DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages for Cyclopropyl 2-fluorobenzyl ketone Cas150322-73-9 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellow oily liquid Package:25kg/drum;200kg/dru
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inquiryhigh quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/261.html Product Name Cyclopropyl 2-fluorobenzyl ketone
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct name Cyclopropyl 2-fluorobenzyl ketone Cas number 150322-73-9 Molecular formula C11H11FO Molecular weight 178.2 App
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
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inquiryProduct Name: Cyclopropyl 2-fluorobenzyl ketone CAS: 150322-73-9 MF: C11H11FO MW: 178.2 Mol File: 150322-73-9.mol Cyclopropyl 2-fluorobenzyl ketone Structure Cyclopropyl 2-fluorobenzyl ketone Chemical Properties Boiling point 61&
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inquiryPrasugrel intermediate Product Name: Cyclopropyl 2-fluorobenzyl ketone Synonyms: clopropyl 2-fluorobenzyl ketone;Cyclopropyl 2-fluorobenzyl ketone;Ethanone, 1-cyclopropyl-2-(2-fluorophenyl)-;1-CYCLOPROPYL-2-(2-FLUORO-PHENYL)-ETHANONE;1-cyclopr
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inquiryProduct name: Prasugrel intermediate Other name: Cyclopropyl 2-fluorobenzylketone CAS: 150322-73-9 Stock: Fresh Purity: not less than 97% Standard: In-house Package:25kg drum Application:Prasugrel intermediate
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryAppearance:Colorless liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Co
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inquirydimethylsulfoxonium methylide
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 4h; Temperature; | 93.6% |
cyclopropanecarboxylic acid chloride
methyl o-fluorophenylacetate
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 20 - 60℃; for 6h; Solvent; Reagent/catalyst; Temperature; | 92% |
o-fluorophenylacetic acid ethyl ester
cyclopropanecarboxylic acid chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
With pyridine In N,N-dimethyl-formamide at 20 - 30℃; for 8h; Solvent; Reagent/catalyst; Temperature; | 91.4% |
ethyl cyclopropylcarboxylate
(2-fluorophenyl)acetic acid
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
With sodium hydride In dimethyl sulfoxide; toluene at 95 - 110℃; for 1.5h; Large scale; | 88% |
Stage #1: (2-fluorophenyl)acetic acid With magnesium; isopropyl bromide In tetrahydrofuran; toluene at 15 - 65℃; Stage #2: ethyl cyclopropylcarboxylate In tetrahydrofuran; toluene at 5 - 65℃; |
cyclopropanecarboxylic acid dimethylamide
2-fluorobenzyl chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux; Stage #2: cyclopropanecarboxylic acid dimethylamide In tetrahydrofuran; diethyl ether for 0.5h; Product distribution / selectivity; | 79.8% |
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In tert-butyl methyl ether for 2h; Heating / reflux; Stage #2: cyclopropanecarboxylic acid dimethylamide In tetrahydrofuran; tert-butyl methyl ether for 0.5h; Product distribution / selectivity; | 60.9% |
With iodine; magnesium In tetrahydrofuran; 2-methyltetrahydrofuran at 40 - 45℃; for 1.5h; Solvent; Concentration; Inert atmosphere; |
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide
cyclopropylmagnesium bromide
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
In tetrahydrofuran at 45℃; for 1h; Inert atmosphere; Sealed tube; | 78% |
In tetrahydrofuran at 45℃; for 1h; Sealed tube; Inert atmosphere; | 78% |
o-fluorobenzyl bromide
cyclopropropanecarbonitrile
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: o-fluorobenzyl bromide With magnesium; methyl iodide In diethyl ether at 20℃; Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃; Stage #3: With water; ammonium chloride In diethyl ether at 0℃; Product distribution / selectivity; | 72.18% |
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 20℃; for 1h; Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃; for 3.16667h; Heating / reflux; Stage #3: With water; ammonium chloride In diethyl ether; ethyl acetate Product distribution / selectivity; Saturated solution; | |
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 25 - 30℃; for 0.5h; Stage #2: cyclopropropanecarbonitrile In diethyl ether at 25 - 30℃; for 4h; Heating / reflux; Stage #3: With water; ammonium chloride In diethyl ether Product distribution / selectivity; | |
Stage #1: o-fluorobenzyl bromide With iodine; magnesium In diethyl ether at 30℃; for 2.75h; Stage #2: cyclopropropanecarbonitrile In diethyl ether at 30℃; for 3h; |
cyclopropanecarboxylic acid diethylamide
2-fluorobenzyl chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux; Stage #2: cyclopropanecarboxylic acid diethylamide In tetrahydrofuran; diethyl ether for 0.5h; Product distribution / selectivity; | 48.7% |
cyclopropanecarboxylic acid diisopropylamide
2-fluorobenzyl chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux; Stage #2: cyclopropanecarboxylic acid diisopropylamide In tetrahydrofuran; diethyl ether for 2h; Product distribution / selectivity; | 22.5% |
o-fluorobenzyl bromide
magnesium dihydride
cyclopropropanecarbonitrile
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
In diethyl ether |
cyclopropropanecarbonitrile
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 20℃; for 1h; Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃; for 3.16667h; Heating / reflux; |
cyclopropanecarboxylic acid chloride
2-fluorobenzyl chloride
A
1-cyclopropyl-2-(2-fluorophenyl)ethanone
B
2-Fluorotoluene
C
2-fluorobenzyl alcohol
D
cyclopropanecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux; Stage #2: cyclopropanecarboxylic acid chloride In tetrahydrofuran; diethyl ether at -70 - 20℃; Stage #3: With water; ammonium chloride Product distribution / selectivity; |
2-fluorobenzyl chloride
cyclopropropanecarbonitrile
A
1-cyclopropyl-2-(2-fluorophenyl)ethanone
B
2-Fluorotoluene
C
2-fluorobenzyl alcohol
Conditions | Yield |
---|---|
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux; Stage #2: cyclopropropanecarbonitrile In tetrahydrofuran; diethyl ether at -50℃; for 0.5h; Heating / reflux; Stage #3: With hydrogenchloride; water Product distribution / selectivity; |
(2-fluorophenyl)acetic acid
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C View Scheme |
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide
cyclopropyl bromide
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: cyclopropyl bromide With iodine; magnesium In tetrahydrofuran at 25 - 50℃; Stage #2: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide In tetrahydrofuran at 40 - 50℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0 - 30℃; for 0.25h; | |
Stage #1: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide; cyclopropyl bromide With iodine; magnesium In tetrahydrofuran at 40 - 50℃; Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0 - 30℃; for 0.25h; |
methyl cyclopropylcarboxylate
(2-fluorophenyl)acetic acid
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: (2-fluorophenyl)acetic acid With magnesium; isopropyl bromide In tetrahydrofuran; toluene at 15 - 65℃; Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran; toluene at 5 - 65℃; |
2-fluorobenzyl chloride
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C View Scheme |
2-fluorophenyl acetonitrile
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 40 - 50 °C 2.2: 0.25 h / 0 - 30 °C View Scheme |
cyclopropanecarboxylic acid dimethylamide
2-fluorobenzyl chloride
A
1-cyclopropyl-2-(2-fluorophenyl)ethanone
B
1,2-bis(2-fluorophenyl)ethane
Conditions | Yield |
---|---|
With iodine; magnesium In tetrahydrofuran; toluene at 40 - 45℃; for 1.5h; Inert atmosphere; | A n/a B 7.6 %Chromat. |
2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; copper(II) bis(trifluoromethanesulfonate) / N,N-dimethyl acetamide / 80 h / 20 °C / Sealed tube 2: tetrahydrofuran / 1 h / 45 °C / Inert atmosphere; Sealed tube View Scheme |
fluorobenzene
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tin(IV) chloride / tetrahydrofuran / 4 h / 45 °C 2: dichloromethane / 4 h / 20 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide In tetrahydrofuran at 40℃; for 4h; Temperature; Time; Concentration; | 95.3% |
With bromine In methanol at 25 - 30℃; for 6h; Concentration; | 94.65% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In cyclohexane at 10℃; Product distribution / selectivity; Reflux; | 93.28% |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
[2H]-cyclopropyl 2-fluorobenzyl ketone
Conditions | Yield |
---|---|
With pyrrolidine; water-d2 In 1,4-dioxane at 20℃; for 12h; | 90% |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
α-cyclopropylcarbonyl-2-fluorobenzyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; dihydrogen peroxide In 1,4-dioxane; water at 20 - 80℃; for 2 - 72h; Product distribution / selectivity; | 82.9% |
With chlorine In dichloromethane at 5 - 20℃; for 5.5h; Product distribution / selectivity; | 81% |
With chlorine In dichloromethane at 0℃; for 5.3h; | 80% |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
4-methoxy-aniline
cyclopropanecarboxylic acid (4-methoxy-phenyl)-amide
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine; trifluorormethanesulfonic acid; oxygen In m-xylene at 130℃; under 760.051 Torr; for 6h; Sealed tube; | 60% |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
5-chloro-1-(2-fluorophenyl)-pentan-2-one
Conditions | Yield |
---|---|
With hydrogenchloride; water at 100℃; for 2.5h; | |
With hydrogenchloride In water for 3h; |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
prasugel
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 6 h / 25 - 30 °C 2.3: 6.5 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 2 steps 1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux 2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C 4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C 5.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 6 h / 25 - 30 °C 2.3: 6.5 h / 0 - 30 °C 3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C 4.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C 4.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 8 h / 0 - 25 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 3.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C 4.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 5.1: ammonia / dichloromethane; water / 0 - 30 °C 5.2: 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 8 h / 0 - 25 °C 3.1: ammonia / dichloromethane; water / 0 - 30 °C 3.2: 1 h / 25 - 30 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux 2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3: hydrogen bromide / water; acetone / 5 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux 2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3: hydrogen bromide / water; acetone / 5.25 h / 0 - 30 °C View Scheme |
1-cyclopropyl-2-(2-fluorophenyl)ethanone
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme |
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