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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Manufacturer/High quality/Best price/In stock

Cas:132335-44-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propylamine supplier in China

Cas:132335-44-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine manufacturer with low price

Cas:132335-44-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Duloxetine intermediate Cas 132335-44-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Package:10g,100g,1kg/foil bag ;25kg/drum or per

High quality Duloxetine intermediate Cas 132335-44-5 with best price and good service

Cas:132335-44-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine[CAS:132335-44-5] Name (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Synonyms (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol Molecu

Good quality (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol

Cas:132335-44-5

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine

Cas:132335-44-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS NO: 132335-44-5 Grade:Medical scientific research and export Molecular formula: C9H15NOS Molecular weight:185.2865 Product Quality 12 years of chemical raw materials Mature op

Henan Tianfu Chemical Co., Ltd.

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Basic information Product Name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Synonyms: (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 132335-44-5 with best price

Cas:132335-44-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Synonyms (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol CAS No. 132335-44-5 Molecular Formula

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS NO.: 132335-44-5

Cas:132335-44-5

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine/ LIDE PHARMA- Factory supply / Best price

Cas:132335-44-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine from Wuhan,

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5

Cas:132335-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 132335-44-5 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

FOB Price: $42.0 / 56.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS:132335-44-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speci

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS:132335-44-5

Cas:132335-44-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

(S) - (-) -N, N-Dimethyl-3-Hydroxy-3- (2-Thienyl) Propanamine

Cas:132335-44-5

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Synonyms: (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-PROPANAMINE;S-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE;(S)-1-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE;(S)-1

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine supplier best quality

Cas:132335-44-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propanamine

Cas:132335-44-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Duloxetine intermediate 2

Cas:132335-44-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of APIs in Chin

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Cas:132335-44-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

(S)-N,N-dimethyl-N-[3-hydroxy-3-(2-thienyl)propyl]-ammonium (S)-mandelate
287737-72-8

(S)-N,N-dimethyl-N-[3-hydroxy-3-(2-thienyl)propyl]-ammonium (S)-mandelate

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With sodium hydroxide In water for 0.5h; pH=11 - 12;95%
With ammonium hydroxide In tert-butyl methyl ether92.1%
With sodium hydroxide In tert-butyl methyl ether; water at 20℃; for 0.5h; pH=9;
3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride
5424-47-5

3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With glucose dehydrogenase; D-glucose; Rhodosporidium toruloides carbonyl reductase 9 from Escherichia coli; NADPH; sodium hydroxide In aq. phosphate buffer at 30℃; for 4h; pH=7; Kinetics; Temperature; Enzymatic reaction; enantioselective reaction;92.1%
With hydrogen; sodium hydrogencarbonate; (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine; di-μ-chloro-bis(1,5-cyclooctadiene)dirhodium In methanol; water at 30℃; under 75007.5 Torr; for 20h;
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; sodium hydroxide / water / 7 h / 20 - 71 °C
2: toluene / 0.5 h / 80 °C
3: sodium hydroxide / water
View Scheme
3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol
13636-02-7, 132335-44-5, 132335-49-0

3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
Stage #1: 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol With tert-butyl methyl ether; (S)-Mandelic acid
Stage #2: With sodium hydroxide
92%
With (S)-Mandelic acid In methanol; toluene at 20 - 95℃; for 1.5h; pH=1 - 12;34%
Multi-step reaction with 2 steps
1: toluene / 0.5 h / 80 °C
2: sodium hydroxide / water
View Scheme
tri(3-dimethylamino-1-(thiophen-2-yl)propyl)borate

tri(3-dimethylamino-1-(thiophen-2-yl)propyl)borate

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With methanol at 80℃; for 20h; Concentration;92%
dimethyl amine
124-40-3

dimethyl amine

(S)-3-chloro-1-(thiophen-2-yl)propan-1-ol
164071-56-1

(S)-3-chloro-1-(thiophen-2-yl)propan-1-ol

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With potassium iodide In methanol; water at 80℃; for 8h;89%
3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one
13196-35-5

3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With potassium tert-butylate; hydrogen; RuCl2[(R)-(DM-BINAP)][(R)-DAIPEN] In isopropyl alcohol; tert-butyl alcohol at 28℃; for 6h;80%
With hydrogen; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane; 1,1-dimethylethylenediamine; [RuCl2(dmf)n]; sodium t-butanolate In ethanol; dichloromethane at 20℃; under 5320 Torr; for 15h;
With RuCl2(1,1'-bis(diphenyphosphino)ferrocene)[(1S,1'S)-6,6'-dibromo-1,1'-biisoindoline]; potassium tert-butylate; hydrogen In propan-1-ol at 20℃; under 38002.6 Torr; for 30h; Inert atmosphere; Autoclave; optical yield given as %ee; enantioselective reaction;
C11H17NO2S

C11H17NO2S

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphoric acid / water / 18 h / 40 - 45 °C
2: ethanol; tert-butyl methyl ether / 50 °C
3: ammonium hydroxide / tert-butyl methyl ether
View Scheme
(S)-N,N-dimethyl-3-(p-nitrobenzoate)-3-(thiophen-2-yl)propylamine

(S)-N,N-dimethyl-3-(p-nitrobenzoate)-3-(thiophen-2-yl)propylamine

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
In methanol at 20℃; for 2h; Alkaline conditions;26.4 g
(S)-N,N-dimethyl-3-hydroxy-3-(thiophen-2-yl)propylamine mandelate

(S)-N,N-dimethyl-3-hydroxy-3-(thiophen-2-yl)propylamine mandelate

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With water; sodium hydroxide30.2 g
3-dimethylamino-1-thiophen-2-ylpropenone
34772-98-0

3-dimethylamino-1-thiophen-2-ylpropenone

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Reflux
2: ethanol; tert-butyl methyl ether / 1 h / Reflux
3: sodium hydroxide / water / 0.5 h / pH 11 - 12
View Scheme
C29H26BNO3S

C29H26BNO3S

A

α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol
132335-49-0

α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol

B

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 20℃; for 1h;A n/a
B 65 mg
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

N-methyl-(S)-duloxetine
132335-46-7

N-methyl-(S)-duloxetine

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide at 60℃; for 1.16667h;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide at 60℃; for 24h; Solvent; Reagent/catalyst;
93.9%
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h;
Stage #2: With Potassium benzoate In dimethyl sulfoxide; mineral oil for 0.5h;
Stage #3: 1-Fluoronaphthalene In dimethyl sulfoxide; mineral oil at 65℃; for 8h;
92%
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide; mineral oil at 40 - 50℃; for 8h;
90%
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

acetyl chloride
75-36-5

acetyl chloride

(S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N,N-dimethylamine

(S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N,N-dimethylamine

Conditions
ConditionsYield
With triethylamine In chloroform at 5 - 20℃; for 2.16667h;92%
With triethylamine In toluene at 25℃; for 6.5h;60 g
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-(1-napthaleneoxy)-2-thiophenepropanamine oxalate

(S)-N,N-dimethyl-3-(1-napthaleneoxy)-2-thiophenepropanamine oxalate

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With potassium hydroxide; 18-crown-6 ether In dimethyl sulfoxide at 60℃; for 1h;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide for 2h;
Stage #3: With oxalic acid In ethyl acetate for 1h;
88%
4-fluorobenzo[1,3]dioxolane
943830-74-8

4-fluorobenzo[1,3]dioxolane

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-[(benzo[1,3]dioxolan-4-yl)-oxy]-3-(thiophen-2-yl)-propylamine

(S)-N,N-dimethyl-3-[(benzo[1,3]dioxolan-4-yl)-oxy]-3-(thiophen-2-yl)-propylamine

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide; mineral oil at 60℃; for 0.5h;
Stage #2: With Potassium benzoate In dimethyl sulfoxide; mineral oil for 0.333333h;
Stage #3: 4-fluorobenzo[1,3]dioxolane In dimethyl sulfoxide; mineral oil at 60℃; for 8h;
82%
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With Potassium benzoate; sodium hydride In dimethyl sulfoxide at 60℃; for 0.5h;
Stage #2: 4-fluorobenzo[1,3]dioxolane In dimethyl sulfoxide at 60℃; for 8h;
4.8 g
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

isobutyl chloroformate
543-27-1

isobutyl chloroformate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol; isobutyl chloroformate With triethylamine In toluene at 20 - 30℃; for 6h;
Stage #2: With potassium hydroxide In methanol at 75℃; for 3.5h; Heating / reflux;
79.6%
4-bromo-2-chloro-1-((3-fluorobenzyl)oxy)benzene

4-bromo-2-chloro-1-((3-fluorobenzyl)oxy)benzene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

C22H23ClFNO2S

C22H23ClFNO2S

Conditions
ConditionsYield
With copper(l) iodide; N1, N2-diphenethyloxalamide; sodium t-butanolate In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating;70%
1-Bromonaphthalene
90-11-9

1-Bromonaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

N-methyl-(S)-duloxetine
132335-46-7

N-methyl-(S)-duloxetine

Conditions
ConditionsYield
With copper(l) iodide; N1, N2-diphenethyloxalamide; sodium t-butanolate In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating;65%
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

oxalic acid
144-62-7

oxalic acid

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
Stage #1: 1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With tetrabutylammomium bromide; sodium hydroxide In dimethyl sulfoxide at 50 - 65℃;
Stage #2: oxalic acid In toluene at 55 - 60℃; for 1h; optical yield given as %ee; enantioselective reaction;
59.9%
Stage #1: 1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With potassium tert-butylate at 90 - 100℃;
Stage #2: oxalic acid In methanol at 0 - 30℃;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

duloxetine hydrochloride
136434-34-9

duloxetine hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 1-Fluoronaphthalene In dimethyl sulfoxide at 60℃; Inert atmosphere;
56%
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.5 h / 20 °C
1.2: 8 h / 40 - 50 °C
2.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 3 h / 0 - 5 °C / Reflux
2.2: 1 h / 50 °C
View Scheme
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate
132335-47-8

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

Conditions
ConditionsYield
With sodium hydride 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C; Yield given. Multistep reaction;
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) NaH / 1) DMSO, 25 deg C, 25 min 2) 48-72 h, 45-50 deg C
2: 1) ClCO2CH2CCl3, Et3N, HCl 2) Zn-dust, 2.5percent formic acid / 1) toluene, 30 min, 25 deg C 2) DMF
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 25 °C
1.2: 0.25 h / 25 - 30 °C
1.3: 48 h / 25 - 30 °C
2.1: N-ethyl-N,N-diisopropylamine / toluene / 0.17 h
2.2: Reflux
3.1: potassium hydroxide / polyethylene glycol-400 / 16 h / 65 - 70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.5 h / 20 °C
1.2: 0.5 h
1.3: 8 h / 65 °C
2.1: N-ethyl-N,N-diisopropylamine / toluene / 0.17 h / 45 °C
2.2: 2 h / 55 °C
3.1: sodium hydroxide / water; dimethyl sulfoxide / 8 h / 45 - 55 °C / Alkaline conditions
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride
2: potassium hydroxide / ethanol; toluene / 2 h / 85 - 100 °C
View Scheme
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

phenyl chloroformate
1885-14-9

phenyl chloroformate

(S)-3-methylamino-1-(2-thienyl)-1-propanol
116539-55-0

(S)-3-methylamino-1-(2-thienyl)-1-propanol

Conditions
ConditionsYield
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol; phenyl chloroformate With triethylamine In tert-butyl methyl ether at -5 - 20℃; for 4h;
Stage #2: With potassium hydroxide In methanol; tert-butyl methyl ether for 2h; Heating / reflux;
(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl (RS)-N-methyl-N-[3-phenyloxycarbonyloxy-3-(thien-2-yl)propyl]carbamate
625853-19-2

phenyl (RS)-N-methyl-N-[3-phenyloxycarbonyloxy-3-(thien-2-yl)propyl]carbamate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 5 - 20℃; for 2h;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

Potassium benzoate
582-25-2

Potassium benzoate

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt
161005-84-1

(S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt

Conditions
ConditionsYield
With phosphoric acid In hexane; water; dimethyl sulfoxide; mineral oil
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Conditions
ConditionsYield
With potassium hydroxide In 1,2-dimethoxyethane at 60℃; for 8h; Product distribution / selectivity;
With potassium hydroxide In Tetraethylene glycol dimethyl ether at 60℃; for 8h; Product distribution / selectivity;
With potassium hydroxide In diethylene glycol dimethyl ether at 60℃; for 8h; Product distribution / selectivity;
With potassium hydroxide In Triethylene glycol dimethyl ether at 60℃; for 8h; Product distribution / selectivity;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

A

(R)-Duloxetine
116539-60-7

(R)-Duloxetine

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 60℃; for 8h; Product distribution / selectivity;
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol
132335-44-5

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

(S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt
161005-84-1

(S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt

Conditions
ConditionsYield
Stage #1: 1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With potassium hydroxide In diethylene glycol dimethyl ether at 120℃; for 3 - 6h;
Stage #2: With phosphoric acid In water; ethyl acetate for 1.08333 - 1.25h;
Stage #1: (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol With sodium hydride In dimethyl sulfoxide at 20℃; for 2h;
Stage #2: 1-Fluoronaphthalene With potassium p-methyl benzoate In dimethyl sulfoxide at 20 - 65℃; for 5h;
Stage #3: With phosphoric acid In ethyl acetate for 0.5h; pH=2;
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