Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:134790-39-9
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryHigh quality 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate CAS 134790-39-9 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Ph
Cas:134790-39-9
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Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:134790-39-9
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/554.html Product Name 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate
Cas:134790-39-9
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inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:134790-39-9
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:134790-39-9
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Chemical Properties Melting point 229-232°C Boiling point 608.4±65.0 °C(Predicted) density 1.45±0.1 g/cm3(Predicted) storage temp. Sealed in dr
Cas:134790-39-9
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inquiry2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate CAS:134790-39-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interme
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquirywe are reliable supplier for APIs and intermediates for international markets. We supply good quality with competitive price. We pursue long term business relations and win-win. Storage:Refrigerator Package:25kg/drum Application
Cas:134790-39-9
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
Cas:134790-39-9
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Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:134790-39-9
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inquiryProduct name: 3',5'-Di-O-Benzoyl--2,2'-Difluoro-2'-Deoxy Cytidine CAS No.: 134790-39-9 Molecule Formula:C23H19F2N3O6 Molecule Weight:471.41 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standard
Cas:134790-39-9
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:134790-39-9
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:134790-39-9
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:134790-39-9
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Cas:134790-39-9
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Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:134790-39-9
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryProduct Name: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Synonyms: 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate (Gemcitabine impurity);2'-deoxy-2,2'-difluoro-3,5-dibenzyl-cytidine;2',
Cas:134790-39-9
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiry3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
2,4-O,N-bis(trimethylsilyl)cytosine
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
In toluene at 120℃; for 6h; Temperature; | 97.38% |
4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With phosphomolybdic acid In pentan-1-ol at 70 - 137℃; for 5h; Reagent/catalyst; Solvent; Temperature; Reflux; | 95% |
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
2,4-O,N-bis(trimethylsilyl)cytosine
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
at 120℃; for 3h; Heating; | 85.5% |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
2,4-O,N-bis(trimethylsilyl)cytosine
A
C23H19F2N3O6
B
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given; |
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 5 - 20 °C 2: 3 h / 120 °C / Heating View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme |
Cytosine
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
A
C23H19F2N3O6
B
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With potassium sulfate; lithium chloride at 120 - 125℃; for 4h; Overall yield = 85.7 %; Overall yield = 405.2 g; | A n/a B n/a |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / 50 - 60 °C 2: 3 h / 120 °C / Heating View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; acetic acid In water; ethyl acetate at 50 - 60℃; under 3750.38 Torr; for 18h; | 95.6% |
Stage #1: (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate With hydrogenchloride In water; ethyl acetate for 0.0833333h; Stage #2: With formic acid; 5%-palladium/activated carbon In water; ethyl acetate at 68 - 70℃; for 24h; Inert atmosphere; |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
gemcitabine
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 3h; | 82.7% |
With sodium t-butanolate In methanol at 20℃; for 2h; |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With ammonia In methanol |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: dmap / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: N,N-lutidine / N,N-dimethyl-formamide / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C View Scheme |
di-tert-butyl dicarbonate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With dmap; triethylamine In 1,4-dioxane at 40℃; for 5h; | |
With N,N-lutidine In 1,4-dioxane at 40℃; for 5h; |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
2,4-O,N-bis(trimethylsilyl)cytosine
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
In toluene at 120℃; for 6h; Temperature; | 97.38% |
4-Amino-1-trimethylsilanyl-1H-pyrimidin-2-one
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With phosphomolybdic acid In pentan-1-ol at 70 - 137℃; for 5h; Reagent/catalyst; Solvent; Temperature; Reflux; | 95% |
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
2,4-O,N-bis(trimethylsilyl)cytosine
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
at 120℃; for 3h; Heating; | 85.5% |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
2,4-O,N-bis(trimethylsilyl)cytosine
A
C23H19F2N3O6
B
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given; |
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 5 - 20 °C 2: 3 h / 120 °C / Heating View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme |
Cytosine
2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-diphenylmethyl ester-1-methanesulfonate
A
C23H19F2N3O6
B
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With potassium sulfate; lithium chloride at 120 - 125℃; for 4h; Overall yield = 85.7 %; Overall yield = 405.2 g; | A n/a B n/a |
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / 50 - 60 °C 2: 3 h / 120 °C / Heating View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; acetic acid In water; ethyl acetate at 50 - 60℃; under 3750.38 Torr; for 18h; | 95.6% |
Stage #1: (2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate With hydrogenchloride In water; ethyl acetate for 0.0833333h; Stage #2: With formic acid; 5%-palladium/activated carbon In water; ethyl acetate at 68 - 70℃; for 24h; Inert atmosphere; |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
gemcitabine
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 3h; | 82.7% |
With sodium t-butanolate In methanol at 20℃; for 2h; |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With ammonia In methanol |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
2’-deoxy-2’,2’-difluorotetrahydrouridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C 3.1: ammonia / methanol / 27 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 3 h / 40 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
(4R)-2’-deoxy-2’,2’-difluoro-3,4,5,6-tetrahydrouridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / ethyl acetate; water / 0.08 h 1.2: 24 h / 68 - 70 °C / Inert atmosphere 2.1: cerium(III) chloride heptahydrate / dichloromethane; ethanol / 0.08 h 2.2: 2 h / 0 - 6 °C 3.1: ammonia / methanol / 27 h / 25 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / water; acetonitrile / 74 h / 25 °C / Large scale 4.2: 16 h / 0 - 40 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1: acetic acid; palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 18 h / 50 - 60 °C / 3750.38 Torr 2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / water; dichloromethane; ethanol / 2 h / 6 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 3 h / 40 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / water; acetonitrile / 48 h / 20 - 30 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonium hydroxide / methanol / 3 h / 20 °C 2.1: pyridine; trichlorophosphate / 0 - 20 °C 2.2: 0.5 h / pH 3 - 4 3.1: sodium hydrogencarbonate / ethanol; water / 3 h View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / methanol / 3 h / 20 °C 2.1: pyridine; trichlorophosphate / 0 - 20 °C 2.2: 0.5 h / pH 3 - 4 View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: triethylamine / dichloromethane / 20 °C 4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C 3: dmap / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C 3: N,N-lutidine / N,N-dimethyl-formamide / 20 °C View Scheme |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; triethylamine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide / methanol / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-lutidine / 1,4-dioxane / 5 h / 40 °C 2: sodium hydroxide; sodium methylate / 4 h / 20 °C View Scheme |
di-tert-butyl dicarbonate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With dmap; triethylamine In 1,4-dioxane at 40℃; for 5h; | |
With N,N-lutidine In 1,4-dioxane at 40℃; for 5h; |
n-decyl chloroformate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1.5h; |
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
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