Zhuozhou Wenxi import and Export Co., Ltd
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1378388-35-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryLIDE PHARMACEUTICALS LIMITED
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co., Ltd.
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAfine Chemicals Limited
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:1378388-35-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryTaiChem Taizhou Limited
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:1378388-35-2
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryXiamen Jenny Chemical Technology Co., Ltd.
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:1378388-35-2
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryWin-Win chemical Co.Ltd
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAntimex Chemical Limied
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryGuangdong Juda Chemical Industrial Co.,Limited
Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryHenan Kanbei Chemical Co.,LTD
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryShanghai Chinqesen Biotechnology Co., Ltd.
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Chemsigma International Co.,Ltd.
bulk?production Application:Pharmaceutical intermediates
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd
home-produced Application:medicine
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZHEJIANG JIUZHOU CHEM CO.,LTD
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryQingdao KMS Biochemical Technology Co.,Ltd.
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAmadis Chemical Co., Ltd.
1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:1378388-35-2
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Cyanochem Co; Ltd.
superior product, rigorous quality test, GMP management and auditable plant, stable supply in industry park, advantage in R&D CMO CRO Appearance:white or off-white powder Storage:storage in norm temperature and against damp Package:Aluminum dru
Cas:1378388-35-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJilin haofei import and export trade Co.,Ltd
Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryNanjing Chemlin Chemical Co., Ltd.
Nanjing Chemlin Chemical Industry Co., Ltd was established in Aug,1999, located in the industrial park of Nanjing University of Technology, It is a private enterprises in Jiangsu Province with 1200 square meters’ R&D center. Our R&D center has a well
Wuhan MoonZY Biological Technology Co.,Ltd
instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirySynova( Tianjin ) Chemical Technology Co,.Ltd
The company have effective management team, professional technical R & D personnel, the service spirit of customer oriented. We have long-term cooperation with famous domestic manufacturer, and excellent customer resources overseas. We are skilled in
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHangzhou utanpharma Co., Ltd
Hangzhou Utanpharma Biology Co., Ltd. is a R&D and manufacturing based, market oriented enterprise,specialized in the R&D and marketing of active pharmaceutical ingredients and intermediates. Supported by our highly qualified professor and
Cas:1378388-35-2
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquirySuzhou Youzhihe Medical Science and Technology Co., Ltd.
Being efficient R&D company for years, YOUZH warmly welcomes you to our factory for on-site audit!Appearance:SOLID Package:Generally in drums Application:Sound customized scale to meet CMO/CRO need, grams to tons. Port:Shanghai
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirycoolpharm Ltd
Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar
Cas:1378388-35-2
Min.Order:0
Negotiable
Type:Other
inquirySynthetic route
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1378388-30-7
(2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide In tert-Amyl alcohol at 0℃; for 5.25h; Cooling with ice; | 70% |
| Stage #1: (2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester With water; sodium hydroxide In tetrahydrofuran at 0℃; for 5h; Stage #2: With hydrogenchloride In water | 70% |
| With sodium hydroxide In tetrahydrofuran; water at 0℃; for 5.25h; | 70% |
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487048-28-2
(2S,4S)-4-cyano-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C 1.2: 12 h / 20 °C 2.1: water; sodium hydroxide / tert-Amyl alcohol / 5.25 h / 0 °C / Cooling with ice View Scheme | |
| Multi-step reaction with 2 steps 1.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C 1.3: 12 h / 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 0 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C 1.2: 12 h / 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 0 °C View Scheme |
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24424-99-5
di-tert-butyl dicarbonate
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 12 h / 20 °C 2: sodium hydroxide / tetrahydrofuran; water / 5.25 h / 0 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: ethyl acetate / 0.1 h / Industrial scale 2.1: water; sodium hydroxide / tetrahydrofuran / -1 °C / Industrial scale 2.2: pH 1 / Industrial scale View Scheme | |
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 16 h / 20 °C 2: sodium hydroxide / tetrahydrofuran / 5 h / 0 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; ethyl acetate / 12 h / 20 °C 2: sodium hydroxide / tetrahydrofuran; water / 5.25 h / 0 °C View Scheme |
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64750-03-4
(2S,4S)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 16 h / 20 °C 2: sodium hydroxide / tetrahydrofuran / 5 h / 0 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1194059-42-1
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(hydroxymethyl)-pyrrolidine-2-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
| Stage #1: (3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.75h; Stage #2: With sodium tetrahydroborate; water In tetrahydrofuran at 0℃; for 2h; | 60% |
| Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice View Scheme | |
| Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C 2: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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541-41-3
chloroformic acid ethyl ester
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1194059-42-1
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(hydroxymethyl)-pyrrolidine-2-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
| Stage #1: (3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid; chloroformic acid ethyl ester With triethylamine In tetrahydrofuran at 0℃; for 0.75h; Stage #2: With sodium tetrahydroborate; water In tetrahydrofuran at 0℃; for 2h; | 60% |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-61-4
(2S,5S)-2-(2-(9-((2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / acetone / 16 h / 40 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-63-6
tert-butyl (2S,4S)-2-(5-{2-[(2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidin-2-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / acetone / 16 h / 40 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 24 h / 110 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / acetone / 16 h / 40 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 24 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 505 h / 40 °C 8: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 1.5 h View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1377049-78-9
methyl {(2S,3S)-1-[(2S,5S)-2-(5-{2-[(2S,4S)-1-{(2S,3S)-2-[(methoxycarbonyl)amino]-3-methylpentanoyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-5-methylpyrrolidin-l-yl]-3-methyl-1-oxopentan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / acetone / 16 h / 40 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 24 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 505 h / 40 °C 8: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 1.5 h 9: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-65-8
tert-butyl (2S,4S)-2-(5-{2-[(2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidin-2-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-5-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / acetone / 16 h / 40 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 24 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 505 h / 40 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-71-6
(2S,4S)-2-(2-(9-((2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-methylpyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 16 h / 50 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 16 h / 50 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-72-7
tert-butyl (2S,5S)-2-(9-{2-[(2S,5S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,4,5,11-tetrahydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 16 h / 50 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 20 h / 110 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378390-73-8
tert-butyl (2S,4S)-2-[5-(2-{(2S,4S)-1-[N-(methoxycarbonyl)-L-valyl]-4-(methoxymethyl)pyrrolidin-2-yl}-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 16 h / 50 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 20 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 15 h / 35 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 16 h / 50 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 20 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 15 h / 35 °C 8: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 5 h View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1377604-60-8
methyl {(2S,3R)-3-methoxy-1-[(2S,4S)-2-[9-(2-{(2S,4S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]-4-methylpyrrolidin-2-yl}-1H-imidazol-5-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-1-oxobutan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 16 h / 50 °C 6: ammonium acetate / toluene; 2-methoxy-ethanol / 20 h / 110 °C 7: manganese(IV) oxide / dichloromethane / 15 h / 35 °C 8: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 5 h 9: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.58 h View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378391-39-9
(2S,4S)-1-tert-butyl 2-(2-oxo-2-(8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)ethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C View Scheme |
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1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
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1378391-42-4
(2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C View Scheme | |
| Multi-step reaction with 5 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: borane-THF / 2-methyltetrahydrofuran; tetrahydrofuran / 25 °C / Industrial scale 2.1: water; sodium hydroxide / tert-butyl methyl ether / 2 h / 0.1 - 0.2 °C / Industrial scale 2.2: 0.2 h / 0.5 °C / Industrial scale 3.1: sodium t-butanolate / tetrahydrofuran / 0 h / 0.1 - 0.2 °C / Industrial scale 4.1: potassium carbonate / dichloromethane / 0.2 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378391-43-5
(2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C View Scheme | |
| Multi-step reaction with 6 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378391-44-6
tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,4,5,11-tetrahydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C View Scheme | |
| Multi-step reaction with 7 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378391-45-7
tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h View Scheme | |
| Multi-step reaction with 8 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 8.1: manganese(IV) oxide / dichloromethane / 13 h View Scheme | |
| Multi-step reaction with 9 steps 1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 4.1: borane dimethyl sulfide complex / tetrahydrofuran / 22 h / 0 - 20 °C 5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide; sodium hydrogencarbonate; sodium hypochlorite / dichloromethane; water / 2 h / 20 °C 6.1: ammonium hydroxide / water; methanol / 20 °C 7.1: iodine; sodium carbonate / 1,4-dioxane / Darkness 8.1: sodium thiosulfate / ethanol; water / 22 h / 90 - 100 °C 9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; dimethyl sulfoxide / 5 h / 95 °C / Inert atmosphere View Scheme | |
| Multi-step reaction with 9 steps 1.1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C 3.1: methanol; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C 4.1: dimethylsulfide borane complex / tetrahydrofuran / 22 h / 0 - 20 °C 5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / dichloromethane / 2 h / 20 °C 6.1: ammonium hydroxide / water; methanol / 20 °C 7.1: iodine; sodium carbonate / 1,4-dioxane / Darkness 8.1: sodium dithionite / ethanol; water / 22 h / 90 - 100 °C 9.1: tetrakis(triphenylphosphine) palladium(0); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; dimethyl sulfoxide / 5 h / 95 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h 10: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1377050-41-3
methyl {(2S,3S)-1-[(2S,4S)-2-(5-{2-[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h 10: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C 11: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.1 h View Scheme | |
| Multi-step reaction with 9 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 8.1: manganese(IV) oxide / dichloromethane / 13 h 9.1: hydrogenchloride / dichloromethane / 1 h / 20 °C 9.2: 0.1 h View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1377604-63-1
methyl {(1R)-2-[(2S,4S)-2-(5-{2-[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]-1,4,5,11-tetrahydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl}-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / 20 °C 10: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378392-78-9
(2S,4S)-1-tert-butyl 2-methyl 4-((difluoromethoxy)methyl)pyrrolidine-1,2-dicarboxylate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: copper(l) iodide / acetonitrile / 1 h / 45 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: copper(l) iodide / acetonitrile / 1 h / 45 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378389-61-7
(2S,4S)-1-(tert-butoxycarbonyl)-4-((difluoromethoxy)methyl)pyrrolidine-2-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: copper(l) iodide / acetonitrile / 1 h / 45 °C 4: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: copper(l) iodide / acetonitrile / 1 h / 45 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1377049-84-7
methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h 10: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C 11: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 9 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 8.1: manganese(IV) oxide / dichloromethane / 13 h 9.1: hydrogenchloride / ethanol / 3 h / 50 °C 9.2: 2 h / 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1377049-87-0
methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h 10: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C 11: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h View Scheme | |
| Multi-step reaction with 9 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 8.1: manganese(IV) oxide / dichloromethane / 13 h 9.1: hydrogenchloride / ethanol / 3 h / 50 °C 9.2: 3 h View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1377050-15-1
methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2S,3S)-3-methoxy-2-[(methoxycarbonyl)amino]butanoyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C 5: caesium carbonate / 4 h / 20 °C 6: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 7: caesium carbonate / 20 h / 50 °C 8: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 9: manganese(IV) oxide / dichloromethane / 13 h 10: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C 11: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h View Scheme | |
| Multi-step reaction with 9 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C 4.1: caesium carbonate / 2-methyltetrahydrofuran / 4 h / 20 °C 5.1: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C 6.1: caesium carbonate / 2-methyltetrahydrofuran / 20 h / 50 °C 7.1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C 8.1: manganese(IV) oxide / dichloromethane / 13 h 9.1: hydrogenchloride / ethanol / 3 h / 50 °C 9.2: 3 h View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378388-37-4
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice View Scheme | |
| Multi-step reaction with 2 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C 2: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C View Scheme |
-
-
1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid
-
-
1378388-16-9
(2S,4S)-N-(tert-butyloxycarbonyl)-4-(methoxymethyl)-pyrrolidine-2-carboxylic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice 2: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.75 h / 0 °C 1.2: 2 h / 0 °C 2.1: 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate / 3 h / 0 - 20 °C 3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1: triethylamine / tetrahydrofuran / 0.75 h / 0 °C 2: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C 3: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C 4: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C View Scheme |
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