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Ality Chemical Corporation

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Basic information Product Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester;4,4-Difluorocyclohexanecarboxylic

Factory Supply methyl 4,4-difluorocyclohexane-1-carboxylate

Cas:121629-14-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 121629-14-9 with competitive price

Cas:121629-14-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

4,4-Difluorocyclohexanecarboxylic acid methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester CAS:121629-14-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spec

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester CAS:121629-14-9

Cas:121629-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Boiling point 182℃ density 1.13

Cyclohexanecarboxylic acid, 4,4-difluoro-, Methyl ester

Cas:121629-14-9

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Methyl 4,4-difluorocyclohexanecarboxylate

Cas:121629-14-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Wholesaler 121629-14-9 factory Methyl 4,4-difluorocyclohexanecarboxylate in China Molecular Formula C8H12F2O2 Molar Mass 178.18 Density 1.13 Boling Point 182℃ Flash Point 62℃ Vapo

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4,4-Difluoro-cyclohexanecarboxylic acid methyl ester

Cas:121629-14-9

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4,4-difluoroCyclohexanecarboxylic acid methyl ester

Cas:121629-14-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester;4,4-Difluorocyclohexanecarboxylic acid methyl ester;methyl 4,4-difluorocyclohexane-1-carboxylate CAS: 121

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kunshan Push Trading Co.,LTD

Methyl 4,4-difluorocyclohexanecarboxylate Alias: Benzene,(3,3-difluoropropyl); 1,1-difluoro-3-phenylpropane; 1,1-difluoro-4-carbomethoxy-cyclohexane; CAS RN:121629-14-9 Purity:98% Molecular formula: C8H12F2O2

methyl 4,4-difluorocyclohexane-1-carboxylate 121629-14-9

Cas:121629-14-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

ProductName:Methyl 4,4-difluorocyclohexanecarboxylate Synonyms:1,1-difluoro-3-phenylpropane;Benzene,(3,3-difluoropropyl);1,1-difluoro-4-carbomethoxy-cyclohexane; CAS:121629-14-9 Molecular Formula: C8H12F2O2 Molecular Weight:178.17600 Puri

Methyl 4,4-difluorocyclohexanecarboxylate

Cas:121629-14-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4,4-Difluorocyclohexanecarboxylic acid methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Methyl 4,4-difluorocyclohexanecarboxylate cas no. 121629-14-9 98%

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

Methyl 4,4-difluorocyclohexanecarboxylate

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

excellent quality and reliable supplierAppearance:COA mentioned Storage:COA mentioned Package:Standard or custom package Application:pharmaceutical raw materails Transportation:sea/air /courier Port:China main port

METHYL 4,4-DIFLUOROCYCLOHEXANECARBOXYLATE

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

4,4-Difluorocyclohexanecarboxylic acid methyl es

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester 121629-14-9

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

4,4-difluoro-Cyclohexanecarboxylic acid, methyl ester

Cas:121629-14-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

Cas:121629-14-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

4,4-difluorocyclohexanecarboxylic acid
122665-97-8

4,4-difluorocyclohexanecarboxylic acid

methanol
67-56-1

methanol

methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 0 - 70℃; for 16h;90.82%
sulfuric acid for 16h; Reflux;
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

dimethyl [2-(4,4-difluorocyclohexyl)-2-oxoethyl]phosphonate
1402838-40-7

dimethyl [2-(4,4-difluorocyclohexyl)-2-oxoethyl]phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: methyl 4,4-difluorocyclohexane-1-carboxylate In tetrahydrofuran at -78 - 0℃; for 1.5h; Inert atmosphere;
82%
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluorocyclohexyl)methanol
178312-48-6

(4,4-difluorocyclohexyl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;81%
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: With potassium hydroxide In tetrahydrofuran; diethyl ether; water at 0℃; for 1h; Inert atmosphere;
81%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 18h; Inert atmosphere;77%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;71.55%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 0 - 20℃;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

((4,4-difluorocyclohexylidene)(methoxy)methoxy)trimethylsilane

((4,4-difluorocyclohexylidene)(methoxy)methoxy)trimethylsilane

Conditions
ConditionsYield
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h;
72%
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

methyl iodide
74-88-4

methyl iodide

methyl 4,4-difluoro-1-methylcyclohexanecarboxylate
1360568-90-6

methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

Conditions
ConditionsYield
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 2h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃;
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(2S,3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-methylphenyl)6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
1360569-34-1

(2S,3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-methylphenyl)6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
1360569-47-6

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(2S,3R4R5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
1360569-48-7

(2S,3R4R5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
8.1: ammonia / methanol / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluoro-1-methylcyclohexyl)methanol
1360568-91-7

(4,4-difluoro-1-methylcyclohexyl)methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluoro-1-methylcyclohexyl)methyl 4-methylbenzenesulfonate
1360568-92-8

(4,4-difluoro-1-methylcyclohexyl)methyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

4-bromo-1-chloro-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)benzene
1360569-03-4

4-bromo-1-chloro-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene
1360569-12-5

4-bromo-2-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-1-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(3R,4S,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1360569-13-6

(3R,4S,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
1360569-14-7

(3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
1360569-41-0

(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
8.1: ammonia / methanol / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)tetratydro-2H-3,4,5-triyl triacetate
1360569-42-1

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)tetratydro-2H-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(3R,4S,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1360569-04-5

(3R,4S,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
1360569-05-6

(3R,4R,5S,6R)-2-(4-chloro-3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluorocyclohexyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamate

(4,4-difluorocyclohexyl)methyl N-[(3S)-2-oxoazetidin-3-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluorocyclohexyl)methyl 2-pyridyl carbonate

(4,4-difluorocyclohexyl)methyl 2-pyridyl carbonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluorocyclohexyl)methyl 2-oxopyridine-1-carboxylate

(4,4-difluorocyclohexyl)methyl 2-oxopyridine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
2: dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

4,4-difluorocyclohexane carboxyaldehyde
265108-36-9

4,4-difluorocyclohexane carboxyaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 2 h / 0 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

A

[(Z)-4-(4,4-difluorocyclohexyl)but-3-enoxy]methylbenzene

[(Z)-4-(4,4-difluorocyclohexyl)but-3-enoxy]methylbenzene

B

[(E)-4-(4,4-difluorocyclohexyl)but-3-enoxy]methylbenzene

[(E)-4-(4,4-difluorocyclohexyl)but-3-enoxy]methylbenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -30 °C / Inert atmosphere
3.2: 16.5 h / -30 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -30 °C / Inert atmosphere
3.2: 16 h / -30 - 20 °C / Inert atmosphere
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

methyl (R)-4,4-difluoro-1-(1-(4-methoxyphenyl)allyl)cyclohexane-1-carboxylate

methyl (R)-4,4-difluoro-1-(1-(4-methoxyphenyl)allyl)cyclohexane-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 12 h / 20 °C
2.1: C55H54IrNO4P(1+)*BF4(1-); tetrabutylammonium benzoate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Sealed tube
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(4,4-difluorocyclohexyl)methyl methanesulfonate
194427-24-2

(4,4-difluorocyclohexyl)methyl methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere
2: triethylamine / dichloromethane / 4 h / 0 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1-(4,4-difluorocyclohexylmethyl)-3,7-dimethyl-3,7-dihydropurine-2,6-dione

1-(4,4-difluorocyclohexylmethyl)-3,7-dimethyl-3,7-dihydropurine-2,6-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere
2: triethylamine / dichloromethane / 4 h / 0 °C
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 120 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(3-bromo-2-thienyl)-(4,4-difluorocyclohexyl)methanol

(3-bromo-2-thienyl)-(4,4-difluorocyclohexyl)methanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C
3.1: n-butyllithium; diisopropylamine / diethyl ether / 1 h / -78 °C
3.2: 1 h / -78 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1-[(3-bromothien-2-yl)(4,4-difluorocyclohexyl)methyl]-1H-imidazole

1-[(3-bromothien-2-yl)(4,4-difluorocyclohexyl)methyl]-1H-imidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C
3.1: n-butyllithium; diisopropylamine / diethyl ether / 1 h / -78 °C
3.2: 1 h / -78 °C
4.1: acetonitrile / 16 h / 80 °C
View Scheme
methyl 4,4-difluorocyclohexane-1-carboxylate
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

(1S)-1-(4,4-difluorocyclohexyl)but-3-en-1-ol

(1S)-1-(4,4-difluorocyclohexyl)but-3-en-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C
3.1: indium; (1S,2R)-2-Amino-1,2-diphenylethanol; pyridine / tetrahydrofuran / 3 h / 18 °C / Inert atmosphere
3.2: 2 h / -78 °C / Inert atmosphere
View Scheme

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