We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:1408282-26-7
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Type:Manufacturers
inquiry8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one CAS No.:1408282-26-7 Name: 8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one Molecular Structure Molecular Form
Cas:1408282-26-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:1408282-26-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:1408282-26-7
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryCAS No.1408282-26-7 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher
Cas:1408282-26-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:1408282-26-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1408282-26-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:1408282-26-7
Min.Order:1 Gram
FOB Price: $1029.0
Type:Trading Company
inquiryAppearance:white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingdao/Shanghai
Cas:1408282-26-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1408282-26-7
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:1408282-26-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:1408282-26-7
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:1408282-26-7
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct name: 8-Fluoro-4,5-Dihydro-1H-Azepino[5,4,3-cd]indol-6(3H)-One CAS No.: 1408282-26-7 Molecule Formula:C11H9FN2O Molecule Weight:204.00 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
Cas:1408282-26-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1408282-26-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:1408282-26-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1408282-26-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:1408282-26-7
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryCAS 1408282-26-7 Molecular formula C11H9FN2O Molecular weight 204.20000 Accurate mass 204.07000 Appearance:Detailed see specifications Storage:keep sealed and keep from direct light Package:According to client's requiremen
Cas:1408282-26-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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Min.Order:0
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Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:1408282-26-7
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:1408282-26-7
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Trading Company
inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
Cas:1408282-26-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:1408282-26-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryShanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service
Cas:1408282-26-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryProduct Name:8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one;Alice:8-Fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one;8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one;8-fluoro-3,4-dihydro-2H-azepino[5,4,3-cd]indol
Cas:1408282-26-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 40℃; under 4500.45 Torr; Pressure; Reagent/catalyst; Temperature; | 95.7% |
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With methylamine In water at 0 - 20℃; for 24h; | 94% |
With methylamine In water at 20℃; for 17h; Large scale; | 89% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 40℃; under 15001.5 Torr; for 8h; Solvent; Temperature; Industrial scale; | 81.4% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With tributylsilane; trifluoroacetic acid In dichloromethane at 0 - 20℃; for 8h; Reagent/catalyst; | 78% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With water; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 24h; | 75% |
4-chlorobutyraldehyde
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
In ethanol; water for 7h; Reflux; | 73.2% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With tributylsilane; boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; for 12h; Reagent/catalyst; | 69% |
4-chlorobutyraldehyde
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In ethanol; water for 10h; Reflux; | 65.8% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With 10% Pt/activated carbon; hydrogen In methanol at 20℃; for 6h; Time; | 1.2 g |
3-fluoro-5-nitrobenzoic acid
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 35 °C 2: tetrahydrofuran / 1 h / -30 °C 3: thionyl chloride / 4 h / 0 - 30 °C 4: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice 5: ammonium acetate / 3.5 h / 60 °C 6: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: tetrahydrofuran / 1 h / -30 °C 2: thionyl chloride / 4 h / 0 - 30 °C 3: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice 4: ammonium acetate / 3.5 h / 60 °C 5: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 4 h / 0 - 30 °C 2: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice 3: ammonium acetate / 3.5 h / 60 °C 4: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice 2: ammonium acetate / 3.5 h / 60 °C 3: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C 2: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C 3: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C 2: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
6-fluoro-1H-indole
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: acetic anhydride; acetic acid / 48 h / 50 °C 2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 2.2: 1 h 3.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C 4.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C 5.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C 6.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
6-Fluoroindole-3-propionic acid
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 1.2: 1 h 2.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C 3.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C 4.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C 5.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C 2: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C 3: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C 4: thionyl chloride / 1,4-dioxane / 6 h / 70 °C 5: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C View Scheme |
methyl 5-fluoro-2-hydroxybenzoate
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium nitrate; acetic anhydride; acetic acid / 2 h / 10 °C 2: bis-triphenylphosphine-palladium(II) chloride; trifluoromethylsulfonic anhydride; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C 4: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C 5: acetic acid / 12 h / 50 °C 6: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr View Scheme |
5-fluoro-2-hydroxy-3-nitrobenzoic acid methyl ester
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: bis-triphenylphosphine-palladium(II) chloride; trifluoromethylsulfonic anhydride; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C 3: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C 4: acetic acid / 12 h / 50 °C 5: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C 2: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C 3: acetic acid / 12 h / 50 °C 4: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C 2: acetic acid / 12 h / 50 °C 3: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
With hydrogen In methanol at 50℃; under 7600.51 Torr; for 12h; Temperature; Pressure; | 10.1 g |
methyl 3-amino-5-fluorobenzoate
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium nitrite; hydrogenchloride / water / 1.75 h / -10 °C 1.2: 2 h 2.1: water; ethanol / 7 h / Reflux View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrazine hydrate / dimethyl sulfoxide / 24 h / 60 °C 2: water; ethanol / 7 h / Reflux View Scheme |
6-fluoro-1H-indole-4-carbonitrile
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water / 8 h / 120 °C 2.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C 2.2: 2 h / Heating 3.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 8 h / 120 °C 2: HATU / N,N-dimethyl-formamide / 8 h / 20 °C 3: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C View Scheme |
4-bromo-6-fluoro-1H-indole
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 8 h / 120 °C / Inert atmosphere 2.1: sodium hydroxide / water / 8 h / 120 °C 3.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C 3.2: 2 h / Heating 4.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N,N-dimethyl-formamide / 6 h / 150 °C / Inert atmosphere 2.1: sodium hydroxide / water / 8 h / 120 °C 3.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C 3.2: 2 h / Heating 4.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 8 h / 120 °C / Inert atmosphere 2: sodium hydroxide / water / 8 h / 120 °C 3: HATU / N,N-dimethyl-formamide / 8 h / 20 °C 4: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 6 h / 150 °C / Inert atmosphere 2: sodium hydroxide / water / 8 h / 120 °C 3: HATU / N,N-dimethyl-formamide / 8 h / 20 °C 4: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C 1.2: 2 h / Heating 2.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C View Scheme |
6-fluoro-1H-indole-4-carboxylic acid methyl ester
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylsilane; trifluoroacetic acid / dichloromethane / 90 h / 8 - 20 °C 2: methylamine / water / 24 h / 0 - 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
Conditions | Yield |
---|---|
With sodium carbonate; pyridinium hydrobromide perbromide In tetrahydrofuran; dichloromethane at 10 - 20℃; for 1h; | 91% |
With pyridinium hydrobromide perbromide In tetrahydrofuran at 10℃; for 1h; Temperature; | 90.65% |
With pyridinium hydrobromide perbromide In tetrahydrofuran; dichloromethane at 0 - 5℃; for 1h; Large scale; | 83% |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: pyridinium hydrobromide perbromide / tetrahydrofuran / 1 h / 10 °C 2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 2 h / 90 - 100 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere 2.2: 2 h / 20 - 98 °C / Inert atmosphere View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
A
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale 4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale 4.2: 1 h / Large scale 4.3: 18 h / Large scale View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
A
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Rucaparib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale 4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 5 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale 4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale 4.2: 1 h / Large scale 4.3: 18 h / Large scale 5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C 3.1: methanol / 2 h / 20 °C 3.2: 0 - 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridinium hydrobromide perbromide / dichloromethane / 0 - 5 °C 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / isopropyl alcohol / 1 h / 20 °C / Inert atmosphere 2.2: 3 h / 80 - 85 °C / Inert atmosphere 3.1: methanol; tetrahydrofuran / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: pyridinium hydrobromide perbromide / tetrahydrofuran / 1 h / 10 °C 2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 2 h / 90 - 100 °C / Inert atmosphere 3: toluene-4-sulfonic acid / ethanol / 2 h / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere 2.2: 2 h / 20 - 98 °C / Inert atmosphere 3.1: tetrahydrofuran; methanol; ethanol / 12 h / 25 - 33 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale 4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale 5.1: water; isopropyl alcohol / 1 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale 2.2: 9 h / 20 °C / Large scale 3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale 4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale 4.2: 1 h / Large scale 4.3: 18 h / Large scale 5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale 6.1: water; isopropyl alcohol / 1 h / 70 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere 2.2: 2 h / 20 - 98 °C / Inert atmosphere 3.1: tetrahydrofuran; methanol; ethanol / 12 h / 25 - 33 °C 4.1: palladium 10% on activated carbon; hydrogen / 12 h 5.1: water; methanol / 29 h / 0 - 40 °C / Reflux View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C 3: hydroxylamine hydrochloride; sodium acetate / methanol; water / 1 h / 50 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C 3: hydroxylamine hydrochloride; sodium acetate / methanol; water / 1 h / 50 °C 4: zinc; hydrogenchloride / water; ethanol / 3 h / 0 - 20 °C View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 5 - 20 °C 2.1: potassium carbonate; bis(acetato)bis(triphenylphosphine)palladium(0) / ethanol; water / 17 h / 60 °C / Inert atmosphere 2.2: 17 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridinium hydrobromide perbromide / dichloromethane / 0 - 5 °C 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / isopropyl alcohol / 1 h / 20 °C / Inert atmosphere 2.2: 3 h / 80 - 85 °C / Inert atmosphere 3.1: methanol; tetrahydrofuran / 2 h / 0 - 20 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C 4.2: 2 h View Scheme |
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 5 - 20 °C 2: bis(acetato)bis(triphenylphosphine)palladium(0); sodium carbonate / methanol; water / 4 h / 60 °C / Inert atmosphere 3: methanol; water / 48 h / 20 °C View Scheme |
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