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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Zoledronic acid Manufacturer/High quality/Best price/In stock

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Zoledronic acid 118072-93-8 with best price

Cas:118072-93-8

Min.Order:1 Gram

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Zoledronic acid Cas 118072-93-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:N/A Package:10g,100g,1kg/foil bag Ap

Factory supply Zoledronic acid Cas 118072-93-8 with high quality and best price

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $1492.0 / 1495.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

118072-93-8 Zoledronic acid

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Zoledronic Acid

Cas:118072-93-8

Min.Order:1

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Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Zoledronic acid 118072-93-8 ISO Manufacturer

Cas:118072-93-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

zoledronic acid

Cas:118072-93-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Zoledronic Acid CAS 118072-93-8

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Zoledronic acid CAS NO:118072-93-8 Grade:Medical scientific research and export Molecular formula: C5H10N2O7P2 ·H2O Molecular weight:272.09 Product Quality 12 years of chemical raw materials Mature operation of the industry S

Zoledronic acid /cas:118072-93-8 /Raw material spot

Cas:118072-93-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can

Zoledronic acid CAS 118072-93-8

Cas:118072-93-8

Min.Order:1 Metric Ton

FOB Price: $5.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

[1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid Chemical Name : [1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid CAS: 118072-93-8

[1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid -

Cas:118072-93-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 118072-93-8 with best quality

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

China supply 118072-93-8 Zoledronic acid

Cas:118072-93-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Zoledronic acid/ LIDE PHARMA- Factory supply / Best price

Cas:118072-93-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Zoledronic acid

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $75.0 / 78.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Synonym: Zoledronate Application: A protein kinase C activator with apoptotic effects CAS Number: 118072-93-8 Purity: ≥99% Molecular Weight:

Zoledronic Acid 99%

Cas:118072-93-8

Min.Order:100 Gram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Zoledronic Acid For Anti-neoplastic Agents

Cas:118072-93-8

Min.Order:10 Gram

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:white crystalline powder Storage:Room temperature Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China

High purity Zoledronic acid

Cas:118072-93-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Buy key product Zoledronic acid CAS NO.118072-93-8

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

A bone resorption inhibitor Zoledronic acid/CAS:118072-93-8

Cas:118072-93-8

Min.Order:200 Gram

FOB Price: $1453.0 / 1867.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Zoledronic acid CAS 118072-93-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in Chin

High quality Zoledronic acid CAS 118072-93-8

Cas:118072-93-8

Min.Order:1 Gram

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Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Zoledronic acid

Cas:118072-93-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Zoledronic acid CAS NO.118072-93-8

Cas:118072-93-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Zoledronic acid

Cas:118072-93-8

Min.Order:0

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Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Zoledronic acid

Cas:118072-93-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Zoledronic acid

Cas:118072-93-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Zoledronic acid 118072-93-8

Cas:118072-93-8

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

118072-93-8 Zoledronic acid

Cas:118072-93-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Factory 4-amino-3,5-dichloropyridine low price

Cas:118072-93-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

118072-93-8 Zoledronic acid

Cas:118072-93-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Synthetic route

imidazol-1-ylacetic acid
22884-10-2

imidazol-1-ylacetic acid

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-ylacetic acid With phosphoric acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 40 - 60℃;
Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 85℃; for 18h; Product distribution / selectivity;
99%
Stage #1: imidazol-1-ylacetic acid With phosphorous acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 at 40 - 60℃;
Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 at 85℃; for 18h; Product distribution / selectivity;
99%
With sulfolane; phosphonic Acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; phosphorus trichloride at 75℃; for 3h; Reagent/catalyst; Green chemistry;93%
C8H8N4O2*ClH

C8H8N4O2*ClH

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: C8H8N4O2*ClH With phosphoric acid; phosphorus trichloride In toluene at 90℃;
Stage #2: With hydrogenchloride In water; toluene at 20℃; Reagent/catalyst; Temperature; Solvent; Reflux;
85.27%
2-(1-imidazolyl)acetic acid hydrochloride

2-(1-imidazolyl)acetic acid hydrochloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In silicon oil at 80℃; for 11 - 24h;
Stage #2: With water In toluene; silicon oil at 80 - 100℃; for 16 - 19h; Product distribution / selectivity;
74%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In toluene at 100℃; for 3h;
Stage #2: With water In toluene at 80 - 100℃; for 16h; Product distribution / selectivity;
69%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphonic Acid; trichlorophosphate In chlorobenzene at 85 - 95℃; for 4.5h;
Stage #2: With water for 18h; Reflux;
64%
1H-imidazole
288-32-4

1H-imidazole

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: 1H-imidazole; chloroacetic acid ethyl ester With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In 1,4-dioxane at 20℃; for 0.5h; Reflux;
Stage #2: With phosphoric acid; phosphorus trichloride In 1,4-dioxane at 20℃; for 1h;
Stage #3: With hydrogenchloride In water for 6h; Reagent/catalyst;
60.5%
imidazol-1-yl-acetyl chloride
160975-66-6

imidazol-1-yl-acetyl chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-yl-acetyl chloride With methanesulfonic acid; phosphorus trichloride at 26 - 80℃; for 16h;
Stage #2: With water at 26 - 110℃; for 5h;
Stage #3: With sodium hydroxide In water for 12h; pH=1.8;
tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid
1392687-52-3

tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
With water In ethanol for 0.5h;
1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium
827573-10-4

1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 89.84℃; for 0.25h; pH=1.5;
imidazol-1-ylacetic acid
22884-10-2

imidazol-1-ylacetic acid

phosphorus trichloride
7719-12-2, 52843-90-0

phosphorus trichloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-ylacetic acid; phosphorus trichloride With methanesulfonic acid at 80℃; Green chemistry;
Stage #2: In water Green chemistry;
Stage #3: With sodium hydroxide In water Green chemistry;
ethyl 2-(1H-imidazol-1-yl)acetate
17450-34-9

ethyl 2-(1H-imidazol-1-yl)acetate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 7 h / 100 °C / pH 1.5
2.1: phosphoric acid / water / 0.5 h / 100 °C
2.2: 3 h / 65 - 100 °C
2.3: 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water
2: water; phosphoric acid; phosphorus trichloride / chlorobenzene
View Scheme
C11H14N4O2

C11H14N4O2

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / Reflux
2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C
2.2: 20 °C / Reflux
View Scheme
C9H10N4O2

C9H10N4O2

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / Reflux
2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C
2.2: 20 °C / Reflux
View Scheme
C13H18N4O2

C13H18N4O2

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / Reflux
2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C
2.2: 20 °C / Reflux
View Scheme
C10H12N4O2

C10H12N4O2

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / Reflux
2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C
2.2: 20 °C / Reflux
View Scheme
choline chloride
67-48-1

choline chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

2-hydroxy-N,N,N-trimethylethan-1-aminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

2-hydroxy-N,N,N-trimethylethan-1-aminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
choline chloride
67-48-1

choline chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

bis(2-hydroxy-N,N,N-trimethylethan-1-aminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

bis(2-hydroxy-N,N,N-trimethylethan-1-aminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions
ConditionsYield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
3-ethyl-1-methyl-1H-imidazol-3-ium bromide
65039-08-9

3-ethyl-1-methyl-1H-imidazol-3-ium bromide

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

(1-ethyl-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

(1-ethyl-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
Stage #1: 3-ethyl-1-methyl-1H-imidazol-3-ium bromide With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

(1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

(1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

bis(1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

bis(1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

bis(1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

bis(1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions
ConditionsYield
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

N,N,N',N'-tetramethylguanidine
80-70-6

N,N,N',N'-tetramethylguanidine

bis(dimethylamino)methaniminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

bis(dimethylamino)methaniminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
In methanol; water for 1h;100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

N,N,N',N'-tetramethylguanidine
80-70-6

N,N,N',N'-tetramethylguanidine

bis(bis(dimethylamino)methaniminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

bis(bis(dimethylamino)methaniminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions
ConditionsYield
In methanol; water for 1h;100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions
ConditionsYield
In methanol; water for 1h;100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

bis(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogenphosphonate)

bis(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogenphosphonate)

Conditions
ConditionsYield
In methanol; water for 1h;100%
1-ethyl-3-methyl-1H-imidazol-3-ium chloride
65039-09-0

1-ethyl-3-methyl-1H-imidazol-3-ium chloride

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

bis(1-ethyl-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

bis(1-ethyl-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions
ConditionsYield
Stage #1: 1-ethyl-3-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol
Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;
100%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium
827573-10-4

1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium

Conditions
ConditionsYield
With sodium hydroxide In methanol for 16h; Product distribution / selectivity; Heating / reflux;99%
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux;98%
With sodium hydroxide In ethanol for 16h; Product distribution / selectivity; Heating / reflux;96%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

zoledronate disodium

zoledronate disodium

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 19h; Heating / reflux;99%
With sodium hydroxide In ethanol; water for 18.5h; Product distribution / selectivity; Heating / reflux;98%
With sodium hydroxide In methanol; water for 17h; Product distribution / selectivity; Heating / reflux;97%
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

zoledronic acid monohydrate
165800-06-6

zoledronic acid monohydrate

Conditions
ConditionsYield
With water at 70 - 80℃; Heating / reflux;89%
With water In ethanol at 60℃; for 2h;
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

zoledronate trisodium

zoledronate trisodium

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 20h; Product distribution / selectivity; Heating / reflux;84%
With sodium hydroxide In water; isopropyl alcohol for 16h; Product distribution / selectivity; Heating / reflux;79%
With sodium hydroxide In methanol; water for 16h; Product distribution / selectivity; Heating / reflux;64%
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux;58%
[Pt(ethylenediamine)(H2O)(OSO3)]

[Pt(ethylenediamine)(H2O)(OSO3)]

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

{[Pt(ethylenediamine)]2(1-hydroxy-3-(1H-imidazol-1-yl)ethane-1,1-diylbisphosphonic acid-H4)}

{[Pt(ethylenediamine)]2(1-hydroxy-3-(1H-imidazol-1-yl)ethane-1,1-diylbisphosphonic acid-H4)}

Conditions
ConditionsYield
Stage #1: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid With barium hydroxide octahydrate In water at 0℃; for 0.166667h;
Stage #2: [Pt(ethylenediamine)(H2O)(OSO3)] In water at 0 - 4℃; pH=5;
84%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

nickel(II) sulfate hexahydrate

nickel(II) sulfate hexahydrate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

[Ni3(zoledronic acid)2(4,4′-dipyridyl)2](4,4′-dipyridyl)4H2O

[Ni3(zoledronic acid)2(4,4′-dipyridyl)2](4,4′-dipyridyl)4H2O

Conditions
ConditionsYield
Stage #1: nickel(II) sulfate hexahydrate; 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In ethanol; water for 0.166667h;
Stage #2: 4,4'-bipyridine In ethanol; water at 180℃; for 72h; pH=6.08; Autoclave;
83%
sodium metavanadate * water

sodium metavanadate * water

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

V3(Zol)3

V3(Zol)3

Conditions
ConditionsYield
With triethylamine In water ligand added to aq. soln. of NaVO3*H2O, stirred for 1 h, triethylamine added dropwise to pH 5, stirred for 1 h at 80°C; evapd. at room temp. for 5 d; elem. anal.;79%
[Re(2,2′-bipyridine)(CO)3(H2O)](CF3SO3)
537030-00-5

[Re(2,2′-bipyridine)(CO)3(H2O)](CF3SO3)

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Re(CO)3(2,2'-bipyridine)(zoledronic acid(-H))

Re(CO)3(2,2'-bipyridine)(zoledronic acid(-H))

Conditions
ConditionsYield
With sodium hydroxide In water pH=7; Reflux;77%
water
7732-18-5

water

copper(II) sulfate
7758-99-8

copper(II) sulfate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Cu3(2-(1-imidazole)-1-hydroxy-1,1'-ethylidenediphosphonicacid-3H)2 dihydrate

Cu3(2-(1-imidazole)-1-hydroxy-1,1'-ethylidenediphosphonicacid-3H)2 dihydrate

Conditions
ConditionsYield
In water High Pressure; hydrothermal treatment of a mixt. of a ligand (0.10 mmol), CuSO4 (0.15 mmol) in H2O (pH=2.14) at 140°C for 24 h; elem. anal.; powder XRD;70.6%
manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

manganese zoledronate

manganese zoledronate

Conditions
ConditionsYield
With hydrogenchloride In water; N,N-dimethyl-formamide at 100℃; for 0.333333h; Sealed tube; Microwave irradiation;70%
hexaammonium heptamolybdate tetrahydrate

hexaammonium heptamolybdate tetrahydrate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Mo6(Zol)2

Mo6(Zol)2

Conditions
ConditionsYield
With CH3CO2NH4/CH3CO2H In water High Pressure; ligand and (NH4)6Mo7O24*4H2O dissolved in CH3CO2NH4/CH3CO2H, placed in autoclave, heated to 130°C for 4 h, kept for 20 h, cooled to room temp. over 36 h; filtered; elem. anal.;68%
hexaammonium heptamolybdate tetrahydrate

hexaammonium heptamolybdate tetrahydrate

iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

ammonia
7664-41-7

ammonia

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Mo4(zoledronate)2Fe

Mo4(zoledronate)2Fe

Conditions
ConditionsYield
With ammonium acetate In aq. acetate buffer at 20 - 130℃; for 60h; pH=6; Autoclave;67%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) choride dihydrate

copper(II) choride dihydrate

water
7732-18-5

water

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

C25H25ClCu2N6O8P2*4H2O

C25H25ClCu2N6O8P2*4H2O

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 140℃; for 72h; pH=2.52; Autoclave; High pressure;67%
ammonium molybdate tetrahydrate

ammonium molybdate tetrahydrate

iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

5H3N*7H(1+)*2Mo2O6*2C5H5N2O7P2(5-)*Fe(3+)*5H2O

5H3N*7H(1+)*2Mo2O6*2C5H5N2O7P2(5-)*Fe(3+)*5H2O

Conditions
ConditionsYield
With ammonium hydroxide In aq. acetate buffer at 130℃; for 24h; pH=6; Autoclave;67%

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