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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99.9% up USP standard GMP certified DMF documents API Valsartan powder

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Nanjing Yuance Industry&Trade Co., Ltd.

Purity: 99% Excellent quality with competitive price Fast delivery Appearance:white powder,tasteless Storage:Store in cool dry place Package:25 kg/drum Application:used clinical for receptor antagonist of angiotensin AT1, has good effect t

Valsartan, CAS: 137862-53-4

Cas:137862-53-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Zhejiang Huili Pharmaceutical Co., Ltd

ProName:99.9% up USP standard GMP certified DM... CasNo:137862-53-4 Molecular Formula:C24H29N5O3 Appearance:White or almost white hygroscopic powd... Application:Treat the hypertension DeliveryTime:7 working days PackAge:25kg per drum Port:s

Valsartan

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

Superiority kono is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in

Factory Supply Bulk High Quality Valsartan cas 137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $60.0 / 120.0

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Test Items Specification Test Results Assay by (HPLC) 99%-101% 99.43% Characters/appearance

High purity Valsartan CAS:137862-53-4

Cas:137862-53-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for USP Valsartan Cas 137862-53-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:-20°C Freezer Package:1kg/bag,25kg/drum A

Factory supply USP Valsartan Cas 137862-53-4 with good quality favorable price

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 300.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Fast delivery Valsartan in stock cas:137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $198.0 / 298.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to

Good quality Valsartan//137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Valsartan CAS:137862-53-4 GMP DMF factory

Cas:137862-53-4

Min.Order:1 Gram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Valsartan manufacturer with low price

Cas:137862-53-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Valsartan 137862-53-4 ISO Producer

Cas:137862-53-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Purity: 99% Excellent quality with competitive price Fast delivery Appearance:whilt powder Storage:cool and dryer Package:durm Application:api Transportation:by sea or by air Port:shanghai

valsartan, CAS: 137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

VALSARTAN

Cas:137862-53-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Valsartan Manufacturer/High quality/In stock

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Valsartan

Cas:137862-53-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Valsartan CAS NO:137862-53-4 Grade:Antihypertensive drugs, non peptide angiotensin Ⅱ, AT1 receptor antagonist Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security with

Valsartan CAS:137862-53-4 Chinese manufacturers high-quality

Cas:137862-53-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Valsartan CAS 137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid Basic information Product Name: 3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid Sy

VALSARTAN USP GRADE

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 137862-53-4 with best quality

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Specifications 1.Name:valsartan 2.CAS:137862-53-4 3.Quality: USP33 4.M.F:C24H29N5O3 5.Use:Anti-hypertension 6.specification of valsartan in USP33 version: ITEMS SPECIFICATION

Valsartan 137862-53-4

Cas:137862-53-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:white crystalline powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

Factory Supply Best Quality Valsartan CAS:137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Valsartan powder Medicine Raw Material for Antihypertensive CAS 137862-53-4

Cas:137862-53-4

Min.Order:100 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

China Factory Supply Parmaceutical Intermediates Valsartan Powder with Cheap Price

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Topsale Valsartan 99% with lower price

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Huarong Pharm Co., Ltd.

1. USDMF is available. 2. EUDMF is available. 3. CEP is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Hu

Valsartan

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antihypertensive Valsartan API,CAS:137862-53-4

Cas:137862-53-4

Min.Order:1 Kilogram

FOB Price: $34.0 / 45.0

Type:Trading Company

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Synthetic route

(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentarloyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl-methyl]amine barium salt

(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentarloyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl-methyl]amine barium salt

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With hydrogenchloride; water pH=2 - 2.5;99.9%
With hydrogenchloride In water; ethyl acetate pH=2 - 2.2; Product distribution / selectivity;
With hydrogenchloride; water In ethyl acetate pH=~ 2 - 2.5;
With hydrogenchloride In water; ethyl acetate pH=2.5 - 3.5; Product distribution / selectivity; Industry scale;
methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate
137863-17-3

methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With sodium hydroxide In diethyl ether; water at 20℃;99%
With water; sodium hydroxide In methanol at 25℃; for 12h;95%
Stage #1: methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate With sodium hydroxide In water at 20℃; for 20h;
Stage #2: With hydrogenchloride; water pH=2;
93%
N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester
781664-81-1

N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester With methanol; potassium hydroxide for 4h; Heating / reflux;
Stage #2: With water for 5h; Heating / reflux;
95%
With sodium hydroxide In methanol for 6h; Reflux;90%
C26H32N2O3

C26H32N2O3

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With sodium azide; dichloro[(-)-sparteine-N,N']copper(II) In ethyl acetate at 70 - 80℃; for 4h; Concentration; Reagent/catalyst; Large scale;92%
With sodium azide; zinc(II) chloride In N,N-dimethyl-formamide at 120 - 130℃;61%
N-pentanoyl-N-(4-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)phenyl)methyl-L-valine
783369-52-8

N-pentanoyl-N-(4-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)phenyl)methyl-L-valine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With TRILITE SCR-10 gel type In methanol for 6h; Product distribution / selectivity; Reflux;91%
With sodium hydroxide In methanol at 20℃;84%
(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid
1033772-60-9

(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With hydrogen; nickel In methanol at 20℃; for 24h;90%
potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

A

valsartan

valsartan

B

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate With methanol for 3h; Heating / reflux;
Stage #2: In water; ethyl acetate
Stage #3: With hydrogenchloride In water Product distribution / selectivity;
A n/a
B 89%
2-(tetrazol-5'-yl)phenylboronic acid

2-(tetrazol-5'-yl)phenylboronic acid

N-(4-iodobenzyl)-N-valeryl-L-valine

N-(4-iodobenzyl)-N-valeryl-L-valine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; N-(4-iodobenzyl)-N-valeryl-L-valine With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) In methanol; water for 2.08333h; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2; Product distribution / selectivity;
88%
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; N-(4-iodobenzyl)-N-valeryl-L-valine With sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride In methanol; water at 70℃; for 3h;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=1 - 2; Product distribution / selectivity;
85%
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; N-(4-iodobenzyl)-N-valeryl-L-valine With sodium methylate; 5%-palladium/activated carbon; triphenylphosphine In methanol at 70℃; for 10h;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=3; Product distribution / selectivity;
71.4%
3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}pentanamido)but-2-enoic acid

3-methyl-2-(N-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}pentanamido)but-2-enoic acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 100 - 120℃; for 12h; Temperature; Solvent; Reagent/catalyst;88%
sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

A

valsartan

valsartan

B

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate With methanol Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
Stage #3: With hydrogenchloride In water Product distribution / selectivity;
A n/a
B 82%
N-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl-4-yl-methyl]-N-pentanoyl-L-valinate
943019-61-2

N-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl-4-yl-methyl]-N-pentanoyl-L-valinate

N-trityl-5-(2-bromophenyl)tetrazole
143945-72-6

N-trityl-5-(2-bromophenyl)tetrazole

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: N-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl-4-yl-methyl]-N-pentanoyl-L-valinate; N-trityl-5-(2-bromophenyl)tetrazole With potassium phosphate; palladium diacetate; triphenylphosphine In tetrahydrofuran at 60℃;
Stage #2: With methanol for 3h; Product distribution / selectivity; Heating / reflux;
77%
N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine barium

N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine barium

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate at 25 - 35℃; Large scale reaction;77%
potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate With methanol for 3h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water
Stage #3: With hydrogenchloride In water at 20℃; for 1h; Product distribution / selectivity;
73%
Stage #1: potassium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate With methanol for 3h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
Stage #3: With hydrogenchloride In water Product distribution / selectivity;
66%
(S)-N-(1-benzyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine
137863-20-8

(S)-N-(1-benzyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With sodium hydroxide In water at 65℃; for 2.5h; optical yield given as %ee;72.5%
With hydrogen; 5%-palladium/activated carbon In methanol at 20℃; Product distribution / selectivity;70%
With hydrogen; 5% palladium over charcoal In methanol at 20℃; Product distribution / selectivity;70%
benzyl N-{4-[2-(1-benzyl-1H-tetrazole-5-yl)phenyl]benzyl}-N-valeryl-L-valinate

benzyl N-{4-[2-(1-benzyl-1H-tetrazole-5-yl)phenyl]benzyl}-N-valeryl-L-valinate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With 5% palladium on barium sulphate; ammonium formate In water; isopropyl alcohol at 65℃; for 11h;70.7%
3-methyl-(2S)-{pentanoyl-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid dilithium salt trihydrate

3-methyl-(2S)-{pentanoyl-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid dilithium salt trihydrate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
With hydrogenchloride; water pH=4.0 - 4.2;70%
(S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one
852212-82-9

(S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: (S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one With ammonium formate; 5%-palladium/activated carbon In ISOPROPYLAMIDE at 90℃;
Stage #2: With sulfuric acid In tert-butyl methyl ether; ISOPROPYLAMIDE pH=2;
70%
With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran at 60℃; under 3750.38 Torr;53%
sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: sodium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate With methanol Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
Stage #3: With hydrogenchloride In water Product distribution / selectivity;
70%
2-(tetrazol-5'-yl)phenylboronic acid

2-(tetrazol-5'-yl)phenylboronic acid

(S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid
867022-57-9

(S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; (S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid With sodium hydroxide; 5%-palladium/activated carbon; trisodium tris(3-sulfophenyl)phosphine In water at 70℃; for 2h;
Stage #2: With acetic acid In water Product distribution / selectivity;
68%
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; (S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; ethanol; water for 12.0833h; Heating / reflux;
Stage #2: With hydrogenchloride In water pH=1 - 2; Product distribution / selectivity;
60.5%
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; (S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid With sodium methylate; 5%-palladium/activated carbon; triphenylphosphine In methanol at 70℃; for 10h;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=3; Product distribution / selectivity;
58%
Stage #1: 2-(tetrazol-5'-yl)phenylboronic acid; (S)-2-[(4-bromo-benzyl)-pentanoyl-amino]-3-methyl-butyric acid With sodium methylate; triphenylphosphine; palladium dichloride In methanol at 70℃; for 5h;
Stage #2: With hydrogenchloride In water; ethyl acetate pH=1 - 2; Product distribution / selectivity;
55.6%
N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester
137864-44-9

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester In methanol for 8h; Heating / reflux;
Stage #2: With hydrogen; palladium on activated charcoal In methanol at 40℃; under 760.051 Torr; for 16h;
67%
With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine In methanol under 2250.23 - 3750.38 Torr; for 6h; Autoclave;110 g
With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine In methanol under 2250.23 - 3750.38 Torr; for 6h; Autoclave;110 g
Multi-step reaction with 2 steps
1.1: methanol; oxalic acid / 1.5 h / 5 - 65 °C
1.2: pH 7.5
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 - 10 h / 25 - 30 °C
View Scheme
methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate
137863-90-2

methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate With sodium azide; zinc chloride bis(dimethylformamide) complex In N,N-dimethyl-formamide at 130 - 140℃; for 24h; Large scale;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 25 - 30℃; pH=1.5; Large scale;
Stage #3: With water; sodium hydroxide In chloroform Large scale;
66.5%
Multi-step reaction with 2 steps
1.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
1.2: 55 percent / acetic acid / toluene; H2O
2.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Stage #1: methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate With sodium azide; tributyltin chloride In xylene at 25℃; Heating / reflux;
Stage #2: With sodium hydroxide In water; xylene at 25 - 35℃; for 24 - 30h;
Stage #3: With acetic acid In water pH=7;
N-(5-(phenyIthio)-1-oxo-pentyI)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine

N-(5-(phenyIthio)-1-oxo-pentyI)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Stage #1: N-(5-(phenyIthio)-1-oxo-pentyI)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine With sodium hydroxide; sodium tetrahydroborate; nickel dichloride In methanol; water at 0 - 5℃; for 0.333333h;
Stage #2: With acetic acid In water at 25 - 35℃; pH=5.3; Product distribution / selectivity;
46.2%
C16H15O2N

C16H15O2N

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 165.9 mg / aq. HCl / 2 h / 50 °C
2.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
2.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
3.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
4.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
4.2: 55 percent / acetic acid / toluene; H2O
5.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester
137863-89-9

N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
2.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
2.2: 55 percent / acetic acid / toluene; H2O
3.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 2,6-dimethylpyridine / toluene / 2 h / 5 - 30 °C
2.1: sodium azide / toluene / 50 h / Reflux
3.1: sodium hydroxide; water / toluene / 12 h / 20 - 30 °C
3.2: pH 1 - 2.5
View Scheme
Multi-step reaction with 3 steps
1: 2,6-dimethylpyridine / water; toluene / 2 h / 5 - 30 °C
2: sodium azide / toluene / 50 h / Reflux
3: sodium hydroxide; water / toluene / 12 h / 20 - 30 °C
View Scheme
C16H13O2N
400747-06-0

C16H13O2N

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 167.9 mg / aq. HCl / 2 h / 50 °C
2.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
2.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
3.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
4.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
4.2: 55 percent / acetic acid / toluene; H2O
5.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
p-bromobenzaldehyde 1,3-dioxolane
10602-01-4

p-bromobenzaldehyde 1,3-dioxolane

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
2.1: 167.9 mg / aq. HCl / 2 h / 50 °C
3.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
3.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
4.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
5.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
5.2: 55 percent / acetic acid / toluene; H2O
6.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
2-cyanobenzoic acid
3839-22-3

2-cyanobenzoic acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 50 percent / basic copper(II) carbonate; potassium carbonate; triphenylphosphine / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
2.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
2.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
3.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
4.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
4.2: 55 percent / acetic acid / toluene; H2O
5.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
2.1: 167.9 mg / aq. HCl / 2 h / 50 °C
3.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
3.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
4.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
5.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
5.2: 55 percent / acetic acid / toluene; H2O
6.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
2.1: 165.9 mg / aq. HCl / 2 h / 50 °C
3.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
3.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
4.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
5.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
5.2: 55 percent / acetic acid / toluene; H2O
6.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
ammonium 2-(aminocarbonyl)benzoate
131-63-5

ammonium 2-(aminocarbonyl)benzoate

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 72 percent / acetic anhydride; pyridine
2.1: 50 percent / basic copper(II) carbonate; potassium carbonate; triphenylphosphine / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
3.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
3.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
4.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
5.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
5.2: 55 percent / acetic acid / toluene; H2O
6.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 72 percent / acetic anhydride; pyridine
2.1: copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
3.1: 167.9 mg / aq. HCl / 2 h / 50 °C
4.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
4.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
5.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
6.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
6.2: 55 percent / acetic acid / toluene; H2O
7.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 72 percent / acetic anhydride; pyridine
2.1: copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C
3.1: 165.9 mg / aq. HCl / 2 h / 50 °C
4.1: molecular sieves 3 Angstroem / tetrahydrofuran / 60 h / 20 °C
4.2: 90 percent / sodium cyanoborohydride / tetrahydrofuran; ethanol / 24 h / 23 °C
5.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
6.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
6.2: 55 percent / acetic acid / toluene; H2O
7.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
n-valeryl chloride
638-29-9

n-valeryl chloride

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 98 percent / pyridine / CH2Cl2 / 2 h / 40 °C
2.1: sodium azide; tri-n-butyltin chloride; tetrabutylammonium bromide / toluene / 72 h / Heating
2.2: 55 percent / acetic acid / toluene; H2O
3.1: 99 percent / NaOH / diethyl ether; H2O / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / dichloromethane / 5.5 h / 0 - 5 °C
2.1: sodium azide; zinc(II) chloride / diethylene glycol dimethyl ether / 26 h / 120 °C
3.1: sodium hydroxide / water / 4 h / 40 °C
3.2: pH 1.5 - 2 / Cooling; Acidic conditions
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / dichloromethane / 5.5 h / 0 - 5 °C
2.1: sodium azide; zinc(II) chloride / diethylene glycol dimethyl ether / 24 h / 120 °C
3.1: sodium hydroxide / water / 4 h / 40 °C
3.2: pH 1.5 - 2 / Cooling; Acidic conditions
View Scheme
trityl chloride
76-83-5

trityl chloride

triethylamine
121-44-8

triethylamine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

triethylammonium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

triethylammonium N-pentanoyl-N-[{2'-(1-(triphenylmethyl)-1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl}methyl]-L-valinate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 5h; Product distribution / selectivity;100%
N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C24H28(3)HN5O3

C24H28(3)HN5O3

Conditions
ConditionsYield
With tritium; η4-cycloocta-1,5-diene(1,3-dimesitylimidazoline-2-ylidene)(triphenylphosphine)iridium(I) tetrakis[(3,5-trifluoromethylphenyl)]borate; caesium carbonate In methanol at 20 - 50℃; for 3.25h;98.9%
N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

magnesium-valsartan-hexahydrate

magnesium-valsartan-hexahydrate

Conditions
ConditionsYield
With water; magnesium oxide In ethanol at 20 - 40℃; pH=4 - 7.5;95%
4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 15 - 35℃; for 1h; Solvent; Temperature;94.23%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C28H38N6O3

C28H38N6O3

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 1h; Reflux;93.1%
2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C30H42N6O3

C30H42N6O3

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 1h; Reflux;92.5%
N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-(2R)-methylbutanoic acid ethyl ester calcium salt

N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-(2R)-methylbutanoic acid ethyl ester calcium salt

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

trisodium [3-((1S,3R)-1-biphenyl-4-yl-methyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-yl-methyl}amino)butyrate] hemipentahydrate
936623-90-4

trisodium [3-((1S,3R)-1-biphenyl-4-yl-methyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-yl-methyl}amino)butyrate] hemipentahydrate

Conditions
ConditionsYield
Stage #1: N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-(2R)-methylbutanoic acid ethyl ester calcium salt With hydrogenchloride; water In Isopropyl acetate
Stage #2: N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine With sodium hydroxide In n-heptane; water; acetone at 45℃; Temperature;
91.9%
N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine disodium salt

(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine disodium salt

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 25 - 35℃; for 5h;91.66%
With sodium carbonate In water; acetone for 3h; Reflux;
With sodium hydroxide In ethanol
α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt
149690-05-1

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

Conditions
ConditionsYield
With sodium hydroxide In Isopropyl acetate; water; acetonitrile at 40 - 65℃;91%
Stage #1: N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine With sodium hydroxide In methanol at 25 - 35℃; for 0.5h;
Stage #2: α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt In acetone at 25 - 35℃; for 0.166667h; Solvent;
6.3 g
(2R,4S)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester dicyclohexylamine salt

(2R,4S)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester dicyclohexylamine salt

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

LCZ696

LCZ696

Conditions
ConditionsYield
With sodium hydroxide In Isopropyl acetate; water; acetone at 25 - 55℃; for 4.5h; Solvent; Temperature;91%
4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

trisodium [3-((1S,3R)-1-biphenyl-4-yl-methyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-yl-methyl}amino)butyrate] hemipentahydrate
936623-90-4

trisodium [3-((1S,3R)-1-biphenyl-4-yl-methyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-yl-methyl}amino)butyrate] hemipentahydrate

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 25 - 35℃; for 1h;90.83%
N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C24H28(2)HN5O3

C24H28(2)HN5O3

Conditions
ConditionsYield
With η4-cycloocta-1,5-diene(1,3-dimesitylimidazoline-2-ylidene)(triphenylphosphine)iridium(I) tetrakis[(3,5-trifluoromethylphenyl)]borate; water-d2; caesium carbonate In methanol at 50℃; for 6h;88%
C24H30N2O5

C24H30N2O5

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C47H54N7O8(2-)*3Na(1+)*2.5H2O

C47H54N7O8(2-)*3Na(1+)*2.5H2O

Conditions
ConditionsYield
With water; sodium hydroxide In acetone at 20℃; for 2h;87%
C26H34N2O5

C26H34N2O5

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C49H58N7O8(2-)*3Na(1+)*2.5H2O

C49H58N7O8(2-)*3Na(1+)*2.5H2O

Conditions
ConditionsYield
With water; sodium hydroxide In acetone for 2h;85.6%
3C24H28NO5(1-)*3Na(1+)*C24H29NO5*2C2H4O2

3C24H28NO5(1-)*3Na(1+)*C24H29NO5*2C2H4O2

water
7732-18-5

water

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C24H28NO5(1-)*C24H28N5O3(1-)*2Na(1+)*2.5H2O

C24H28NO5(1-)*C24H28N5O3(1-)*2Na(1+)*2.5H2O

Conditions
ConditionsYield
With sodium hydroxide In Isopropyl acetate; acetone at 40 - 45℃; for 2h;85%
C28H38N2O5

C28H38N2O5

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C51H62N7O8(2-)*3Na(1+)*2.5H2O

C51H62N7O8(2-)*3Na(1+)*2.5H2O

Conditions
ConditionsYield
With water; sodium hydroxide In acetone for 2h;84.2%
methanol
67-56-1

methanol

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate
137863-17-3

methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate

Conditions
ConditionsYield
With thionyl chloride at 0 - 25℃; for 4.5h;83%
With thionyl chloride at 4 - 20℃; for 3h;
C30H42N2O5

C30H42N2O5

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C53H66N7O8(2-)*3Na(1+)*2.5H2O

C53H66N7O8(2-)*3Na(1+)*2.5H2O

Conditions
ConditionsYield
With water; sodium hydroxide In acetone for 3.5h;82.2%
(2R,4S)-5-biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid ethyl ester 1-(naphthalen-1-yl)ethan-1-amine salt

(2R,4S)-5-biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid ethyl ester 1-(naphthalen-1-yl)ethan-1-amine salt

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3’-methyl-2’-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate]hemipentahydrate

Conditions
ConditionsYield
Stage #1: (2R,4S)-5-biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid ethyl ester 1-(naphthalen-1-yl)ethan-1-amine salt; N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine In acetone at 10℃;
Stage #2: With sodium hydroxide In water; acetone
80%

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