As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:150322-43-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:150322-43-3
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages for Prasugrel Cas150322-43-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg/
Cas:150322-43-3
Min.Order:1 Kilogram
FOB Price: $2500.0
Type:Trading Company
inquiryQuanao supply New product Motherwort Extract powder 10:1 price Professional Factory We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and proportion of extract accordin
Cas:150322-43-3
Min.Order:100 Kilogram
FOB Price: $18.0 / 23.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:150322-43-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryPrasugrel CAS NO:150322-43-3: 1.large quantity in stock; 2.good&high quality 3.fast carriage Appearance:WHITE Storage:COOL AND DRYER Package:DRUM Application:API Transportation:BY SEA OR BY AIR Port:SHANGHAI
Cas:150322-43-3
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Prasugrel The alias: Efient;Prasugrel CAS NO: 150322-43-3 Molecular formula:C20H20FNO3S Molecular weight:373.4411 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Securi
Cas:150322-43-3
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:150322-43-3
Min.Order:1 Kilogram
FOB Price: $1300.0
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:150322-43-3
Min.Order:1 Kilogram
FOB Price: $48.0 / 58.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:150322-43-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:150322-43-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal powder Storage:Store in sealed containers at c
Cas:150322-43-3
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:150322-43-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:150322-43-3
Min.Order:10 Gram
FOB Price: $0.6
Type:Trading Company
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:150322-43-3
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryPrasugrel CAS:150322-43-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:150322-43-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:150322-43-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product name: Prasugrel CAS: 150322-43-3 Stock: Fresh Purity: not less than 99% Standard: In-house Package:25kg drum Application:antiobsessional agent
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:150322-43-3
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:150322-43-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:150322-43-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryPrasugrel CAS: 150322-43-3, Good Quality, Low PriceAppearance:powder Storage:store in a cool dry place and keep away from strong Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect
Cas:150322-43-3
Min.Order:1 Gram
Negotiable
Type:Other
inquirySuperior quality, moderate price & quick delivery. Appearance:Beige powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:antiobsessiona
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
acetyl chloride
prasugel
Conditions | Yield |
---|---|
Stage #1: 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one; acetyl chloride With acetic acid In toluene at 20℃; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In water; toluene | 99% |
With D201 macroporous strong basic styrene anion exchange resin, average particle diameter: 1.0 mm In tetrahydrofuran at 45℃; for 1.5h; Reagent/catalyst; Temperature; | 87.1% |
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
acetyl chloride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; acetyl chloride With acetic acid In toluene at 20℃; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In water; toluene Product distribution / selectivity; | 99% |
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
acetic anhydride
prasugel
Conditions | Yield |
---|---|
With triethylamine; sodium hydroxide In water; ethyl acetate at 7 - 50℃; pH=2.8; Temperature; pH-value; | 92.58% |
With triethylamine In dichloromethane for 3h; Reflux; | 90.2% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 4h; Temperature; Reagent/catalyst; Solvent; | 83.2% |
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine With dmap; triethylamine In acetone at 0℃; for 0.166667h; Stage #2: acetic anhydride In acetone Solvent; Temperature; | 90% |
With triethylamine; dmap In acetonitrile at -15℃; for 1h; | |
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine With dmap; triethylamine In acetonitrile at 20℃; for 0.25h; Stage #2: acetic anhydride In acetonitrile at 20℃; | |
With dmap; triethylamine In acetonitrile at 0℃; | |
With dmap; triethylamine In acetonitrile at -4 - -3℃; for 2.25h; |
acetic anhydride
prasugel
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0℃; | 85% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Inert atmosphere; | 85% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 25℃; | 46% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h; |
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: acetic anhydride In dichloromethane | 73% |
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 25 - 30℃; for 0.25h; Stage #2: acetic anhydride In dichloromethane at 0 - 5℃; for 6h; | |
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 25 - 30℃; for 0.25h; Stage #2: acetic anhydride In dichloromethane at 0 - 5℃; for 6h; | |
With triethylamine In dichloromethane at 0℃; for 3.5h; |
prasugrel maleate salt
prasugel
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate for 0.25h; pH=6.8; Solvent; | 68.5% |
Conditions | Yield |
---|---|
With zinc sulfide; acetic acid; triethylamine In tetrahydrofuran at -10 - 55℃; for 8h; Green chemistry; | 68.5% |
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
prasugel
Conditions | Yield |
---|---|
With acetic anhydride In N-methyl-acetamide; mineral oil | 65% |
With acetic anhydride; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 3.5h; | 65% |
Multi-step reaction with 2 steps 1.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 2.2: 6 h / 0 - 5 °C View Scheme |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In acetonitrile at 30℃; for 0.5h; Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile Product distribution / selectivity; | 60.3% |
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
Isopropenyl acetate
prasugel
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid at 65 - 70℃; for 3.5h; | 59.72% |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 20℃; for 1h; | 55% |
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Cooling with ice; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 20℃; for 1h; | 55% |
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Cooling; Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 20℃; for 1h; | 55% |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride
prasugel
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at -15 - 20℃; Product distribution / selectivity; | 36.6% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25 - 30℃; for 2 - 3h; Product distribution / selectivity; |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate With sodium hydrogencarbonate In N,N-dimethyl-formamide at 5 - 10℃; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In N,N-dimethyl-formamide at 20℃; for 5h; Stage #3: acetic anhydride In N,N-dimethyl-formamide at 20℃; for 3h; | 32.85% |
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h; Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile at 20℃; for 2h; | 29% |
3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate
2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride
acetic anhydride
prasugel
Conditions | Yield |
---|---|
Stage #1: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With tetraethylammonium bromide; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h; Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile at 20℃; for 2h; | 12% |
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
prasugel
Conditions | Yield |
---|---|
With acetic acid In acetyl chloride; toluene | |
With p-toluenesulfonic acid monohydrate; acetic anhydride; acetic acid In toluene | |
With p-toluenesulfonic acid monohydrate; acetic anhydride In toluene | |
Multi-step reaction with 2 steps 1: hydrogenchloride; water / ethyl acetate / 20 °C 2: acetic acid / toluene / 20 °C / Inert atmosphere View Scheme |
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
prasugel
Conditions | Yield |
---|---|
With dmap; triethylamine In tetrahydrofuran; ethanol; acetic anhydride |
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
prasugel
Conditions | Yield |
---|---|
With dmap; triethylamine In acetic anhydride; acetonitrile |
prasugel
prasugel
prasugel
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate for 0.5h; Purification / work up; |
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide
acetic anhydride
prasugel
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 1.25h; |
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
acetic anhydride
prasugel
Conditions | Yield |
---|---|
dmap In acetonitrile at 22 - 25℃; | |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 4h; Inert atmosphere; | |
With triethylamine In N,N-dimethyl-formamide at -10 - 20℃; for 2.5h; Inert atmosphere; | |
With triethylamine In N,N-dimethyl-formamide at -10 - 20℃; for 2.5h; Inert atmosphere; |
5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice-water bath 2: hydrogenchloride / diethyl ether 3: triethylamine / dichloromethane / -15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetone / 0.42 h / 25 - 30 °C 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 8 h / 0 - 25 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 6 h / 25 - 30 °C 2.3: 6.5 h / 0 - 30 °C View Scheme |
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 1.2: 1 h / -78 °C 1.3: 1 h / -60 - 0 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 1.2: 1 h / -78 °C 1.3: 1 h / -60 - 0 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C / Inert atmosphere 1.2: 1 h / -10 - 0 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C View Scheme |
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 °C 2.3: 1 h / -60 - 0 °C 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 °C 2.3: 1 h / -60 - 0 °C 3.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 4.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 4.2: 6 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C / Inert atmosphere 2.3: 2 h / 0 - 30 °C 3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C 4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 4.2: 6 h / 25 - 30 °C 4.3: 6.5 h / 0 - 30 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 6 h / 25 - 30 °C 2.3: 6.5 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme |
(2-fluorophenyl)acetic acid
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 4.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 5.2: 1 h / -78 °C 5.3: 1 h / -60 - 0 °C 6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 4.2: 6 h / 25 - 30 °C 4.3: 6.5 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 4.2: 7 h / 25 - 30 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme |
prasugel
Conditions | Yield |
---|---|
With hydrogenchloride In di-isopropyl ether; water; ethyl acetate at 20℃; Inert atmosphere; | 99% |
With hydrogenchloride In tetrahydrofuran at -5 - 20℃; for 16h; Solvent; Temperature; Concentration; | 98% |
With acetyl chloride; tert-butyl alcohol In acetone at 20℃; Reagent/catalyst; Solvent; | 98.2% |
prasugel
prasugrel hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide In acetone at 5 - 10℃; for 1h; Product distribution / selectivity; | 99% |
With hydrogen bromide In water; acetone at 5 - 10℃; for 1h; Product distribution / selectivity; | 99% |
With Acetyl bromide; acetic acid In ethyl acetate at 20 - 60℃; for 5.33333h; Product distribution / selectivity; | 89% |
Conditions | Yield |
---|---|
In acetone at 20℃; for 6h; Product distribution / selectivity; | 96% |
benzenesulfonic acid
prasugel
5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate
Conditions | Yield |
---|---|
In diethyl ether; acetone at -10 - 35℃; for 12h; | 93% |
In diethyl ether; acetone at 20℃; | 93% |
In acetone at 30℃; for 6h; Product distribution / selectivity; | 79% |
In methanol Product distribution / selectivity; |
acetic acid
prasugel
Conditions | Yield |
---|---|
With hydrogen bromide In water at 40℃; for 0.166667h; Solvent; | 92.2% |
Conditions | Yield |
---|---|
In acetone at 25 - 30℃; for 3h; Concentration; | 89.84% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 20 - 50℃; Product distribution / selectivity; | 89% |
prasugel
prasugrel monohydrogensulfate
Conditions | Yield |
---|---|
With sulfuric acid In acetone at -5℃; for 1.25h; | 86% |
With sulfuric acid In isopropyl alcohol at 20℃; for 6h; Product distribution / selectivity; | 84% |
With sulfuric acid In acetone at -32 - -28℃; for 5.5h; Product distribution / selectivity; | 78% |
prasugel
Conditions | Yield |
---|---|
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 6h; Inert atmosphere; | 85% |
prasugel
Conditions | Yield |
---|---|
With sulfuric acid In water; acetone at -32 - -28℃; for 5.5h; Product distribution / selectivity; | 78% |
naphthalene-1,5-disulfonate
prasugel
Conditions | Yield |
---|---|
In isopropyl alcohol at 20 - 50℃; Product distribution / selectivity; | 75% |
In acetone at 20℃; |
prasugel
5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydroiodide
Conditions | Yield |
---|---|
With hydrogen iodide In water; acetone at 5 - 10℃; for 1.5h; | 74% |
With hydrogen iodide In water; acetone at 5 - 10℃; for 1.5h; | 74% |
Conditions | Yield |
---|---|
In acetone at 20 - 26℃; Cooling; | 70% |
In methanol Product distribution / selectivity; |
naphthalene-2-sulfonate
prasugel
prasugrel 2-naphthalenesulfonic acid salt
Conditions | Yield |
---|---|
In acetone at 20℃; for 0.75h; Product distribution / selectivity; | 69% |
In methanol Product distribution / selectivity; |
1-naphthalenesulfonic acid
prasugel
prasugrel 1-naphthalenesulfonic acid salt
Conditions | Yield |
---|---|
In acetone at 20℃; for 0.333333h; | 66% |
In acetone at 20℃; |
cyclohexylsulfamic acid
prasugel
5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate cyclamate
Conditions | Yield |
---|---|
In acetone at -10℃; for 12h; | 45% |
In acetone | 45% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View