As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiryUnique advantages for Zoledronic acid Cas 118072-93-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:N/A Package:10g,100g,1kg/foil bag Ap
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inquiryHebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiryName:Zoledronic acid CAS NO:118072-93-8 Grade:Medical scientific research and export Molecular formula: C5H10N2O7P2 ·H2O Molecular weight:272.09 Product Quality 12 years of chemical raw materials Mature operation of the industry S
Cas:118072-93-8
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
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inquiry[1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid Chemical Name : [1-hydroxy-2-(1h-imidazol-1-yl)-ethylidene]bisphosphonic acid CAS: 118072-93-8
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:118072-93-8
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inquirySynonym: Zoledronate Application: A protein kinase C activator with apoptotic effects CAS Number: 118072-93-8 Purity: ≥99% Molecular Weight:
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiryAppearance:white crystalline powder Storage:Room temperature Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China
Cas:118072-93-8
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:118072-93-8
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Type:Trading Company
inquiryBeluga chemical professional supply High quality Zoledronic acid CAS 118072-93-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in Chin
Cas:118072-93-8
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:118072-93-8
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:118072-93-8
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:118072-93-8
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryimidazol-1-ylacetic acid
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: imidazol-1-ylacetic acid With phosphoric acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 40 - 60℃; Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 85℃; for 18h; Product distribution / selectivity; | 99% |
Stage #1: imidazol-1-ylacetic acid With phosphorous acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 at 40 - 60℃; Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 at 85℃; for 18h; Product distribution / selectivity; | 99% |
With sulfolane; phosphonic Acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; phosphorus trichloride at 75℃; for 3h; Reagent/catalyst; Green chemistry; | 93% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: C8H8N4O2*ClH With phosphoric acid; phosphorus trichloride In toluene at 90℃; Stage #2: With hydrogenchloride In water; toluene at 20℃; Reagent/catalyst; Temperature; Solvent; Reflux; | 85.27% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In silicon oil at 80℃; for 11 - 24h; Stage #2: With water In toluene; silicon oil at 80 - 100℃; for 16 - 19h; Product distribution / selectivity; | 74% |
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In toluene at 100℃; for 3h; Stage #2: With water In toluene at 80 - 100℃; for 16h; Product distribution / selectivity; | 69% |
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphonic Acid; trichlorophosphate In chlorobenzene at 85 - 95℃; for 4.5h; Stage #2: With water for 18h; Reflux; | 64% |
1H-imidazole
chloroacetic acid ethyl ester
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 1H-imidazole; chloroacetic acid ethyl ester With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In 1,4-dioxane at 20℃; for 0.5h; Reflux; Stage #2: With phosphoric acid; phosphorus trichloride In 1,4-dioxane at 20℃; for 1h; Stage #3: With hydrogenchloride In water for 6h; Reagent/catalyst; | 60.5% |
imidazol-1-yl-acetyl chloride
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: imidazol-1-yl-acetyl chloride With methanesulfonic acid; phosphorus trichloride at 26 - 80℃; for 16h; Stage #2: With water at 26 - 110℃; for 5h; Stage #3: With sodium hydroxide In water for 12h; pH=1.8; |
tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With water In ethanol for 0.5h; |
1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water at 89.84℃; for 0.25h; pH=1.5; |
imidazol-1-ylacetic acid
phosphorus trichloride
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: imidazol-1-ylacetic acid; phosphorus trichloride With methanesulfonic acid at 80℃; Green chemistry; Stage #2: In water Green chemistry; Stage #3: With sodium hydroxide In water Green chemistry; |
ethyl 2-(1H-imidazol-1-yl)acetate
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 7 h / 100 °C / pH 1.5 2.1: phosphoric acid / water / 0.5 h / 100 °C 2.2: 3 h / 65 - 100 °C 2.3: 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: water 2: water; phosphoric acid; phosphorus trichloride / chlorobenzene View Scheme |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme |
choline chloride
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
choline chloride
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
3-ethyl-1-methyl-1H-imidazol-3-ium bromide
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 3-ethyl-1-methyl-1H-imidazol-3-ium bromide With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
N,N,N',N'-tetramethylguanidine
Conditions | Yield |
---|---|
In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
N,N,N',N'-tetramethylguanidine
Conditions | Yield |
---|---|
In methanol; water for 1h; | 100% |
DBN
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
In methanol; water for 1h; | 100% |
DBN
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
In methanol; water for 1h; | 100% |
1-ethyl-3-methyl-1H-imidazol-3-ium chloride
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 1-ethyl-3-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h; | 100% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 16h; Product distribution / selectivity; Heating / reflux; | 99% |
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux; | 98% |
With sodium hydroxide In ethanol for 16h; Product distribution / selectivity; Heating / reflux; | 96% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water for 19h; Heating / reflux; | 99% |
With sodium hydroxide In ethanol; water for 18.5h; Product distribution / selectivity; Heating / reflux; | 98% |
With sodium hydroxide In methanol; water for 17h; Product distribution / selectivity; Heating / reflux; | 97% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
zoledronic acid monohydrate
Conditions | Yield |
---|---|
With water at 70 - 80℃; Heating / reflux; | 89% |
With water In ethanol at 60℃; for 2h; |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water for 20h; Product distribution / selectivity; Heating / reflux; | 84% |
With sodium hydroxide In water; isopropyl alcohol for 16h; Product distribution / selectivity; Heating / reflux; | 79% |
With sodium hydroxide In methanol; water for 16h; Product distribution / selectivity; Heating / reflux; | 64% |
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux; | 58% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid With barium hydroxide octahydrate In water at 0℃; for 0.166667h; Stage #2: [Pt(ethylenediamine)(H2O)(OSO3)] In water at 0 - 4℃; pH=5; | 84% |
4,4'-bipyridine
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
Stage #1: nickel(II) sulfate hexahydrate; 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In ethanol; water for 0.166667h; Stage #2: 4,4'-bipyridine In ethanol; water at 180℃; for 72h; pH=6.08; Autoclave; | 83% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With triethylamine In water ligand added to aq. soln. of NaVO3*H2O, stirred for 1 h, triethylamine added dropwise to pH 5, stirred for 1 h at 80°C; evapd. at room temp. for 5 d; elem. anal.; | 79% |
[Re(2,2′-bipyridine)(CO)3(H2O)](CF3SO3)
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=7; Reflux; | 77% |
water
copper(II) sulfate
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
In water High Pressure; hydrothermal treatment of a mixt. of a ligand (0.10 mmol), CuSO4 (0.15 mmol) in H2O (pH=2.14) at 140°C for 24 h; elem. anal.; powder XRD; | 70.6% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water; N,N-dimethyl-formamide at 100℃; for 0.333333h; Sealed tube; Microwave irradiation; | 70% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With CH3CO2NH4/CH3CO2H In water High Pressure; ligand and (NH4)6Mo7O24*4H2O dissolved in CH3CO2NH4/CH3CO2H, placed in autoclave, heated to 130°C for 4 h, kept for 20 h, cooled to room temp. over 36 h; filtered; elem. anal.; | 68% |
ammonia
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With ammonium acetate In aq. acetate buffer at 20 - 130℃; for 60h; pH=6; Autoclave; | 67% |
[2,2]bipyridinyl
water
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 140℃; for 72h; pH=2.52; Autoclave; High pressure; | 67% |
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
Conditions | Yield |
---|---|
With ammonium hydroxide In aq. acetate buffer at 130℃; for 24h; pH=6; Autoclave; | 67% |
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