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Hangzhou Think Chemical Co. Ltd

Rucaparib CAS No.:283173-50-2 Name: Rucaparib phosphate Synonyms: Rucaparib, AG 014699, 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one Molecular Structure: M

High purity Rucaparib CAS No.:283173-50-2

Cas:283173-50-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Rucaparib

Cas:283173-50-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)-methyl]-phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Cas:283173-50-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Ality Chemical Corporation

Rucaparib Basic information Description Application Mechanism of action Product Name: Rucaparib Synonyms: 8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON;8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-

Factory Supply Rikapbu

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Rucaparib CAS 283173-50-2

Cas:283173-50-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON

Cas:283173-50-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 283173-50-2 with best quality

Cas:283173-50-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

USDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the re

Rucaparib USDMF EDMF

Cas:283173-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Rucaparib CAS:283173-50-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Rucaparib CAS:283173-50-2

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Rucaparib 283173-50-2

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Rucaparib

Cas:283173-50-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Rucaparib CAS NO.283173-50-2

Cas:283173-50-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Rucaparib CAS No.:283173-50-2 Molecule Formula:C19H18FN3O Molecule Weight:N/A Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECIFI

Best Quality Rucaparib with good supplier

Cas:283173-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

rucaparib (PARP inhibitor) ORPHAN DRUG

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Rucaparib

Cas:283173-50-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Rucaparib Basic information Description Application Mechanism of action Product Name: Rucaparib Synonyms: 8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON;8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-

Rucaparib

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON

Cas:283173-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 8-FLUOR-2-{4-[(METHYLAMINO)METHYL]FENYL}-1,3,4,5-TETRAHYDRO-6HAZEPINO[5,4,3-CD]INDOOL-6-ON Synonyms: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one;8-Fluoro-2-[4-[(methylamino)m

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our rese

Rucaparib

Cas:283173-50-2

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Rucaparib

Cas:283173-50-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Rucaparib 25mg

Cas:283173-50-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

Rucaparib

Cas:283173-50-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Rucaparib

Cas:283173-50-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

Rucaparib

Cas:283173-50-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Synthetic route

C19H16FN3O

C19H16FN3O

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Stage #1: C19H16FN3O With sodium tetrahydroborate In ethanol for 1h;
Stage #2: With sodium hydroxide In water at 10℃; for 2h;
90.83%
With palladium 10% on activated carbon; hydrogen for 12h; Reagent/catalyst;84%
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
1.2: 1 h / Large scale
1.3: 18 h / Large scale
2.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C
1.2: 2 h
2.1: sodium hydroxide / water; methanol / 12 h / 0 - 5 °C
View Scheme
[4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester
880160-69-0

[4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 20℃; for 12h;89.7%
Stage #1: [4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester With hydrogen bromide; acetic acid at 20℃; for 46h;
Stage #2: With sodium hydroxide In water at 0 - 35℃; pH=10;
88%
tert-butyl (4-(6-(tert-butyl)-8-fluoro-2-(4-methoxybenzyl)-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)carbamate

tert-butyl (4-(6-(tert-butyl)-8-fluoro-2-(4-methoxybenzyl)-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)carbamate

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With trifluoroacetic acid at 100℃; for 24h; Sealed tube;88%
C35H40FN3O4

C35H40FN3O4

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With diphenylether; trifluoroacetic acid at 100℃; for 24h;88%
C27H24FN3O3

C27H24FN3O3

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In ethanol; ethyl acetate at 20℃; for 2h;87.4%
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-aza-[5,4,3-cd]indol-2-yl)benzyl(methyl)benzyl amine

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-aza-[5,4,3-cd]indol-2-yl)benzyl(methyl)benzyl amine

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In tetrahydrofuran; ethanol at 20℃; for 2h;86.8%
8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride
773059-19-1

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one hydrochloride

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol; water at 20℃; for 18h; Large scale;84%
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde
283173-84-2

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde

methylamine
74-89-5

methylamine

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Stage #1: 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde; methylamine In methanol at 20℃; for 2h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃;
66%
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde
283173-84-2

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde

2-phenyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one
283172-68-9

2-phenyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With methylamine
4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde
283173-84-2

4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd] indol-2-yl)-benzaldehyde

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
2: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
2.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
2.2: 1 h / Large scale
2.3: 18 h / Large scale
3.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: methanol; tetrahydrofuran / 2 h / 0 - 20 °C
2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 20 °C
2.2: 2 h
3.1: sodium hydroxide / water; methanol / 12 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / ethanol / 2 h / 10 °C
2.1: sodium tetrahydroborate / ethanol / 1 h
2.2: 2 h / 10 °C
View Scheme
3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester
1408282-25-6

3-(2-(phthalimido)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: methylamine / water / 17 h / 20 °C / Large scale
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
3.2: 9 h / 20 °C / Large scale
4.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 6 steps
1.1: methylamine / water / 17 h / 20 °C / Large scale
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
3.2: 9 h / 20 °C / Large scale
4.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
5.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
5.2: 1 h / Large scale
5.3: 18 h / Large scale
6.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1.1: methylamine / water / 24 h / 0 - 20 °C
2.1: pyridinium hydrobromide perbromide; sodium carbonate / dichloromethane; tetrahydrofuran / 1 h / 10 - 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 1 h / 20 - 95 °C / Inert atmosphere
3.2: 2 h / 20 - 98 °C / Inert atmosphere
4.1: tetrahydrofuran; methanol; ethanol / 12 h / 25 - 33 °C
5.1: palladium 10% on activated carbon; hydrogen / 12 h
View Scheme
6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one
1408282-26-7

6-fluoro-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraen-9-one

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / Large scale
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
2.2: 9 h / 20 °C / Large scale
3.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
4.2: 1 h / Large scale
4.3: 18 h / Large scale
5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
3.1: methanol / 2 h / 20 °C
3.2: 0 - 20 °C
View Scheme
2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
283173-80-8

2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
1.2: 9 h / 20 °C / Large scale
2.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / Large scale
3.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / Large scale
1.2: 9 h / 20 °C / Large scale
2.1: methanol; tetrahydrofuran; ethanol / 2 h / Large scale
3.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C / Large scale
3.2: 1 h / Large scale
3.3: 18 h / Large scale
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
2.1: methanol / 2 h / 20 °C
2.2: 0 - 20 °C
View Scheme
C16H17ClFNO2

C16H17ClFNO2

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
2.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
3.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
5.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
7.1: methanol / 2 h / 20 °C
7.2: 0 - 20 °C
View Scheme
C16H16FNO2

C16H16FNO2

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
2.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
4.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
6.1: methanol / 2 h / 20 °C
6.2: 0 - 20 °C
View Scheme
6-fluoro-1H-indole
399-51-9

6-fluoro-1H-indole

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: acetic anhydride; acetic acid / 48 h / 50 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
2.2: 1 h
3.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
4.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
5.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
6.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
8.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
9.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
10.1: methanol / 2 h / 20 °C
10.2: 0 - 20 °C
View Scheme
C16H17FN2O2

C16H17FN2O2

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
3.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
5.1: methanol / 2 h / 20 °C
5.2: 0 - 20 °C
View Scheme
C16H17FN2O2

C16H17FN2O2

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
2.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
4.1: methanol / 2 h / 20 °C
4.2: 0 - 20 °C
View Scheme
6-Fluoroindole-3-propionic acid
141071-78-5

6-Fluoroindole-3-propionic acid

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: 1 h
2.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
3.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
5.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
7.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
8.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
9.1: methanol / 2 h / 20 °C
9.2: 0 - 20 °C
View Scheme
C16H18FNO3

C16H18FNO3

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 20 °C
2.1: aluminum (III) chloride; chloroacetyl chloride / 2 h / 20 °C
3.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol; water / 2 h / 50 °C
4.1: thionyl chloride / 1,4-dioxane / 6 h / 70 °C
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; water / tetrahydrofuran / 24 h / 20 °C
6.1: Pyr·HBr3 / tetrahydrofuran; dichloromethane / 2 h / 0 - 20 °C
7.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 12 h / 90 °C
8.1: methanol / 2 h / 20 °C
8.2: 0 - 20 °C
View Scheme
4-formylphenylboronic acid,
87199-17-5

4-formylphenylboronic acid,

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 0 - 20 °C
2: hydrogen / ethanol / 5 h / 40 °C / 3750.38 Torr / Autoclave
3: bis(acetato)bis(triphenylphosphine)palladium(0); sodium carbonate / methanol; water / 4 h / 60 °C / Inert atmosphere
View Scheme
8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one phosphate

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one phosphate

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 30℃; for 1.5h;
C8H10BNO2

C8H10BNO2

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / ethanol / 5 h / 40 °C / 3750.38 Torr / Autoclave
2: bis(acetato)bis(triphenylphosphine)palladium(0); sodium carbonate / methanol; water / 4 h / 60 °C / Inert atmosphere
View Scheme
2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
283173-80-8

2-bromo-8-fluoro-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

(4-((methylamino)methyl)phenyl)boronic acid
518336-26-0

(4-((methylamino)methyl)phenyl)boronic acid

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With bis(acetato)bis(triphenylphosphine)palladium(0); sodium carbonate In methanol; water at 60℃; for 4h; Reagent/catalyst; Inert atmosphere;6.82 g
ADDQNPWRAYLDLLFPTDTLLLDLLWC{[(2R)-1-({[(4-{6-fluoro-9-oxo-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-2-yl}phenyl)methyl](methyl)carbamoyl}oxy)propan-2-yl]sulfanyl}G

ADDQNPWRAYLDLLFPTDTLLLDLLWC{[(2R)-1-({[(4-{6-fluoro-9-oxo-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-2-yl}phenyl)methyl](methyl)carbamoyl}oxy)propan-2-yl]sulfanyl}G

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With GLUTATHIONE In aq. buffer at 37℃;
2-(4-(4-((methylamino)methyl)phenyl)but-3-yn-1-yl)isoindoline-1,3-dione

2-(4-(4-((methylamino)methyl)phenyl)but-3-yn-1-yl)isoindoline-1,3-dione

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 18.22 h / 0 - 20 °C
2: trifluoroacetic acid; trifluorormethanesulfonic acid / water / 18 h / 20 °C
3: boron trifluoride diethyl etherate; acetic acid / 18 h / 90 °C / Inert atmosphere
4: hydrazine / ethanol; tetrahydrofuran / 9 h / 110 °C
5: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 18 h / 20 °C
View Scheme
N-(4-(4-(1,3-dioxoisoindolin-2-yl)but-1-yn-1-yl)benzyl)-2,2,2-trifluoro-N-methylacetamide

N-(4-(4-(1,3-dioxoisoindolin-2-yl)but-1-yn-1-yl)benzyl)-2,2,2-trifluoro-N-methylacetamide

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trifluoroacetic acid; trifluorormethanesulfonic acid / water / 18 h / 20 °C
2: boron trifluoride diethyl etherate; acetic acid / 18 h / 90 °C / Inert atmosphere
3: hydrazine / ethanol; tetrahydrofuran / 9 h / 110 °C
4: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 18 h / 20 °C
View Scheme
N-(4-(4-(1,3-dioxoisoindolin-2-yl)butanoyl)benzyl)-2,2,2-trifluoro-N-methylacetamide

N-(4-(4-(1,3-dioxoisoindolin-2-yl)butanoyl)benzyl)-2,2,2-trifluoro-N-methylacetamide

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate; acetic acid / 18 h / 90 °C / Inert atmosphere
2: hydrazine / ethanol; tetrahydrofuran / 9 h / 110 °C
3: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 18 h / 20 °C
View Scheme
9-bromo-8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

9-bromo-8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
With hydrogenchloride; 5%-palladium/activated carbon; hydrogen In methanol; water at 20℃; for 18h;734 mg
N-methyl-4-bromobenzylamine
699-03-6

N-methyl-4-bromobenzylamine

Rucaparib
283173-50-2

Rucaparib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: copper(l) iodide; caesium carbonate / 1,4-dioxane / 1.25 h / Inert atmosphere
1.2: 19 h / 80 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 18.22 h / 0 - 20 °C
3.1: trifluoroacetic acid; trifluorormethanesulfonic acid / water / 18 h / 20 °C
4.1: boron trifluoride diethyl etherate; acetic acid / 18 h / 90 °C / Inert atmosphere
5.1: hydrazine / ethanol; tetrahydrofuran / 9 h / 110 °C
6.1: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 18 h / 20 °C
View Scheme
Rucaparib
283173-50-2

Rucaparib

methanesulfonic acid
75-75-2

methanesulfonic acid

8-fluoro-2-(4-methylaminomethylphenyl)-1,3,4,5-tetrahydroazepino[5,4,3-cd]indol-6-one mesylate
773059-20-4

8-fluoro-2-(4-methylaminomethylphenyl)-1,3,4,5-tetrahydroazepino[5,4,3-cd]indol-6-one mesylate

Conditions
ConditionsYield
In methanol97%
In tetrahydrofuran; acetone at 50℃; Solvent;
Rucaparib
283173-50-2

Rucaparib

maleic acid
110-16-7

maleic acid

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one maleate salt

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one maleate salt

Conditions
ConditionsYield
In isopropyl alcohol Product distribution / selectivity;97%
Rucaparib
283173-50-2

Rucaparib

[(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid
76-26-6, 3144-16-9, 5872-08-2, 35963-20-3

[(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one (S)-camphorsulfonate

8-fluoro-2-((4-methylaminomethyl)phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one (S)-camphorsulfonate

Conditions
ConditionsYield
In water; isopropyl alcohol at 70℃; for 1h;95%
In methanol; water at 0 - 40℃; for 29h; Reflux;81%
Rucaparib
283173-50-2

Rucaparib

17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecanal

17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecanal

C44H51FN6O10

C44H51FN6O10

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In dichloromethane at 0 - 23℃; for 2h;90%
Rucaparib
283173-50-2

Rucaparib

(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

Conditions
ConditionsYield
In methanol at 60 - 65℃; for 0.5h;89.86%
In tetrahydrofuran; water for 0.833333h; Product distribution / selectivity; Reflux;
for 2.5h;
In 1,4-dioxane; water at 30℃; for 12h; Time;
Rucaparib
283173-50-2

Rucaparib

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C24H26FN3O3

C24H26FN3O3

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 0.5h;89%
Rucaparib
283173-50-2

Rucaparib

5-hexynal
29329-03-1

5-hexynal

C25H26FN3O

C25H26FN3O

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In dichloromethane at 23℃; for 1h; Inert atmosphere;74%
Rucaparib
283173-50-2

Rucaparib

methyl 4-formylbutanoate
6026-86-4

methyl 4-formylbutanoate

C24H26FN3O3

C24H26FN3O3

Conditions
ConditionsYield
Stage #1: Rucaparib; methyl 4-formylbutanoate With sodium tris(acetoxy)borohydride In dichloromethane at 23℃; for 1h; Inert atmosphere;
Stage #2: With water; lithium hydroxide In tetrahydrofuran at 23℃; for 2h;
54%
Rucaparib
283173-50-2

Rucaparib

Trimethylboroxine
823-96-1

Trimethylboroxine

C20H20FN3O

C20H20FN3O

Conditions
ConditionsYield
With pentamethylcyclopentadienyl(benzene)cobalt(III) hexafluorophosphate; potassium carbonate; silver carbonate In 2-methyltetrahydrofuran at 100℃; for 16h; Inert atmosphere; Sealed tube;39%
methanol
67-56-1

methanol

Rucaparib
283173-50-2

Rucaparib

phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one

phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one

Conditions
ConditionsYield
Stage #1: methanol; Rucaparib for 0.166667h;
Stage #2: With phosphoric acid In methanol at 20℃; for 0.5h;
Rucaparib
283173-50-2

Rucaparib

A

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

B

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

Conditions
ConditionsYield
In water; isopropyl alcohol at 70℃; for 0.166667h; Product distribution / selectivity;
Rucaparib
283173-50-2

Rucaparib

CO-338

CO-338

Conditions
ConditionsYield
In water; isopropyl alcohol at 70℃; for 0.166667h;
Rucaparib
283173-50-2

Rucaparib

(R)-10-camphorsulfonic acid
35963-20-3

(R)-10-camphorsulfonic acid

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic acid salt

Conditions
ConditionsYield
In water; isopropyl alcohol at 70℃; for 0.166667h;
In ethanol at 75 - 85℃; for 3h; Solvent; Temperature;0.25 g
Rucaparib
283173-50-2

Rucaparib

C27H38ClN6O4Pt(1+)*NO3(1-)

C27H38ClN6O4Pt(1+)*NO3(1-)

C46H54ClFN9O4Pt(1+)*NO3(1-)

C46H54ClFN9O4Pt(1+)*NO3(1-)

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
Rucaparib
283173-50-2

Rucaparib

C31H40ClN6O4Pt(1+)*NO3(1-)

C31H40ClN6O4Pt(1+)*NO3(1-)

C50H56ClFN9O4Pt(1+)*NO3(1-)

C50H56ClFN9O4Pt(1+)*NO3(1-)

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;

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