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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Hispidulin

Cas:1447-88-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Dinatin CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

shanghai Tauto Biotech Co., Ltd

17-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China

hispidulin

Cas:1447-88-7

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract hispidulin HACCP manufacturer

Cas:1447-88-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Hispidulin CAS 1447-88-7

Cas:1447-88-7

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 1447-88-7 with best quality

Cas:1447-88-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy- 1447-88-7

Cas:1447-88-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

HISPIDULIN CAS:1447-88-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

HISPIDULIN CAS:1447-88-7

Cas:1447-88-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-

Cas:1447-88-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

HISPIDULIN CAS NO.1447-88-7 CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Hispidulin

Cas:1447-88-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

(1)our services We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand. we will

High Content Natural Extract hispidulin HACCP manufacturer

Cas:1447-88-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Hispidulin

Cas:1447-88-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

HISPIDULIN CAS NO.1447-88-7 CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

HISPIDULINCAS NO.: 1447-88-7

Cas:1447-88-7

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory SellsHISPIDULIN

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Hispedulin 99%

Cas:1447-88-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

HISPIDULIN CAS NO.1447-88-7 CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Hispidulin

Cas:1447-88-7

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

HISPIDULIN

Cas:1447-88-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

HISPIDULIN

Cas:1447-88-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

HISPIDULIN CAS NO.1447-88-7 CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Hispidulin

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

HISPIDULIN

Cas:1447-88-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

HISPIDULIN CAS NO.1447-88-7 CAS NO.1447-88-7

Cas:1447-88-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

HISPIDULIN

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

HISPIDULIN CAS 1447-88-7

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Other

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:Herbal extr

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your re

hispidulin

Cas:1447-88-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-6-methoxy-4H-chromen-4-one
28736-83-6

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-6-methoxy-4H-chromen-4-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol under 760.051 Torr; for 8h; Inert atmosphere;96%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol under 760.051 Torr; for 8h;96%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol for 8h;96.1%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; ethanol at 20℃; for 8h;96%
5-hydroxy-6-methoxy-7-(methoxymethoxy)-2-(4-(methoxymethoxy)phenyl)-4H-chromen-4-one

5-hydroxy-6-methoxy-7-(methoxymethoxy)-2-(4-(methoxymethoxy)phenyl)-4H-chromen-4-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; dichloromethane at 0 - 25℃; for 1h;92%
With hydrogenchloride In diethyl ether; dichloromethane; water at 0 - 25℃; for 1h;
hispidulin-7-O-β-D-methylglucuronopyranoside

hispidulin-7-O-β-D-methylglucuronopyranoside

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With sulfuric acid In ethanol; water at 20 - 100℃; Solvent; Temperature; Reagent/catalyst;91%
With sulfuric acid In ethanol; water at 100℃; Inert atmosphere;90%
4'-benzyloxy-6-methoxy-5-benzyloxy-7-hydroxyflavone

4'-benzyloxy-6-methoxy-5-benzyloxy-7-hydroxyflavone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With boron trichloride In dichloromethane at -78℃; for 1.33333h;85%
With boron trichloride In dichloromethane at -78℃; for 1.33333h;85%
4'-benzyloxy-6-methoxy-5,7-dihydroxyflavone

4'-benzyloxy-6-methoxy-5,7-dihydroxyflavone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With boron trichloride In dichloromethane at -78 - 20℃; for 1h; Inert atmosphere;80%
tectoridin
17680-84-1

tectoridin

A

D-Glucose
2280-44-6

D-Glucose

B

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With hydrolysis
5,7-dihydroxy-6-methoxy-flavone-4'-O-neohesperidoside

5,7-dihydroxy-6-methoxy-flavone-4'-O-neohesperidoside

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With sulfuric acid for 8h;95 mg
7-benzyloxy-2-(4-benzyloxy-phenyl)-5,6-dimethoxy-chromen-4-one

7-benzyloxy-2-(4-benzyloxy-phenyl)-5,6-dimethoxy-chromen-4-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
With boron trichloride In dichloromethane at -65℃; for 1.5h;
2-hydroxy-4,6-dimethoxyacetophenone
90-24-4

2-hydroxy-4,6-dimethoxyacetophenone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating
2: 99 percent / K2CO3 / acetone / Heating
3: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C
4: 59 percent / K2CO3 / acetone / Heating
5: pyridine / 3 h / 20 °C
6: KOH / pyridine / 4 h / 60 °C
7: sulfuric acid / acetic acid / 1.5 h / 60 °C
8: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
4-(benzyloxy)benzoic acid chloride
1486-50-6

4-(benzyloxy)benzoic acid chloride

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / 3 h / 20 °C
2: KOH / pyridine / 4 h / 60 °C
3: sulfuric acid / acetic acid / 1.5 h / 60 °C
4: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
2,4,6-trihydroxyacetophenone
480-66-0

2,4,6-trihydroxyacetophenone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 92 percent / K2CO3 / acetone / 3 h / 65 °C
2: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating
3: 99 percent / K2CO3 / acetone / Heating
4: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C
5: 59 percent / K2CO3 / acetone / Heating
6: pyridine / 3 h / 20 °C
7: KOH / pyridine / 4 h / 60 °C
8: sulfuric acid / acetic acid / 1.5 h / 60 °C
9: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
Multi-step reaction with 9 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C
2: silver trifluoroacetate; iodine / dichloromethane / 0 °C
3: potassium carbonate / N,N-dimethyl-formamide / 0 °C
4: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / water; 1,4-dioxane / 90 °C
5: potassium carbonate / acetone / 5 h / 56 °C
6: potassium hydroxide / water; ethanol / 24.5 h / 0 - 20 °C
7: hydrogenchloride / methanol; tetrahydrofuran / 8 h / 0 - 20 °C
8: iodine / dimethyl sulfoxide / 2 h / 120 °C
9: boron trichloride / dichloromethane / 1.33 h / -78 °C
View Scheme
1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one
25892-95-9

1-(4-(benzyloxy)-6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / 3 h / 20 °C
2: KOH / pyridine / 4 h / 60 °C
3: sulfuric acid / acetic acid / 1.5 h / 60 °C
4: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
4,6-dihydroxy-2-methoxyacetophenone
3602-54-8

4,6-dihydroxy-2-methoxyacetophenone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 99 percent / K2CO3 / acetone / Heating
2: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C
3: 59 percent / K2CO3 / acetone / Heating
4: pyridine / 3 h / 20 °C
5: KOH / pyridine / 4 h / 60 °C
6: sulfuric acid / acetic acid / 1.5 h / 60 °C
7: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
p-(benzyloxy)benzoic acid
1486-51-7

p-(benzyloxy)benzoic acid

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: oxalyl chloride / CH2Cl2 / 8 h / 20 °C
2: pyridine / 3 h / 20 °C
3: KOH / pyridine / 4 h / 60 °C
4: sulfuric acid / acetic acid / 1.5 h / 60 °C
5: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
1-(4-(benzyloxy)-3,6-dihydroxy-2-methoxyphenyl)ethan-1-one
25892-94-8

1-(4-(benzyloxy)-3,6-dihydroxy-2-methoxyphenyl)ethan-1-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 59 percent / K2CO3 / acetone / Heating
2: pyridine / 3 h / 20 °C
3: KOH / pyridine / 4 h / 60 °C
4: sulfuric acid / acetic acid / 1.5 h / 60 °C
5: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one
39548-89-5

1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C
2: 59 percent / K2CO3 / acetone / Heating
3: pyridine / 3 h / 20 °C
4: KOH / pyridine / 4 h / 60 °C
5: sulfuric acid / acetic acid / 1.5 h / 60 °C
6: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

acid

acid

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: KOH / H2O; ethanol / 6 h / Heating
2: oxalyl chloride / CH2Cl2 / 8 h / 20 °C
3: pyridine / 3 h / 20 °C
4: KOH / pyridine / 4 h / 60 °C
5: sulfuric acid / acetic acid / 1.5 h / 60 °C
6: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
4-benzyloxy-benzoic acid 2-acetyl-5-benzyloxy-3,4-dimethoxy-phenyl ester

4-benzyloxy-benzoic acid 2-acetyl-5-benzyloxy-3,4-dimethoxy-phenyl ester

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH / pyridine / 4 h / 60 °C
2: sulfuric acid / acetic acid / 1.5 h / 60 °C
3: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
1-(4-benzyloxy-6-hydroxy-2,3-dimethoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione

1-(4-benzyloxy-6-hydroxy-2,3-dimethoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / acetic acid / 1.5 h / 60 °C
2: BCl3 / CH2Cl2 / 1.5 h / -65 °C
View Scheme
scutellarin
27740-01-8

scutellarin

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: hydrogenchloride / ethanol; water / 36 h / Inert atmosphere; Reflux
2: diphenylether / 0.5 h / 175 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 14 h / 0 - 25 °C
4: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere
6: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere
7: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1: hydrogenchloride / water; ethanol / 36 h / Inert atmosphere; Reflux
2: diphenylether / 0.5 h / 175 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
4: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
5: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
7: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / water; ethanol / 36 h / Inert atmosphere; Reflux
2: potassium carbonate / acetone / 6 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
4: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 8 h
View Scheme
scutellarein
529-53-3

scutellarein

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: diphenylether / 0.5 h / 175 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 0 - 25 °C
3: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere
6: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: diphenylether / 0.5 h / 175 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
3: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
4: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
6: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 6 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 8 h
View Scheme
9-hydroxy-6-(4-hydroxyphenyl)-2,2-diphenyl-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one
1105056-24-3

9-hydroxy-6-(4-hydroxyphenyl)-2,2-diphenyl-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 0 - 25 °C
2: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
2: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
5: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
9-hydroxy-2,2-diphenyl-6-[4-(phenylmethoxy)phenyl]-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one
1402607-40-2

9-hydroxy-2,2-diphenyl-6-[4-(phenylmethoxy)phenyl]-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere
4: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: acetic acid / water / 1.5 h / Inert atmosphere; Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
4: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
5,6,7-trihydroxy-2-[4-(phenylmethoxy)phenyl]-4H-1-benzopyran-4-one
1351585-69-7

5,6,7-trihydroxy-2-[4-(phenylmethoxy)phenyl]-4H-1-benzopyran-4-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 0 - 25 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5,6-dihydroxy-4H-chromen-4-one
62252-32-8

7-(benzyloxy)-2-(4-(benzyloxy)phenyl)-5,6-dihydroxy-4H-chromen-4-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere
2: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 760.05 Torr
View Scheme
Iretol
487-71-8

Iretol

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / 20 °C / Cooling with ice; Inert atmosphere
2.1: potassium carbonate / acetone / 56 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: sodium acetate / water; ethanol / 78 °C / Inert atmosphere
4.1: pyridine; iodine / 3 h / 90 °C
5.1: boron trichloride / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
2,4,6-trihydroxy-3-methoxyacetophenone
16297-01-1

2,4,6-trihydroxy-3-methoxyacetophenone

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 56 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium acetate / water; ethanol / 78 °C / Inert atmosphere
3.1: pyridine; iodine / 3 h / 90 °C
4.1: boron trichloride / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
(E)-1-(6-hydroxy-3-methoxy-2,4-bis-(methoxymethoxy)phenyl)-3-(4-benzyloxyphenyl)prop-2-en-1-one

(E)-1-(6-hydroxy-3-methoxy-2,4-bis-(methoxymethoxy)phenyl)-3-(4-benzyloxyphenyl)prop-2-en-1-one

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate / water; ethanol / 78 °C / Inert atmosphere
2: pyridine; iodine / 3 h / 90 °C
3: boron trichloride / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

hispidulin
1447-88-7

hispidulin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 20 °C
3.1: potassium carbonate / acetone / 56 °C / Inert atmosphere
4.1: hydrogenchloride / water; methanol / 20 °C
5.1: boron trifluoride diethyl etherate / 20 °C / Cooling with ice; Inert atmosphere
6.1: potassium carbonate / acetone / 56 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
7.1: sodium acetate / water; ethanol / 78 °C / Inert atmosphere
8.1: pyridine; iodine / 3 h / 90 °C
9.1: boron trichloride / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 10 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 - 20 °C / Inert atmosphere
2.1: silver trifluoroacetate; iodine / dichloromethane / 5 h / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
4.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 12 h / 100 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 9 h / 0 - 20 °C
5.2: 1.5 h / 20 °C
6.1: potassium carbonate / acetone / 5 h / 56 °C
7.1: potassium hydroxide / water; ethanol / 24.5 h / 0 - 20 °C
8.1: hydrogenchloride / methanol; tetrahydrofuran / 8 h / 0 - 20 °C
9.1: iodine / dimethyl sulfoxide / 2 h / 120 °C
10.1: boron trichloride / dichloromethane / 1.33 h / -78 °C
View Scheme
Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / Cooling with ice; Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: silver trifluoroacetate; iodine / dichloromethane / 3 h / 0 - 20 °C
2.2: 3 h / 0 - 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 12 h / 100 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 0 - 20 °C
5.1: potassium carbonate / acetone / 5 h / 56 °C
6.1: potassium hydroxide / ethanol; water / 24.5 h / 0 - 20 °C
6.2: 8 h / 0 - 20 °C
7.1: iodine / dimethyl sulfoxide / 2 h / 120 °C
8.1: boron trichloride / dichloromethane / 1.33 h / -78 °C
View Scheme
hispidulin
1447-88-7

hispidulin

methyl iodide
74-88-4

methyl iodide

A

salvigenin
6601-62-3

salvigenin

B

pectolinarigenin
520-12-7

pectolinarigenin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 6h; Inert atmosphere;A 38%
B 49%
hispidulin
1447-88-7

hispidulin

scutellarein
529-53-3

scutellarein

Conditions
ConditionsYield
With pyridine hydrochloride for 3h;
hispidulin
1447-88-7

hispidulin

acetic anhydride
108-24-7

acetic anhydride

5,7,4'-trihydroxy-6-methoxyflavone triacetate
1178-23-0

5,7,4'-trihydroxy-6-methoxyflavone triacetate

Conditions
ConditionsYield
With pyridine
hispidulin
1447-88-7

hispidulin

acetic anhydride
108-24-7

acetic anhydride

luteolin tetraacetate
1061-93-4

luteolin tetraacetate

Conditions
ConditionsYield
With pyridine Acetylation;

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