3,4-diyl diacetate

Cas:161599-46-8

Min.Order:10 Gram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Manufacturer/High quality/Best price/In stock

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2',3'-di-O-Acetyl-5'-deoxy-5-fluoro-D-cytidine supplier in China

Cas:161599-46-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance A white or off-white crystalline powder White crystalline powder Solubility

High purity 2',3'-Di-O-Acetyl-5'-Deoxy-5-Fluorocytidine CAS:161599-46-8

Cas:161599-46-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1023.html Product Name 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine CAS No.

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine

Cas:161599-46-8

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine CAS NO.161599-46-8

Cas:161599-46-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine manufacturer/supplier

Cas:161599-46-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Cas161599-46-8 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry pla

High quality 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Cas161599-46-8 with best price

Cas:161599-46-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine[CAS:161599-46-8] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contra

Good quality 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine

Cas:161599-46-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2',3'-Di-O-Acetyl-5'-Deoxy-5-Fluoro-D-Cytidine

Cas:161599-46-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 161599-46-8 GMP Manufacturer

Cas:161599-46-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine

Cas:161599-46-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:2',3'-DI-O-ACETYL-5'-DEOXY-5-FLUOROCYTIDINE CAS:161599-46-8 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

High quality 2',3'-di-O-Acetyl-5'-deoxy-5-fluoro-D-cytidine supplier in China

Cas:161599-46-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--161599-46-8-- 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we

TIANFUCHEM--161599-46-8-- 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine in stock

Cas:161599-46-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Item Specification Test Results Appearance White crystalline powder Conform

China Largest Factory Manufacturer Supply High Quality 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine CAS 161599-46-8

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2′, 3′-Di-O-Acetyl-5′-Deoxy-5-Fuluro-D-Cytidine Pharmaceutical Chemical CAS 161599-46-8

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 161599-46-8 with best quality

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS:161599-46-8 ,Cytidine,5'-deoxy-5-fluoro-, 2',3'-diacetate

Cas:161599-46-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine/ LIDE PHARMA- Factory supply / Best price

Cas:161599-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product name 2’,3’-Di-O-Acetyl-5’-Deoxy-5-Fluoro Cytidine Synonyms 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine CAS N

2’,3’-Di-O-acetyl-5’-deoxy-5-fuluro-D-cytidine

Cas:161599-46-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Capecitabine Intermediates//2',3'-Di-O-Acetyl-5'-Deoxy-5-Fluorocytidine CAS 161599-46-8

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $260.0 / 300.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cytidine,5'-deoxy-5-fluoro-, 2',3'-diacetate 161599-46-8

Cas:161599-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Cas:161599-46-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine CAS: 161599-46-8 MF: C13H16FN3O6 MW: 329.28 EINECS: 605-260-4 Mol File: 161599-46-8.mol 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Structure

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Cas:161599-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Cas:161599-46-8

Min.Order:1 Kilogram

FOB Price: $75.0 / 89.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine CAS:161599-46-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine CAS:161599-46-8

Cas:161599-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-2-fluoro-5-methyltetrahydrofuran-3,4-diyl diacetate

Cas:161599-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Flucytosine
2022-85-7

Flucytosine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at 10 - 20℃; for 4h; Solvent;88.6%
Stage #1: Flucytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 3h; Reflux;
Stage #2: 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose With tin(IV) chloride In dichloromethane at -5℃; Inert atmosphere; Heating;
83.6%
Stage #1: Flucytosine With trifluorormethanesulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile for 2h; Reflux;
Stage #2: 1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose With trifluorormethanesulfonic acid at 20 - 55℃;
80%
di-O-acetyl-5-deoxy-ξ-D-ribofuranosyl chloride
110022-91-8

di-O-acetyl-5-deoxy-ξ-D-ribofuranosyl chloride

2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine
111878-21-8

2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Stage #1: di-O-acetyl-5-deoxy-ξ-D-ribofuranosyl chloride; 2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine In 1,2-dichloro-ethane for 4h; Inert atmosphere; Schlenk technique; Reflux;
Stage #2: With water Inert atmosphere; Schlenk technique;
86%
5-fluoro-2-trimethylsilanyloxy-pyrimidin-4-ylamine
41108-04-7

5-fluoro-2-trimethylsilanyloxy-pyrimidin-4-ylamine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With tin(IV) chloride; sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃; for 0.5h;78.4%
5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose
37076-71-4

5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose

5-fluorocytosine

5-fluorocytosine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Stage #1: 5-fluorocytosine With 1,1,1,3,3,3-hexamethyl-disilazane In toluene for 4h; Autoclave; Reflux; Industrial scale;
Stage #2: 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose With tin(IV) chloride In dichloromethane at 2 - 20℃; for 12h; Industrial scale;
74%
5'-deoxy-5-fluorocytidine
66335-38-4

5'-deoxy-5-fluorocytidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With acetic anhydride In pyridine; water
5'-deoxy-2',3'-di-O-acetyl-5-fluoro-N4-((5-nitrothien-2-yl)methoxycarbonyl)cytidine
880633-97-6

5'-deoxy-2',3'-di-O-acetyl-5-fluoro-N4-((5-nitrothien-2-yl)methoxycarbonyl)cytidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
In water; isopropyl alcohol G-values; Irradiation;
acetic anhydride
108-24-7

acetic anhydride

5'-deoxy-5-fluorocytidine
66335-38-4

5'-deoxy-5-fluorocytidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With pyridine at 0℃; for 3h;
With pyridine at 0℃; for 3h;
Flucytosine
2022-85-7

Flucytosine

5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose
37076-71-4

5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Stage #1: Flucytosine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In toluene at 110℃; for 0.5h;
Stage #2: 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose With tin(IV) chloride In dichloromethane at 0 - 30℃;
Stage #3: With water; sodium hydrogencarbonate In dichloromethane for 2h;
5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose
37076-71-4

5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose

5-fluoro-2-trimethylsilanyloxy-pyrimidin-4-ylamine
41108-04-7

5-fluoro-2-trimethylsilanyloxy-pyrimidin-4-ylamine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
tin(IV) chloride In dichloromethane at 0℃; for 2h;
2',3',5'-tri-O-acetyl-5-fluorocytidine
128963-10-0

2',3',5'-tri-O-acetyl-5-fluorocytidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 1.5 h / 0 °C
2: alcalase enzyme cross linked aggregate / ethanol / 100 h / 20 °C / Enzymatic reaction
3: carbon tetrabromide / dichloromethane / 3 h / 20 °C / Inert atmosphere
4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / tetrahydrofuran / Reflux
View Scheme
N1-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluoro-N4-(n-pentyloxycarbonyl)cytosine
396684-34-7

N1-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-5-fluoro-N4-(n-pentyloxycarbonyl)cytosine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: alcalase enzyme cross linked aggregate / ethanol / 100 h / 20 °C / Enzymatic reaction
2: carbon tetrabromide / dichloromethane / 3 h / 20 °C / Inert atmosphere
3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / tetrahydrofuran / Reflux
View Scheme
2',3'-di-O-acetyl-5-fluoro-N4-(pentyloxycarbonyl)cytidine

2',3'-di-O-acetyl-5-fluoro-N4-(pentyloxycarbonyl)cytidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: carbon tetrabromide / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / tetrahydrofuran / Reflux
View Scheme
5'-bromo-2',3'-di-O-acetyl-5-fluoro-N4-(pentyloxycarbonyl)cytidine

5'-bromo-2',3'-di-O-acetyl-5-fluoro-N4-(pentyloxycarbonyl)cytidine

A

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

B

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine
162204-20-8

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In tetrahydrofuran Reflux; Overall yield = 45 %;
methyl 2,3-O-isopropylidene-5-O-p-tolylsulfonyl-β-D-ribofuranoside
4137-56-8

methyl 2,3-O-isopropylidene-5-O-p-tolylsulfonyl-β-D-ribofuranoside

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / dimethyl sulfoxide
2: sulfuric acid / water / 80 - 90 °C / Large scale
3: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
4: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; acetic acid / dimethyl sulfoxide / 20 h / 80 - 85 °C
2.1: sulfuric acid / 17 h / 80 - 90 °C
2.2: 16 h / 20 °C
3.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 100 °C
3.2: 2.33 h / 20 °C / Cooling with ice
View Scheme
methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside
23202-81-5

methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / water / 80 - 90 °C / Large scale
2: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
3: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sulfuric acid / 17 h / 80 - 90 °C
1.2: 16 h / 20 °C
2.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 100 °C
2.2: 2.33 h / 20 °C / Cooling with ice
View Scheme
(2R,3R,4S,5R)-5-methyltetrahydrofuran-2,3,4-triol
279673-09-5

(2R,3R,4S,5R)-5-methyltetrahydrofuran-2,3,4-triol

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
2: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine
111878-21-8

2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at 5 - 10℃;
With tin(IV) chloride In dichloromethane at -1 - 10℃; Temperature; Inert atmosphere;31 g
β-D-ribofuranose
36468-53-8

β-D-ribofuranose

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sulfuric acid / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: sodium tetrahydroborate; lithium chloride / diethylene glycol dimethyl ether / 20 h / 80 - 90 °C
4: sulfuric acid / water / 80 - 90 °C / Large scale
5: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
6: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sulfuric acid; tin(II) chloride dihdyrate / 40 - 45 °C
2.1: pyridine / dichloromethane / 20 h / 0 - 5 °C
3.1: sodium tetrahydroborate; acetic acid / dimethyl sulfoxide / 20 h / 80 - 85 °C
4.1: sulfuric acid / 17 h / 80 - 90 °C
4.2: 16 h / 20 °C
5.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 100 °C
5.2: 2.33 h / 20 °C / Cooling with ice
View Scheme
((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
4099-85-8

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: sodium tetrahydroborate; lithium chloride / diethylene glycol dimethyl ether / 20 h / 80 - 90 °C
3: sulfuric acid / water / 80 - 90 °C / Large scale
4: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
5: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 20 h / 0 - 5 °C
2.1: sodium tetrahydroborate; acetic acid / dimethyl sulfoxide / 20 h / 80 - 85 °C
3.1: sulfuric acid / 17 h / 80 - 90 °C
3.2: 16 h / 20 °C
4.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 100 °C
4.2: 2.33 h / 20 °C / Cooling with ice
View Scheme
1-O-methyl-2,3-O-isopropylidene-5-O-(methanesulfonyl)-β-D-ribofuranoside
50610-99-6, 75100-24-2, 81026-76-8, 96896-28-5

1-O-methyl-2,3-O-isopropylidene-5-O-(methanesulfonyl)-β-D-ribofuranoside

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; lithium chloride / diethylene glycol dimethyl ether / 20 h / 80 - 90 °C
2: sulfuric acid / water / 80 - 90 °C / Large scale
3: triethylamine; dmap / 4 h / -5 - 5 °C / Large scale
4: tin(IV) chloride / dichloromethane / 5 - 10 °C
View Scheme
(3aS,4S,6aR)-4-(iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
50600-40-3

(3aS,4S,6aR)-4-(iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethylpiperidine hypophosphite; di-isopropyl azodicarboxylate; triethylamine / 1,4-dioxane / Reflux; Inert atmosphere
2.1: sulfuric acid / water / 2 h / Reflux
2.2: 20 h / 20 °C
3.1: tin(IV) chloride; sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; triethylamine / palladium on activated charcoal / methanol / 24 h / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 2 h / Reflux
3: pyridine / 24 h / 20 °C
4: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
1-O-methyl-2,3-O-isopropylidene-5-deoxy-D-ribofuranose
78341-97-6

1-O-methyl-2,3-O-isopropylidene-5-deoxy-D-ribofuranose

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / water / 2 h / Reflux
1.2: 20 h / 20 °C
2.1: tin(IV) chloride; sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride; water / 2 h / Reflux
2: pyridine / 24 h / 20 °C
3: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogenchloride / water / 3 h / Reflux
2.1: triethylamine / dichloromethane / 4 h / 0 - 5 °C
3.1: sodium iodide / acetonitrile / 12 h / Reflux
4.1: 1-ethylpiperidine hypophosphite; di-isopropyl azodicarboxylate; triethylamine / 1,4-dioxane / Reflux; Inert atmosphere
5.1: sulfuric acid / water / 2 h / Reflux
5.2: 20 h / 20 °C
6.1: tin(IV) chloride; sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1: hydrogenchloride / water / 2 h / Reflux
2: pyridine / 18 h / 20 °C
3: sodium iodide / butanone / 24 h / Reflux
4: hydrogen; triethylamine / palladium on activated charcoal / methanol / 24 h / 20 °C / Inert atmosphere
5: hydrogenchloride; water / 2 h / Reflux
6: pyridine / 24 h / 20 °C
7: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 4 h / 0 - 5 °C
2.1: sodium iodide / acetonitrile / 12 h / Reflux
3.1: 1-ethylpiperidine hypophosphite; di-isopropyl azodicarboxylate; triethylamine / 1,4-dioxane / Reflux; Inert atmosphere
4.1: sulfuric acid / water / 2 h / Reflux
4.2: 20 h / 20 °C
5.1: tin(IV) chloride; sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1: pyridine / 18 h / 20 °C
2: sodium iodide / butanone / 24 h / Reflux
3: hydrogen; triethylamine / palladium on activated charcoal / methanol / 24 h / 20 °C / Inert atmosphere
4: hydrogenchloride; water / 2 h / Reflux
5: pyridine / 24 h / 20 °C
6: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
((3aR,4R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate
4137-56-8, 5531-22-6, 6953-71-5, 52631-00-2, 63087-95-6, 84894-43-9, 13007-50-6

((3aR,4R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl 4-methylbenzenesulfonate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium iodide / acetonitrile / 12 h / Reflux
2.1: 1-ethylpiperidine hypophosphite; di-isopropyl azodicarboxylate; triethylamine / 1,4-dioxane / Reflux; Inert atmosphere
3.1: sulfuric acid / water / 2 h / Reflux
3.2: 20 h / 20 °C
4.1: tin(IV) chloride; sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium iodide / butanone / 24 h / Reflux
2: hydrogen; triethylamine / palladium on activated charcoal / methanol / 24 h / 20 °C / Inert atmosphere
3: hydrogenchloride; water / 2 h / Reflux
4: pyridine / 24 h / 20 °C
5: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
5-O-deoxy-D-ribofuranose
158112-55-1

5-O-deoxy-D-ribofuranose

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 24 h / 20 °C
2: tin(IV) chloride / dichloromethane / 2 h / 0 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluorocytidine
66335-38-4

5'-deoxy-5-fluorocytidine

Conditions
ConditionsYield
With ammonia In methanol; water at 45 - 55℃; Product distribution / selectivity;95%
With methanol; diethylamine at 20 - 50℃; for 2h; Inert atmosphere;80%
With methanol; diethylamine at 55℃; for 2h;
pentyl chloroformate
638-41-5

pentyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine
162204-20-8

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine

Conditions
ConditionsYield
With potassium phosphate In dichloromethane; isopropyl alcohol at 0 - 25℃; for 4h; Reagent/catalyst; Inert atmosphere;94.2%
With pyridine In dichloromethane at 0℃; for 1h;93%
With dmap; potassium carbonate In dichloromethane at 5℃; for 0.75h; Temperature; Solvent; Reagent/catalyst;90.6%
pentan-1-ol
71-41-0

pentan-1-ol

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine
162204-20-8

N1-(2',3'-di-O-acetyl-5'-deoxy-β-D-ribofuranosyl)-5-fluoro-N4-(pentyloxycarbonyl)cytosine

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h;91.6%
1,3-thiazolone formyl chloride

1,3-thiazolone formyl chloride

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

C17H19FN4O8S

C17H19FN4O8S

Conditions
ConditionsYield
With pyridine In dichloromethane at -15 - 20℃; for 2h;85%
3,7,11,15-tetramethyl-hexadecyl chloroformate

3,7,11,15-tetramethyl-hexadecyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

2’,3’-di-O-acetyl-5’-deoxy-5-fluoro-N4-(3,7,11,15-tetramethylhexadecyloxycarbonyl)cytidine

2’,3’-di-O-acetyl-5’-deoxy-5-fluoro-N4-(3,7,11,15-tetramethylhexadecyloxycarbonyl)cytidine

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;84.1%
CH2 Cl

CH2 Cl

neopentyl chloroformate
20412-38-8

neopentyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(neopentyloxycarbonyl)-cytidine
162204-44-6

5'-deoxy-5-fluoro-N4-(neopentyloxycarbonyl)-cytidine

Conditions
ConditionsYield
With pyridine; sodium hydroxide; sodium carbonate In methanol; ethanol; dichloromethane84%
pentyl chloroformate
638-41-5

pentyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

capecitabine
154361-50-9

capecitabine

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 30℃; for 5h; Green chemistry;82%
Stage #1: pentyl chloroformate; (2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate With pyridine In dichloromethane at 0℃; for 1h;
Stage #2: With sodium hydroxide In ethanol; water at -5 - 0℃; for 0.233333h;
80.2%
Multi-step reaction with 2 steps
1: dichloromethane
2: sodium hydroxide / methanol
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 1 h / 0 °C
2: sodium methylate / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium phosphate / isopropyl alcohol; dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere
2: sodium hydroxide / methanol; water / 1 h / -10 - 5 °C / Autoclave
View Scheme
pentyl chloroformate
638-41-5

pentyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

C27H42FN3O10

C27H42FN3O10

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 30℃; for 1h; Flow reactor;35%
n-hexyl chloroformate
6092-54-2

n-hexyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-hexyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester
162204-21-9

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-hexyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
n-heptyl chloroformate
33758-34-8

n-heptyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-heptyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-heptyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
octyl chloroformate
7452-59-7

octyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-octyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester
161599-33-3

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-octyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
chloroformic acid n-nonyl ester
57045-82-6

chloroformic acid n-nonyl ester

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-nonyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-nonyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
3,5-dichlorobenzoyl chloride
2905-62-6

3,5-dichlorobenzoyl chloride

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dichloro-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dichloro-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(4-ethoxycarbonylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(4-ethoxycarbonylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[5-fluoro-2-oxo-4-(3,4,5-trimethoxy-benzoylamino)-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester
161599-31-1

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[5-fluoro-2-oxo-4-(3,4,5-trimethoxy-benzoylamino)-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
3,5-dimethoxybenzoyl chloride
17213-57-9

3,5-dimethoxybenzoyl chloride

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dimethoxy-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dimethoxy-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
methyl chloroformate
79-22-1

methyl chloroformate

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-methoxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-4-methoxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
carbonochloridic acid, butyl ester
592-34-7

carbonochloridic acid, butyl ester

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(4-butoxycarbonylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester
162204-19-5

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(4-butoxycarbonylamino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
3,5-dimethylbenzoyl chloride
6613-44-1

3,5-dimethylbenzoyl chloride

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dimethyl-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-[4-(3,5-dimethyl-benzoylamino)-5-fluoro-2-oxo-2H-pyrimidin-1-yl]-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

propoxycarbonyl chloride
109-61-5

propoxycarbonyl chloride

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-2-oxo-4-propoxycarbonylamino-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester
162204-18-4

Acetic acid (2R,3R,4R,5R)-4-acetoxy-2-(5-fluoro-2-oxo-4-propoxycarbonylamino-2H-pyrimidin-1-yl)-5-methyl-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -20 - 20℃; Acylation;
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine
124012-42-6

5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / -20 - 20 °C
2: NaOH / methanol; H2O / -20 - -5 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(methoxycarbonyl)cytidine

5'-deoxy-5-fluoro-N4-(methoxycarbonyl)cytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / -20 - 20 °C
2: NaOH / methanol; H2O / -20 - -5 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(ethoxycarbonyl)cytidine

5'-deoxy-5-fluoro-N4-(ethoxycarbonyl)cytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / -20 - 20 °C
2: NaOH / methanol; H2O / -20 - -5 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(propoxycarbonyl)cytidine

5'-deoxy-5-fluoro-N4-(propoxycarbonyl)cytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / -20 - 20 °C
2: NaOH / methanol; H2O / -20 - -5 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

5'-deoxy-5-fluoro-N4-(butoxycarbonyl)cytidine

5'-deoxy-5-fluoro-N4-(butoxycarbonyl)cytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / CH2Cl2 / -20 - 20 °C
2: NaOH / methanol; H2O / -20 - -5 °C
View Scheme
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate
161599-46-8

(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

capecitabine
154361-50-9

capecitabine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1311 g / pyridine / CH2Cl2 / -20 - 20 °C
2: 170 g / NaOH / methanol; H2O / -20 - -5 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 20 - 30 °C / Inert atmosphere
2: sodium hydroxide / acetone / 2 h / -15 - 10 °C
View Scheme
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