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Qingdao Beluga Import and Export Co., LTD

α-propargylhomoterephthalic acid dimethyl ester CAS:146464-90-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, special

α-propargylhomoterephthalic acid dimethyl ester CAS:146464-90-6

Cas:146464-90-6

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

α-propargylhomoterephthalic acid dimethyl ester

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Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

α-propargylhomoterephthalic acid dimethyl ester

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

α-propargylhomoterephthalic acid dimethyl ester

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

α-propargylhomoterephthalic acid dimethyl ester

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Min.Order:10 Gram

FOB Price: $100.0

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

α-propargylhomoterephthalic acid dimethyl ester

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Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

α-propargylhomoterephthalic acid dimethyl ester

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API;Pharmaceutical intermediates Transportation:air,sea,courier

α-propargylhomoterephthalic acid dimethyl ester

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

α-propargylhomoterephthalic acid dimethyl ester supplier in China

Cas:146464-90-6

Min.Order:100 Gram

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

α-propargylhomoterephthalic acid dimethyl ester

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

α-propargylhomoterephthalic acid dimethyl ester

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as:

α-propargylhomoterephthalic acid dimethyl ester

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low price Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

α-propargylhomoterephthalic acid dimethyl ester CAS 146464-90-6 with low price

Cas:146464-90-6

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Chemsigma International Co.,Ltd.

bulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine ch

α-propargylhomoterephthalic acid dimethyl ester

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

α-propargylhomoterephthalic acid dimethyl ester

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

α-propargylhomoterephthalic acid dimethyl ester

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DB BIOTECH CO., LTD

best seller Application:API

α-propargylhomoterephthalic acid dimethyl ester

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

α-propargylhomoterephthalic acid dimethyl ester

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

146464-90-6

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

α-propargylhomoterephthalic acid dimethyl ester

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

α-propargylhomoterephthalic acid dimethyl ester

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NUTROCHEM- MANUFACTURE PLACE

best seller Application:API

α-propargylhomoterephthalic acid dimethyl ester

Cas:146464-90-6

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Methyl 4-(1-methoxy-1-oxo-4-pentyn-2-yl)benzoate

Cas:146464-90-6

Min.Order:10 Milligram

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HENAN SUNLAKE ENTERPRISE CORPORATION

HENAN SUNLAKE ENTERPRISE CORPORATION Our company advantages: 1、The highest quality with the competitive price. 2、Professional human services. 3、The fastest and safest delivery service. 4、The faster and safest delivery service. 5、The hig

α-propargylhomoterephthalic acid dimethyl ester

Cas:146464-90-6

Min.Order:1 Gram

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Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization..Company has strong ability of research and development

α-propargylhomoterephthalic acid dimethyl ester

Cas:146464-90-6

Min.Order:1 Gram

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Jiangsu Mingchem Corporation

1.We are production factory which can provide commercial production of direct. 2. We could offer you competitive prices with satisfied quality. 3. We will choose the safest shipping methods to your addresses. 4. Our company provides af

α-propargylhomoterephthalic acid dimethyl ester

Cas:146464-90-6

Min.Order:10 Gram

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Henan Wising Chem Co., Ltd

Henan Wising Chem specializes in sourcing chemicals in China. We are associated with many trusted manufacturers each having different areas of expertise required for meeting the needs of our local as well as overseas buyers. We have access to custom

Best price α-propargylhomoterephthalic acid dimethyl ester

Cas:146464-90-6

Min.Order:500 Gram

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

α-propargylhomoterephthalic acid dimethyl ester

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Nanjing Raymon Biotech Co., Ltd.

α-propargylhomoterephthalic acid dimethyl ester Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Shan

α-propargylhomoterephthalic acid dimethyl ester

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Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

146464-90-6

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Synthetic route

methyl 4-(2-methoxy-2-oxoethyl)benzoate
52787-14-1

methyl 4-(2-methoxy-2-oxoethyl)benzoate

propargyl bromide
106-96-7

propargyl bromide

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

Conditions
ConditionsYield
Stage #1: methyl 4-(2-methoxy-2-oxoethyl)benzoate; propargyl bromide In tetrahydrofuran at -10℃; Inert atmosphere;
Stage #2: With lithium hexamethyldisilazane In tetrahydrofuran at -10℃; Temperature; Solvent; Reagent/catalyst;
87%
Stage #1: methyl 4-(2-methoxy-2-oxoethyl)benzoate With sodium hydride In tetrahydrofuran at 0 - 15℃; Autoclave;
Stage #2: propargyl bromide In tetrahydrofuran at -20 - 10℃; for 5h;
64.5%
With potassium hydride 1.) THF, 0 deg C, 1 h, 2.) THF, a0) o deg C, 30 min, b) RT, 16 h; Yield given. Multistep reaction;
methyl 4-(2-methoxy-2-oxoethyl)benzoate
52787-14-1

methyl 4-(2-methoxy-2-oxoethyl)benzoate

propargyl bromide
106-96-7

propargyl bromide

A

dipropargyl homoterephthalic acid dimethyl ester
1026380-17-5

dipropargyl homoterephthalic acid dimethyl ester

B

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl acetamide at 25 - 30℃; for 26h; Concentration;A n/a
B 65.6%
Stage #1: methyl 4-(2-methoxy-2-oxoethyl)benzoate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h;
Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; for 17h;
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl acetamide at 25 - 30℃; Concentration;
propargyl bromide
106-96-7

propargyl bromide

A

dipropargyl homoterephthalic acid dimethyl ester
1026380-17-5

dipropargyl homoterephthalic acid dimethyl ester

B

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

Conditions
ConditionsYield
Stage #1: methyl 4-(2-methoxy-2-oxoethyl)benzoate With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: propargyl bromide In tetrahydrofuran at 0 - 20℃; for 17h;
Stage #3: With acetic acid In tetrahydrofuran
4-(carboxymethyl)benzoic acid
501-89-3

4-(carboxymethyl)benzoic acid

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 24 h / Reflux; Autoclave
2.1: sodium hydride / tetrahydrofuran / 0 - 15 °C / Autoclave
2.2: 5 h / -20 - 10 °C
View Scheme
C8H9BrN6*BrH

C8H9BrN6*BrH

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate
146464-91-7

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

Conditions
ConditionsYield
Stage #1: α-propargylhomoterephthalic acid dimethyl ester With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 1.5h;
Stage #2: C8H9BrN6*BrH In N,N-dimethyl-formamide at -25 - 20℃; for 5h;
85%
6-bromomethyl-2,4-diaminopteridine hydrobromide
52853-40-4

6-bromomethyl-2,4-diaminopteridine hydrobromide

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt
1548618-47-8

10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt

Conditions
ConditionsYield
Stage #1: 6-bromomethyl-2,4-diaminopteridine hydrobromide; α-propargylhomoterephthalic acid dimethyl ester With sodium hydride In N,N-dimethyl acetamide at -20 - -10℃;
Stage #2: With hydrogen bromide In methanol; dichloromethane; water; isopropyl alcohol at 0 - 5℃; Concentration;
73.7%
6-bromomethyl-2,4-diaminopteridine hydrobromide
52853-40-4

6-bromomethyl-2,4-diaminopteridine hydrobromide

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate
146464-91-7

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

Conditions
ConditionsYield
With potassium hydride 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h; Multistep reaction;
Stage #1: α-propargylhomoterephthalic acid dimethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 5℃;
Stage #2: 6-bromomethyl-2,4-diaminopteridine hydrobromide In N,N-dimethyl-formamide; mineral oil at -25 - 20℃; for 6h;
With sodium hydride In N,N-dimethyl acetamide at -20 - -10℃; Concentration;
2,4-diamino-5-methyl-6-(bromomethyl)pyrido<2,3-d>pyrimidine
101348-32-7

2,4-diamino-5-methyl-6-(bromomethyl)pyrido<2,3-d>pyrimidine

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-1-methoxycarbonyl-but-3-ynyl]-benzoic acid methyl ester
184918-77-2

4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-1-methoxycarbonyl-but-3-ynyl]-benzoic acid methyl ester

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, from -25 deg C to 25 deg C; Yield given. Multistep reaction;
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoic acid
184918-81-8

4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, from -25 deg C to 25 deg C
2: 74 percent / 4N NaOH / dimethylsulfoxide / 96 h / 20 - 60 °C
3: 89 percent / dimethylsulfoxide / 0.83 h / 105 - 110 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

4-[1-Carboxy-1-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoic acid
184918-79-4

4-[1-Carboxy-1-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, from -25 deg C to 25 deg C
2: 74 percent / 4N NaOH / dimethylsulfoxide / 96 h / 20 - 60 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

C25H27N5O4

C25H27N5O4

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, from -25 deg C to 25 deg C
2: 74 percent / 4N NaOH / dimethylsulfoxide / 96 h / 20 - 60 °C
3: 89 percent / dimethylsulfoxide / 0.83 h / 105 - 110 °C
4: Et3N / dimethylformamide / 0.25 h / 20 - 25 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

(S)-2-{4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoylamino}-pentanedioic acid diethyl ester

(S)-2-{4-[1-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-but-3-ynyl]-benzoylamino}-pentanedioic acid diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 0.5 h, 2.) DMF, from -25 deg C to 25 deg C
2: 74 percent / 4N NaOH / dimethylsulfoxide / 96 h / 20 - 60 °C
3: 89 percent / dimethylsulfoxide / 0.83 h / 105 - 110 °C
4: Et3N / dimethylformamide / 0.25 h / 20 - 25 °C
5: dimethylformamide / 0.5 h
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid
146464-93-9

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) KH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h
2: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 4 h / Ambient temperature
3: dimethylsulfoxide / 0.08 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 6 h / -25 - 20 °C
2.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
3.1: dimethyl sulfoxide / 0.17 h / 115 - 120 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / -5 - 0 °C
1.2: 2.5 h / -25 - -20 °C
2.1: water; sodium hydroxide / 2-methoxy-ethanol / 4 h / 15 - 20 °C
3.1: dimethyl sulfoxide / 0.75 h / 120 - 125 °C
3.2: 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
3: potassium hydroxide / water; 2-methoxy-ethanol / 6 h / 25 - 30 °C
4: dimethyl sulfoxide / 110 - 115 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
3: potassium hydroxide / water; 2-methoxy-ethanol / 6 h / 25 - 30 °C
4: methanol / 0 - 5 °C
5: N,N-dimethyl acetamide / 1 h / 50 - 110 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid
146464-92-8

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) KH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h
2: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 4 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 6 h / -25 - 20 °C
2.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / water / 4 h / 20 - 25 °C
2.2: 15 h / 20 - 25 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

C23H24N6O4
948552-65-6

C23H24N6O4

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) KH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h
2: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 4 h / Ambient temperature
3: dimethylsulfoxide / 0.08 h / 120 °C
4: Et3N / dimethylformamide / 1 h / Ambient temperature
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

pralatrexate

pralatrexate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) KH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h
2: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 4 h / Ambient temperature
3: dimethylsulfoxide / 0.08 h / 120 °C
4: Et3N / dimethylformamide / 1 h / Ambient temperature
5: Et3N / dimethylformamide / 2 h / Ambient temperature
6: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 6 h / -25 - 20 °C
2.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
3.1: dimethyl sulfoxide / 0.17 h / 115 - 120 °C
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 25 °C
5.1: sodium hydroxide; methanol / 8 h / 20 - 25 °C
5.2: 24 h / 20 - 25 °C
5.3: pH 4
View Scheme
Multi-step reaction with 5 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride / mineral oil / 0.5 h / -10 - 0 °C
1.2: -5 - 20 °C
2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C
2.2: pH 7.5
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 - 130 °C
3.2: 0 - 20 °C
4.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
5.1: sodium hydroxide; water / methanol / 15 - 20 °C
5.2: pH 7 - 8
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-deazaaminopterin diethyl ester
146464-94-0

10-propargyl-10-deazaaminopterin diethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) KH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 2-propanol, 10 deg C, 2,5 h
2: 10percent aq. NaOH / 2-methoxy-ethanol; H2O / 4 h / Ambient temperature
3: dimethylsulfoxide / 0.08 h / 120 °C
4: Et3N / dimethylformamide / 1 h / Ambient temperature
5: Et3N / dimethylformamide / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / -5 - 0 °C
1.2: 2.5 h / -25 - -20 °C
2.1: water; sodium hydroxide / 2-methoxy-ethanol / 4 h / 15 - 20 °C
3.1: dimethyl sulfoxide / 0.75 h / 120 - 125 °C
3.2: 24 h / 20 °C
4.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / -5 - 0 °C
4.2: 2 h / -15 - -10 °C
View Scheme
2,4-diamino-6-bromomethylpteridine hydrobromide.0.2 isopropanol

2,4-diamino-6-bromomethylpteridine hydrobromide.0.2 isopropanol

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate
146464-91-7

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

Conditions
ConditionsYield
In N-methyl-acetamide
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-deazaaminopterin dimethyl ester
374777-77-2

10-propargyl-10-deazaaminopterin dimethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 6 h / -25 - 20 °C
2.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
3.1: dimethyl sulfoxide / 0.17 h / 115 - 120 °C
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride / mineral oil / 0.5 h / -10 - 0 °C
1.2: -5 - 20 °C
2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C
2.2: pH 7.5
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 - 130 °C
3.2: 0 - 20 °C
4.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / water / 4 h / 20 - 25 °C
2.2: 15 h / 20 - 25 °C
3.1: dimethyl sulfoxide / 110 - 115 °C
3.2: 50 - 55 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 0.5 h / 0 - 5 °C / Inert atmosphere
4.2: 21 h / 0 - 25 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

A

C25H27N7O5
1320211-82-2

C25H27N7O5

B

C25H27N7O5
1320211-79-7

C25H27N7O5

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 6 h / -25 - 20 °C
2.1: sodium hydroxide; water / 2-methoxy-ethanol / 4 h / 20 °C
3.1: dimethyl sulfoxide / 0.17 h / 115 - 120 °C
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 25 °C
5.1: CHIRALPAK AD 20μ, 11 cm id.x.27 cm L / ethanol / 30 °C
View Scheme
6-bromomethyl-pteridine-2,4-diamine
59368-16-0

6-bromomethyl-pteridine-2,4-diamine

α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate
146464-91-7

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

Conditions
ConditionsYield
Stage #1: α-propargylhomoterephthalic acid dimethyl ester With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride In mineral oil at -10 - 0℃; for 0.5h;
Stage #2: 6-bromomethyl-pteridine-2,4-diamine In mineral oil at -5 - 20℃;
40.2 g
Stage #1: α-propargylhomoterephthalic acid dimethyl ester With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 0.75h;
Stage #2: 6-bromomethyl-pteridine-2,4-diamine In N,N-dimethyl-formamide at -25 - -20℃; for 2.5h;
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

C19H16N6O4*ClH

C19H16N6O4*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride / mineral oil / 0.5 h / -10 - 0 °C
1.2: -5 - 20 °C
2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C
2.2: pH 7.5
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt
1445586-50-4

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride / mineral oil / 0.5 h / -10 - 0 °C
1.2: -5 - 20 °C
2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C
2.2: pH 7.5
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 - 130 °C
3.2: 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / water / 4 h / 20 - 25 °C
2.2: 15 h / 20 - 25 °C
3.1: dimethyl sulfoxide / 110 - 115 °C
3.2: 50 - 55 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / water / 4 h / 20 - 25 °C
2.2: 15 h / 20 - 25 °C
3.1: methanol / 0 - 5 °C
4.1: N,N-dimethyl acetamide / 1 h / 50 - 110 °C
4.2: 0 - 15 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
3: potassium hydroxide / water; 2-methoxy-ethanol / 6 h / 25 - 30 °C
4: dimethyl sulfoxide / 110 - 115 °C
5: sodium hydroxide / water / 0 - 15 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
3: potassium hydroxide / water; 2-methoxy-ethanol / 6 h / 25 - 30 °C
4: methanol / 0 - 5 °C
5: N,N-dimethyl acetamide / 1 h / 50 - 110 °C
6: sodium hydroxide / water / 0 - 15 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid bis(dicyclohexylamine) salt

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid bis(dicyclohexylamine) salt

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / water / 4 h / 20 - 25 °C
2.2: 15 h / 20 - 25 °C
3.1: methanol / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
3: potassium hydroxide / water; 2-methoxy-ethanol / 6 h / 25 - 30 °C
4: methanol / 0 - 5 °C
View Scheme
α-propargylhomoterephthalic acid dimethyl ester
146464-90-6

α-propargylhomoterephthalic acid dimethyl ester

10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt
1548618-47-8

10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl acetamide / -20 - -10 °C
2: hydrogen bromide / methanol; isopropyl alcohol; dichloromethane; water / 0 - 5 °C
View Scheme

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