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Hangzhou Huarong Pharm Co., Ltd.

KDMF would be available soon! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re

Olanzapine KDMF

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Olanzapine Manufacturer/High quality/Best price/In stock

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance yellow crystalline powder Yellow crystalline powder Solution

High quality Olanzapine with best price cas:132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Factory supply top quality Olanzapine CAS 132539-06-1

Cas:132539-06-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Olanzapine

Cas:132539-06-1

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Olanzapine

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Olanzapine CAS NO: 132539-06-1 Grade:Medical scientific research and export Molecular formula:C17H20N4S Molecular weight:312.43 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Olanzapine/cas:132539-06-1 /Raw material spot

Cas:132539-06-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Olanzapine

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 132539-06-1 with best quality

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Olanzapine 132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Olanzapine CAS132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Olanzapine/ LIDE PHARMA- Factory supply / Best price

Cas:132539-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name Olanzapine Synonyms 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; Molecular Formula C17H20N4S Molecula

Olanzapine

Cas:132539-06-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla

Yellow Pharmaceutical Powder Olanzapine CAS 132539-06-1

Cas:132539-06-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

We are one of the domestic largest manufacturers of API; We are always supplier of products with higher quality and at more competitive price; We are supplier of safe and ecofriendly products ; We provide stable supply and efficient servic

Manufacturer of Olanzapine at Factory Price

Cas:132539-06-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Price Olanzapine for Schizophrenia Treatment CAS No 132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- 132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Antidepressants, Olanzapine CAS:132539-06-1

Cas:132539-06-1

Min.Order:1 Gram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Olanzapine CAS:132539-06-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Olanzapine CAS:132539-06-1

Cas:132539-06-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of h

Olanzapine CAS 132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

High Quality Product China Supplier DDP Olanzapine CAS 132539-06-1

Cas:132539-06-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Olanzapine CAS NO.132539-06-1

Cas:132539-06-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-

Cas:132539-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

FandaChem,a China-based chemical company, specialize in exporting Olanzapine cas no 132539-06-1 Please contact us by email freely. Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Applicati

Olanzapine cas no 132539-06-1

Cas:132539-06-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Olanzapine

Cas:132539-06-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

LY-170052 Olanzapine 132539-06-1

Cas:132539-06-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Olanzapine

Cas:132539-06-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
at 65 - 70℃; for 18h; Vacuo;100%
N-desmethyl olanzapine
161696-76-0

N-desmethyl olanzapine

methyl iodide
74-88-4

methyl iodide

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 2h; Product distribution / selectivity;99%
With sodium hydride In tetrahydrofuran at -10℃; for 3h; Product distribution / selectivity;98%
With sodium hydroxide In tetrahydrofuran at -15℃; for 4h; Product distribution / selectivity;98%
With triethylamine In tetrahydrofuran at -10℃; for 4h; Product distribution / selectivity;82%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

4-amino-2-methyl-10H-thiene [2,3-b][1,5]-benzodiazepine hydrochloride

4-amino-2-methyl-10H-thiene [2,3-b][1,5]-benzodiazepine hydrochloride

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In ethanol; dimethyl sulfoxide at 100 - 130℃; Solvent; Temperature;92.5%
In dimethyl sulfoxide at 100 - 120℃; for 8h;84.2%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine
612503-08-9

2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In propan-1-ol at 110℃; Product distribution / selectivity; Heating / reflux;89%
In iso-butanol at 118℃; Product distribution / selectivity; Heating / reflux;84%
In isopropyl alcohol at 100 - 102℃; Product distribution / selectivity; Heating / reflux;80%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
at 125 - 145℃; for 5 - 12h; Product distribution / selectivity; Neat (no solvent);84%
at 120℃; for 5h;83.8%
In dimethyl sulfoxide at 112 - 115℃; for 16h;82%
olanzapinium oxalate

olanzapinium oxalate

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With sodium hydroxide In water pH=9;72.6%
With sodium hydroxide In water pH=8 - 10;
With sodium hydroxide In water pH=9 - 10; Product distribution / selectivity;
2,4-bis(4-methyl-1-piperazinyl)-3-propylidene-3H-[1,5]benzodiazepine

2,4-bis(4-methyl-1-piperazinyl)-3-propylidene-3H-[1,5]benzodiazepine

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With quinoline p-toluenesulfonate; sulfur In benzonitrile at 140℃; for 13.5h;69.5%
With pyridinium p-toluenesulfonate; sulfur In benzonitrile at 140℃; for 13.5h;66.6%
With sulfur; 1-methyl-imidazolium p-toluenesulfonic acid In benzonitrile at 140℃; for 10h;54.2%
With toluene-4-sulfonic acid; sulfur In benzonitrile at 140℃; for 9h;51.7%
With sulfur; triethylamine In propan-1-ol; dimethyl sulfoxide at 100℃; for 120h;12%
dimethyl sulfate
77-78-1

dimethyl sulfate

N-desmethyl olanzapine
161696-76-0

N-desmethyl olanzapine

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With potassium carbonate In methanol at 25℃; for 2h; Product distribution / selectivity;60%
With potassium carbonate In acetone at -10℃; for 4h; Product distribution / selectivity;46%
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide In methanol at 0 - 5℃;
Stage #2: With water In methanol Product distribution / selectivity;
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide In methanol; dichloromethane at 0 - 5℃;
Stage #2: With water In methanol; dichloromethane Product distribution / selectivity;
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide; potassium carbonate In tetrahydrofuran; water at 10 - 30℃; for 7.5 - 8.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 50℃;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile
138564-59-7

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With hydrogen In mesytilene at 160℃; for 48h; chemoselective reaction;54%
N-{5-methyl-3-[(4-methylpiperazin-1-yl)carbonyl]thien-2-yl}-N-(2-nitrophenyl)amine

N-{5-methyl-3-[(4-methylpiperazin-1-yl)carbonyl]thien-2-yl}-N-(2-nitrophenyl)amine

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With tributylphosphine at 220℃; for 48h;41%
Olanzapine N-Oxide

Olanzapine N-Oxide

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With osmium(VIII) oxide; (2E)-3-phenyl-2-propen-1-ol In water; tert-butyl alcohol at 20℃; for 19h; Inert atmosphere;30%
10-Benzyl-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
765244-26-6

10-Benzyl-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water at 60℃; for 6 - 6.5h;20%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile
138564-59-7

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

A

zyprexa
132539-06-1

zyprexa

B

2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one

2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one

Conditions
ConditionsYield
With hydrogen In mesytilene at 160℃; for 24h; chemoselective reaction;A 20%
B 25 %Chromat.
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 23 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 25 °C
2: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating
3: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: LiOH / dimethylsulfoxide
2: SnCl2 / ethanol
3: toluene; dimethylsulfoxide
View Scheme
2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile
138564-59-7

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating
2: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: SnCl2 / ethanol
2: toluene; dimethylsulfoxide
View Scheme
Multi-step reaction with 2 steps
1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol; water / 1 h / Reflux
2: dimethyl sulfoxide; toluene / 20 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: iron(III)-acetylacetonate; hydrazine hydrate / ethanol / 0.08 h / 150 °C / Sealed tube
2: hydrogenchloride / ethanol; water; ethyl acetate / 0.17 h / 120 °C / Sealed tube
3: 0.5 h / 160 °C / Sealed tube
View Scheme
2-amino-5-methylthiophene-3-carbonitrile
138564-58-6

2-amino-5-methylthiophene-3-carbonitrile

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 23 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 25 °C
2: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating
3: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: LiOH / dimethylsulfoxide
2: SnCl2 / ethanol
3: toluene; dimethylsulfoxide
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 20 °C / Inert atmosphere; Cooling with ice
2: tin(II) chloride dihdyrate; hydrogenchloride / ethanol; water / 1 h / Reflux
3: dimethyl sulfoxide; toluene / 20 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene; ethyl acetate / 0.17 h / 130 °C / Sealed tube
2: iron(III)-acetylacetonate; hydrazine hydrate / ethanol / 0.08 h / 150 °C / Sealed tube
3: hydrogenchloride / ethanol; water; ethyl acetate / 0.17 h / 120 °C / Sealed tube
4: 0.5 h / 160 °C / Sealed tube
View Scheme
2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

zyprexa
132539-06-1

zyprexa

Reaxys ID: 12045368

Reaxys ID: 12045368

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With silica gel In dichloromethane at 0℃; for 0.0833333h; Purification / work up;
C4H10O*2C17H20N4S

C4H10O*2C17H20N4S

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
at 65℃; for 2.5h;
olanzapine monohydrate
402586-77-0

olanzapine monohydrate

zyprexa
132539-06-1

zyprexa

olanzapine methylene chloride hemisolvate

olanzapine methylene chloride hemisolvate

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; for 0.5 - 1h; Product distribution / selectivity;
Stage #1: olanzapine methylene chloride hemisolvate at 50℃; for 12h;
Stage #2: In isopropyl alcohol at 20℃; for 0.333333h; Product distribution / selectivity;
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine propan-2-ol hemisolvate monohydrate

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine propan-2-ol hemisolvate monohydrate

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
Stage #1: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine propan-2-ol hemisolvate monohydrate at 50℃; for 16h;
Stage #2: In isopropyl alcohol at 20℃; for 0.25h; Product distribution / selectivity;
olanzapine-CH2Cl2-water

olanzapine-CH2Cl2-water

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In dichloromethane Product distribution / selectivity;
olanzapine-DMSO-water

olanzapine-DMSO-water

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In dichloromethane Product distribution / selectivity;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile
873895-41-1

2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With acetic acid at 120℃; Product distribution / selectivity;
With acetic acid at 120℃; Product distribution / selectivity;
With platinum doped titanium oxide; hydrogen In mesytilene at 140℃; for 24h;24 %Chromat.
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile
873895-41-1

2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile

1-methylpiperazine hydrochloride
34352-59-5, 50398-09-9, 51545-09-6

1-methylpiperazine hydrochloride

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;
olanzapine tetrahydrofuran water solvate

olanzapine tetrahydrofuran water solvate

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
at 40℃; under 1 - 20 Torr; for 4 - 10h; Product distribution / selectivity; vacuum drying;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
In water; toluene
In water; toluene
In water; toluene
In water; toluene
In water; toluene
5-methyl-2-(2-nitro-anilino)-thiophene-3-carboxylic acid methyl ester
72242-31-0

5-methyl-2-(2-nitro-anilino)-thiophene-3-carboxylic acid methyl ester

zyprexa
132539-06-1

zyprexa

Conditions
ConditionsYield
With ammonia; palladium on charcoal catalyst; titanium tetrachloride In 1-methyl-piperazine; ethanol ethyl acetate; ethyl acetate; methoxybenzene; isopropyl alcohol
With ammonia; palladium on charcoal catalyst; titanium tetrachloride In 1-methyl-piperazine; ethanol ethyl acetate; ethyl acetate; methoxybenzene; isopropyl alcohol
zyprexa
132539-06-1

zyprexa

2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

Conditions
ConditionsYield
With water In dimethyl sulfoxide at 0 - 80℃; for 48h;100%
With water In 1,3-dioxane at 0 - 80℃;93.5%
With water In acetone at 0 - 80℃;87.5%
With water In ethyl acetate; toluene at 20 - 60℃; for 1.5h;63.3%
In water at 30 - 35℃; for 0.5h;
zyprexa
132539-06-1

zyprexa

olanzapine sesquihydrate

olanzapine sesquihydrate

Conditions
ConditionsYield
Stage #1: zyprexa With hydrogenchloride; water
Stage #2: With sodium hydroxide; water at 0℃; for 0.5h; pH=8.5;
100%
zyprexa
132539-06-1

zyprexa

aspirin
50-78-2

aspirin

C7H6O3*C17H20N4S
929209-00-7

C7H6O3*C17H20N4S

Conditions
ConditionsYield
In methanol for 24h; Product distribution / selectivity;99%
zyprexa
132539-06-1

zyprexa

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine monohydrochloride

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile Heating / reflux;98.5%
With hydrogenchloride In Isopropyl acetate; water
zyprexa
132539-06-1

zyprexa

2-methyl-4-(4-methyl-piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride

2-methyl-4-(4-methyl-piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 0℃; for 0.166667h;97%
With hydrogenchloride In ethyl acetate at 0℃; for 0.166667h;97%
With hydrogenchloride In isopropyl alcohol at 0℃; for 0.166667h;97%
zyprexa
132539-06-1

zyprexa

Pamoic acid
130-85-8

Pamoic acid

olanzapine pamoate monohydrate

olanzapine pamoate monohydrate

Conditions
ConditionsYield
Stage #1: Pamoic acid With ammonium hydroxide In water
Stage #2: zyprexa With hydrogenchloride; water at 25 - 30℃; Reagent/catalyst;
97%
Stage #1: zyprexa; Pamoic acid In dimethyl sulfoxide at 20 - 25℃; for 0.333333h;
Stage #2: With water In dimethyl sulfoxide at 20 - 40℃; for 1.16667h;
maleic acid
110-16-7

maleic acid

zyprexa
132539-06-1

zyprexa

olanzapinium monomaleate
861390-74-1

olanzapinium monomaleate

Conditions
ConditionsYield
In ethanol for 24h; Product distribution / selectivity;88%
In hexane for 24h; Product distribution / selectivity;83%
In 1,4-dioxane for 24h; Product distribution / selectivity;75%
In acetonitrile for 0.25h;
maleic acid
110-16-7

maleic acid

zyprexa
132539-06-1

zyprexa

olanzapinium dimaleate

olanzapinium dimaleate

Conditions
ConditionsYield
In methanol for 24h; Product distribution / selectivity;88%
In methanol for 24h; Product distribution / selectivity;44%
In acetonitrile for 0.25h;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

zyprexa
132539-06-1

zyprexa

olanzapine fumarate

olanzapine fumarate

Conditions
ConditionsYield
In dimethyl sulfoxide at 0 - 30℃; for 3h; Product distribution / selectivity;85.2%
In methanol; dichloromethane; water at 0 - 25℃; for 3h; Product distribution / selectivity;65.7%
In isopropyl alcohol at 0 - 25℃; for 2h; Product distribution / selectivity;
tetrahydrofuran
109-99-9

tetrahydrofuran

zyprexa
132539-06-1

zyprexa

olanzapine tetrahydrofuran water solvate

olanzapine tetrahydrofuran water solvate

Conditions
ConditionsYield
With water at 0 - 50℃; for 2.5h; Product distribution / selectivity;85%
With water at 5℃; Heating / reflux;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

zyprexa
132539-06-1

zyprexa

3C4H4O4*C17H20N4S

3C4H4O4*C17H20N4S

Conditions
ConditionsYield
In methanol for 4h;84%
acetonitrile
75-05-8

acetonitrile

zyprexa
132539-06-1

zyprexa

2,10-Dimethyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine
155817-84-8

2,10-Dimethyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine

Conditions
ConditionsYield
With 18-crown-6 ether; carbon dioxide at 80℃; under 750.075 Torr; for 72h; Inert atmosphere; Schlenk technique; Glovebox;83%
zyprexa
132539-06-1

zyprexa

salicylic acid
69-72-7

salicylic acid

C7H6O3*C17H20N4S
929209-00-7

C7H6O3*C17H20N4S

Conditions
ConditionsYield
In methanol for 24h; Product distribution / selectivity;82%
zyprexa
132539-06-1

zyprexa

Olanzapine N-Oxide

Olanzapine N-Oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 12℃; for 12h;79.1%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane
With α-D-glucose 6-phosphate; glucose phosphate dehydrogenase; human cytochrome P450 (CYP) 2D6.10, recombinant; NADP In aq. phosphate buffer at 37℃; for 0.75h; Kinetics; Reagent/catalyst; Enzymatic reaction;
acetic acid
64-19-7

acetic acid

zyprexa
132539-06-1

zyprexa

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

Conditions
ConditionsYield
In ethyl acetate at 4 - 20℃; Product distribution / selectivity;79%
In acetone at 4 - 20℃; Product distribution / selectivity;56%
In dimethyl sulfoxide at 4℃; for 4h; Product distribution / selectivity;
In isopropyl alcohol Product distribution / selectivity;
3-chloro-benzenecarboperoxoic acid
937-14-4

3-chloro-benzenecarboperoxoic acid

zyprexa
132539-06-1

zyprexa

olanzapine N-oxide-m-chlorobenzoate

olanzapine N-oxide-m-chlorobenzoate

Conditions
ConditionsYield
In chloroform at 23℃; for 0.166667h; Inert atmosphere;78%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

zyprexa
132539-06-1

zyprexa

2C4H4O4*C17H20N4S

2C4H4O4*C17H20N4S

Conditions
ConditionsYield
In methanol for 22h;74%
carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

zyprexa
132539-06-1

zyprexa

chloromethyl 2-methyl-4-(4-methyl(y)pi(y)perazin-1-yl)-5H-benzo[b]thieno[2,3-e][1,4]diaze(y)pine-5-carboxylate
1443629-16-0

chloromethyl 2-methyl-4-(4-methyl(y)pi(y)perazin-1-yl)-5H-benzo[b]thieno[2,3-e][1,4]diaze(y)pine-5-carboxylate

Conditions
ConditionsYield
Stage #1: zyprexa With triethylamine In dichloromethane at 5 - 35℃;
Stage #2: carbonochloridic acid, chloromethyl ester In dichloromethane at 5 - 25℃; for 1.08333h; regioselective reaction;
73%
With triethylamine In dichloromethane at 5 - 35℃; for 0.833333h;73%
Stage #1: zyprexa With triethylamine In dichloromethane at 35℃;
Stage #2: carbonochloridic acid, chloromethyl ester at 5 - 20℃; for 1.08333h;
73%
With triethylamine In dichloromethane at 20℃; for 0.75h;73%
With triethylamine In dichloromethane at 5 - 35℃; for 1.08333h;73%
zyprexa
132539-06-1

zyprexa

olanzapine trihydrate

olanzapine trihydrate

Conditions
ConditionsYield
Stage #1: zyprexa With water; acetic acid at 20℃;
Stage #2: With ammonia; water at 20℃; pH=9.75;
68.5%
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