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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Cyclopropyl 2-fluorobenzyl ketone Manufacturer/High quality/Best price/In stock

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Cyclopropyl 2-Fluorobenzyl Ketone supplier in China

Cas:150322-73-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Cyclopropyl 2-fluorobenzyl ketone Cas150322-73-9 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellow oily liquid Package:25kg/drum;200kg/dru

High quality Cyclopropyl 2-fluorobenzyl ketone Cas150322-73-9 with favorable price

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cyclopropyl 2-Fluorobenzyl Ketone

Cas:150322-73-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 150322-73-9 Ethanone,1-cyclopropyl-2-(2-fluorophenyl)-

Cas:150322-73-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-Cyclopropyl-2-(2-fluorophenyl)-ethanone

Cas:150322-73-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/261.html Product Name Cyclopropyl 2-fluorobenzyl ketone

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Gram

FOB Price: $52.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

150322-73-9

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 150322-73-9 with best quality

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-Cyclopropyl-2-(2-fluorophenyl) acetone

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Cyclopropyl 2-fluorobenzyl ketone/ LIDE PHARMA- Factory supply / Best price

Cas:150322-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product name Cyclopropyl 2-fluorobenzyl ketone Cas number 150322-73-9 Molecular formula C11H11FO Molecular weight 178.2 App

1- Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone,1-cyclopropyl-2-(2-fluorophenyl)- 150322-73-9

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Cyclopropyl 2-fluorobenzyl ketone CAS: 150322-73-9 MF: C11H11FO MW: 178.2 Mol File: 150322-73-9.mol Cyclopropyl 2-fluorobenzyl ketone Structure Cyclopropyl 2-fluorobenzyl ketone Chemical Properties Boiling point 61&

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Prasugrel intermediate, Cyclopropyl 2-fluorobenzyl ketone CAS:150322-73-9

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $80.0 / 84.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Cyclopropyl 2-fluorobenzyl ketone 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expor

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanone,1-cyclopropyl-2-(2-fluorophenyl)-

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanone,1-cyclopropyl-2-(2-fluorophenyl)-

Cas:150322-73-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Prasugrel intermediate Product Name: Cyclopropyl 2-fluorobenzyl ketone Synonyms: clopropyl 2-fluorobenzyl ketone;Cyclopropyl 2-fluorobenzyl ketone;Ethanone, 1-cyclopropyl-2-(2-fluorophenyl)-;1-CYCLOPROPYL-2-(2-FLUORO-PHENYL)-ETHANONE;1-cyclopr

Prasugrel intermediate Cyclopropyl 2-fluorobenzyl ketone Manufactory best quality

Cas:150322-73-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: Prasugrel intermediate Other name: Cyclopropyl 2-fluorobenzylketone CAS: 150322-73-9 Stock: Fresh Purity: not less than 97% Standard: In-house Package:25kg drum Application:Prasugrel intermediate

Intermediate of Prasugrel

Cas:150322-73-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:Colorless liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Co

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-Cyclopropyl-2-(2-fluorophenyl) acetone

Cas:150322-73-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Cyclopropyl 2-fluorobenzyl ketone

Cas:150322-73-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Cyclopropyl 2-fluorobenzylketone in stock

Cas:150322-73-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

1-(2-fluorophenyl)but-3-en-2-one

1-(2-fluorophenyl)but-3-en-2-one

dimethylsulfoxonium methylide
70775-39-2, 5367-24-8

dimethylsulfoxonium methylide

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h; Temperature;93.6%
cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

methyl o-fluorophenylacetate
57486-67-6

methyl o-fluorophenylacetate

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20 - 60℃; for 6h; Solvent; Reagent/catalyst; Temperature;92%
o-fluorophenylacetic acid ethyl ester
584-74-7

o-fluorophenylacetic acid ethyl ester

cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide at 20 - 30℃; for 8h; Solvent; Reagent/catalyst; Temperature;91.4%
ethyl cyclopropylcarboxylate
4606-07-9

ethyl cyclopropylcarboxylate

(2-fluorophenyl)acetic acid
451-82-1

(2-fluorophenyl)acetic acid

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide; toluene at 95 - 110℃; for 1.5h; Large scale;88%
Stage #1: (2-fluorophenyl)acetic acid With magnesium; isopropyl bromide In tetrahydrofuran; toluene at 15 - 65℃;
Stage #2: ethyl cyclopropylcarboxylate In tetrahydrofuran; toluene at 5 - 65℃;
cyclopropanecarboxylic acid dimethylamide
17696-23-0

cyclopropanecarboxylic acid dimethylamide

2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux;
Stage #2: cyclopropanecarboxylic acid dimethylamide In tetrahydrofuran; diethyl ether for 0.5h; Product distribution / selectivity;
79.8%
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In tert-butyl methyl ether for 2h; Heating / reflux;
Stage #2: cyclopropanecarboxylic acid dimethylamide In tetrahydrofuran; tert-butyl methyl ether for 0.5h; Product distribution / selectivity;
60.9%
With iodine; magnesium In tetrahydrofuran; 2-methyltetrahydrofuran at 40 - 45℃; for 1.5h; Solvent; Concentration; Inert atmosphere;
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide
946402-23-9

2-(2-fluorophenyl)-N-methoxy-N-methylacetamide

cyclopropylmagnesium bromide
23719-80-4

cyclopropylmagnesium bromide

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
In tetrahydrofuran at 45℃; for 1h; Inert atmosphere; Sealed tube;78%
In tetrahydrofuran at 45℃; for 1h; Sealed tube; Inert atmosphere;78%
o-fluorobenzyl bromide
446-48-0

o-fluorobenzyl bromide

cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: o-fluorobenzyl bromide With magnesium; methyl iodide In diethyl ether at 20℃;
Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃;
Stage #3: With water; ammonium chloride In diethyl ether at 0℃; Product distribution / selectivity;
72.18%
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 20℃; for 1h;
Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃; for 3.16667h; Heating / reflux;
Stage #3: With water; ammonium chloride In diethyl ether; ethyl acetate Product distribution / selectivity; Saturated solution;
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 25 - 30℃; for 0.5h;
Stage #2: cyclopropropanecarbonitrile In diethyl ether at 25 - 30℃; for 4h; Heating / reflux;
Stage #3: With water; ammonium chloride In diethyl ether Product distribution / selectivity;
Stage #1: o-fluorobenzyl bromide With iodine; magnesium In diethyl ether at 30℃; for 2.75h;
Stage #2: cyclopropropanecarbonitrile In diethyl ether at 30℃; for 3h;
cyclopropanecarboxylic acid diethylamide
10374-28-4

cyclopropanecarboxylic acid diethylamide

2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux;
Stage #2: cyclopropanecarboxylic acid diethylamide In tetrahydrofuran; diethyl ether for 0.5h; Product distribution / selectivity;
48.7%
cyclopropanecarboxylic acid diisopropylamide
61259-30-1

cyclopropanecarboxylic acid diisopropylamide

2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux;
Stage #2: cyclopropanecarboxylic acid diisopropylamide In tetrahydrofuran; diethyl ether for 2h; Product distribution / selectivity;
22.5%
o-fluorobenzyl bromide
446-48-0

o-fluorobenzyl bromide

magnesium dihydride
7439-95-4

magnesium dihydride

cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
In diethyl ether
cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: o-fluorobenzyl bromide With magnesium In diethyl ether at 20℃; for 1h;
Stage #2: cyclopropropanecarbonitrile In diethyl ether at 20℃; for 3.16667h; Heating / reflux;
cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

A

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

B

2-Fluorotoluene
95-52-3

2-Fluorotoluene

C

2-fluorobenzyl alcohol
446-51-5

2-fluorobenzyl alcohol

D

cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux;
Stage #2: cyclopropanecarboxylic acid chloride In tetrahydrofuran; diethyl ether at -70 - 20℃;
Stage #3: With water; ammonium chloride Product distribution / selectivity;
2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

A

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

B

2-Fluorotoluene
95-52-3

2-Fluorotoluene

C

2-fluorobenzyl alcohol
446-51-5

2-fluorobenzyl alcohol

Conditions
ConditionsYield
Stage #1: 2-fluorobenzyl chloride With iodine; magnesium In diethyl ether for 2h; Heating / reflux;
Stage #2: cyclopropropanecarbonitrile In tetrahydrofuran; diethyl ether at -50℃; for 0.5h; Heating / reflux;
Stage #3: With hydrogenchloride; water Product distribution / selectivity;
(2-fluorophenyl)acetic acid
451-82-1

(2-fluorophenyl)acetic acid

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C
1.2: 6 h / 0 - 5 °C
2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C
2.2: 40 - 50 °C
2.3: 0.25 h / 0 - 30 °C
View Scheme
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide
946402-23-9

2-(2-fluorophenyl)-N-methoxy-N-methylacetamide

cyclopropyl bromide
4333-56-6

cyclopropyl bromide

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: cyclopropyl bromide With iodine; magnesium In tetrahydrofuran at 25 - 50℃;
Stage #2: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide In tetrahydrofuran at 40 - 50℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0 - 30℃; for 0.25h;
Stage #1: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide; cyclopropyl bromide With iodine; magnesium In tetrahydrofuran at 40 - 50℃;
Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0 - 30℃; for 0.25h;
methyl cyclopropylcarboxylate
2868-37-3

methyl cyclopropylcarboxylate

(2-fluorophenyl)acetic acid
451-82-1

(2-fluorophenyl)acetic acid

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Stage #1: (2-fluorophenyl)acetic acid With magnesium; isopropyl bromide In tetrahydrofuran; toluene at 15 - 65℃;
Stage #2: methyl cyclopropylcarboxylate In tetrahydrofuran; toluene at 5 - 65℃;
2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C
2.1: sodium hydroxide; water / 5 - 95 °C
2.2: pH 2 - 3
3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C
3.2: 5 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C
2.1: sodium hydroxide; water / 5 - 95 °C
2.2: pH 2 - 3
3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C
3.2: 5 - 65 °C
View Scheme
2-fluorophenyl acetonitrile
326-62-5

2-fluorophenyl acetonitrile

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / 5 - 95 °C
1.2: pH 2 - 3
2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C
2.2: 5 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / 5 - 95 °C
1.2: pH 2 - 3
2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C
2.2: 5 - 65 °C
View Scheme
2-(2-fluorophenyl acetic acid)

2-(2-fluorophenyl acetic acid)

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 6 h / 0 - 5 °C
2.1: iodine; magnesium / tetrahydrofuran / 40 - 50 °C
2.2: 0.25 h / 0 - 30 °C
View Scheme
cyclopropanecarboxylic acid dimethylamide
17696-23-0

cyclopropanecarboxylic acid dimethylamide

2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

A

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

B

1,2-bis(2-fluorophenyl)ethane
349-38-2

1,2-bis(2-fluorophenyl)ethane

Conditions
ConditionsYield
With iodine; magnesium In tetrahydrofuran; toluene at 40 - 45℃; for 1.5h; Inert atmosphere;A n/a
B 7.6 %Chromat.
2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane
346656-39-1

2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; copper(II) bis(trifluoromethanesulfonate) / N,N-dimethyl acetamide / 80 h / 20 °C / Sealed tube
2: tetrahydrofuran / 1 h / 45 °C / Inert atmosphere; Sealed tube
View Scheme
fluorobenzene
462-06-6

fluorobenzene

1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tin(IV) chloride / tetrahydrofuran / 4 h / 45 °C
2: dichloromethane / 4 h / 20 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
204205-33-4

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

Conditions
ConditionsYield
With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide In tetrahydrofuran at 40℃; for 4h; Temperature; Time; Concentration;95.3%
With bromine In methanol at 25 - 30℃; for 6h; Concentration;94.65%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In cyclohexane at 10℃; Product distribution / selectivity; Reflux;93.28%
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

[2H]-cyclopropyl 2-fluorobenzyl ketone
1646868-75-8

[2H]-cyclopropyl 2-fluorobenzyl ketone

Conditions
ConditionsYield
With pyrrolidine; water-d2 In 1,4-dioxane at 20℃; for 12h;90%
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

α-cyclopropylcarbonyl-2-fluorobenzyl chloride
178688-43-2

α-cyclopropylcarbonyl-2-fluorobenzyl chloride

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In 1,4-dioxane; water at 20 - 80℃; for 2 - 72h; Product distribution / selectivity;82.9%
With chlorine In dichloromethane at 5 - 20℃; for 5.5h; Product distribution / selectivity;81%
With chlorine In dichloromethane at 0℃; for 5.3h;80%
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

4-methoxy-aniline
104-94-9

4-methoxy-aniline

cyclopropanecarboxylic acid (4-methoxy-phenyl)-amide
2759-47-9

cyclopropanecarboxylic acid (4-methoxy-phenyl)-amide

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; trifluorormethanesulfonic acid; oxygen In m-xylene at 130℃; under 760.051 Torr; for 6h; Sealed tube;60%
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

5-chloro-1-(2-fluorophenyl)-pentan-2-one
1056459-35-8

5-chloro-1-(2-fluorophenyl)-pentan-2-one

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 2.5h;
With hydrogenchloride In water for 3h;
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

prasugel
150322-43-3

prasugel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 6 h / 25 - 30 °C
2.3: 6.5 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
150322-38-6

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
View Scheme
Multi-step reaction with 2 steps
1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux
2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

CS-747 hydrochloride

CS-747 hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
5.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 6 h / 25 - 30 °C
2.3: 6.5 h / 0 - 30 °C
3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C
4.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide
1243654-57-0

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
4.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
2.3: 8 h / 0 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
3.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
150322-39-7

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -60 - 0 °C
4.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C
5.1: ammonia / dichloromethane; water / 0 - 30 °C
5.2: 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
2.3: 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C
2.2: 7 h / 25 - 30 °C
2.3: 8 h / 0 - 25 °C
3.1: ammonia / dichloromethane; water / 0 - 30 °C
3.2: 1 h / 25 - 30 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt
1287752-37-7

1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux
2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3: hydrogen bromide / water; acetone / 5 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / toluene-4-sulfonic acid / dichloromethane / 4.75 h / 0 - 5 °C / Reflux
2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C
3: hydrogen bromide / water; acetone / 5.25 h / 0 - 30 °C
View Scheme
1-cyclopropyl-2-(2-fluorophenyl)ethanone
150322-73-9

1-cyclopropyl-2-(2-fluorophenyl)ethanone

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
952340-38-4

2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dibenzoyl peroxide; N-Bromosuccinimide / ethyl acetate / 25 - 60 °C
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere
View Scheme

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