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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-6-Fluorochromanic acid

Cas:129101-36-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

(2S)-6-Fluoro-2-chromanecarboxylic acid

Cas:129101-36-6

Min.Order:1000 Gram

FOB Price: $1300.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

tianfu chem 2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 129101-36-6 with competitive price

Cas:129101-36-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Cas:129101-36-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(S)-6-Fluorochromane-2-carboxylic acid

Cas:129101-36-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Cas:129101-36-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Cas:129101-36-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Cas:129101-36-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/(S)-6-Fluoro-2-chromanecarboxylic acid/Manufacturer in China

Cas:129101-36-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylicacid

Cas:129101-36-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2S)-6-Fluoro-2-chromanecarboxylic acid cas no. 129101-36-6 98%

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2H-1-Benzopyran-2-carboxylic acid

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

129101-36-6

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, (2S)-

Cas:129101-36-6

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

6-fluoro-4H-chromene-2-carboxylic acid

6-fluoro-4H-chromene-2-carboxylic acid

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
With C63H78IrNOP(2+)*C32H12BF24(1-); hydrogen; caesium carbonate In methanol at 60℃; under 4560.31 Torr; for 12h; Autoclave; enantioselective reaction;99%
(S)-methyl 6-fluorochroman-2-carboxylate
1219915-01-1

(S)-methyl 6-fluorochroman-2-carboxylate

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: (S)-methyl 6-fluorochroman-2-carboxylate With sodium hydroxide In tetrahydrofuran; methanol; water at 0 - 20℃; for 6h; Schlenk technique;
Stage #2: With hydrogenchloride In tetrahydrofuran; methanol; water Schlenk technique;
95%
5-fluoro-2-hydroxybenzaldehyde
347-54-6

5-fluoro-2-hydroxybenzaldehyde

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C / Schlenk technique
2.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Schlenk technique
3.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
5.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
6.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
7.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
8.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
9.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
10.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
10.2: Schlenk technique
View Scheme
Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C / Schlenk technique
2.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Schlenk technique
3.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
5.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
6.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
7.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
8.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
9.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
10.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
10.2: Schlenk technique
View Scheme
2-[2-(benzyloxy)-5-fluorophenyl]ethan-1-ol

2-[2-(benzyloxy)-5-fluorophenyl]ethan-1-ol

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
2.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
4.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
5.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
6.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
6.2: Schlenk technique
View Scheme
Multi-step reaction with 6 steps
1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
2.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
4.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
5.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
6.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
6.2: Schlenk technique
View Scheme
C16H15FO2

C16H15FO2

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
4.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
6.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
7.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
8.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
8.2: Schlenk technique
View Scheme
Multi-step reaction with 8 steps
1.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
4.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
6.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
7.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
8.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
8.2: Schlenk technique
View Scheme
C15H14FIO

C15H14FIO

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
3.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
4.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
5.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
5.2: Schlenk technique
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
3.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
4.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
5.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
5.2: Schlenk technique
View Scheme
C13H15FO4

C13H15FO4

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
3.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
3.2: Schlenk technique
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
3.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
3.2: Schlenk technique
View Scheme
methyl 2-diazo-4-(5-fluoro-2-hydroxyphenyl)butanoate

methyl 2-diazo-4-(5-fluoro-2-hydroxyphenyl)butanoate

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
2.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
2.2: Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
2.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
2.2: Schlenk technique
View Scheme
2-(benzyloxy)-5-fluorobenzaldehyde
312314-37-7

2-(benzyloxy)-5-fluorobenzaldehyde

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Schlenk technique
2.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
5.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
7.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
8.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
9.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
9.2: Schlenk technique
View Scheme
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Schlenk technique
2.1: hydrogenchloride / tetrahydrofuran; water / Schlenk technique; Reflux
3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
5.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
7.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
8.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
9.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
9.2: Schlenk technique
View Scheme
2-(2-(benzyloxy)-5-fluorophenyl)acetaldehyde

2-(2-(benzyloxy)-5-fluorophenyl)acetaldehyde

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
3.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
5.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
6.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
7.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
7.2: Schlenk technique
View Scheme
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Schlenk technique
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 20 °C / Schlenk technique
3.1: sodium hydride / mineral oil; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
5.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
6.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
7.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
7.2: Schlenk technique
View Scheme
C20H21FO4

C20H21FO4

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
2.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
3.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C35H30N2O2 / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
4.2: Schlenk technique
View Scheme
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3040.2 Torr / Schlenk technique
2.1: triethylamine; Methanesulfonyl azide / acetonitrile / 20 °C / Schlenk technique
3.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; C23H22N2O2; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique; Glovebox
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 20 °C / Schlenk technique
4.2: Schlenk technique
View Scheme
6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - -30 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
2.1: dihydrogen peroxide / tetrahydrofuran; hexane / 3 h / 0 °C / Inert atmosphere
3.1: sodium hydroxide / water; methanol / 5 h / 50 °C
4.1: caesium carbonate; hydrogen; C63H78IrNOP(2+)*C32H12BF24(1-) / methanol / 12 h / 60 °C / 4560.31 Torr / Autoclave
View Scheme
C18H17FO3Se

C18H17FO3Se

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dihydrogen peroxide / tetrahydrofuran; hexane / 3 h / 0 °C / Inert atmosphere
2: sodium hydroxide / water; methanol / 5 h / 50 °C
3: caesium carbonate; hydrogen; C63H78IrNOP(2+)*C32H12BF24(1-) / methanol / 12 h / 60 °C / 4560.31 Torr / Autoclave
View Scheme
methyl 6-fluoro-4H-chromene-2-carboxylate

methyl 6-fluoro-4H-chromene-2-carboxylate

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; methanol / 5 h / 50 °C
2: caesium carbonate; hydrogen; C63H78IrNOP(2+)*C32H12BF24(1-) / methanol / 12 h / 60 °C / 4560.31 Torr / Autoclave
View Scheme
1,1'-oxybis(2-bromo-ethane)
5414-19-7

1,1'-oxybis(2-bromo-ethane)

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C24H24F2O7

C24H24F2O7

Conditions
ConditionsYield
With calcium oxide In dimethyl sulfoxide at 160℃; for 5h;90%
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

1,2-bis(2-chloroethoxy)ethane
112-26-5

1,2-bis(2-chloroethoxy)ethane

C26H28F2O8

C26H28F2O8

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide; toluene at 150℃; for 5h;86%
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

C24H24F2O7

C24H24F2O7

Conditions
ConditionsYield
With sodium hydrogencarbonate In toluene at 100℃; for 5.5h;85%
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

C24H24F2O6

C24H24F2O6

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 120℃; for 5h;82%
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

N-[(2S)-4-amino-2-hydroxybicyclo[2.2.2]octan-1-yl]-2-(4-chloro-3-fluorophenoxy)acetamide

N-[(2S)-4-amino-2-hydroxybicyclo[2.2.2]octan-1-yl]-2-(4-chloro-3-fluorophenoxy)acetamide

(2S)-N-{(3S)-4-[2-(4-chloro-3-fluorophenoxy)acetamido]-3-hydroxybicyclo[2.2.2]octan-1-yl}-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxamide

(2S)-N-{(3S)-4-[2-(4-chloro-3-fluorophenoxy)acetamido]-3-hydroxybicyclo[2.2.2]octan-1-yl}-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxamide

Conditions
ConditionsYield
With triethylamine; HATU In N,N-dimethyl-formamide30%
With triethylamine; HATU In N,N-dimethyl-formamide30%
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

(+)-(S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carbonyl chloride

(+)-(S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carbonyl chloride

Conditions
ConditionsYield
With thionyl chloride In toluene at 65 - 70℃;
With thionyl chloride In toluene at 65 - 70℃;
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone
1219915-00-0

2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pivaloyl chloride; dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C / Large scale
2: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
4: acetic acid; hydrogenchloride / water / 7 h / 30 - 40 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
4: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
5: acetic acid; hydrogenchloride / water / 7 h / 30 - 40 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 20 - 25 °C / Large scale
1.2: 20 - 50 °C / Large scale
2.1: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3.1: sulfuryl dichloride; sodium phosphate / ethyl acetate / 10 - 20 °C
4.1: hydrogenchloride / water; ethyl acetate; acetic acid / 3 h / 40 °C
View Scheme
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

(R)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
1315508-93-0

(R)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pivaloyl chloride; dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C / Large scale
2: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
4: acetic acid; hydrogenchloride / water / 7 h / 30 - 40 °C / Large scale
5: isopropyl alcohol; NAD; (R)-selective alcohol dehydrogenase / aq. buffer / 24 h / 0 - 25 °C / pH 6.99 / Enzymatic reaction
View Scheme
Multi-step reaction with 6 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
4: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
5: acetic acid; hydrogenchloride / water / 7 h / 30 - 40 °C / Large scale
6: isopropyl alcohol; NAD; (R)-selective alcohol dehydrogenase / aq. buffer / 24 h / 0 - 25 °C / pH 6.99 / Enzymatic reaction
View Scheme
Multi-step reaction with 5 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 20 - 25 °C / Large scale
1.2: 20 - 50 °C / Large scale
2.1: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3.1: sulfuryl dichloride; sodium phosphate / ethyl acetate / 10 - 20 °C
4.1: hydrogenchloride / water; ethyl acetate; acetic acid / 3 h / 40 °C
5.1: hydrogenchloride; NAD; triethanolamine; zinc(II) chloride / isopropyl alcohol; water; glycerol / 24 h / 0 - 25 °C / pH 6.99 / Enzymatic reaction
View Scheme
Multi-step reaction with 6 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
4: sulfuryl dichloride; sodium phosphate / ethyl acetate / 10 - 20 °C
5: hydrogenchloride / water; ethyl acetate; acetic acid / 3 h / 40 °C
6: hydrogenchloride; NAD; triethanolamine; zinc(II) chloride / isopropyl alcohol; water; glycerol / 24 h / 0 - 25 °C / pH 6.99 / Enzymatic reaction
View Scheme
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C16H15FO6

C16H15FO6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
View Scheme
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C16H19FO4

C16H19FO4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pivaloyl chloride; dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C / Large scale
2: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 20 - 25 °C / Large scale
1.2: 20 - 50 °C / Large scale
2.1: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
View Scheme
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C16H18ClFO4

C16H18ClFO4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pivaloyl chloride; dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 - 50 °C / Large scale
2: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
4: sodium phosphate; sulfuryl dichloride / ethyl acetate / 10 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 20 - 25 °C / Large scale
1.2: 20 - 50 °C / Large scale
2.1: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
3.1: sulfuryl dichloride; sodium phosphate / ethyl acetate / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: thionyl chloride / toluene / 65 - 70 °C
2: pyridine / dichloromethane / 6 h / 0 - 25 °C
3: trifluoroacetic acid / acetonitrile / 7 h / 50 - 55 °C / Large scale
4: sulfuryl dichloride; sodium phosphate / ethyl acetate / 10 - 20 °C
View Scheme
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C16H15FO6

C16H15FO6

Conditions
ConditionsYield
With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20 - 50℃; Large scale;
Stage #1: cycl-isopropylidene malonate; (S)-6-fluorochroman-2-carboxylic acid With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 20 - 25℃; for 0.333333h; Large scale;
Stage #2: With pivaloyl chloride In acetonitrile at 20 - 50℃; Large scale;
(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

1,5-dichloropentane
628-76-2

1,5-dichloropentane

C25H26F2O6

C25H26F2O6

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide; toluene at 80℃; for 6h;1.7 g
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

(S)-6-fluorochroman-2-carboxylic acid
129101-36-6

(S)-6-fluorochroman-2-carboxylic acid

C26H28F2O6

C26H28F2O6

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 140℃; for 4.5h;1.7 g

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