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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------
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inquiryProduct Description Product Name 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate CAS No. 122111-01-7 Appearance White powder Assay ≥99% Capacity 200
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inquiryUnique advantages of 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate Cas 122111-01-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:97%min Storage:cool dry plac
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate CAS NO: 122111-01-7 Grade:Medical scientific research and export Molecular formula:C19H14F2O6 Molecular weight:376.3077 Product Quality 12 years of chemical raw materia
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inquiryTIANFUCHEM--122111-01-7-- 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China
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inquiryAbout Product Details Item Specification Test Results Appearance White crystalline powder Conform
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Name 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate CAS NO 122111-01-7 Appearance White crystalline powder Assay 99.0-101.0%
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:white Storage:Sealed in dr
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiry2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate CAS:122111-01-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:122111-01-7
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inquirybenzoyl chloride
2-deoxy-2,2-difluoro-1-carbonylribose
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane for 1.5h; Reflux; | 67% |
With pyridine; dmap In ethyl acetate at 20℃; for 12h; Reflux; | 58.3 g |
With pyridine In dichloromethane at 0 - 20℃; for 0.666667h; | |
With pyridine; dmap at 30 - 50℃; for 8h; Inert atmosphere; Large scale; |
C19H16F2O7
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
toluene-4-sulfonic acid In toluene Product distribution / selectivity; Heating / reflux; Dean and Stark apparatus; | 34% |
benzoyl chloride
2-deoxy-2,2-difluoro-1-carbonylribose
B
C19H16F2O7
C
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
With pyridine; dmap In ethyl acetate at 60 - 65℃; for 6h; Product distribution / selectivity; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
toluene-4-sulfonic acid In toluene Product distribution / selectivity; Heating / reflux; Dean and Stark apparatus; |
pyridine
benzoyl chloride
2-deoxy-2,2-difluoro-1-carbonylribose
A
pyridine hydrochloride
B
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
With dmap In ethyl acetate at 60 - 65℃; for 6.25h; |
ethyl 2-deoxy-2,2-difluoro-D-erythro,D-threo-pentonate
benzoyl chloride
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Stage #1: ethyl 2-deoxy-2,2-difluoro-D-erythro,D-threo-pentonate; toluene-4-sulfonic acid In water at 75 - 80℃; for 3h; Stage #2: benzoyl chloride With pyridine; dmap In ethyl acetate at 60 - 65℃; for 3h; Product distribution / selectivity; Dean and Stark apparatus; |
benzoyl chloride
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
With pyridine In ethyl acetate at 25 - 60℃; Inert atmosphere; |
benzoyl chloride
ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Stage #1: ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate With water; pyridinium trifluroacetate In water; acetonitrile for 3h; Heating / reflux; Stage #2: benzoyl chloride With pyridine; dmap In ethyl acetate at 0 - 65℃; for 10h; Product distribution / selectivity; | |
Stage #1: ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate With water; pyridinium p-toluenesulfonate In water; acetonitrile for 12h; Heating / reflux; Stage #2: benzoyl chloride With pyridine; dmap In ethyl acetate at 0 - 65℃; for 10h; Product distribution / selectivity; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetic acid / chloroform / 2 h / 50 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h 2.2: 2 h / 25 °C 3.1: pyridine; dmap / dichloromethane / 1.5 h / Reflux View Scheme |
ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 70 - 80 °C / Large scale 2: pyridine; dmap / 8 h / 30 - 50 °C / Inert atmosphere; Large scale View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
Conditions | Yield |
---|---|
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran; diethyl ether at 10 - 30℃; for 1h; | 100% |
Stage #1: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran; toluene at -30℃; for 1h; Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene | 99.5% |
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran; diethyl ether at -78℃; for 1h; Inert atmosphere; | 84% |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h 4: ammonia / methanol View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-acetamidopyrimidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,2-dichloroethane, 30 deg C, 1 h, 2) 1,2-dichloroethane, 83 deg C, overnight View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
2’-deoxy-2’,2’-difluoro-cytidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,2-dichloroethane, 30 deg C, 1 h, 2) 1,2-dichloroethane, 83 deg C, overnight 4: 1.73 kg / ammonia (gas) / methanol / Ambient temperature View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium tri-(tert-butoxy)aluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C23H19F2N3O6
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 3: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
With hydrogenchloride In water at 45 - 50℃; for 3h; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Stage #1: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran; toluene at -70 - -50℃; for 1h; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran; toluene for 0.5h; | |
With lithium tri-t-butoxyaluminum hydride In tetrahydrofuran; diethyl ether at 20℃; for 1.5h; Inert atmosphere; Overall yield = 99.8 %; Overall yield = 10 g; | A n/a B n/a |
With sodium tetrahydroborate; zinc(II) chloride; tert-butyl alcohol In tetrahydrofuran; ethyl acetate at 15℃; Overall yield = 100 %; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Stage #1: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate With C10H22(3)HB In tetrahydrofuran at 0 - 20℃; for 17.5h; Inert atmosphere; Cooling with ice; Stage #2: With water In tetrahydrofuran for 0.5h; Inert atmosphere; Reflux; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
Conditions | Yield |
---|---|
Stage #1: 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate With C10H22(2)HB In tetrahydrofuran at 0 - 20℃; for 17.5h; Inert atmosphere; Cooling with ice; Stage #2: With water In tetrahydrofuran for 0.5h; Inert atmosphere; Reflux; |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-chlorouracil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)thymine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C25H25F2IN3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C19H21F2IN3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C29H27F2IN3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C23H23F2IN3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C25H25BrF2N3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
C25H25ClF2N3O9P
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite 5.1: 1-methyl-1H-imidazole / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-bromouracil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C 4.1: sodium methylate / methanol / 20 °C / Inert atmosphere 4.2: Amberlite View Scheme |
2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate
A
1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate / 1,1-dichloroethane / 10 h / 90 - 100 °C / Inert atmosphere 3.2: 20 °C View Scheme |
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