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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hot Sales Ethyl 4-bromo-3-oxobutanoate CAS NO.13176-46-0 CAS NO.13176-46-0

Cas:13176-46-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 4-Vromoacetoacetate supplier in China

Cas:13176-46-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:1 Gram

FOB Price: $5.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromoacetoacetic acid ethyl ester

Cas:13176-46-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

13176-46-0

Cas:13176-46-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 13176-46-0 with competitive price

Cas:13176-46-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Ethyl 4-bromoacetoacetate CAS 13176-46-0 Molecular Formula C6H9BrO3 Appearance:Colorless clear liquid Storage:Preserve in well-closed, light-r

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl 4-bromoacetoacetate 13176-46-0

Cas:13176-46-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Ethyl 4-bromoacetoacetate CAS NO.: 13176-46-0

Cas:13176-46-0

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 4-Vromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Ethyl 4-bromo-3-oxobutanoate

Cas:13176-46-0

Min.Order:1 Gram

FOB Price: $178.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

ETHYL 4-BROMOACETOACETATE

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 4-Vromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

Ethyl 4-bromoacetoacetate CAS NO.: 13176-46-0

Cas:13176-46-0

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Ethyl 4-bromoacetoacetate Chemical Properties Boiling point 231.6 °C density 1.511 refractive index 1.5281 (estimate) storage temp. Keep in dark place,Sealed in dry,2-8°C pka 9.56±0.46(Predicted) Safety Information H

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Intermediates,ect. Transportation:as per your request

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Ethyl 4-bromoacetoacetate cas no. 13176-46-0 98%

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

C-5317 Ethyl 4-bromoacetoacetate M.F:C6H9BrO3Appearance:Colorless, transparent liquid Package:on yr requirement

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Ethyl 4-Vromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chemsigma International Co.,Ltd.

bulk productiongoods in stockswe have the best competitive price in the marketmeantime,we are committed to service to our every customer Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethyl 4-broMoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:white crystalline power Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Ethyl 4-bromoacetoacetate

Cas:13176-46-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl acetoacetate
141-97-9

ethyl acetoacetate

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
With bromine In dichloromethane at -5 - 5℃; for 2h;92.54%
With bromine; acetic acid at 0℃; for 1.16667h;85%
With bromine; acetic acid at 0℃; for 1.16667h;85%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

B

ethyl 4-bromoacetoacetate

ethyl 4-bromoacetoacetate

Conditions
ConditionsYield
Stage #1: ethyl acetoacetate With bromine In acetic acid at 20℃; for 0.5h;
Stage #2: With hydroquinone In acetic acid at 20℃; for 1h; Further stages.;
A 90%
B 3%
With bromine In acetic acid at 20℃; for 3h;
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

ethanol
64-17-5

ethanol

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
Stage #1: 4-methyleneoxetan-2-one With bromine In dichloromethane at -20 - -10℃; Inert atmosphere;
Stage #2: ethanol With pyridine In dichloromethane at -10 - 20℃; for 1h; Inert atmosphere;
84%
With bromine 1.) CCl4; Multistep reaction;
With bromine at -30 - 5℃; for 1h;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
With isopropylmagnesium bromide In diethyl ether77%
With samarium diiodide In tetrahydrofuran at -78℃;45%
ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
zur Umlagerung ist ausser der Anwesenheit von HBr auch Belichtung oder Gegenwart von Luftsauerstoff oder Peroxyd erforderlich;
Bildung durch Umlagerung;
With hydrogen bromide; acetic acid at 100℃;
ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

B

ethyl acetoacetate
141-97-9

ethyl acetoacetate

Conditions
ConditionsYield
With diethyl ether; iodine; magnesium Zersetzung des Reaktionsprodukts mit Schwefelsaeure;
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

1-bromo-2-hexanone
26818-07-5

1-bromo-2-hexanone

B

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C

ethyl acetoacetate
141-97-9

ethyl acetoacetate

D

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With methanol In hexane at -60 - -50℃; for 1h; Product distribution; other temp.: -78 deg C;
water
7732-18-5

water

bromine
7726-95-6

bromine

ethyl acetoacetate
141-97-9

ethyl acetoacetate

CS2

CS2

A

ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

B

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

magnesium compound of bromoacetic acid ethyl ester

magnesium compound of bromoacetic acid ethyl ester

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
With diethyl ether
ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

B

ethyl acetate and acetoacetic acid ethyl ester

ethyl acetate and acetoacetic acid ethyl ester

Conditions
ConditionsYield
With aluminium; xylene
ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

B

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C

ethyl 2,2-dibromoacetoacetate
89415-67-8

ethyl 2,2-dibromoacetoacetate

Conditions
ConditionsYield
With bromine In acetic acid at 20℃; for 0.0166667h;
ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

ethyl 2-bromoacetoacetate
84911-18-2, 609-13-2

ethyl 2-bromoacetoacetate

B

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
With N-Bromosuccinimide In diethyl ether at 30℃; for 3h; UV-irradiation;
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

Conditions
ConditionsYield
With bromine In chloroform at 0 - 20℃; for 17.5h; Inert atmosphere;
Cbz-L-proline thioamide
63808-47-9

Cbz-L-proline thioamide

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C19H22N2O4S
320608-49-9

C19H22N2O4S

Conditions
ConditionsYield
In ethanol for 2h; Heating / reflux;100%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 1-methyl-2-oxoindolin-3-ylidenecarbamate
1373942-83-6

tert-butyl 1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-06-5

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Reagent/catalyst; Solvent; Time; Mannich Aminomethylation; enantioselective reaction;98%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;92%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Reagent/catalyst; Solvent; enantioselective reaction;92%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

triphenylphosphine
603-35-0

triphenylphosphine

(3-Ethoxycarbonyl-2-oxo-propyl)-triphenyl-phosphonium; bromide
13176-47-1

(3-Ethoxycarbonyl-2-oxo-propyl)-triphenyl-phosphonium; bromide

Conditions
ConditionsYield
In benzene for 18h; Ambient temperature;97%
for 24h;
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 5-methoxy-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-17-9

tert-butyl 5-methoxy-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-5-methoxy-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-11-2

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-5-methoxy-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 5-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-19-1

tert-butyl 5-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[5-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-13-4

tert-butyl (R)-[5-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 7-fluoro-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-22-6

tert-butyl 7-fluoro-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-7-fluoro-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-17-8

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-7-fluoro-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 7-chloro-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-23-7

tert-butyl 7-chloro-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[7-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-18-9

tert-butyl (R)-[7-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 7-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-24-8

tert-butyl 7-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[7-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-19-0

tert-butyl (R)-[7-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C15H15F3N2O3
1432059-32-9

C15H15F3N2O3

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxo-7-(trifluoromethyl)indolin-3-yl]carbamate
1580515-20-3

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxo-7-(trifluoromethyl)indolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;97%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 5-methoxy-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-17-9

tert-butyl 5-methoxy-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,5-dimethyl-2-oxoindolin-3-yl]carbamate
1580515-10-1

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,5-dimethyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;97%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

triphenyl-arsane
603-32-7

triphenyl-arsane

(3-Ethoxycarbonyl-2-oxo-propyl)-triphenyl-arsonium; bromide

(3-Ethoxycarbonyl-2-oxo-propyl)-triphenyl-arsonium; bromide

Conditions
ConditionsYield
at 80℃; for 2h;96%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl (5-chloro-1-methyl-2-oxoindolin-3-ylidene)carbamate
1403338-22-6

tert-butyl (5-chloro-1-methyl-2-oxoindolin-3-ylidene)carbamate

tert-butyl (R)-[5-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-12-3

tert-butyl (R)-[5-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;96%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 6-chloro-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-20-4

tert-butyl 6-chloro-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[6-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-14-5

tert-butyl (R)-[6-chloro-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;96%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 6-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate
1373943-21-5

tert-butyl 6-bromo-1-methyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[6-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate
1580515-15-6

tert-butyl (R)-[6-bromo-3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-methyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;96%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;96%
N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-phenylpyrrolidine-2,5-dione

3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-phenylpyrrolidine-2,5-dione

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 2h; Michael Addition;96%
N-phenylmaleimide
83-25-0

N-phenylmaleimide

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-phenylpyrrolidine-2,5-dione

3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1-phenylpyrrolidine-2,5-dione

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Michael Addition;96%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

S-tert-butyl sodium trithiocarbonate
71127-42-9

S-tert-butyl sodium trithiocarbonate

4-tert-Butylsulfanylthiocarbonylsulfanyl-3-oxo-butyric acid ethyl ester
90403-75-1

4-tert-Butylsulfanylthiocarbonylsulfanyl-3-oxo-butyric acid ethyl ester

Conditions
ConditionsYield
In acetone for 2h; Ambient temperature;95%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester
32224-01-4, 95310-94-4, 128052-98-2, 95537-36-3

(S)-4-bromo-3-hydroxy-butyric acid ethyl ester

Conditions
ConditionsYield
With D-glucose; broth E. coli HB101; pNTS1G; NADP In various solvent(s) at 30℃; for 20h; pH=6.5; Enzymatic reaction;95%
Daucas carota root; extract of In water at 37 - 40℃; for 62h; pH=7.0; Conversion of starting material; Enzymatic reaction; Aqueous phosphate buffer;53%
With yeast pH=8 and further enzymes;
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C15H18N2O3
1432059-33-0

C15H18N2O3

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,7-dimethyl-2-oxoindolin-3-yl]carbamate
1580515-16-7

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,7-dimethyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;95%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;95%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;95%
2-aminopyridine
504-29-0

2-aminopyridine

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester
101820-69-3

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester

Conditions
ConditionsYield
In 1,4-dioxane; water at 20 - 70℃; for 3.5h; Temperature; Time; Concentration; Reagent/catalyst;94.1%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

1-((10-ethyl-10H-phenothiazin-3-yl)methylidene)thiosemicarbazide
507277-64-7

1-((10-ethyl-10H-phenothiazin-3-yl)methylidene)thiosemicarbazide

ethyl 2-(2-(2-((10-ethyl-10H-phenothiazin-3-yl)-methylene)hydrazinyl)thiazol-4-yl)acetate
1393117-05-9

ethyl 2-(2-(2-((10-ethyl-10H-phenothiazin-3-yl)-methylene)hydrazinyl)thiazol-4-yl)acetate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60℃; under 1275.13 Torr; for 1.5h; Hantzsch cyclization; Microwave irradiation;94%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

4-bromo-2-diazo-3-oxobutyric acid ethyl ester
188475-10-7

4-bromo-2-diazo-3-oxobutyric acid ethyl ester

Conditions
ConditionsYield
With 4-acetamidobenzenesulfonyl azide; tert-butylamine In tetrahydrofuran at 25℃; Inert atmosphere;94%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl (2-oxo-1-phenylindolin-3-ylidene)carbamate
1443052-58-1

tert-butyl (2-oxo-1-phenylindolin-3-ylidene)carbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-2-oxo-1-phenylindolin-3-yl]carbamate
1580515-09-8

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-2-oxo-1-phenylindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;93%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;93%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;93%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

tert-butyl 1,5-dimethyl-2-oxoindolin-3-ylidenecarbamate
1373943-16-8

tert-butyl 1,5-dimethyl-2-oxoindolin-3-ylidenecarbamate

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,5-dimethyl-2-oxoindolin-3-yl]carbamate
1580515-10-1

tert-butyl (R)-[3-(2-ethoxy-4-oxo-4,5-dihydrofuran-3-yl)-1,5-dimethyl-2-oxoindolin-3-yl]carbamate

Conditions
ConditionsYield
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; Mannich Aminomethylation; enantioselective reaction;93%
With sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;93%
With C31H26F6N4O2; sodium carbonate In dichloromethane at 25℃; for 48h; enantioselective reaction;93%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

ethyl α,γ-dibromoacetoacetate
24499-76-1

ethyl α,γ-dibromoacetoacetate

Conditions
ConditionsYield
With pyrrolidone hydrotribromide In tetrahydrofuran for 3h;91%
1-benzyl-1H-pyrrole-2,5-dione
1631-26-1

1-benzyl-1H-pyrrole-2,5-dione

4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

C17H17NO5

C17H17NO5

Conditions
ConditionsYield
With sodium carbonate; Quinine In chloroform at 0℃; for 24h; enantioselective reaction;91%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

(R)-5-ethoxy-4-(2-nitro-1-phenylethyl)furan-3(2H)-one
1361938-46-6

(R)-5-ethoxy-4-(2-nitro-1-phenylethyl)furan-3(2H)-one

Conditions
ConditionsYield
With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-1-(piperidin-1-yl)butan-2-yl)thiourea; ammonium carbonate In toluene at 20℃; for 24h; Feist-Benary synthesis; optical yield given as %ee; enantioselective reaction;90%
4-bromoethyl acetoacetate
13176-46-0

4-bromoethyl acetoacetate

2,4-Xylenol
105-67-9

2,4-Xylenol

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (6,8-dimethyl-2-oxo-2H-chromen-4-yl)methylphosphoramidate

dimethyl (6,8-dimethyl-2-oxo-2H-chromen-4-yl)methylphosphoramidate

Conditions
ConditionsYield
Stage #1: 4-bromoethyl acetoacetate With sodium azide In ethanol at 20℃; for 0.166667h; Pechmann Condensation;
Stage #2: phosphorous acid trimethyl ester With iodine In ethanol at 20℃; for 0.333333h; Pechmann Condensation;
Stage #3: 2,4-Xylenol In ethanol for 3h; Pechmann Condensation; Reflux;
90%

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