Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Basic information Product Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester;4,4-Difluorocyclohexanecarboxylic
Cas:121629-14-9
Min.Order:1 Gram
Negotiable
Type:Other
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:121629-14-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryCyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester CAS:121629-14-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spec
Cas:121629-14-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:121629-14-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBoiling point 182℃ density 1.13
Cas:121629-14-9
Min.Order:100 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:121629-14-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWholesaler 121629-14-9 factory Methyl 4,4-difluorocyclohexanecarboxylate in China Molecular Formula C8H12F2O2 Molar Mass 178.18 Density 1.13 Boling Point 182℃ Flash Point 62℃ Vapo
Cas:121629-14-9
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:121629-14-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:121629-14-9
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryProduct Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester;4,4-Difluorocyclohexanecarboxylic acid methyl ester;methyl 4,4-difluorocyclohexane-1-carboxylate CAS: 121
Cas:121629-14-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryMethyl 4,4-difluorocyclohexanecarboxylate Alias: Benzene,(3,3-difluoropropyl); 1,1-difluoro-3-phenylpropane; 1,1-difluoro-4-carbomethoxy-cyclohexane; CAS RN:121629-14-9 Purity:98% Molecular formula: C8H12F2O2
Cas:121629-14-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryProductName:Methyl 4,4-difluorocyclohexanecarboxylate Synonyms:1,1-difluoro-3-phenylpropane;Benzene,(3,3-difluoropropyl);1,1-difluoro-4-carbomethoxy-cyclohexane; CAS:121629-14-9 Molecular Formula: C8H12F2O2 Molecular Weight:178.17600 Puri
Cas:121629-14-9
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Manufacturers
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Other
inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Trading Company
inquiryexcellent quality and reliable supplierAppearance:COA mentioned Storage:COA mentioned Package:Standard or custom package Application:pharmaceutical raw materails Transportation:sea/air /courier Port:China main port
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryCas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Trading Company
inquirybulk?production Application:Pharmaceutical intermediates
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Trading Company
inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Cas:121629-14-9
Min.Order:0
Negotiable
Type:Trading Company
inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:121629-14-9
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiry
Cas:121629-14-9
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry4,4-difluorocyclohexanecarboxylic acid
methanol
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 70℃; for 16h; | 90.82% |
sulfuric acid for 16h; Reflux; |
methyl 4,4-difluorocyclohexane-1-carboxylate
dimethyl methane phosphonate
dimethyl [2-(4,4-difluorocyclohexyl)-2-oxoethyl]phosphonate
Conditions | Yield |
---|---|
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: methyl 4,4-difluorocyclohexane-1-carboxylate In tetrahydrofuran at -78 - 0℃; for 1.5h; Inert atmosphere; | 82% |
methyl 4,4-difluorocyclohexane-1-carboxylate
(4,4-difluorocyclohexyl)methanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere; | 81% |
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: With potassium hydroxide In tetrahydrofuran; diethyl ether; water at 0℃; for 1h; Inert atmosphere; | 81% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 18h; Inert atmosphere; | 77% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; | 71.55% |
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 0 - 20℃; |
chloro-trimethyl-silane
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h; | 72% |
methyl 4,4-difluorocyclohexane-1-carboxylate
methyl iodide
methyl 4,4-difluoro-1-methylcyclohexanecarboxylate
Conditions | Yield |
---|---|
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 2h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; |
methyl 4,4-difluorocyclohexane-1-carboxylate
(2S,3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-methylphenyl)6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere 5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere 7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(2S,3R4R5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere 5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere 7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 8.1: ammonia / methanol / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(4,4-difluoro-1-methylcyclohexyl)methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(4,4-difluoro-1-methylcyclohexyl)methyl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
4-bromo-1-chloro-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(3R,4S,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere 5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere 5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere 5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere 7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere 8.1: ammonia / methanol / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)tetratydro-2H-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere 5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere 7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(3R,4S,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere 5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C 3.1: triethylamine / dmap / 20 °C 4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere 5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere 5.2: 2 h / -78 °C 5.3: 12 h / 20 °C 6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
4,4-difluorocyclohexane carboxyaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2: Dess-Martin periodane / dichloromethane / 2 h / 0 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -30 °C / Inert atmosphere 3.2: 16.5 h / -30 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -30 °C / Inert atmosphere 3.2: 16 h / -30 - 20 °C / Inert atmosphere View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C 1.2: 12 h / 20 °C 2.1: C55H54IrNO4P(1+)*BF4(1-); tetrabutylammonium benzoate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Sealed tube View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
(4,4-difluorocyclohexyl)methyl methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere 2: triethylamine / dichloromethane / 4 h / 0 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere 2: triethylamine / dichloromethane / 4 h / 0 °C 3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 120 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C 3.1: n-butyllithium; diisopropylamine / diethyl ether / 1 h / -78 °C 3.2: 1 h / -78 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C 3.1: n-butyllithium; diisopropylamine / diethyl ether / 1 h / -78 °C 3.2: 1 h / -78 °C 4.1: acetonitrile / 16 h / 80 °C View Scheme |
methyl 4,4-difluorocyclohexane-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C 3.1: indium; (1S,2R)-2-Amino-1,2-diphenylethanol; pyridine / tetrahydrofuran / 3 h / 18 °C / Inert atmosphere 3.2: 2 h / -78 °C / Inert atmosphere View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View