Products

Refine

Country

Business Type

Certificate

Display

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one manufacturer/supplier

Cas:1408282-26-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one CAS No.:1408282-26-7 Name: 8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one Molecular Structure Molecular Form

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

8-Fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Cas:1408282-26-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one CAS 1408282-26-7

Cas:1408282-26-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

CAS No.1408282-26-7 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher

CAS No.1408282-26-7 8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1408282-26-7 with best quality

Cas:1408282-26-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one CAS: 1408282-26-7

Cas:1408282-26-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one/ LIDE PHARMA- Factory supply / Best price

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

8-Fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one

Cas:1408282-26-7

Min.Order:1 Gram

FOB Price: $1029.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingdao/Shanghai

Poroduce/Synthesis Rucaparib intermediate 1408282-26-7 99% white solid

Cas:1408282-26-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Rucaparib intermediate 1408282-26-7

Cas:1408282-26-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one

Cas:1408282-26-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

8-FLUORO-1,3,4,5-TETRAHYDRO-AZEPINO[5,4,3-CD]INDOL-6-ONE

Cas:1408282-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

6-fluoro-3,10-diazatricyclo[6.4.1.0?,13]trideca-1,4(13),5,7-tetraen-9-one

Cas:1408282-26-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one CAS: 1408282-26-7

Cas:1408282-26-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 8-Fluoro-4,5-Dihydro-1H-Azepino[5,4,3-cd]indol-6(3H)-One CAS No.: 1408282-26-7 Molecule Formula:C11H9FN2O Molecule Weight:204.00 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price 8-Fluoro-4,5-Dihydro-1H-Azepino[5,4,3-cd]indol-6(3H)-One on stock

Cas:1408282-26-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Cas:1408282-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one

Cas:1408282-26-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one CAS: 1408282-26-7

Cas:1408282-26-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

CAS 1408282-26-7 Molecular formula C11H9FN2O Molecular weight 204.20000 Accurate mass 204.07000 Appearance:Detailed see specifications Storage:keep sealed and keep from direct light Package:According to client's requiremen

8-FLUORO-4,5-DIHYDRO-1H-AZEPINO[5,4,3-CD]INDOL-6(3H)-ONE supplier

Cas:1408282-26-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

8-fluoro-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one

Cas:1408282-26-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

8-fluoro-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one

Cas:1408282-26-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Luhan Pharmachem Co., Lt

Product Name:8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one;Alice:8-Fluoro-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one;8-Fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one;8-fluoro-3,4-dihydro-2H-azepino[5,4,3-cd]indol

8-fluoro-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one

Cas:1408282-26-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C12H9FN2O2

C12H9FN2O2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 40℃; under 4500.45 Torr; Pressure; Reagent/catalyst; Temperature;95.7%
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester
1408282-25-6

3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With methylamine In water at 0 - 20℃; for 24h;94%
With methylamine In water at 20℃; for 17h; Large scale;89%
6-fluoro-3-(2-nitroethyl)-1H-indole-4-carboxylic acid methyl ester

6-fluoro-3-(2-nitroethyl)-1H-indole-4-carboxylic acid methyl ester

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 40℃; under 15001.5 Torr; for 8h; Solvent; Temperature; Industrial scale;81.4%
N-(2,2-dimethoxyethyl)-6-fluoro-1H-indole-4-carboxamide

N-(2,2-dimethoxyethyl)-6-fluoro-1H-indole-4-carboxamide

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With tributylsilane; trifluoroacetic acid In dichloromethane at 0 - 20℃; for 8h; Reagent/catalyst;78%
C16H17FN2O2

C16H17FN2O2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With water; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 24h;75%
4-chlorobutyraldehyde
6139-84-0

4-chlorobutyraldehyde

3-fluoro-5-hydrazinobenzoic acid methyl ester

3-fluoro-5-hydrazinobenzoic acid methyl ester

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
In ethanol; water for 7h; Reflux;73.2%
N-(2,2-diethoxyethyl)-6-fluoro-1H-indole-4-carboxamide

N-(2,2-diethoxyethyl)-6-fluoro-1H-indole-4-carboxamide

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With tributylsilane; boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; for 12h; Reagent/catalyst;69%
4-chlorobutyraldehyde
6139-84-0

4-chlorobutyraldehyde

methyl 3-[2-(diphenylmethylene)hydrazino]-5-fluorobenzoate

methyl 3-[2-(diphenylmethylene)hydrazino]-5-fluorobenzoate

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol; water for 10h; Reflux;65.8%
C12H8ClFN2O4

C12H8ClFN2O4

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With 10% Pt/activated carbon; hydrogen In methanol at 20℃; for 6h; Time;1.2 g
3-fluoro-5-nitrobenzoic acid
14027-75-9

3-fluoro-5-nitrobenzoic acid

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 35 °C
2: tetrahydrofuran / 1 h / -30 °C
3: thionyl chloride / 4 h / 0 - 30 °C
4: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice
5: ammonium acetate / 3.5 h / 60 °C
6: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C
View Scheme
4-chloro-3-fluoro-5-nitrobenzoic acid

4-chloro-3-fluoro-5-nitrobenzoic acid

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / 1 h / -30 °C
2: thionyl chloride / 4 h / 0 - 30 °C
3: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice
4: ammonium acetate / 3.5 h / 60 °C
5: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C
View Scheme
C9H5ClFNO2

C9H5ClFNO2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 4 h / 0 - 30 °C
2: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice
3: ammonium acetate / 3.5 h / 60 °C
4: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C
View Scheme
C10H7ClFNO2

C10H7ClFNO2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trichlorophosphate / 2.67 h / 60 °C / Cooling with ice
2: ammonium acetate / 3.5 h / 60 °C
3: 10% Pt/activated carbon; hydrogen / methanol / 6 h / 20 °C
View Scheme
C16H17ClFNO2

C16H17ClFNO2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
2: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
3: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
C16H16FNO2

C16H16FNO2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
2: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
6-fluoro-1H-indole
399-51-9

6-fluoro-1H-indole

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: acetic anhydride; acetic acid / 48 h / 50 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
2.2: 1 h
3.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
4.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
5.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
6.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
C16H17FN2O2

C16H17FN2O2

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
6-Fluoroindole-3-propionic acid
141071-78-5

6-Fluoroindole-3-propionic acid

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: 1 h
2.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
3.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
5.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
C16H18FNO3

C16H18FNO3

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
2: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
3: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
4: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
5: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
View Scheme
methyl 5-fluoro-2-hydroxybenzoate
391-92-4

methyl 5-fluoro-2-hydroxybenzoate

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium nitrate; acetic anhydride; acetic acid / 2 h / 10 °C
2: bis-triphenylphosphine-palladium(II) chloride; trifluoromethylsulfonic anhydride; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C
4: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C
5: acetic acid / 12 h / 50 °C
6: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr
View Scheme
5-fluoro-2-hydroxy-3-nitrobenzoic acid methyl ester
880160-63-4

5-fluoro-2-hydroxy-3-nitrobenzoic acid methyl ester

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: bis-triphenylphosphine-palladium(II) chloride; trifluoromethylsulfonic anhydride; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C
3: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C
4: acetic acid / 12 h / 50 °C
5: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr
View Scheme
C13H14FNO4Si

C13H14FNO4Si

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 50 °C
2: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C
3: acetic acid / 12 h / 50 °C
4: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr
View Scheme
C13H16FNO2Si

C13H16FNO2Si

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 90 °C
2: acetic acid / 12 h / 50 °C
3: hydrogen / methanol / 12 h / 50 °C / 7600.51 Torr
View Scheme
C12H9FN2O4

C12H9FN2O4

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
With hydrogen In methanol at 50℃; under 7600.51 Torr; for 12h; Temperature; Pressure;10.1 g
methyl 3-amino-5-fluorobenzoate
884497-46-5

methyl 3-amino-5-fluorobenzoate

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium nitrite; hydrogenchloride / water / 1.75 h / -10 °C
1.2: 2 h
2.1: water; ethanol / 7 h / Reflux
View Scheme
methyl 3,5-difluorobenzoate

methyl 3,5-difluorobenzoate

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / dimethyl sulfoxide / 24 h / 60 °C
2: water; ethanol / 7 h / Reflux
View Scheme
6-fluoro-1H-indole-4-carbonitrile
1082040-44-5

6-fluoro-1H-indole-4-carbonitrile

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 8 h / 120 °C
2.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C
2.2: 2 h / Heating
3.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 8 h / 120 °C
2: HATU / N,N-dimethyl-formamide / 8 h / 20 °C
3: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C
View Scheme
4-bromo-6-fluoro-1H-indole
885520-70-7

4-bromo-6-fluoro-1H-indole

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 8 h / 120 °C / Inert atmosphere
2.1: sodium hydroxide / water / 8 h / 120 °C
3.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C
3.2: 2 h / Heating
4.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-formamide / 6 h / 150 °C / Inert atmosphere
2.1: sodium hydroxide / water / 8 h / 120 °C
3.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C
3.2: 2 h / Heating
4.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 8 h / 120 °C / Inert atmosphere
2: sodium hydroxide / water / 8 h / 120 °C
3: HATU / N,N-dimethyl-formamide / 8 h / 20 °C
4: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 6 h / 150 °C / Inert atmosphere
2: sodium hydroxide / water / 8 h / 120 °C
3: HATU / N,N-dimethyl-formamide / 8 h / 20 °C
4: tributylsilane; boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C
View Scheme
6-fluoro-1H-indole-4-carboxylic acid

6-fluoro-1H-indole-4-carboxylic acid

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C
1.2: 2 h / Heating
2.1: trifluoroacetic acid; tributylsilane / dichloromethane / 8 h / 0 - 20 °C
View Scheme
6-fluoro-1H-indole-4-carboxylic acid methyl ester
1082040-43-4

6-fluoro-1H-indole-4-carboxylic acid methyl ester

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylsilane; trifluoroacetic acid / dichloromethane / 90 h / 8 - 20 °C
2: methylamine / water / 24 h / 0 - 20 °C
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
283173-80-8

2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Conditions
ConditionsYield
With sodium carbonate; pyridinium hydrobromide perbromide In tetrahydrofuran; dichloromethane at 10 - 20℃; for 1h;91%
With pyridinium hydrobromide perbromide In tetrahydrofuran at 10℃; for 1h; Temperature;90.65%
With pyridinium hydrobromide perbromide In tetrahydrofuran; dichloromethane at 0 - 5℃; for 1h; Large scale;83%
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde
283173-84-2

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
View Scheme
Multi-step reaction with 2 steps
1: pyridinium hydrobromide perbromide / tetrahydrofuran / 1 h / 10 °C
2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 2 h / 90 - 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere
2.2: 2 h / 20 - 98 °C / Inert atmosphere
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

A

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride
773059-19-1

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

B

C18H15FN2O2

C18H15FN2O2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
4.2: 1 h / Large scale
4.3: 18 h / Large scale
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

A

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride
773059-19-1

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

B

C37H31F2N5O2

C37H31F2N5O2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
4.2: 1 h / Large scale
4.3: 18 h / Large scale
5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
3.1: methanol / 2 h / 20 °C
3.2: 0 - 20 °C
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

C19H16FN3O

C19H16FN3O

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide / dichloromethane / 0 - 5 °C
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / isopropyl alcohol / 1 h / 20 °C / Inert atmosphere
2.2: 3 h / 80 - 85 °C / Inert atmosphere
3.1: methanol; tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridinium hydrobromide perbromide / tetrahydrofuran / 1 h / 10 °C
2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide; water / 2 h / 90 - 100 °C / Inert atmosphere
3: toluene-4-sulfonic acid / ethanol / 2 h / 10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere
2.2: 2 h / 20 - 98 °C / Inert atmosphere
3.1: tetrahydrofuran; methanol; ethanol / 12 h / 25 - 33 °C
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one (S)-camphorsulfonate

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one (S)-camphorsulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
5.1: water; isopropyl alcohol / 1 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
4.2: 1 h / Large scale
4.3: 18 h / Large scale
5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
6.1: water; isopropyl alcohol / 1 h / 70 °C
View Scheme
Multi-step reaction with 5 steps
1.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere
2.2: 2 h / 20 - 98 °C / Inert atmosphere
3.1: tetrahydrofuran; methanol; ethanol / 12 h / 25 - 33 °C
4.1: palladium 10% on activated carbon; hydrogen / 12 h
5.1: water; methanol / 29 h / 0 - 40 °C / Reflux
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

C18H14FN3O2

C18H14FN3O2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
3: hydroxylamine hydrochloride; sodium acetate / methanol; water / 1 h / 50 °C
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

C18H16FN3O

C18H16FN3O

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
3: hydroxylamine hydrochloride; sodium acetate / methanol; water / 1 h / 50 °C
4: zinc; hydrogenchloride / water; ethanol / 3 h / 0 - 20 °C
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one hydrochloride

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 5 - 20 °C
2.1: potassium carbonate; bis(acetato)bis(triphenylphosphine)palladium(0) / ethanol; water / 17 h / 60 °C / Inert atmosphere
2.2: 17 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: pyridinium hydrobromide perbromide / dichloromethane / 0 - 5 °C
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / isopropyl alcohol / 1 h / 20 °C / Inert atmosphere
2.2: 3 h / 80 - 85 °C / Inert atmosphere
3.1: methanol; tetrahydrofuran / 2 h / 0 - 20 °C
4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C
4.2: 2 h
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one acetate

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 5 - 20 °C
2: bis(acetato)bis(triphenylphosphine)palladium(0); sodium carbonate / methanol; water / 4 h / 60 °C / Inert atmosphere
3: methanol; water / 48 h / 20 °C
View Scheme

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View