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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Manufacturer/High quality/Best price/In stock

Cas:132335-47-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Duloxetine intermediate Cas 132335-47-8 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Package:10g,100g,1kg/foil bag ;25kg/drum or per

High quality Duloxetine intermediate Cas 132335-47-8 with best price and good service

Cas:132335-47-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

(S)-(+)-N, N-Dimethyl-3- (1-Naphthyloxy) -3- (2-Thienyl) Propylamine Oxalate

Cas:132335-47-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(τS)-N,N-Dimethyl-τ-(1-naphthalenyloxy)-2-thiophenepropaneamine ethanedioate

Cas:132335-47-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Duloxetin Pharmaceutical Intermediates CAS No.: 132335-47-8

Cas:132335-47-8

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamineoxalate CAS NO: 132335-47-8 Grade:Medical scientific research and export Molecular formula:C19H21NOS.C2H2O4 Molecular weight:401.48 Product Quality 12 years of chemical ra

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Cas:132335-47-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 132335-47-8 with competitive price

Cas:132335-47-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate cas132335-47-8

Cas:132335-47-8

Min.Order:1 Metric Ton

FOB Price: $7.0 / 9.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate 132335-47-8

Cas:132335-47-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate/ LIDE PHARMA- Factory supply / Best price

Cas:132335-47-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate CAS:132335-47-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical inter

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate CAS:132335-47-8

Cas:132335-47-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Cas:132335-47-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalat CAS NO.132335-47-8

Cas:132335-47-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Cas:132335-47-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Synonyms: S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-;S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate supplier best quality

Cas:132335-47-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

S-(+)-N,N-Dimethyl-3-(1-Naphthoxy)-3-(2-Thienyl)-1-Propylamine Oxalate

Cas:132335-47-8

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Duloxetine intermediate 1

Cas:132335-47-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

132335-47-8

Cas:132335-47-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-(+)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-propanamine oxalate

Cas:132335-47-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

S-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamineoxalate

Cas:132335-47-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Cas:132335-47-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality S-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)-Propanamineoxalate

Cas:132335-47-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Basic information Product Name: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Synonyms: Duloxetine N-Methyl Oxalate;(S)-(+)-N,N-diMethyl-3-(naphthloxy

TIANFU-CHEM S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate 132335-47-8

Cas:132335-47-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: S-(+)-N,N-Dimethyl-3-(1-Naphthoxy)-3-(2-Thienyl)-1-Propylamine Oxalate CAS No.: 132335-47-8 Molecule Formula:C19H21NOS Molecule Weight:311.44 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standard

Lower Price S-(+)-N,N-Dimethyl-3-(1-Naphthoxy)-3-(2-Thienyl)-1-Propylamine Oxalate

Cas:132335-47-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Cas:132335-47-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Synthetic route

oxalic acid
144-62-7

oxalic acid

N-methyl-(S)-duloxetine
132335-46-7

N-methyl-(S)-duloxetine

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
In Isopropyl acetate; water at 20℃; for 21h; Product distribution / selectivity;84.2%
In Isopropyl acetate; isopropyl alcohol at 20℃; for 2h; Product distribution / selectivity;78.6%
In methanol; Isopropyl acetate at 20℃; for 16h; Product distribution / selectivity;78.9%
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

oxalic acid
144-62-7

oxalic acid

α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol
132335-49-0

α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Stage #1: oxalic acid; α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol With sodium hydride In N,N-dimethyl acetamide at 70℃; for 0.333333h;
Stage #2: 1-Fluoronaphthalene In N,N-dimethyl acetamide at 110℃; for 1h;
75.6%
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

oxalic acid
144-62-7

oxalic acid

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Stage #1: 1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With tetrabutylammomium bromide; sodium hydroxide In dimethyl sulfoxide at 50 - 65℃;
Stage #2: oxalic acid In toluene at 55 - 60℃; for 1h; optical yield given as %ee; enantioselective reaction;
59.9%
Stage #1: 1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With potassium tert-butylate at 90 - 100℃;
Stage #2: oxalic acid In methanol at 0 - 30℃;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
With sodium hydride 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C; Yield given. Multistep reaction;
2-Acetylthiophene
88-15-3

2-Acetylthiophene

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / 12N HCl / ethanol / 24 h / Heating
2: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C
3: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C
View Scheme
3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride
5424-47-5

3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4, (2R,3S)-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-butanol / tetrahydrofuran; toluene / 16 h / -70 °C
2: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 2 h / 35 - 40 °C
2.1: sodium hydride / dimethyl sulfoxide / 20 °C
2.2: 48 - 50 °C
2.3: 5 h / 20 °C
View Scheme
oxalic acid
144-62-7

oxalic acid

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine
116817-11-9

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine

A

(R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate
932013-45-1

(R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate

B

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 1h;
oxalic acid
144-62-7

oxalic acid

(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine
878757-08-5

(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine

N-methyl-(S)-duloxetine
132335-46-7

N-methyl-(S)-duloxetine

A

(R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate
932013-45-1

(R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate

B

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 1h;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
With oxalic acid In ISOPROPYLAMIDE; water; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol; ethyl acetate; mineral oil3.5 g (80 %)
3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol
13636-02-7, 132335-44-5, 132335-49-0

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol

1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

oxalic acid
144-62-7

oxalic acid

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Stage #1: 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol With sodium hydride In dimethyl sulfoxide at 20℃;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide at 48 - 50℃;
Stage #3: oxalic acid In ethyl acetate at 20℃; for 5h;
N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine mandelate

N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine mandelate

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / dichloromethane; water / 0.5 h / 20 - 25 °C / pH 11 - 12
2.1: sodium hydride / dimethyl sulfoxide / 20 °C
2.2: 48 - 50 °C
2.3: 5 h / 20 °C
View Scheme
(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
With hydrogenchloride; formic acid; triethylamine; zinc; 2,2,2-Trichloroethyl chloroformate 1) toluene, 30 min, 25 deg C 2) DMF; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1.1: potassium carbonate / toluene; water / 0.5 h
1.2: 3 h / 35 - 45 °C
2.1: potassium hydroxide / water; tetrahydrofuran / 4 h / 55 °C
View Scheme
(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

N-methyl-(S)-duloxetine
132335-46-7

N-methyl-(S)-duloxetine

Conditions
ConditionsYield
With ammonium hydroxide In water; toluene at 25℃; for 0.333333 - 0.5h;
With sodium hydroxide In water; toluene at 40℃; for 0.5h; Product distribution / selectivity;
With sodium hydroxide In water at 20 - 25℃; Product distribution / selectivity;
(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

duloxetine hydrochloride
136434-34-9

duloxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate With ammonia In water; toluene at 40℃; for 0.166667h;
Stage #2: With N-ethyl-N,N-diisopropylamine; phenyl chloroformate In toluene at 55℃; for 1.25h;
Stage #3: With hydrogenchloride; sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages;
Multi-step reaction with 3 steps
1.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12
2.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 15 - 20 °C
2.2: 1 h / 40 - 45 °C
3.1: potassium hydroxide / toluene / 7 h / 80 - 85 °C
3.2: 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene; water / 0.5 h
1.2: 3 h / 35 - 45 °C
2.1: potassium hydroxide / water; tetrahydrofuran / 4 h / 55 °C
3.1: hydrogenchloride / water; ethyl acetate
View Scheme
(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

phenyl chloroformate
1885-14-9

phenyl chloroformate

C26H25NO3S

C26H25NO3S

Conditions
ConditionsYield
Stage #1: (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate With water; sodium hydroxide In dichloromethane
Stage #2: phenyl chloroformate With N-ethyl-N,N-diisopropylamine In dichloromethane at 25 - 30℃;
(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine
947686-09-1

(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / toluene; water / 20 - 45 °C / pH 11 - 12
2.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 15 - 20 °C
2.2: 1 h / 40 - 45 °C
View Scheme
carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

1-chloroethyl-N-methyl-((S)-3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl)carbamate
953028-77-8

1-chloroethyl-N-methyl-((S)-3-(naphthalene-1-yloxy)-3-(thiophen-2-yl)propyl)carbamate

Conditions
ConditionsYield
Stage #1: (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate With potassium carbonate In water; toluene for 0.5h;
Stage #2: carbonochloridic acid 1-chloro-ethyl ester With N-ethyl-N,N-diisopropylamine In toluene at 35 - 45℃; for 3h;
184.7 g

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