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Hangzhou Think Chemical Co. Ltd

Iguratimod[CAS:123663-49-0] N-{[4-[2-(Formylamino)acetyl]-5-hydroxy-2-phenoxyphenyl}methanesulfonamide[CAS:149457-03-4] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture.

Iguratimod and Intermediate

Cas:123663-49-0

Min.Order:10 Gram

Negotiable

Type:Other

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Iguratimod( R&D) supplier in China

Cas:123663-49-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Iguratimod CAS 123663-49-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing

Iguratimod CAS 123663-49-0

Cas:123663-49-0

Min.Order:10 Gram

FOB Price: $50.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Iguratimod 123663-49-0 GMP Manufacturer

Cas:123663-49-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Iguratimod in stock

Cas:123663-49-0

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Iguratimod

Cas:123663-49-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Iguratimod

Cas:123663-49-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Iguratimod 123663-49-0

Cas:123663-49-0

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 123663-49-0 with best quality

Cas:123663-49-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Iguratimod CAS 123663-49-0

Cas:123663-49-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Iguratimod in stock

Cas:123663-49-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methanesulfonamide,N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]- 123663-49-0

Cas:123663-49-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Iguratimod Basic information Product Name: Iguratimod Synonyms: IGURATIMOD;iguratimod( R&D);T 614;N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide;3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one;N-[3-(

Iguratimod

Cas:123663-49-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Iguratimod CAS:123663-49-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Iguratimod CAS:123663-49-0

Cas:123663-49-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methanesulfonamide,N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-

Cas:123663-49-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Iguratimod in stock CAS NO.123663-49-0

Cas:123663-49-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methanesulfonamide,N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-

Cas:123663-49-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Iguratimod Synonyms: IGURATIMOD;iguratimod( R&D);T 614;N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide;3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one;N-[3-(Formylamino)-4-oxo-6-phenoxy-4

Iguratimod free sample available best quality

Cas:123663-49-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Lorcaserin(8566 Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,DHL/TNT/FEd

Iguratimod

Cas:123663-49-0

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Iguratimod 123663-49-0

Cas:123663-49-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical Ingr

Iguratimod

Cas:123663-49-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Iguratimod

Cas:123663-49-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

buy-IGURATIMOD

Cas:123663-49-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Iguratimod( R&D)

Cas:123663-49-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Iguratimod

Cas:123663-49-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Iguratimod

Cas:123663-49-0

Min.Order:0

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: Lguratimod(CAS:123663-49-0) CAS No.:123663-49-0 Molecule Formula:C17H14N2O6S Molecule Weight:374.37 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Best Quality Lguratimod(CAS:123663-49-0)

Cas:123663-49-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Iguratimod

Cas:123663-49-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Iguratimod

Cas:123663-49-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Iguratimod 123663-49-0

Cas:123663-49-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Synthetic route

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

α-formamido-2'-hydroxy-4'-methanesulfonamido-5'-phenoxyacetophenone
149457-03-4

α-formamido-2'-hydroxy-4'-methanesulfonamido-5'-phenoxyacetophenone

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 15℃; for 8h; Cyclization;87%
Acetic formic anhydride
2258-42-6

Acetic formic anhydride

N-(3-amino-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl)methanesulfonamide
123663-48-9

N-(3-amino-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl)methanesulfonamide

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h; Formylation;73%
N-(3-amino-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl)methanesulfonamide
123663-48-9

N-(3-amino-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl)methanesulfonamide

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
With formic acid; acetic anhydride In dichloromethane; di-isopropyl ether73%
4-methoxy-2-nitro-1-phenoxybenzene
84594-95-6

4-methoxy-2-nitro-1-phenoxybenzene

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
2: 82 percent / pyridine / 1 h / 20 °C
3: 90 percent / AlCl3; HCl / nitrobenzene / 10 h / 25 - 30 °C
4: 91 percent / acetone / 3 h
5: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
6: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
Multi-step reaction with 9 steps
1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
2: 82 percent / pyridine / 1 h / 20 °C
3: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
4: 70 percent aq. HClO4 / 1 h / 20 °C
5: H2O / 0.08 h / Heating
6: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
7: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
8: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
9: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
5-methoxy-2-phenoxyaniline
76838-72-7

5-methoxy-2-phenoxyaniline

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 percent / pyridine / 1 h / 20 °C
2: 90 percent / AlCl3; HCl / nitrobenzene / 10 h / 25 - 30 °C
3: 91 percent / acetone / 3 h
4: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
5: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
Multi-step reaction with 8 steps
1: 82 percent / pyridine / 1 h / 20 °C
2: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
3: 70 percent aq. HClO4 / 1 h / 20 °C
4: H2O / 0.08 h / Heating
5: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
6: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
7: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
8: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
2-chloro-5-methoxynitrobenzene
10298-80-3

2-chloro-5-methoxynitrobenzene

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 percent / potassium tert-butoxide / dimethylformamide / 4 h / 110 °C
2: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
3: 82 percent / pyridine / 1 h / 20 °C
4: 90 percent / AlCl3; HCl / nitrobenzene / 10 h / 25 - 30 °C
5: 91 percent / acetone / 3 h
6: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
7: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
Multi-step reaction with 10 steps
1: 84 percent / potassium tert-butoxide / dimethylformamide / 4 h / 110 °C
2: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
3: 82 percent / pyridine / 1 h / 20 °C
4: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
5: 70 percent aq. HClO4 / 1 h / 20 °C
6: H2O / 0.08 h / Heating
7: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
8: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
9: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
10: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide
123664-84-6

N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / AlCl3; HCl / nitrobenzene / 10 h / 25 - 30 °C
2: 91 percent / acetone / 3 h
3: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
4: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
Multi-step reaction with 7 steps
1: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
2: 70 percent aq. HClO4 / 1 h / 20 °C
3: H2O / 0.08 h / Heating
4: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
5: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
6: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
7: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
methyl 2-hydroxy-4-methylsulfonylamino-5-phenoxyphenyl ketone
123664-52-8

methyl 2-hydroxy-4-methylsulfonylamino-5-phenoxyphenyl ketone

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 70 percent aq. HClO4 / 1 h / 20 °C
2: H2O / 0.08 h / Heating
3: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
4: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
5: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
6: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
123662-55-5

7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
2: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
3: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
4: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
N-(4-oxo-6-phenoxy-2,3-dihydro-4H-7-chromenyl)methanesulfonamide
123664-21-1

N-(4-oxo-6-phenoxy-2,3-dihydro-4H-7-chromenyl)methanesulfonamide

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
2: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
3: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
123664-34-6

3-bromo-2,3-dihydro-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
2: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide
149456-98-4

N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
2: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride

α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / acetone / 3 h
2: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
3: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
4-ethoxy-7-methanesulfonylamino-6-phenoxy-chromenylium; perchlorate

4-ethoxy-7-methanesulfonylamino-6-phenoxy-chromenylium; perchlorate

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2O / 0.08 h / Heating
2: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
3: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
4: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
5: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
phenol
108-95-2

phenol

pentacarbonyl(3-cyclohex-1-enyl-1-ethoxy-2-propyn-1-ylidene)tungsten

pentacarbonyl(3-cyclohex-1-enyl-1-ethoxy-2-propyn-1-ylidene)tungsten

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 percent / potassium tert-butoxide / dimethylformamide / 4 h / 110 °C
2: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
3: 82 percent / pyridine / 1 h / 20 °C
4: 90 percent / AlCl3; HCl / nitrobenzene / 10 h / 25 - 30 °C
5: 91 percent / acetone / 3 h
6: 95 percent / NaI; AlCl3 / acetonitrile / 3 h / 20 °C
7: 87 percent / dimethylformamide / 8 h / 15 °C
View Scheme
Multi-step reaction with 10 steps
1: 84 percent / potassium tert-butoxide / dimethylformamide / 4 h / 110 °C
2: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
3: 82 percent / pyridine / 1 h / 20 °C
4: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
5: 70 percent aq. HClO4 / 1 h / 20 °C
6: H2O / 0.08 h / Heating
7: H2 / 5 percent Pd/C / acetic acid / 1 h / 40 - 45 °C / 760 Torr
8: 97 percent / Br2 / CHCl3 / 0.5 h / 25 - 30 °C
9: 80 percent / NaN3; DMF / 1 h / 70 - 75 °C
10: 73 percent / CH2Cl2 / 1 h / 20 °C
View Scheme
N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide monohydrate
761454-93-7

N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide monohydrate

Iguratimod
123663-49-0

Iguratimod

Conditions
ConditionsYield
at 160℃; for 1h; Product distribution / selectivity;
In acetonitrile at 25℃; for 24h; Product distribution / selectivity;
Iguratimod
123663-49-0

Iguratimod

methyl iodide
74-88-4

methyl iodide

3-(N-formyl-N-methyl)amino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

3-(N-formyl-N-methyl)amino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Conditions
ConditionsYield
In diethyl ether; water; N,N-dimethyl-formamide75%
Iguratimod
123663-49-0

Iguratimod

N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide monohydrate
761454-93-7

N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide monohydrate

Conditions
ConditionsYield
With water at 25℃; for 168h; Product distribution / selectivity;
With water at 25℃; for 24h; Product distribution / selectivity;

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