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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

buy-LAMIVUDINE

Cas:134678-17-4

Min.Order:0

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Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price Lamivudine / 3-TC powder

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 999.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product informations Product Name 4-Amino-1-(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one CAS No.

4-Amino-1-(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

Cas:134678-17-4

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white solid Storage:Freezer Package:1kg/foil bag

Favorable price Lamivudine CAS 134678-17-4 of USP standard

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $180.0 / 230.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Lamivudine manufacturer with low price

Cas:134678-17-4

Min.Order:1 Gram

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Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Lamivudine 134678-17-4 ISO Producer

Cas:134678-17-4

Min.Order:1 Gram

FOB Price: $0.1

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

GMP certificated Specification:USp high purity Appearance:whilt powder Storage:cool and dryer Package:durm Application:API Transportation:by sea or by ar Port:shandong

Lamivudine CAS NO.134678-17-4

Cas:134678-17-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Lamivudine

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Lamivudine

Cas:134678-17-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Lamivudine 134678-17-4

Cas:134678-17-4

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Lamivudine CAS NO: 134678-17-4 Grade:Medical scientific research and export Molecular formula:C8H11N3O3S Molecular weight:229.2562 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability D

Lamivudine/cas:134678-17-4/Raw material spot

Cas:134678-17-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Ality Chemical Corporation

Lamivudine Basic information New antiviral drug Methods of production What kind of patients suitable for use Lamivudine Zidovudine Pharmacokinetics drug withdrawal Adverse reactions and side effects Disabling condition Chemical property Uses Pro

Factory Supply Lamivudine

Cas:134678-17-4

Min.Order:1 Gram

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Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Lamivudine 134678-17-4

Cas:134678-17-4

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

High Quality API Pharmaceutical Hepatitis B Lamivudine Powder CAS 134678-17-4

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 134678-17-4 with best quality

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Lamivudine

Cas:134678-17-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Lamivudine/ LIDE PHARMA- Factory supply / Best price

Cas:134678-17-4

Min.Order:0

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Henan Sinotech Import&Export Corporation

134678-17-4;131086-21-0 Lamivudine product Name Lamivudine Synonyms 2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-,(2R-

Lamivudine, 134678-17-4

Cas:134678-17-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:25kg/drum Application:API, New antiviral drugs Transportation:Express/Air/Sea Port:Any port in china

High Purity Lamivudine(3TC) Antiviral Drug

Cas:134678-17-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1.Good capacity; 2.Safe deliver 3. High quality with best price Appearance:White Powder Storage:Dry and cool place Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Application:For Pharmaceutical Intermediates Transportation:By DHL, TNT

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Lamivudine 134678-17-4

Cas:134678-17-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Lamivudine

Cas:134678-17-4

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Lamivudine CAS: 134678-17-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Lamivudine CAS: 134678-17-4

Cas:134678-17-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

CAS 134678-17-4 Lamivudine

Cas:134678-17-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Lamivudine

Cas:134678-17-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;

High Quality Lamivudine Powder Price CAS 134678-17-4

Cas:134678-17-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Lamivudine

Cas:134678-17-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Lamivudine

Cas:134678-17-4

Min.Order:25 Kilogram

FOB Price: $220.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie

LamivudineCAS: 134678-17-4

Cas:134678-17-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

USP Appearance:White or off- white crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Lamivudine USP Pharmaceutical Pharmaceutical API Antiviral drugs Nucleoside made in china

Cas:134678-17-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

C9H11N3O4S*CH4O

C9H11N3O4S*CH4O

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With sodium tetrahydroborate; ethanol at 0 - 20℃; for 4h;97.9%
Carbonic acid (2R,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

Carbonic acid (2R,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With potassium carbonate In methanol at 0℃; for 10h;95%
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-[2-oxo-4-(phenylcarboxamido)-1,2-dihydro-1-pyrimidinyl]-1,3-oxathiolane-2-carboxylate With methanol at 40℃; Inert atmosphere;
Stage #2: With sodium tetrahydroborate; dipotassium hydrogenphosphate; water; sodium hydroxide In methanol at 20℃; for 1h; diastereoselective reaction;
95%
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carbaxylate
147027-10-9

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carbaxylate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 0.5h; Ambient temperature;94%
With methanol; sodium tetrahydroborate; dipotassium hydrogenphosphate; sodium hydroxide In water at 20℃; for 0.055h; Flow reactor;94%
With sodium tetrahydroborate In ethanol83%
lamivudine salicyclic acid salt
173522-96-8

lamivudine salicyclic acid salt

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With triethylamine In ethanol at 50℃; for 1h;92.63%
With triethylamine In water; ethyl acetate at 25 - 50℃; for 5h; Product distribution / selectivity;
With triethylamine In water; ethyl acetate at 45 - 50℃; for 4.5h;
4-amino-1-[(2R,5S)-(2-hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one (S)-BINOL co-crystal

4-amino-1-[(2R,5S)-(2-hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one (S)-BINOL co-crystal

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Stage #1: 4-amino-1-[(2R,5S)-(2-hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one (S)-BINOL co-crystal With hydrogenchloride In water; ethyl acetate at 20℃; for 1h; pH=3 - 4;
Stage #2: With sodium hydroxide In water pH=~ 7; Product distribution / selectivity;
90%
With hydrogenchloride In water; ethyl acetate pH=2 - 3; Large scale reaction; optical yield given as %ee;70.02%
With hydrogenchloride In water; ethyl acetate pH=2 - 2.5;
Stage #1: 4-amino-1-[(2R,5S)-(2-hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one (S)-BINOL co-crystal With hydrogenchloride In water; ethyl acetate at 20℃; for 0.0833333h; pH=3 - 4;
Stage #2: With sodium hydroxide In water pH=6.8 - 7.2; Reagent/catalyst;
7 g
In water; ethyl acetate at 2 - 45℃; Industrial scale;33.3 kg
C7H5NO4*C8H11N3O3S

C7H5NO4*C8H11N3O3S

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With triethylamine In ethanol at 70 - 75℃; Inert atmosphere; Industry scale;90%
((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 14h; Inert atmosphere;89%
(-)-cis-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one salicylate

(-)-cis-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one salicylate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With triethylamine In Isopropyl acetate; water at 23 - 27℃; for 10h; Product distribution / selectivity;88%
(2R,5S)-5-(4"-amino-2"-oxo-pyrimidin-1"-yl)-1,3-oxathiolane-2-methyl-(2'S-isopropyl-5'R-methyl-1'R-cyclohexyl)-carbonic acid diester
1012053-56-3

(2R,5S)-5-(4"-amino-2"-oxo-pyrimidin-1"-yl)-1,3-oxathiolane-2-methyl-(2'S-isopropyl-5'R-methyl-1'R-cyclohexyl)-carbonic acid diester

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With potassium carbonate In methanol at 0 - 25℃; for 3h;87.17%
With potassium carbonate In methanol at 0 - 25℃; for 2h;86%
(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine
145985-97-3

(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.5h; Ambient temperature;75%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;75%
Conditions
ConditionsYield
Stage #1: (+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine With (S)-N-acetyl-2-phenylglycine In methanol; acetone at -30 - 0℃; for 48h;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Product distribution / selectivity;
32%
Stage #1: (+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine With (S)-N-acetyl-2-phenylglycine In methanol; acetone at -30 - 0℃; for 48h; Resolution of racemate;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Purification / work up;
32%
Multi-step reaction with 3 steps
1: 95 percent / dimethylformamide / 20 °C
2: 50.6 percent / pyridine / acetonitrile / 48 h / 0 °C
3: 95 percent / K2CO3 / methanol / 10 h / 0 °C
View Scheme
Benzoic acid (2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester
143957-12-4

Benzoic acid (2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With Amberlite IRA400(OH) In ethanol Heating;
Benzoic acid (R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester

Benzoic acid (R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolan-2-ylmethyl ester

B

lamivudine
134678-17-4

lamivudine

C

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine
139757-68-9

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With Amberlit IRA400 In methanol Heating; Yield given. Yields of byproduct given;
With Amberlit IRA400 In methanol Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

B

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With ammonia In methanol Yield given. Title compound not separated from byproducts;
cis-2-(hydroxymethyl)-5-(N4-acetylcytosin-1'-yl)-1,3-oxathiolane

cis-2-(hydroxymethyl)-5-(N4-acetylcytosin-1'-yl)-1,3-oxathiolane

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 50.6 percent / pyridine / acetonitrile / 48 h / 0 °C
2: 95 percent / K2CO3 / methanol / 10 h / 0 °C
View Scheme
(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N4-acetylcytosine
139757-74-7

(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N4-acetylcytosine

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / methanolic NH3 / 3 h / Ambient temperature
2: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 73 percent / NH3 / methanol / Ambient temperature
2: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature
View Scheme
Conditions
ConditionsYield
Stage #1: (+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine With (S)-N-acetyl-2-phenylglycine In ethanol at -30 - -20℃; for 48h;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Product distribution / selectivity;
A n/a
B n/a
Stage #1: (+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine With O,O'-dibenzoyl-L-tartaric acid In methanol; acetone at -30 - 20℃; for 48h;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Product distribution / selectivity;
A n/a
B n/a
Stage #1: (+/-)-cis-N-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine With (S)-N-acetyl-2-phenylglycine In methanol; acetone at -50 - 25℃; for 48h;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Product distribution / selectivity;
A n/a
B n/a
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carbaxylate
147027-10-9

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathialane-2-carbaxylate

salicylic acid
69-72-7

salicylic acid

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate With sodium tetrahydroborate; dipotassium hydrogenphosphate In ethanol; water at 18 - 22℃; for 8 - 9h;
Stage #2: salicylic acid In water at 10 - 82℃;
(2R)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(6'-methoxy)-2'(S)-naphthalene isopropionate

(2R)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(6'-methoxy)-2'(S)-naphthalene isopropionate

A

lamivudine
134678-17-4

lamivudine

B

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine
139757-68-9

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃;
(2R)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(2'(R)-hydroxy)phenyl acetate

(2R)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(2'(R)-hydroxy)phenyl acetate

A

lamivudine
134678-17-4

lamivudine

B

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine
139757-68-9

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃;
((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate

A

lamivudine
134678-17-4

lamivudine

B

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine
139757-68-9

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃;
(2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate
1091585-31-7

(2R,5S)-5-(4'-acetamido-2'-oxo-pyrimidin-1'-yl)-1,3-oxathiolane-2-methyl-(4'-chloro)-benzoate

A

lamivudine
134678-17-4

lamivudine

B

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine
139757-68-9

(+)-(2R,5R)-1-<2-(hydroxymethyl)-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With methanol; potassium carbonate at 20℃;
(2R-cis)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

(2R-cis)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Stage #1: (2R-cis)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate With hydrogenchloride In ethanol; water at 20 - 50℃;
Stage #2: With sodium hydroxide In ethanol; water at 5 - 50℃; pH=7.5; Product distribution / selectivity;
n/a
cis-(+/-)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

cis-(+/-)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

(S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate
35193-63-6, 35193-64-7, 39648-67-4, 50574-52-2

(S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
Stage #1: cis-(+/-)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate With sodium hydroxide In water at 20 - 45℃;
Stage #2: With hydrogenchloride In ethanol; water at 20℃;
Stage #3: With sodium hydroxide In ethanol; water at 5 - 50℃; pH=7.5; Product distribution / selectivity;
n/a
4-amino-1-[(2R,5S)-2-(hydroxymethyl-1,3-oxathiolane-5-yl)-(1H)]-pyrimidin-2-one dicinnamate

4-amino-1-[(2R,5S)-2-(hydroxymethyl-1,3-oxathiolane-5-yl)-(1H)]-pyrimidin-2-one dicinnamate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With triethylamine In water; ethyl acetate at 22 - 30℃; for 4.5h;
With triethylamine In ethanol; water at 18 - 80℃;
With triethylamine In water; ethyl acetate at 22 - 30℃; for 4.5h; Product distribution / selectivity;
4-amino-1-[(2R,5S)-2-(hydroxymethyl-1,3-oxathiolane-5-yl)-(1H)]-pyrimidin-2-one succinate

4-amino-1-[(2R,5S)-2-(hydroxymethyl-1,3-oxathiolane-5-yl)-(1H)]-pyrimidin-2-one succinate

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With triethylamine In methanol; water at 22 - 30℃; for 4.5h; Product distribution / selectivity;
With triethylamine In ethanol; ethyl acetate at 47 - 80℃; Product distribution / selectivity;
Lamivudine sulfoxide

Lamivudine sulfoxide

lamivudine
134678-17-4

lamivudine

Conditions
ConditionsYield
With pyridine; tetraphosphorus decasulfide at 22 - 42℃; for 10h; Inert atmosphere;
With pyridine; tetraphosphorus decasulfide at 22 - 42℃; for 10h; Inert atmosphere;
benzoic acid anhydride
93-97-0

benzoic acid anhydride

lamivudine
134678-17-4

lamivudine

N4-benzoyl-1-(2',3'-dideoxy-3'-thia-β-L-ribofuranosyl)-cytosine

N4-benzoyl-1-(2',3'-dideoxy-3'-thia-β-L-ribofuranosyl)-cytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 24h;98%
In ethanol at 70℃; for 2.5h; Sealed tube;80%
lamivudine
134678-17-4

lamivudine

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

Conditions
ConditionsYield
Stage #1: lamivudine With diphenyl hydrogen phosphite In pyridine at 20℃; for 0.5h;
Stage #2: With triethylamine In water
95%
N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

lamivudine
134678-17-4

lamivudine

C11H16N4O3S
672313-92-7

C11H16N4O3S

Conditions
ConditionsYield
With pyridine at 20℃; for 24h;95%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

lamivudine
134678-17-4

lamivudine

(-)-5'-O-(t-butyldimethylsilyl)-2',3'-dideoxy-3'-thiacytidine
956896-97-2

(-)-5'-O-(t-butyldimethylsilyl)-2',3'-dideoxy-3'-thiacytidine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 18h;95%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;
lamivudine
134678-17-4

lamivudine

triethylamine
121-44-8

triethylamine

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

triethylammonium α-L-2',3'-dideoxy-3'-thiacytadin-5'-yl phosphonate

Conditions
ConditionsYield
Stage #1: lamivudine With diphenyl hydrogen phosphite In pyridine for 0.5h;
Stage #2: triethylamine With water In pyridine
93%
lamivudine
134678-17-4

lamivudine

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine
145985-97-3

(2R,5S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>cytosine

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 3h; Substitution;90%
lamivudine
134678-17-4

lamivudine

C8H10(125)IN3O3S

C8H10(125)IN3O3S

Conditions
ConditionsYield
With sodium (¹²⁵I)iodide; 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril In aq. buffer at 60℃; for 0.166667h; pH=7;89%
2-((2-(((4-nitrophenoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl methacrylate

2-((2-(((4-nitrophenoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl methacrylate

lamivudine
134678-17-4

lamivudine

2-((2-(((lamivudine)carbonyl)oxy)ethyl)disulfanyl)ethyl methacrylate

2-((2-(((lamivudine)carbonyl)oxy)ethyl)disulfanyl)ethyl methacrylate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;88%
cis-[RuCl2(triphenylphosphine)2(2,2′-bipyridine)]
159593-90-5, 192506-86-8

cis-[RuCl2(triphenylphosphine)2(2,2′-bipyridine)]

sodium perchlorate

sodium perchlorate

lamivudine
134678-17-4

lamivudine

trans-bis(triphenylphosphine)(lamivudinate)(2,2′-bipyridine)ruthenium(II) perchlorate

trans-bis(triphenylphosphine)(lamivudinate)(2,2′-bipyridine)ruthenium(II) perchlorate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane for 24h; Reflux; Inert atmosphere;85%
acetic anhydride
108-24-7

acetic anhydride

lamivudine
134678-17-4

lamivudine

4-acetylamino-1-[(2'R,5'S)-2'-(hydroxymethyl)-1,3-oxathiolan-5'-yl]-1,2-dihydropyrimidin-2-one
158704-08-6

4-acetylamino-1-[(2'R,5'S)-2'-(hydroxymethyl)-1,3-oxathiolan-5'-yl]-1,2-dihydropyrimidin-2-one

Conditions
ConditionsYield
Stage #1: lamivudine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: acetic anhydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
82%
lamivudine
134678-17-4

lamivudine

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate

4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate

C15H14N4O3S

C15H14N4O3S

Conditions
ConditionsYield
Stage #1: lamivudine With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: 4-cyano-N,N,N-trimethylanilinium trifluoromethansulfonate In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere; Schlenk technique;
82%
C8H10O8Pol

C8H10O8Pol

lamivudine
134678-17-4

lamivudine

C24H28N6O12PolS2

C24H28N6O12PolS2

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 60℃; for 7h; solid phase reaction;80%
dimethyl-4-nitrophenylsulfonium trifluoromethanesulfonate

dimethyl-4-nitrophenylsulfonium trifluoromethanesulfonate

lamivudine
134678-17-4

lamivudine

4-amino-1-((2R,4S)-2-((4-nitrophenoxy)methyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4S)-2-((4-nitrophenoxy)methyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; Schlenk technique;75%
ethoxycarbonylphosphonic acid
55920-71-3

ethoxycarbonylphosphonic acid

lamivudine
134678-17-4

lamivudine

3TC 5′-ethoxycarbonyl phosphonate

3TC 5′-ethoxycarbonyl phosphonate

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide73%
11-(acetylthio)undecanoic acid
6974-31-8

11-(acetylthio)undecanoic acid

lamivudine
134678-17-4

lamivudine

C21H33N3O5S2

C21H33N3O5S2

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 3h;70%
lamivudine
134678-17-4

lamivudine

(2-(2-methoxyethoxy)ethyl) (4-nitrophenyl) carbonate
105108-59-6

(2-(2-methoxyethoxy)ethyl) (4-nitrophenyl) carbonate

C14H21N3O7S
1240259-44-2

C14H21N3O7S

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione In N,N-dimethyl-formamide at 20℃; for 72h;63%
Octanoic acid
124-07-2

Octanoic acid

lamivudine
134678-17-4

lamivudine

N4-octanoyl-(−)-L-2',3'-dideoxy-3'-thiacytidine

N4-octanoyl-(−)-L-2',3'-dideoxy-3'-thiacytidine

Conditions
ConditionsYield
Stage #1: Octanoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane; N,N-dimethyl-formamide at 10℃; for 1h;
Stage #2: lamivudine In dichloromethane; N,N-dimethyl-formamide for 20h;
56%
lamivudine
134678-17-4

lamivudine

12-azidododecanoyl chloride
200720-60-1

12-azidododecanoyl chloride

(-)-N(4)-5'-di(12-azidododecanoyl)-2',3'-dideoxy-3'-thiacytidine
1373400-17-9

(-)-N(4)-5'-di(12-azidododecanoyl)-2',3'-dideoxy-3'-thiacytidine

Conditions
ConditionsYield
With dmap In benzene at 100℃; for 4h;55%
lamivudine
134678-17-4

lamivudine

methyl iodide
74-88-4

methyl iodide

4-(dimethylamino)-1-[(2R,5S)-2-(methoxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one

4-(dimethylamino)-1-[(2R,5S)-2-(methoxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one

Conditions
ConditionsYield
Stage #1: lamivudine With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; Inert atmosphere;
55%

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