Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:96036-03-2
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryWuhan Fortuna Chemical Co.,Ltd
Unique advantages of Meropenem Cas 96036-03-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellowish crystalline powder Storage:Cool dry place Package:10g/foil bag App
Cas:96036-03-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryEAST CHEMSOURCES LIMITED
Meropenem CAS:96036-03-2 EINECS: Molecularstructure: MolecularFormula:C17H25N3O5S Molecularweight:383.46 Meltingpoint: Assay:99% packing:intightcontainers Our Server 1. Competitive offers with standard high quality or
Ality Chemical Corporation
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Xi'an Xszo Chem Co., Ltd.
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:96036-03-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShandong Jiulong Hisince Pharmaceutical Co.,Ltd.
Meropenem CAS No. : [96036-03-2] Spec : USP/JP Supply : Commercial Appearance:white Storage:cool a
Cas:96036-03-2
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical Co.,Ltd
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryDayang Chem (Hangzhou) Co.,Ltd.
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryHebei yanxi chemical co.,LTD.
CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $2.0 / 3.0
Type:Trading Company
inquiryHubei DiBo chemical co., LTD
Name:Meropenem The alias：MEROPENEM, USP STANDARD;MEROPENAM CAS NO:96036-03-2 EINECS NO:641-424-1 Molecular formula：C17H25N3O5S Molecular weight:383.4625 Product Quality 12 years of chemical raw materials Mature operation of the industry
Cas:96036-03-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryHebei Nengqian Chemical Import and Export Co., LTD
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd.
TIANFUCHEM--96036-03-2--High purity Meropenem factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:96036-03-2
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryZhuozhou Wenxi import and Export Co., Ltd
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHenan Sinotech Import&Export Corporation
Items Specification Results Appearance White or off-white powder Conformed Identification Me
Hebei Sankai Chemical Technology Co., Ltd
1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co., Ltd.
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:96036-03-2
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryHubei Langyou International Trading Co., Ltd
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu
Cas:96036-03-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiryHANWAYS CHEMPHARM CO.,LIMITED
Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:96036-03-2
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiryShanghai Upbio Tech Co.,Ltd
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:96036-03-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryXi'an Faithful Biotech Co., Ltd.
We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:96036-03-2
Min.Order:10 Gram
FOB Price: $1.35
Type:Trading Company
inquiryHangzhou Fonlynn Health Technology Co., Ltd.
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:96036-03-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryBaoji Guokang Healthchem co.,ltd
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Qingdao Beluga Import and Export Co., LTD
Meropenem CAS: 96036-03-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:96036-03-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryShandong Hanjiang Chemical Co., Ltd.
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Hubei Jiutian Bio-medical Technology Co., Ltd
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:96036-03-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHebei Quanhe Biotechnology Co. LTD
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Guangdong Juda Chemical Industrial Co.,Limited
As a leading manufacturer and supplier of chemicals in China, JudaChem not only supply popular chemicals, but also JudaChem's R&D center offer custom synthesis services. JudaChem can provide different quantities of custom synt
Cas:96036-03-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryChangchun Artel lmport and Export trade company
Product Detail Minimum Order Qty. 10 Gram
Cas:96036-03-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryTriumph International Development Limilted
Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Synthetic route
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96036-02-1
p-nitrobenzyl (4R,5S,6S)-3-<(3S,5S)-5-dimethylaminocarbonyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidin-3-ylthio>-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-en-2-carboxylate
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With 2,6-dimethylpyridine; hydrogen In tetrahydrofuran; water at 40℃; under 13446.2 Torr; for 1.16667h; Pressure; Temperature; Reagent/catalyst; | 85% |
| With formaldehyd; sodium isooctanoate; 5%-palladium/activated carbon In water at 7℃; for 2.5h; Reagent/catalyst; Temperature; | 85.3% |
| With platinum on carbon; hydrogen; p-toluidine In tetrahydrofuran at 25℃; under 13501.4 Torr; for 0.683333h; Reagent/catalyst; Solvent; Sealed tube; | 84% |
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Stage #1: (1R,5R,6S)-6-[(1R)-1-hydroxymethyl]-2-diphenylphosphoryloxocarbapen-2-em-3-carboxylic acid p-nitrobenzyl ester; (2R,4S)-4-dimethylaminomercapto-2-formyl-1-p-nitrobenzyl carbonylpyrrolidine at -5℃; Stage #2: With 5%-palladium/activated carbon; hydrogen at 25℃; Reagent/catalyst; | 44% |
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141818-52-2
4-nitrobenzyl (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxy-ethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; hydrogen; acetic acid In water; ethyl acetate at 20 - 25℃; for 3h; pH=~ 7; Product distribution / selectivity; Aqueous buffer; |
| Conditions | Yield |
|---|---|
| Stage #1: 4-nitrobenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at -50 - 25℃; for 1h; Stage #2: With 4-methyl-morpholine; hydrogen; acetic acid; 5%-palladium/activated carbon In water; ethyl acetate; N,N-dimethyl-formamide at 20 - 25℃; for 3h; pH=~ 7; |
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With hydrogen; palladium 10% on activated carbon In tetrahydrofuran; water at 25 - 30℃; for 2 - 3h; |
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93711-81-0, 90776-59-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
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96034-64-9
(2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Stage #1: (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one; water at -20 - -5℃; Stage #2: With 4-methyl-morpholine; hydrogenchloride; 5% Pd(II)/C(eggshell); hydrogen In 1-methyl-pyrrolidin-2-one; water at 25℃; pH=6.5 - 7; | |
| Stage #1: (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at -20 - -5℃; Stage #2: With hydrogen; 5%-palladium/activated carbon In 1-methyl-pyrrolidin-2-one at 25℃; pH=6.5 - 7; N-methylmorpholine - hydrochloric acid - buffer; | |
| Stage #1: (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0 - 5℃; for 5h; Stage #2: With potassium dihydrogenphosphate; zinc In water; ethyl acetate at 25 - 35℃; for 1h; | |
| Stage #1: (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine With N-ethyl-N,N-diisopropylamine In ISOPROPYLAMIDE at 0 - 5℃; for 5h; Stage #2: With hydrogenchloride In water; ethyl acetate Stage #3: With potassium dihydrogenphosphate In water; ethyl acetate at 25 - 35℃; for 1h; |
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: dmap / dichloromethane / 3 h / 20 - 30 °C 2.1: dichloromethane / 3 h / 20 - 45 °C / Reflux 3.1: triethylamine; 4-toluenesulfonyl azide / dichloromethane / 2 h / 20 - 30 °C 4.1: hydrogenchloride; methanol / dichloromethane; water / 3 h / 20 - 30 °C 5.1: dichloromethane; Isopropyl acetate / 25 - 30 °C 6.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 7.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 8.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 8.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: dichloromethane / 3 h / 20 - 45 °C / Reflux 2.1: triethylamine; 4-toluenesulfonyl azide / dichloromethane / 2 h / 20 - 30 °C 3.1: hydrogenchloride; methanol / dichloromethane; water / 3 h / 20 - 30 °C 4.1: dichloromethane; Isopropyl acetate / 25 - 30 °C 5.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 6.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 7.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: triethylamine; 4-toluenesulfonyl azide / dichloromethane / 2 h / 20 - 30 °C 2.1: hydrogenchloride; methanol / dichloromethane; water / 3 h / 20 - 30 °C 3.1: dichloromethane; Isopropyl acetate / 25 - 30 °C 4.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 6.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: hydrogenchloride; methanol / dichloromethane; water / 3 h / 20 - 30 °C 2.1: dichloromethane; Isopropyl acetate / 25 - 30 °C 3.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 5.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: dichloromethane; Isopropyl acetate / 25 - 30 °C 2.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 4.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: zinc dibromide; rhodium (II) octanoate dimer / dichloromethane / 40 °C / Reflux 2.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 0 °C 3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 - -5 °C 3.2: 25 °C / pH 6.5 - 7 / N-methylmorpholine - hydrochloric acid - buffer View Scheme |
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90822-24-5
(γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: rhodium (II) octanoate dimer / dichloromethane / 7 h / Reflux 2: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / -35 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 4: hydrogen; 2,6-dimethylpyridine / palladium 10% on activated carbon / water; tetrahydrofuran / 20 - 25 °C / 13501.4 Torr View Scheme | |
| Multi-step reaction with 4 steps 1: rhodium (II) octanoate dimer / acetone / Reflux 2: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 4: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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104873-15-6
4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]-heptane-2-carboxylate
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / -35 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 3: hydrogen; 2,6-dimethylpyridine / palladium 10% on activated carbon / water; tetrahydrofuran / 20 - 25 °C / 13501.4 Torr View Scheme | |
| Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 3: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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96034-64-9
(2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 2: hydrogen; 2,6-dimethylpyridine / palladium 10% on activated carbon / water; tetrahydrofuran / 20 - 25 °C / 13501.4 Torr View Scheme | |
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / -35 - -30 °C 2: hydrogen; 2,6-dimethylpyridine / palladium 10% on activated carbon / dichloromethane; water; tetrahydrofuran / 20 - 25 °C / 13501.4 Torr View Scheme |
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96034-57-0
(2S,4R)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: triethylamine; isopropyl chloroformate / dichloromethane / -30 - -20 °C 2.1: triethylamine / dichloromethane / -20 °C 3.1: N,N-dimethyl-formamide / 70 - 80 °C 4.1: sodium hydroxide; water / methanol / 5 - 10 °C 4.2: pH 2 5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 6.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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51-35-4
4R-4-hydroxyproline
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: sodium hydroxide / water / 0 - 5 °C 1.2: 0 - 5 °C 1.3: 0 - 5 °C 2.1: triethylamine; isopropyl chloroformate / dichloromethane / -30 - -20 °C 3.1: triethylamine / dichloromethane / -20 °C 4.1: N,N-dimethyl-formamide / 70 - 80 °C 5.1: sodium hydroxide; water / methanol / 5 - 10 °C 5.2: pH 2 6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 7.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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90822-22-3
(3S,4R)-3-<(1R)-1-<(tert-Butyldimethylsilyl)oxy>ethyl>-4-<(1R)-1-methyl-3-(p-nitrobenzyloxycarbonyl)-2-oxopropyl>azetidin-2-one
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: hydrogenchloride; water / ethyl acetate 2: triethylamine / ethyl acetate; toluene 3: rhodium (II) octanoate dimer / acetone / Reflux 4: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 6: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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93711-85-4, 97101-07-0, 113033-46-8, 120710-59-0, 120710-60-3, 90776-58-2
(2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: 1,1'-carbonyldiimidazole / acetonitrile 2: hydrogenchloride; water / ethyl acetate 3: triethylamine / ethyl acetate; toluene 4: rhodium (II) octanoate dimer / acetone / Reflux 5: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 7: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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130625-69-3
(2S,4R)-1-p-Nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-hydroxypyrrolidine
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / -20 °C 2.1: N,N-dimethyl-formamide / 70 - 80 °C 3.1: sodium hydroxide; water / methanol / 5 - 10 °C 3.2: pH 2 4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 5.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
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96034-61-6
4-Nitrobenzyl (2S,4S)-4-(acetylthio)-2-[(dimethylamino)carbonyl]pyrrolidine-1-carboxylate
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96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / methanol / 5 - 10 °C 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 3.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
-
-
90822-23-4
(3S,4R)-3-<(1R)-1-hydroxyethyl>-4-<(1R)-1-methyl-3-p-nitrobenzyloxycarbonyl-2-oxopropyl>-2-azetidin-2-one
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: triethylamine / ethyl acetate; toluene 2: rhodium (II) octanoate dimer / acetone / Reflux 3: N-ethyl-N,N-diisopropylamine; zinc(II) iodide / acetone / -30 °C 4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 5: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
-
-
130625-70-6
(2S,4R)-2-dimethylaminocarbonyl-4-mesyloxy-1-p-nitrobenzyloxycarbonylpyrrolidine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: N,N-dimethyl-formamide / 70 - 80 °C 2.1: sodium hydroxide; water / methanol / 5 - 10 °C 2.2: pH 2 3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -25 °C 4.1: hydrogen / palladium on activated charcoal / ethyl acetate; water / 3-(N-morpholino)propanesulfonic acid buffer View Scheme |
-
-
1450666-42-8
1-[(S)-benzosuber-1-yloxycarbonyloxy]ethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
124-38-9
carbon dioxide
-
B
-
35550-94-8, 65915-63-1, 79416-49-2, 138381-73-4
1-benzosuberol
-
C
-
75-07-0
acetaldehyde
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; pH=7.4; Mechanism; Reagent/catalyst; pH-value; Time; |
-
-
1450666-26-8
indan-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
50-00-0
formaldehyd
-
B
-
4254-29-9
indan-2-ol
-
C
-
124-38-9
carbon dioxide
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; for 2h; pH=7.4; Mechanism; Reagent/catalyst; pH-value; Time; |
-
-
1450666-27-9
tetral-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
50-00-0
formaldehyd
-
B
-
124-38-9
carbon dioxide
-
C
-
530-91-6
1,2,3,4-tetrahydronaphthalen-2 ol
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; for 2h; pH=7.4; Mechanism; Reagent/catalyst; pH-value; Time; |
-
-
1450666-28-0
benzosuber-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
50-00-0
formaldehyd
-
B
-
124-38-9
carbon dioxide
-
C
-
13249-77-9
3,4-benzo-3-cyclohepten-1-ol
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; for 2h; pH=7.4; Mechanism; Reagent/catalyst; pH-value; Time; |
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; for 2h; pH=7.4; Mechanism; Reagent/catalyst; pH-value; Time; |
-
-
1450666-36-0
(S)-indan-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
50-00-0
formaldehyd
-
B
-
124-38-9
carbon dioxide
-
C
-
6351-10-6
1-Indanol
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; pH=7.4; Mechanism; Time; |
-
-
1450666-39-3
(R)-indan-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
-
A
-
50-00-0
formaldehyd
-
B
-
124-38-9
carbon dioxide
-
C
-
6351-10-6
1-Indanol
-
D
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 37℃; pH=7.4; Mechanism; Time; |
-
-
1450666-33-7
[(S)-benzosuber-1-yl] iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-38-2
(S)-benzosuber-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: [(S)-benzosuber-1-yl] iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 84% |
-
-
1450666-32-6
iodomethyl (R)-tetral-1-yl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-40-6
(R)-tetral-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: iodomethyl (R)-tetral-1-yl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 82% |
-
-
1450666-24-6
iodomethyl tetral-2-yl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-27-9
tetral-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: iodomethyl tetral-2-yl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 82% |
-
-
1450666-34-8
(R)-benzosuber-1-yl iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-41-7
(R)-benzosuber-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: (R)-benzosuber-1-yl iodomethyl carbonate | 79% |
-
-
1450666-29-1
(S)-indan-1-yl iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-36-0
(S)-indan-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: (S)-indan-1-yl iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 75% |
-
-
1450666-30-4
(R)-indan-1-yl iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-39-3
(R)-indan-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: (R)-indan-1-yl iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 72% |
-
-
1450666-23-5
indan-2-yl iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-26-8
indan-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: indan-2-yl iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 71% |
-
-
1450666-25-7
benzosuber-2-yl iodomethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-28-0
benzosuber-2-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: benzosuber-2-yl iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 65% |
-
-
84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 1-iodoethyl isopropyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Reagent/catalyst; Concentration; Time; | 64% |
-
-
1450666-33-7
[(S)-benzosuber-1-yl] iodomethyl carbonate
-
-
108-24-7
acetic anhydride
-
-
96036-03-2
meropenem
-
-
1450666-43-9
(S)-benzosuber-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-1-acetyl-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #3: [(S)-benzosuber-1-yl] iodomethyl carbonate In N,N-dimethyl-formamide at 0℃; for 1h; | 62% |
-
-
1450666-31-5
iodomethyl (S)-tetral-1-yl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-37-1
(S)-tetral-1-yloxycarbonyloxymethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: iodomethyl (S)-tetral-1-yl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 57% |
| Conditions | Yield |
|---|---|
| With triethylamine In methanol at 0 - 20℃; for 1h; | 50% |
-
-
1450666-35-9
[(1S)-benzosuber-1-yl] 1-iodoethyl carbonate
-
-
96036-03-2
meropenem
-
-
1450666-42-8
1-[(S)-benzosuber-1-yloxycarbonyloxy]ethyl (1R,5S,6S)-2-{[(3S,5S)-5-(N,N-dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: meropenem With caesium carbonate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: [(1S)-benzosuber-1-yl] 1-iodoethyl carbonate In N,N-dimethyl-formamide at 0℃; for 0.333333h; | 43% |
| Conditions | Yield |
|---|---|
| With triethylamine In dimethyl sulfoxide at 20℃; | 16.3% |
-
-
13943-33-4
iodomethylbenzoate
-
-
96036-03-2
meropenem
-
-
170097-82-2
benzoic acid 4-nitrophenoxycarbonyloxymethyl ester
| Conditions | Yield |
|---|---|
| Stage #1: meropenem; benzoic acid 4-nitrophenoxycarbonyloxymethyl ester In N,N-dimethyl-formamide for 1h; Stage #2: iodomethylbenzoate With sodium carbonate In N,N-dimethyl-formamide for 1h; | 14% |
| Conditions | Yield |
|---|---|
| With potassium dihydrogenphosphate; water at 25℃; Rate constant; Kinetics; var. pH from 4.0 to 8.0, var. temp., var. buffers; |
-
-
921-01-7
D-cysteine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
52-90-4
L-Cysteine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; Further Variations:; pH-values; Temperatures; | |
| With sodium hydroxide at 20℃; for 3h; pH=7; Substitution; ring cleavage; |
-
-
6027-13-0
L-homocysteine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
19246-18-5
cysteinylglycine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
70-18-8
GLUTATHIONE
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
79178-11-3
L-Cysteine isopropyl ester
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
60-23-1
Cysteamine
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; |
-
-
96036-03-2
meropenem
| Conditions | Yield |
|---|---|
| With Hepps buffer at 37℃; pH=8.4; Kinetics; Hydrolysis; |
| Conditions | Yield |
|---|---|
| In water-d2 at 25℃; Equilibrium constant; Carboxylation; |
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