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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Prasugrel Manufacturer/High quality/Best price/In stock

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Prasugrel Manufacturer/High quality/Best price/In stock CAS NO.150322-43-3

Cas:150322-43-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Prasugrel Cas150322-43-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg/

Factory supply Prasugrel Cas150322-43-3 with best price and fast delivery

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $2500.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Quanao supply New product Motherwort Extract powder 10:1 price Professional Factory We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and proportion of extract accordin

Quanao supply New product Motherwort Extract powder 10:1 price

Cas:150322-43-3

Min.Order:100 Kilogram

FOB Price: $18.0 / 23.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Prasugrel

Cas:150322-43-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Prasugrel 150322-43-3 ISO Producer

Cas:150322-43-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Prasugrel CAS NO:150322-43-3: 1.large quantity in stock; 2.good&high quality 3.fast carriage Appearance:WHITE Storage:COOL AND DRYER Package:DRUM Application:API Transportation:BY SEA OR BY AIR Port:SHANGHAI

Prasugrel CAS NO:150322-43-3

Cas:150322-43-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Prasugrel

Cas:150322-43-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Prasugrel The alias: Efient;Prasugrel CAS NO: 150322-43-3 Molecular formula:C20H20FNO3S Molecular weight:373.4411 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Securi

Prasugrel/CAS:150322-43-3/Manufacturer

Cas:150322-43-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM---Prasugrel

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Prasugrel CAS 150322-43-3

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $48.0 / 58.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 150322-43-3 with best quality

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Prasugrel/ LIDE PHARMA- Factory supply / Best price

Cas:150322-43-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal powder Storage:Store in sealed containers at c

Prasugrel CAS 150322-43-3 pharmaceutical materials in bulk

Cas:150322-43-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Prasugrel 150322-43-3

Cas:150322-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API 99% purity Anticoagulant Prasugrel powder and Antiplatelet Drugs Prasugrel price

Cas:150322-43-3

Min.Order:10 Gram

FOB Price: $0.6

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Prasugrel CAS 150322-43-3

Cas:150322-43-3

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Prasugrel CAS:150322-43-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Prasugrel CAS:150322-43-3

Cas:150322-43-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Prasugrel

Cas:150322-43-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Antiplatelet API powder CAS 150322-43-3 99% Prasugrel

Cas:150322-43-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:150322-43-3

Cas:150322-43-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: Prasugrel CAS: 150322-43-3 Stock: Fresh Purity: not less than 99% Standard: In-house Package:25kg drum Application:antiobsessional agent

Prasugrel manufacture

Cas:150322-43-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Prasugrel

Cas:150322-43-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Prasugrel 150322-43-3

Cas:150322-43-3

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Prasugrel

Cas:150322-43-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Prasugrel

Cas:150322-43-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Prasugrel/High quality/Best price

Cas:150322-43-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Prasugrel

Cas:150322-43-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Prasugrel CAS: 150322-43-3, Good Quality, Low PriceAppearance:powder Storage:store in a cool dry place and keep away from strong Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect

Prasugrel CAS: 150322-43-3, Good Quality, Low Price

Cas:150322-43-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Beige powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:antiobsessiona

Prasugrel-

Cas:150322-43-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

acetyl chloride
75-36-5

acetyl chloride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one; acetyl chloride With acetic acid In toluene at 20℃; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In water; toluene
99%
With D201 macroporous strong basic styrene anion exchange resin, average particle diameter: 1.0 mm In tetrahydrofuran at 45℃; for 1.5h; Reagent/catalyst; Temperature;87.1%
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

acetyl chloride
75-36-5

acetyl chloride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; acetyl chloride With acetic acid In toluene at 20℃; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In water; toluene Product distribution / selectivity;
99%
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With triethylamine; sodium hydroxide In water; ethyl acetate at 7 - 50℃; pH=2.8; Temperature; pH-value;92.58%
With triethylamine In dichloromethane for 3h; Reflux;90.2%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 4h; Temperature; Reagent/catalyst; Solvent;83.2%
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine With dmap; triethylamine In acetone at 0℃; for 0.166667h;
Stage #2: acetic anhydride In acetone Solvent; Temperature;
90%
With triethylamine; dmap In acetonitrile at -15℃; for 1h;
Stage #1: 2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine With dmap; triethylamine In acetonitrile at 20℃; for 0.25h;
Stage #2: acetic anhydride In acetonitrile at 20℃;
With dmap; triethylamine In acetonitrile at 0℃;
With dmap; triethylamine In acetonitrile at -4 - -3℃; for 2.25h;
1-cyclopropyl-2-(2-fluorophenyl)-2-(2-hydroxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one

1-cyclopropyl-2-(2-fluorophenyl)-2-(2-hydroxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃;85%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Inert atmosphere;85%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 25℃;46%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
1243654-57-0

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: acetic anhydride In dichloromethane
73%
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 25 - 30℃; for 0.25h;
Stage #2: acetic anhydride In dichloromethane at 0 - 5℃; for 6h;
Stage #1: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide With triethylamine In dichloromethane at 25 - 30℃; for 0.25h;
Stage #2: acetic anhydride In dichloromethane at 0 - 5℃; for 6h;
With triethylamine In dichloromethane at 0℃; for 3.5h;
prasugrel maleate salt
389574-20-3

prasugrel maleate salt

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate for 0.25h; pH=6.8; Solvent;68.5%
C20H24FNO4

C20H24FNO4

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With zinc sulfide; acetic acid; triethylamine In tetrahydrofuran at -10 - 55℃; for 8h; Green chemistry;68.5%
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With acetic anhydride In N-methyl-acetamide; mineral oil65%
With acetic anhydride; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 3.5h;65%
Multi-step reaction with 2 steps
1.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
2.2: 6 h / 0 - 5 °C
View Scheme
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate
178688-49-8

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In acetonitrile at 30℃; for 0.5h;
Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile Product distribution / selectivity;
60.3%
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Isopropenyl acetate
108-22-5

Isopropenyl acetate

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 65 - 70℃; for 3.5h;59.72%
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate
952340-39-5

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 20℃; for 1h;
55%
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Cooling with ice;
Stage #2: acetic anhydride In N,N-dimethyl-formamide at 20℃; for 1h;
55%
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridine-2-one p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Cooling;
Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 20℃; for 1h;
55%
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride
1151904-84-5

4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With triethylamine In dichloromethane at -15 - 20℃; Product distribution / selectivity;36.6%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25 - 30℃; for 2 - 3h; Product distribution / selectivity;
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate
1190589-93-5

2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate With sodium hydrogencarbonate In N,N-dimethyl-formamide at 5 - 10℃;
Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In N,N-dimethyl-formamide at 20℃; for 5h;
Stage #3: acetic anhydride In N,N-dimethyl-formamide at 20℃; for 3h;
32.85%
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride
951380-43-1

2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h;
Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile at 20℃; for 2h;
29%
3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate
1100905-46-1

3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride
951380-43-1

2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Stage #1: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With tetraethylammonium bromide; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h;
Stage #2: acetic anhydride With N-ethyl-N,N-diisopropylamine; dmap In acetonitrile at 20℃; for 2h;
12%
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With acetic acid In acetyl chloride; toluene
With p-toluenesulfonic acid monohydrate; acetic anhydride; acetic acid In toluene
With p-toluenesulfonic acid monohydrate; acetic anhydride In toluene
Multi-step reaction with 2 steps
1: hydrogenchloride; water / ethyl acetate / 20 °C
2: acetic acid / toluene / 20 °C / Inert atmosphere
View Scheme
aqueous potassium dihydrogen phosphate

aqueous potassium dihydrogen phosphate

potassium dihydrogen phosphate

potassium dihydrogen phosphate

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With dmap; triethylamine In tetrahydrofuran; ethanol; acetic anhydride
aqueous potassium dihydrogen phosphate

aqueous potassium dihydrogen phosphate

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With dmap; triethylamine In acetic anhydride; acetonitrile
2-(tert-butyldiphenylsilyloxy)-5-(α-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-(tert-butyldiphenylsilyloxy)-5-(α-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

2-triisopropylsilyloxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-triisopropylsilyloxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine fumarate

2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine fumarate

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate for 0.5h; Purification / work up;
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide
1190589-94-6

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 1.25h;
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
951380-42-0

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

acetic anhydride
108-24-7

acetic anhydride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
dmap In acetonitrile at 22 - 25℃;
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 4h; Inert atmosphere;
With triethylamine In N,N-dimethyl-formamide at -10 - 20℃; for 2.5h; Inert atmosphere;
With triethylamine In N,N-dimethyl-formamide at -10 - 20℃; for 2.5h; Inert atmosphere;
5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
109904-26-9

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice-water bath
2: hydrogenchloride / diethyl ether
3: triethylamine / dichloromethane / -15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetone / 0.42 h / 25 - 30 °C
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
2.3: 8 h / 0 - 25 °C
3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
3.2: 6 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 6 h / 25 - 30 °C
2.3: 6.5 h / 0 - 30 °C
View Scheme
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / -78 °C
1.3: 1 h / -60 - 0 °C
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / -78 °C
1.3: 1 h / -60 - 0 °C
2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
3.2: 6 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C / Inert atmosphere
1.2: 1 h / -10 - 0 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
View Scheme
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 °C
2.3: 1 h / -60 - 0 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 °C
2.3: 1 h / -60 - 0 °C
3.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
4.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
4.2: 6 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
2.2: 1 h / 0 - 15 °C / Inert atmosphere
2.3: 2 h / 0 - 30 °C
3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C
4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
4.2: 6 h / 25 - 30 °C
4.3: 6.5 h / 0 - 30 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 6 h / 25 - 30 °C
2.3: 6.5 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
(2-fluorophenyl)acetic acid
451-82-1

(2-fluorophenyl)acetic acid

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C
2.2: 40 - 50 °C
2.3: 0.25 h / 0 - 30 °C
3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
4.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
5.2: 1 h / -78 °C
5.3: 1 h / -60 - 0 °C
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C
2.2: 40 - 50 °C
2.3: 0.25 h / 0 - 30 °C
3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
4.2: 6 h / 25 - 30 °C
4.3: 6.5 h / 0 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C
2.2: 40 - 50 °C
2.3: 0.25 h / 0 - 30 °C
3.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
4.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
4.2: 7 h / 25 - 30 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
prasugel
150322-43-3

prasugel

CS-747 hydrochloride

CS-747 hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In di-isopropyl ether; water; ethyl acetate at 20℃; Inert atmosphere;99%
With hydrogenchloride In tetrahydrofuran at -5 - 20℃; for 16h; Solvent; Temperature; Concentration;98%
With acetyl chloride; tert-butyl alcohol In acetone at 20℃; Reagent/catalyst; Solvent;98.2%
prasugel
150322-43-3

prasugel

prasugrel hydrobromide
1060616-79-6

prasugrel hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In acetone at 5 - 10℃; for 1h; Product distribution / selectivity;99%
With hydrogen bromide In water; acetone at 5 - 10℃; for 1h; Product distribution / selectivity;99%
With Acetyl bromide; acetic acid In ethyl acetate at 20 - 60℃; for 5.33333h; Product distribution / selectivity;89%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

prasugel
150322-43-3

prasugel

prasugrel 1,5-naphthalene disulfonate

prasugrel 1,5-naphthalene disulfonate

Conditions
ConditionsYield
In acetone at 20℃; for 6h; Product distribution / selectivity;96%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

prasugel
150322-43-3

prasugel

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate
952340-40-8

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate

Conditions
ConditionsYield
In diethyl ether; acetone at -10 - 35℃; for 12h;93%
In diethyl ether; acetone at 20℃;93%
In acetone at 30℃; for 6h; Product distribution / selectivity;79%
In methanol Product distribution / selectivity;
acetic acid
64-19-7

acetic acid

prasugel
150322-43-3

prasugel

5-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxyethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-yl acetate acetic acid hydrobromide

5-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxyethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-yl acetate acetic acid hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water at 40℃; for 0.166667h; Solvent;92.2%
maleic acid
110-16-7

maleic acid

prasugel
150322-43-3

prasugel

prasugrel maleate salt
389574-20-3

prasugrel maleate salt

Conditions
ConditionsYield
In acetone at 25 - 30℃; for 3h; Concentration;89.84%
ethane-1,2-disulphonic acid
110-04-3

ethane-1,2-disulphonic acid

prasugel
150322-43-3

prasugel

prasugrel 1,2-ethane disulfonate

prasugrel 1,2-ethane disulfonate

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 50℃; Product distribution / selectivity;89%
prasugel
150322-43-3

prasugel

prasugrel monohydrogensulfate
1191933-01-3

prasugrel monohydrogensulfate

Conditions
ConditionsYield
With sulfuric acid In acetone at -5℃; for 1.25h;86%
With sulfuric acid In isopropyl alcohol at 20℃; for 6h; Product distribution / selectivity;84%
With sulfuric acid In acetone at -32 - -28℃; for 5.5h; Product distribution / selectivity;78%
prasugel
150322-43-3

prasugel

C20H18(2)H2FNO3S

C20H18(2)H2FNO3S

Conditions
ConditionsYield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 6h; Inert atmosphere;85%
prasugel
150322-43-3

prasugel

2-acetyloxy-5-(α-cycloproylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine bisulfate

2-acetyloxy-5-(α-cycloproylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine bisulfate

Conditions
ConditionsYield
With sulfuric acid In water; acetone at -32 - -28℃; for 5.5h; Product distribution / selectivity;78%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

prasugel
150322-43-3

prasugel

prasugrel 1,5-naphthalenedisulfonic acid salt

prasugrel 1,5-naphthalenedisulfonic acid salt

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 50℃; Product distribution / selectivity;75%
In acetone at 20℃;
prasugel
150322-43-3

prasugel

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydroiodide
1060616-82-1

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydroiodide

Conditions
ConditionsYield
With hydrogen iodide In water; acetone at 5 - 10℃; for 1.5h;74%
With hydrogen iodide In water; acetone at 5 - 10℃; for 1.5h;74%
methanesulfonic acid
75-75-2

methanesulfonic acid

prasugel
150322-43-3

prasugel

prasugrel mesylate salt
1060616-84-3

prasugrel mesylate salt

Conditions
ConditionsYield
In acetone at 20 - 26℃; Cooling;70%
In methanol Product distribution / selectivity;
naphthalene-2-sulfonate
120-18-3

naphthalene-2-sulfonate

prasugel
150322-43-3

prasugel

prasugrel 2-naphthalenesulfonic acid salt
1178975-69-3

prasugrel 2-naphthalenesulfonic acid salt

Conditions
ConditionsYield
In acetone at 20℃; for 0.75h; Product distribution / selectivity;69%
In methanol Product distribution / selectivity;
1-naphthalenesulfonic acid
85-47-2

1-naphthalenesulfonic acid

prasugel
150322-43-3

prasugel

prasugrel 1-naphthalenesulfonic acid salt
1178975-73-9

prasugrel 1-naphthalenesulfonic acid salt

Conditions
ConditionsYield
In acetone at 20℃; for 0.333333h;66%
In acetone at 20℃;
cyclohexylsulfamic acid
100-88-9

cyclohexylsulfamic acid

prasugel
150322-43-3

prasugel

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate cyclamate
1306607-31-7

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate cyclamate

Conditions
ConditionsYield
In acetone at -10℃; for 12h;45%
In acetone45%
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