Zoledronic acid supplier | CasNO.118072-93-8

Name
Zoledronic acid
EINECS 1806241-263-5
CAS No. 118072-93-8
Article Data43
CAS DataBase
Density 2.13 g/cm³
Solubility
Melting Point 193-2040 ºC
Formula C₅H₁₀N₂O₇P₂
Boiling Point 764 ºC at 760 mmHg
Molecular Weight 316.055
Flash Point 415.8 ºC
Transport Information
Appearance white crystalline powder
Safety 24/25-36/37/39
Risk Codes 21/22-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Zometa (Novartis);Zometa;Zoledronate;(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid;Phosphonic acid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-;(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid;Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-;[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis Phosphonic acid;ZoledronicAcid;[1-hydroxy-(1H-imidazol-1-yl)-phosphonoethyl] phosphonic acid monohydrate;1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid;
PSA 172.73000
LogP -1.11540

Synthetic route

: 22884-10-2
imidazol-1-ylacetic acid

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: imidazol-1-ylacetic acid With phosphoric acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 40 - 60℃; Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 85℃; for 18h; Product distribution / selectivity;	99%
Stage #1: imidazol-1-ylacetic acid With phosphorous acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 at 40 - 60℃; Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 at 85℃; for 18h; Product distribution / selectivity;	99%
With sulfolane; phosphonic Acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; phosphorus trichloride at 75℃; for 3h; Reagent/catalyst; Green chemistry;	93%

: C8H8N4O2*ClH

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: C8H8N4O2*ClH With phosphoric acid; phosphorus trichloride In toluene at 90℃; Stage #2: With hydrogenchloride In water; toluene at 20℃; Reagent/catalyst; Temperature; Solvent; Reflux;	85.27%

: 2-(1-imidazolyl)acetic acid hydrochloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In silicon oil at 80℃; for 11 - 24h; Stage #2: With water In toluene; silicon oil at 80 - 100℃; for 16 - 19h; Product distribution / selectivity;	74%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In toluene at 100℃; for 3h; Stage #2: With water In toluene at 80 - 100℃; for 16h; Product distribution / selectivity;	69%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphonic Acid; trichlorophosphate In chlorobenzene at 85 - 95℃; for 4.5h; Stage #2: With water for 18h; Reflux;	64%

: 288-32-4
1H-imidazole

: 105-39-5
chloroacetic acid ethyl ester

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: 1H-imidazole; chloroacetic acid ethyl ester With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In 1,4-dioxane at 20℃; for 0.5h; Reflux; Stage #2: With phosphoric acid; phosphorus trichloride In 1,4-dioxane at 20℃; for 1h; Stage #3: With hydrogenchloride In water for 6h; Reagent/catalyst;	60.5%

: 160975-66-6
imidazol-1-yl-acetyl chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: imidazol-1-yl-acetyl chloride With methanesulfonic acid; phosphorus trichloride at 26 - 80℃; for 16h; Stage #2: With water at 26 - 110℃; for 5h; Stage #3: With sodium hydroxide In water for 12h; pH=1.8;

: 1392687-52-3
tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
With water In ethanol for 0.5h;

: 827573-10-4
1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 89.84℃; for 0.25h; pH=1.5;

: 22884-10-2
imidazol-1-ylacetic acid

: 7719-12-2, 52843-90-0
phosphorus trichloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Stage #1: imidazol-1-ylacetic acid; phosphorus trichloride With methanesulfonic acid at 80℃; Green chemistry; Stage #2: In water Green chemistry; Stage #3: With sodium hydroxide In water Green chemistry;

: 17450-34-9
ethyl 2-(1H-imidazol-1-yl)acetate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 7 h / 100 °C / pH 1.5 2.1: phosphoric acid / water / 0.5 h / 100 °C 2.2: 3 h / 65 - 100 °C 2.3: 5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: water 2: water; phosphoric acid; phosphorus trichloride / chlorobenzene View Scheme

: C11H14N4O2

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme

: C9H10N4O2

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme

: C13H18N4O2

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme

: C10H12N4O2

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / Reflux 2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C 2.2: 20 °C / Reflux View Scheme

: 67-48-1
choline chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 2-hydroxy-N,N,N-trimethylethan-1-aminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 67-48-1
choline chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: bis(2-hydroxy-N,N,N-trimethylethan-1-aminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 65039-08-9
3-ethyl-1-methyl-1H-imidazol-3-ium bromide

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: (1-ethyl-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: 3-ethyl-1-methyl-1H-imidazol-3-ium bromide With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: (1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: bis(1-(2-hydroxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
Stage #1: 3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

: 1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride

: bis(1-(2-methoxyethyl)-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
Stage #1: 1-methyl-3-(2-methoxyethyl)-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: bis(dimethylamino)methaniminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: bis(bis(dimethylamino)methaniminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 3001-72-7
DBN

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: (2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 3001-72-7
DBN

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: bis(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidin-1-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogenphosphonate)

Conditions

Conditions	Yield
In methanol; water for 1h;	100%

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: bis(1-ethyl-3-methyl-1H-imidazol-3-ium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
Stage #1: 1-ethyl-3-methyl-1H-imidazol-3-ium chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 827573-10-4
1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 16h; Product distribution / selectivity; Heating / reflux;	99%
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux;	98%
With sodium hydroxide In ethanol for 16h; Product distribution / selectivity; Heating / reflux;	96%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: zoledronate disodium

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 19h; Heating / reflux;	99%
With sodium hydroxide In ethanol; water for 18.5h; Product distribution / selectivity; Heating / reflux;	98%
With sodium hydroxide In methanol; water for 17h; Product distribution / selectivity; Heating / reflux;	97%

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 165800-06-6
zoledronic acid monohydrate

Conditions

Conditions	Yield
With water at 70 - 80℃; Heating / reflux;	89%
With water In ethanol at 60℃; for 2h;

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: zoledronate trisodium

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 20h; Product distribution / selectivity; Heating / reflux;	84%
With sodium hydroxide In water; isopropyl alcohol for 16h; Product distribution / selectivity; Heating / reflux;	79%
With sodium hydroxide In methanol; water for 16h; Product distribution / selectivity; Heating / reflux;	64%
With sodium hydroxide In ethanol; water for 16h; Product distribution / selectivity; Heating / reflux;	58%

: [Pt(ethylenediamine)(H2O)(OSO3)]

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: {[Pt(ethylenediamine)]2(1-hydroxy-3-(1H-imidazol-1-yl)ethane-1,1-diylbisphosphonic acid-H4)}

Conditions

Conditions	Yield
Stage #1: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid With barium hydroxide octahydrate In water at 0℃; for 0.166667h; Stage #2: [Pt(ethylenediamine)(H2O)(OSO3)] In water at 0 - 4℃; pH=5;	84%

: 553-26-4
4,4'-bipyridine

: nickel(II) sulfate hexahydrate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: [Ni3(zoledronic acid)2(4,4′-dipyridyl)2](4,4′-dipyridyl)4H2O

Conditions

Conditions	Yield
Stage #1: nickel(II) sulfate hexahydrate; 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In ethanol; water for 0.166667h; Stage #2: 4,4'-bipyridine In ethanol; water at 180℃; for 72h; pH=6.08; Autoclave;	83%

...Expand

: sodium metavanadate * water

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: V3(Zol)3

Conditions

Conditions	Yield
With triethylamine In water ligand added to aq. soln. of NaVO3*H2O, stirred for 1 h, triethylamine added dropwise to pH 5, stirred for 1 h at 80°C; evapd. at room temp. for 5 d; elem. anal.;	79%

: 537030-00-5
[Re(2,2′-bipyridine)(CO)3(H2O)](CF3SO3)

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: Re(CO)3(2,2'-bipyridine)(zoledronic acid(-H))

Conditions

Conditions	Yield
With sodium hydroxide In water pH=7; Reflux;	77%

: 7732-18-5
water

: 7758-99-8
copper(II) sulfate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: Cu3(2-(1-imidazole)-1-hydroxy-1,1'-ethylidenediphosphonicacid-3H)2 dihydrate

Conditions

Conditions	Yield
In water High Pressure; hydrothermal treatment of a mixt. of a ligand (0.10 mmol), CuSO4 (0.15 mmol) in H2O (pH=2.14) at 140°C for 24 h; elem. anal.; powder XRD;	70.6%

...Expand

: manganese(II) chloride tetrahydrate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: manganese zoledronate

Conditions

Conditions	Yield
With hydrogenchloride In water; N,N-dimethyl-formamide at 100℃; for 0.333333h; Sealed tube; Microwave irradiation;	70%

: hexaammonium heptamolybdate tetrahydrate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: Mo6(Zol)2

Conditions

Conditions	Yield
With CH3CO2NH4/CH3CO2H In water High Pressure; ligand and (NH4)6Mo7O24*4H2O dissolved in CH3CO2NH4/CH3CO2H, placed in autoclave, heated to 130°C for 4 h, kept for 20 h, cooled to room temp. over 36 h; filtered; elem. anal.;	68%

: hexaammonium heptamolybdate tetrahydrate

: iron(III) chloride hexahydrate

: 7664-41-7
ammonia

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: Mo4(zoledronate)2Fe

Conditions

Conditions	Yield
With ammonium acetate In aq. acetate buffer at 20 - 130℃; for 60h; pH=6; Autoclave;	67%

...Expand

: 366-18-7
[2,2]bipyridinyl

: copper(II) choride dihydrate

: 7732-18-5
water

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: C25H25ClCu2N6O8P2*4H2O

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 140℃; for 72h; pH=2.52; Autoclave; High pressure;	67%

...Expand

: ammonium molybdate tetrahydrate

: iron(III) chloride hexahydrate

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 5H3N*7H(1+)*2Mo2O6*2C5H5N2O7P2(5-)*Fe(3+)*5H2O

Conditions

Conditions	Yield
With ammonium hydroxide In aq. acetate buffer at 130℃; for 24h; pH=6; Autoclave;	67%

...Expand

Zoledronic acid Chemical Properties

IUPAC Name: (1-Hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
Molecular Formula: C₅H₁₀N₂O₇P₂
Molecular Weight: 272.09 g/mol
Canonical SMILES: c1cncn1CC(O)(P(O)(=O)O)P(O)(=O)O
InChI: InChI=1/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
Classification Code: Bone Density Conservation Agents
Product Categories: Pharmaceutical material and intermeidates; Bone resorption inhibitor; Antiosteoporotic; Zoledronate;All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Zoledronic
Density: 2.13 g/cm³
Flash Point: 415.8 °C
Enthalpy of Vaporization: 116.73 kJ/mol
Boiling Point: 764 °C at 760 mmHg
Melting Point: 193-2040 °C
Vapour Pressure of Zoledronic acid (CAS NO.118072-93-8): 1.53E-24 mmHg at 25 °C

Zoledronic acid History

Zoledronic Acid is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the U.S. Food and Drug Administration (FDA) also approved Zoledronic Acid for the treatment of postmenopausal osteoporosis.

Zoledronic acid Uses

Zoledronic acid (CAS NO.118072-93-8) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases.

Zoledronic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 21/22-36/37/38
R21/22: Harmful in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements of Zoledronic acid (CAS NO.118072-93-8): 24/25-36/37/39
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

Zoledronic acid Specification

Zoledronic acid (CAS NO.118072-93-8), its Synonyms are (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid ; Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis- ; Zoledronate ; Zometa ; Reclast ; Aclasta . It is white solid.

Product Name

Zoledronic acid

Synthetic route

Zoledronic acid Chemical Properties

Zoledronic acid History

Zoledronic acid Uses

Zoledronic acid Safety Profile

Zoledronic acid Specification

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