Olanzapine supplier | CasNO.132539-06-1

Name
Olanzapine
EINECS 200-835-2
CAS No. 132539-06-1
Article Data57
CAS DataBase
Density 1.32 g/cm³
Solubility
Melting Point 195 °C
Formula C₁₇H₂₀N₄S
Boiling Point 476.035 °C at 760 mmHg
Molecular Weight 312.439
Flash Point 241.697 °C
Transport Information
Appearance yellowish crystalline powder
Safety 26-36/37-16
Risk Codes 36/38-36-20/21/22-11
Molecular Structure
Hazard Symbols Xi,Xn,F
Synonyms 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine;Olansek;10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-;Symbyax;Zyprexa (TN);Olanzapine [USAN:INN];2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine;Olanzapine;
PSA 59.11000
LogP 2.88860

Synthetic route

: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
at 65 - 70℃; for 18h; Vacuo;	100%

: 161696-76-0
N-desmethyl olanzapine

: 74-88-4
methyl iodide

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 2h; Product distribution / selectivity;	99%
With sodium hydride In tetrahydrofuran at -10℃; for 3h; Product distribution / selectivity;	98%
With sodium hydroxide In tetrahydrofuran at -15℃; for 4h; Product distribution / selectivity;	98%
With triethylamine In tetrahydrofuran at -10℃; for 4h; Product distribution / selectivity;	82%

: 109-01-3
1-methyl-piperazine

: 4-amino-2-methyl-10H-thiene [2,3-b][1,5]-benzodiazepine hydrochloride

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In ethanol; dimethyl sulfoxide at 100 - 130℃; Solvent; Temperature;	92.5%
In dimethyl sulfoxide at 100 - 120℃; for 8h;	84.2%

: 109-01-3
1-methyl-piperazine

: 612503-08-9
2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In propan-1-ol at 110℃; Product distribution / selectivity; Heating / reflux;	89%
In iso-butanol at 118℃; Product distribution / selectivity; Heating / reflux;	84%
In isopropyl alcohol at 100 - 102℃; Product distribution / selectivity; Heating / reflux;	80%

: 109-01-3
1-methyl-piperazine

: 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
at 125 - 145℃; for 5 - 12h; Product distribution / selectivity; Neat (no solvent);	84%
at 120℃; for 5h;	83.8%
In dimethyl sulfoxide at 112 - 115℃; for 16h;	82%

: olanzapinium oxalate

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With sodium hydroxide In water pH=9;	72.6%
With sodium hydroxide In water pH=8 - 10;
With sodium hydroxide In water pH=9 - 10; Product distribution / selectivity;

: 2,4-bis(4-methyl-1-piperazinyl)-3-propylidene-3H-[1,5]benzodiazepine

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With quinoline p-toluenesulfonate; sulfur In benzonitrile at 140℃; for 13.5h;	69.5%
With pyridinium p-toluenesulfonate; sulfur In benzonitrile at 140℃; for 13.5h;	66.6%
With sulfur; 1-methyl-imidazolium p-toluenesulfonic acid In benzonitrile at 140℃; for 10h;	54.2%
With toluene-4-sulfonic acid; sulfur In benzonitrile at 140℃; for 9h;	51.7%
With sulfur; triethylamine In propan-1-ol; dimethyl sulfoxide at 100℃; for 120h;	12%

: 77-78-1
dimethyl sulfate

: 161696-76-0
N-desmethyl olanzapine

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With potassium carbonate In methanol at 25℃; for 2h; Product distribution / selectivity;	60%
With potassium carbonate In acetone at -10℃; for 4h; Product distribution / selectivity;	46%
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide In methanol at 0 - 5℃; Stage #2: With water In methanol Product distribution / selectivity;
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide In methanol; dichloromethane at 0 - 5℃; Stage #2: With water In methanol; dichloromethane Product distribution / selectivity;
Stage #1: dimethyl sulfate; N-desmethyl olanzapine With sodium hydroxide; potassium carbonate In tetrahydrofuran; water at 10 - 30℃; for 7.5 - 8.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 50℃;

: 109-01-3
1-methyl-piperazine

: 138564-59-7
2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With hydrogen In mesytilene at 160℃; for 48h; chemoselective reaction;	54%

: N-{5-methyl-3-[(4-methylpiperazin-1-yl)carbonyl]thien-2-yl}-N-(2-nitrophenyl)amine

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With tributylphosphine at 220℃; for 48h;	41%

: Olanzapine N-Oxide

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With osmium(VIII) oxide; (2E)-3-phenyl-2-propen-1-ol In water; tert-butyl alcohol at 20℃; for 19h; Inert atmosphere;	30%

: 765244-26-6
10-Benzyl-2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water at 60℃; for 6 - 6.5h;	20%

: 109-01-3
1-methyl-piperazine

: 138564-59-7
2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

A: 132539-06-1
zyprexa

B: 2-methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one

Conditions

Conditions	Yield
With hydrogen In mesytilene at 160℃; for 24h; chemoselective reaction;	A 20% B 25 %Chromat.

...Expand

: 1493-27-2
ortho-nitrofluorobenzene

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 23 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 25 °C 2: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating 3: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating View Scheme
Multi-step reaction with 3 steps 1: LiOH / dimethylsulfoxide 2: SnCl2 / ethanol 3: toluene; dimethylsulfoxide View Scheme

: 138564-59-7
2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating 2: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating View Scheme
Multi-step reaction with 2 steps 1: SnCl2 / ethanol 2: toluene; dimethylsulfoxide View Scheme
Multi-step reaction with 2 steps 1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol; water / 1 h / Reflux 2: dimethyl sulfoxide; toluene / 20 h / Reflux; Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: iron(III)-acetylacetonate; hydrazine hydrate / ethanol / 0.08 h / 150 °C / Sealed tube 2: hydrogenchloride / ethanol; water; ethyl acetate / 0.17 h / 120 °C / Sealed tube 3: 0.5 h / 160 °C / Sealed tube View Scheme

: 138564-58-6
2-amino-5-methylthiophene-3-carbonitrile

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 23 percent / NaH / tetrahydrofuran; various solvent(s) / 24 h / 25 °C 2: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating 3: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating View Scheme
Multi-step reaction with 3 steps 1: LiOH / dimethylsulfoxide 2: SnCl2 / ethanol 3: toluene; dimethylsulfoxide View Scheme
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 20 °C / Inert atmosphere; Cooling with ice 2: tin(II) chloride dihdyrate; hydrogenchloride / ethanol; water / 1 h / Reflux 3: dimethyl sulfoxide; toluene / 20 h / Reflux; Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1: palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene; ethyl acetate / 0.17 h / 130 °C / Sealed tube 2: iron(III)-acetylacetonate; hydrazine hydrate / ethanol / 0.08 h / 150 °C / Sealed tube 3: hydrogenchloride / ethanol; water; ethyl acetate / 0.17 h / 120 °C / Sealed tube 4: 0.5 h / 160 °C / Sealed tube View Scheme

: 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

: 132539-06-1
zyprexa

Reaxys ID: 12045368: Reaxys ID: 12045368

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With silica gel In dichloromethane at 0℃; for 0.0833333h; Purification / work up;

: C4H10O*2C17H20N4S

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
at 65℃; for 2.5h;

: 402586-77-0
olanzapine monohydrate

: 132539-06-1
zyprexa

: olanzapine methylene chloride hemisolvate

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; for 0.5 - 1h; Product distribution / selectivity;
Stage #1: olanzapine methylene chloride hemisolvate at 50℃; for 12h; Stage #2: In isopropyl alcohol at 20℃; for 0.333333h; Product distribution / selectivity;

: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine propan-2-ol hemisolvate monohydrate

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
Stage #1: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine propan-2-ol hemisolvate monohydrate at 50℃; for 16h; Stage #2: In isopropyl alcohol at 20℃; for 0.25h; Product distribution / selectivity;

: olanzapine-CH2Cl2-water

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In dichloromethane Product distribution / selectivity;

: olanzapine-DMSO-water

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In dichloromethane Product distribution / selectivity;

: 109-01-3
1-methyl-piperazine

: 873895-41-1
2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With acetic acid at 120℃; Product distribution / selectivity;
With acetic acid at 120℃; Product distribution / selectivity;
With platinum doped titanium oxide; hydrogen In mesytilene at 140℃; for 24h;	24 %Chromat.

: 109-01-3
1-methyl-piperazine

: 873895-41-1
2-((2-aminophenyl)amino)-5-methylthiophene-3-carbonitrile

: 34352-59-5, 50398-09-9, 51545-09-6
1-methylpiperazine hydrochloride

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;
at 120℃; Product distribution / selectivity;

...Expand

: olanzapine tetrahydrofuran water solvate

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
at 40℃; under 1 - 20 Torr; for 4 - 10h; Product distribution / selectivity; vacuum drying;

: 109-01-3
1-methyl-piperazine

: 67-68-5
dimethyl sulfoxide

: 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
In water; toluene
In water; toluene
In water; toluene
In water; toluene
In water; toluene

...Expand

: 72242-31-0
5-methyl-2-(2-nitro-anilino)-thiophene-3-carboxylic acid methyl ester

: 132539-06-1
zyprexa

Conditions

Conditions	Yield
With ammonia; palladium on charcoal catalyst; titanium tetrachloride In 1-methyl-piperazine; ethanol ethyl acetate; ethyl acetate; methoxybenzene; isopropyl alcohol
With ammonia; palladium on charcoal catalyst; titanium tetrachloride In 1-methyl-piperazine; ethanol ethyl acetate; ethyl acetate; methoxybenzene; isopropyl alcohol

: 132539-06-1
zyprexa

: 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine dihydrate

Conditions

Conditions	Yield
With water In dimethyl sulfoxide at 0 - 80℃; for 48h;	100%
With water In 1,3-dioxane at 0 - 80℃;	93.5%
With water In acetone at 0 - 80℃;	87.5%
With water In ethyl acetate; toluene at 20 - 60℃; for 1.5h;	63.3%
In water at 30 - 35℃; for 0.5h;

: 132539-06-1
zyprexa

: olanzapine sesquihydrate

Conditions

Conditions	Yield
Stage #1: zyprexa With hydrogenchloride; water Stage #2: With sodium hydroxide; water at 0℃; for 0.5h; pH=8.5;	100%

: 132539-06-1
zyprexa

: 50-78-2
aspirin

: 929209-00-7
C7H6O3*C17H20N4S

Conditions

Conditions	Yield
In methanol for 24h; Product distribution / selectivity;	99%

: 132539-06-1
zyprexa

: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]-benzodiazepine monohydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; acetonitrile Heating / reflux;	98.5%
With hydrogenchloride In Isopropyl acetate; water

: 132539-06-1
zyprexa

: 2-methyl-4-(4-methyl-piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 0℃; for 0.166667h;	97%
With hydrogenchloride In ethyl acetate at 0℃; for 0.166667h;	97%
With hydrogenchloride In isopropyl alcohol at 0℃; for 0.166667h;	97%

: 132539-06-1
zyprexa

: 130-85-8
Pamoic acid

: olanzapine pamoate monohydrate

Conditions

Conditions	Yield
Stage #1: Pamoic acid With ammonium hydroxide In water Stage #2: zyprexa With hydrogenchloride; water at 25 - 30℃; Reagent/catalyst;	97%
Stage #1: zyprexa; Pamoic acid In dimethyl sulfoxide at 20 - 25℃; for 0.333333h; Stage #2: With water In dimethyl sulfoxide at 20 - 40℃; for 1.16667h;

: 110-16-7
maleic acid

: 132539-06-1
zyprexa

: 861390-74-1
olanzapinium monomaleate

Conditions

Conditions	Yield
In ethanol for 24h; Product distribution / selectivity;	88%
In hexane for 24h; Product distribution / selectivity;	83%
In 1,4-dioxane for 24h; Product distribution / selectivity;	75%
In acetonitrile for 0.25h;

: 110-16-7
maleic acid

: 132539-06-1
zyprexa

: olanzapinium dimaleate

Conditions

Conditions	Yield
In methanol for 24h; Product distribution / selectivity;	88%
In methanol for 24h; Product distribution / selectivity;	44%
In acetonitrile for 0.25h;

: 110-17-8
(2E)-but-2-enedioic acid

: 132539-06-1
zyprexa

: olanzapine fumarate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 0 - 30℃; for 3h; Product distribution / selectivity;	85.2%
In methanol; dichloromethane; water at 0 - 25℃; for 3h; Product distribution / selectivity;	65.7%
In isopropyl alcohol at 0 - 25℃; for 2h; Product distribution / selectivity;

: 109-99-9
tetrahydrofuran

: 132539-06-1
zyprexa

: olanzapine tetrahydrofuran water solvate

Conditions

Conditions	Yield
With water at 0 - 50℃; for 2.5h; Product distribution / selectivity;	85%
With water at 5℃; Heating / reflux;

: 110-17-8
(2E)-but-2-enedioic acid

: 132539-06-1
zyprexa

: 3C4H4O4*C17H20N4S

Conditions

Conditions	Yield
In methanol for 4h;	84%

: 75-05-8
acetonitrile

: 132539-06-1
zyprexa

: 155817-84-8
2,10-Dimethyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine

Conditions

Conditions	Yield
With 18-crown-6 ether; carbon dioxide at 80℃; under 750.075 Torr; for 72h; Inert atmosphere; Schlenk technique; Glovebox;	83%

: 132539-06-1
zyprexa

: 69-72-7
salicylic acid

: 929209-00-7
C7H6O3*C17H20N4S

Conditions

Conditions	Yield
In methanol for 24h; Product distribution / selectivity;	82%

: 132539-06-1
zyprexa

: Olanzapine N-Oxide

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 12℃; for 12h;	79.1%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane
With α-D-glucose 6-phosphate; glucose phosphate dehydrogenase; human cytochrome P450 (CYP) 2D6.10, recombinant; NADP In aq. phosphate buffer at 37℃; for 0.75h; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 64-19-7
acetic acid

: 132539-06-1
zyprexa

: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine acetic acid monosolvate

Conditions

Conditions	Yield
In ethyl acetate at 4 - 20℃; Product distribution / selectivity;	79%
In acetone at 4 - 20℃; Product distribution / selectivity;	56%
In dimethyl sulfoxide at 4℃; for 4h; Product distribution / selectivity;
In isopropyl alcohol Product distribution / selectivity;

: 937-14-4
3-chloro-benzenecarboperoxoic acid

: 132539-06-1
zyprexa

: olanzapine N-oxide-m-chlorobenzoate

Conditions

Conditions	Yield
In chloroform at 23℃; for 0.166667h; Inert atmosphere;	78%

: 110-17-8
(2E)-but-2-enedioic acid

: 132539-06-1
zyprexa

: 2C4H4O4*C17H20N4S

Conditions

Conditions	Yield
In methanol for 22h;	74%

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 132539-06-1
zyprexa

: 1443629-16-0
chloromethyl 2-methyl-4-(4-methyl(y)pi(y)perazin-1-yl)-5H-benzo[b]thieno[2,3-e][1,4]diaze(y)pine-5-carboxylate

Conditions

Conditions	Yield
Stage #1: zyprexa With triethylamine In dichloromethane at 5 - 35℃; Stage #2: carbonochloridic acid, chloromethyl ester In dichloromethane at 5 - 25℃; for 1.08333h; regioselective reaction;	73%
With triethylamine In dichloromethane at 5 - 35℃; for 0.833333h;	73%
Stage #1: zyprexa With triethylamine In dichloromethane at 35℃; Stage #2: carbonochloridic acid, chloromethyl ester at 5 - 20℃; for 1.08333h;	73%
With triethylamine In dichloromethane at 20℃; for 0.75h;	73%
With triethylamine In dichloromethane at 5 - 35℃; for 1.08333h;	73%

: 132539-06-1
zyprexa

: olanzapine trihydrate

Conditions

Conditions	Yield
Stage #1: zyprexa With water; acetic acid at 20℃; Stage #2: With ammonia; water at 20℃; pH=9.75;	68.5%

Olanzapine Specification

The Olanzapine, with the CAS registry number 132539-06-1,is also known as 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; Lanzac; Zyprexa. It belongs to the product categories of Active Pharmaceutical Ingredients;APIs;Olanzapine;Intermediates & Fine Chemicals. This chemical's molecular formula is C₁₇H₂₀N₄S and molecular weight is 312.43. What's more,Its systematic name is 10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-.It is a yellow crystalline powder which is a benzothiazepine.

Physical properties about Olanzapine are:
(1)ACD/LogP: 3.076; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.42; (4)ACD/LogD (pH 7.4): 2.35; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 23.98; (7)ACD/KOC (pH 5.5): 2.50; (8)ACD/KOC (pH 7.4): 210.04; (9)#H bond acceptors: 4; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.709; (13)Molar Refractivity: 92.156 cm3; (14)Molar Volume: 235.993 cm3; (15)Surface Tension: 52.015998840332 dyne/cm; (16)Density: 1.324 g/cm3; (17)Flash Point: 241.697 °C; (18)Enthalpy of Vaporization: 73.967 kJ/mol; (19)Boiling Point: 476.035 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:N=1c4c(N\C(=C/2\C=C(/SC=1\2)C)N3CCN(C)CC3)cccc4;
(2)Std. InChI:InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3;
(3)Std. InChIKey:WXPNDRBBWZMPQG-UHFFFAOYSA-N.

The toxicity data of Olanzapine are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	16560ug/kg/12 (16.56mg/kg)		Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.
human	TDLo	oral	16560ug/kg/12 (16.56mg/kg)	BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Journal of Clinical Psychiatry. Vol. 60, Pg. 767, 1999.
human	TDLo	oral	43mg/kg/30W-I (43mg/kg)		Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 273, 1999.
man	LDLo	oral	7067ug/kg (7.067mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	Journal of Forensic Sciences. Vol. 41, Pg. 1252, 1998.
man	TDLo	oral	2570ug/kg/12D (2.57mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 192, 1999.
women	LDLo	oral	30mg/kg/22W-I (30mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Annals of Pharmacotherpy. Vol. 33, Pg. 787, 1999.
women	TDLo	oral	400ug/kg (.4mg/kg)		American Journal of Psychiatry. Vol. 156, Pg. 1835, 1999.
women	TDLo	oral	400ug/kg (.4mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: REGIDITY	American Journal of Psychiatry. Vol. 156, Pg. 1835, 1999.
women	TDLo	oral	12mg/kg (12mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Annals of Emergency Medicine. Vol. 32, Pg. 275, 1998.
women	TDLo	oral	12mg/kg/60D-I (12mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 131, Pg. 72, 1999.

Product Name

Olanzapine

Synthetic route

Olanzapine Specification

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