Items Standard Test Result Appearance Off-white solid Conform Purity (HPLC) ≥98.0%
Cas:159811-51-5
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUlipristal 11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione[CAS:159811-51-5] Name Ulipristal Synonyms (11beta)-11-[4-(Dimethylami
Cas:159811-51-5
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:159811-51-5
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Ulipristal The alias:Ulipristal acetate intermediate N-1 CAS NO:159811-51-5 EINECS NO:815-032-8 Molecular formula:C28H35NO3 Molecular weight:433.58 Product Quality 12 years of chemical raw materials Mature operation of the industry
Cas:159811-51-5
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inquiryUlipristal Basic information Product Name: Ulipristal Synonyms: (11beta)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione;(8S,11R,13S,14S,17R)-17-acetyl-11-(4-(diMethylaMino)phenyl)-1,2, 7,8,11,12,13,15,16,17-decahydro-
Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:159811-51-5
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:159811-51-5
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:159811-51-5
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:159811-51-5
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers
Cas:159811-51-5
Min.Order:100 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:159811-51-5
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inquiryUlipristal CAS:159811-51-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:159811-51-5
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:159811-51-5
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:159811-51-5
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:159811-51-5
Min.Order:100 Kilogram
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:159811-51-5
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:159811-51-5
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:159811-51-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:159811-51-5
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:159811-51-5
Min.Order:1 Gram
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Ulipristal Chemical Properties Boiling point 638.5±55.0 °C(Predicted) density 1.20 storage temp. Sealed in dry,Room Temperature pka 12.94±0.60(Predicted)
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:159811-51-5
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:159811-51-5
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
CDB-3236
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20℃; for 1h; Industrial scale; | 98.2% |
3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene
CDB-3236
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 1h; Heating; | 88% |
Stage #1: 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene With potassium hydrogensulfate; water at 5℃; for 4h; Stage #2: With potassium hydroxide; water In dichloromethane Product distribution / selectivity; | |
With hydrogenchloride; water at 25℃; for 2h; | |
With hydrogenchloride In water at 25℃; for 2h; |
CDB-3236
Conditions | Yield |
---|---|
With acetic acid In water at 25℃; for 1h; | 74% |
With hydrogenchloride In methanol at 20℃; for 0.5h; | 70% |
11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile
methyllithium
CDB-3236
Conditions | Yield |
---|---|
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine at -50 - -35℃; for 3h; Stage #2: With water at 20℃; Stage #3: With sulfuric acid In methanol at 40℃; for 3h; | 70.7% |
11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile
methyllithium
CDB-3236
Conditions | Yield |
---|---|
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -50 - -40℃; for 3h; Stage #2: With water In tetrahydrofuran at 20℃; Stage #3: With sulfuric acid In methanol at 40℃; for 3h; | 70% |
17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 2.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 2.2: 2 h / 10 - 20 °C / Large scale 3.1: hydrogenchloride / 2 h / 25 °C View Scheme |
5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 1.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 2.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 1.2: 2 h / 10 - 20 °C / Large scale 2.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 98 percent / DMAP; TEA / tetrahydrofuran / 20 °C 2.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C 2.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C 3.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 4.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 4.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 5.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale 2.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale 3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 5.2: 2 h / 10 - 20 °C / Large scale 6.1: hydrogenchloride / 2 h / 25 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale 2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 5.2: 2 h / 10 - 20 °C / Large scale 6.1: hydrogenchloride / 2 h / 25 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale 2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 5.2: 2 h / 10 - 20 °C / Large scale 6.1: hydrogenchloride / 2 h / 25 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale 2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 5.2: 2 h / 10 - 20 °C / Large scale 6.1: hydrogenchloride / 2 h / 25 °C View Scheme |
3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C 1.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C 2.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 3.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 3.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 4.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating View Scheme |
3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: triethylamine; acetic acid / Inert atmosphere 3.1: sodium methylate / methanol 4.1: Acidic conditions View Scheme | |
Multi-step reaction with 5 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 4.2: 2 h / 70 °C / Inert atmosphere 5.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: magnesium / tetrahydrofuran; ethylene dibromide / 3 h / 45 °C / Industrial scale 1.2: 0 °C / Industrial scale 2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale 2.2: 2 h / -5 - 0 °C / Industrial scale 3.1: methanol / 2.5 h / 70 °C / Industrial scale 3.2: 5 h / 70 °C / Industrial scale 4.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale View Scheme |
4-bromo-N,N-dimethylaniline
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: triethylamine; acetic acid / Inert atmosphere 3.1: sodium methylate / methanol 4.1: Acidic conditions View Scheme | |
Multi-step reaction with 5 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 4.2: 2 h / 70 °C / Inert atmosphere 5.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium / tetrahydrofuran; dichloromethane / 3 h / 40 - 50 °C / Large scale 1.2: 2 h / 10 - 20 °C / Cooling with ice; Large scale 2.1: hydrogenchloride; water / 2 h / 25 °C View Scheme |
3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-ethyne
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; acetic acid / Inert atmosphere 2: sodium methylate / methanol 3: Acidic conditions View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 2.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 3.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 3.2: 2 h / 70 °C / Inert atmosphere 4.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 25 °C 1.2: 25 °C 2.1: triethylamine / dichloromethane / -60 °C 3.1: methanol / 6 h / 64 - 65 °C 4.1: acetic acid / water / 1 h / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 25 °C 1.2: 25 °C 2.1: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C 3.1: methanol / 6 h / 64 - 65 °C 4.1: acetic acid / water / 1 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale 1.2: 2 h / -5 - 0 °C / Industrial scale 2.1: methanol / 2.5 h / 70 °C / Industrial scale 2.2: 5 h / 70 °C / Industrial scale 3.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: triethylamine; acetic acid / Inert atmosphere 3.1: sodium methylate / methanol 4.1: Acidic conditions View Scheme | |
Multi-step reaction with 5 steps 1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 4.2: 2 h / 70 °C / Inert atmosphere 5.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 2.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 2.2: 2 h / 70 °C / Inert atmosphere 3.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / -60 °C 2: methanol / 6 h / 64 - 65 °C 3: acetic acid / water / 1 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C 2: methanol / 6 h / 64 - 65 °C 3: acetic acid / water / 1 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 1.2: 2 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: methanol / 6 h / 64 - 65 °C 2: acetic acid / water / 1 h / 25 °C View Scheme |
3-(ethylenedioxy)estra-5,10-epoxy-9(11)-ene-17-one
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: triethylamine; acetic acid / Inert atmosphere 4.1: sodium methylate / methanol 5.1: Acidic conditions View Scheme | |
Multi-step reaction with 6 steps 1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 4.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 5.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 5.2: 2 h / 70 °C / Inert atmosphere 6.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme |
(8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere 2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: triethylamine; acetic acid / Inert atmosphere 4.1: sodium methylate / methanol 5.1: Acidic conditions View Scheme | |
Multi-step reaction with 6 steps 1.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere 2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 4.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 5.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 5.2: 2 h / 70 °C / Inert atmosphere 6.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: disodium hydrogenphosphate; dihydrogen peroxide / dichloromethane / 18 h / 20 °C / Industrial scale 2.1: magnesium / tetrahydrofuran; ethylene dibromide / 3 h / 45 °C / Industrial scale 2.2: 0 °C / Industrial scale 3.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale 3.2: 2 h / -5 - 0 °C / Industrial scale 4.1: methanol / 2.5 h / 70 °C / Industrial scale 4.2: 5 h / 70 °C / Industrial scale 5.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium methylate / methanol 2: Acidic conditions View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Acidic conditions; |
ethylene deltenone
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: tetrahydrofuran / 0 °C 2.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere 3.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 3.2: 1 h / 0 °C / Inert atmosphere 4.1: triethylamine; acetic acid / Inert atmosphere 5.1: sodium methylate / methanol 6.1: Acidic conditions View Scheme | |
Multi-step reaction with 7 steps 1.1: tetrahydrofuran / 0 °C 2.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere 3.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere 3.2: 1 h / 0 °C / Inert atmosphere 4.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere 5.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere 6.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere 6.2: 2 h / 70 °C / Inert atmosphere 7.1: hydrogenchloride / methanol / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: acetic acid / methanol / 20 °C 2.1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale 3.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale 4.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 5.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 6.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 6.2: 2 h / 10 - 20 °C / Large scale 7.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: magnesium / tetrahydrofuran; dichloromethane / 3 h / 40 - 50 °C / Large scale 1.2: 2 h / 10 - 20 °C / Cooling with ice; Large scale 2.1: hydrogenchloride; water / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 4.2: 2 h / 10 - 20 °C / Large scale 5.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 4.2: 2 h / 10 - 20 °C / Large scale 5.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 4.2: 2 h / 10 - 20 °C / Large scale 5.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 2.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 3.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 3.2: 2 h / 10 - 20 °C / Large scale 4.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
With hydrogenchloride at 25℃; for 2h; |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale 2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 4.2: 2 h / 10 - 20 °C / Large scale 5.1: hydrogenchloride / 2 h / 25 °C View Scheme |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C 2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale 3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale 4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale 4.2: 2 h / 10 - 20 °C / Large scale 5.1: hydrogenchloride / 2 h / 25 °C View Scheme |
B
CDB-3236
Conditions | Yield |
---|---|
Stage #1: 11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one With sodium methylate; phosphorous acid trimethyl ester Stage #2: With hydrogenchloride |
CDB-3236
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: magnesium; copper dichloride / tetrahydrofuran; ethylene dibromide / 2.5 h / 10 - 25 °C 2: hydrogenchloride / water / 2 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: acetic anhydride With perchloric acid at -10℃; Inert atmosphere; Stage #2: CDB-3236 In dichloromethane at -30 - -20℃; for 2h; Inert atmosphere; | 93.4% |
Stage #1: acetic anhydride; CDB-3236 With perchloric acid In dichloromethane at -10℃; for 3h; Industrial scale; Stage #2: With pyrographite In isopropyl alcohol for 0.5h; Industrial scale; | 90.9% |
With perchloric acid In dichloromethane at -25 - -20℃; for 0.833333h; | 85% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.333333h; | 68% |
CDB-3236
11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione
Conditions | Yield |
---|---|
With iodine; calcium oxide In tetrahydrofuran; methanol |
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