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Hangzhou Dingyan Chem Co., Ltd

Items Standard Test Result Appearance Off-white solid Conform Purity (HPLC) ≥98.0%

high purity Ulipristal 159811-51-5

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $1.9 / 2.5

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hangzhou Think Chemical Co. Ltd

Ulipristal 11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione[CAS:159811-51-5] Name Ulipristal Synonyms (11beta)-11-[4-(Dimethylami

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)- CAS NO.159811-51-5

Cas:159811-51-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Uliprisnil

Cas:159811-51-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Ulipristal The alias:Ulipristal acetate intermediate N-1 CAS NO:159811-51-5 EINECS NO:815-032-8 Molecular formula:C28H35NO3 Molecular weight:433.58 Product Quality 12 years of chemical raw materials Mature operation of the industry

Ulipristal/CAS:159811-51-5/High quality

Cas:159811-51-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Ality Chemical Corporation

Ulipristal Basic information Product Name: Ulipristal Synonyms: (11beta)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione;(8S,11R,13S,14S,17R)-17-acetyl-11-(4-(diMethylaMino)phenyl)-1,2, 7,8,11,12,13,15,16,17-decahydro-

Factory Supply Ulipristal

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - Ulipristal

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Manufactory Supply: Ulipristal Intermediate 99% Powder CAS 159811-51-5

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 159811-51-5 with competitive price

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)- 159811-51-5

Cas:159811-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Ulipristal CAS:159811-51-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Ulipristal CAS:159811-51-5

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

Cas:159811-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

Cas:159811-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Ulipristal/CAS 159811-51-5/EINECS 815-032-8

Cas:159811-51-5

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ulipristal

Cas:159811-51-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

11Β-[4-(N,N-DIMETHYLAMINO)-PHENYL]-17Α-HYDROXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

Cas:159811-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Ulipristal

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

CAS 159811-51-5 19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

Cas:159811-51-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Deacetyl CDB 2914

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Reliable Quality Ulipristal

Cas:159811-51-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Ulipristal Chemical Properties Boiling point 638.5±55.0 °C(Predicted) density 1.20 storage temp. Sealed in dry,Room Temperature pka 12.94±0.60(Predicted)

Ulipristal

Cas:159811-51-5

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CAS 159811-51-5 19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b)-

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Ulipristal

Cas:159811-51-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ulipristal

Cas:159811-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C31H43NO4

C31H43NO4

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃; for 1h; Industrial scale;98.2%
3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene
126690-41-3

3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
With sulfuric acid In ethanol for 1h; Heating;88%
Stage #1: 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene With potassium hydrogensulfate; water at 5℃; for 4h;
Stage #2: With potassium hydroxide; water In dichloromethane Product distribution / selectivity;
With hydrogenchloride; water at 25℃; for 2h;
With hydrogenchloride In water at 25℃; for 2h;
11β-(4-N,N-dimethylaminophenyl)-17α-hydroxy-20-methoxy-19-norpregna-4,9,20-triene-3-one

11β-(4-N,N-dimethylaminophenyl)-17α-hydroxy-20-methoxy-19-norpregna-4,9,20-triene-3-one

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
With acetic acid In water at 25℃; for 1h;74%
With hydrogenchloride In methanol at 20℃; for 0.5h;70%
11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile
1094602-02-4

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

methyllithium
917-54-4

methyllithium

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5,17α-bis[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine at -50 - -35℃; for 3h;
Stage #2: With water at 20℃;
Stage #3: With sulfuric acid In methanol at 40℃; for 3h;
70.7%
11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile
91934-94-0

11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile

methyllithium
917-54-4

methyllithium

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Stage #1: 11β-[4-(N,N-dimethylamino)phenyl]-3,3-ethylenedioxy-5α-hydroxy-17α-[(trimethylsilyl)oxy]-5α-estr-9-en-17β-carbonitrile; methyllithium With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -50 - -40℃; for 3h;
Stage #2: With water In tetrahydrofuran at 20℃;
Stage #3: With sulfuric acid In methanol at 40℃; for 3h;
70%
17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)
54201-84-2

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal)

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
2.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
2.2: 2 h / 10 - 20 °C / Large scale
3.1: hydrogenchloride / 2 h / 25 °C
View Scheme
5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)
54201-83-1

5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal)

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
1.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
2.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
1.2: 2 h / 10 - 20 °C / Large scale
2.1: hydrogenchloride / 2 h / 25 °C
View Scheme
3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 98 percent / DMAP; TEA / tetrahydrofuran / 20 °C
2.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C
2.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C
3.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
4.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
4.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
5.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 20 °C / Cooling; Large scale
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
3.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
4.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
5.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
5.2: 2 h / 10 - 20 °C / Large scale
6.1: hydrogenchloride / 2 h / 25 °C
View Scheme
3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene
290825-36-4

3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C
1.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C
2.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C
3.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h
3.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C
4.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating
View Scheme
3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene
137532-55-9

3-(ethylenedioxy)estra-5α,10α-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: triethylamine; acetic acid / Inert atmosphere
3.1: sodium methylate / methanol
4.1: Acidic conditions
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
4.2: 2 h / 70 °C / Inert atmosphere
5.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium / tetrahydrofuran; ethylene dibromide / 3 h / 45 °C / Industrial scale
1.2: 0 °C / Industrial scale
2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale
2.2: 2 h / -5 - 0 °C / Industrial scale
3.1: methanol / 2.5 h / 70 °C / Industrial scale
3.2: 5 h / 70 °C / Industrial scale
4.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale
View Scheme
4-bromo-N,N-dimethylaniline
586-77-6

4-bromo-N,N-dimethylaniline

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: triethylamine; acetic acid / Inert atmosphere
3.1: sodium methylate / methanol
4.1: Acidic conditions
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
4.2: 2 h / 70 °C / Inert atmosphere
5.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium / tetrahydrofuran; dichloromethane / 3 h / 40 - 50 °C / Large scale
1.2: 2 h / 10 - 20 °C / Cooling with ice; Large scale
2.1: hydrogenchloride; water / 2 h / 25 °C
View Scheme
3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-ethyne
91934-95-1

3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-ethyne

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; acetic acid / Inert atmosphere
2: sodium methylate / methanol
3: Acidic conditions
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
2.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
3.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
3.2: 2 h / 70 °C / Inert atmosphere
4.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 25 °C
1.2: 25 °C
2.1: triethylamine / dichloromethane / -60 °C
3.1: methanol / 6 h / 64 - 65 °C
4.1: acetic acid / water / 1 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 25 °C
1.2: 25 °C
2.1: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C
3.1: methanol / 6 h / 64 - 65 °C
4.1: acetic acid / water / 1 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale
1.2: 2 h / -5 - 0 °C / Industrial scale
2.1: methanol / 2.5 h / 70 °C / Industrial scale
2.2: 5 h / 70 °C / Industrial scale
3.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale
View Scheme
3-(ethylenedioxy)estra-5,10-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene

3-(ethylenedioxy)estra-5,10-epoxy-17α-ethynyl-17β-hydroxy-9(11)-ene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: triethylamine; acetic acid / Inert atmosphere
3.1: sodium methylate / methanol
4.1: Acidic conditions
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
4.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
4.2: 2 h / 70 °C / Inert atmosphere
5.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
17α-ethynyl-17β-hydroxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3-one

17α-ethynyl-17β-hydroxy-11β-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3-one

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
2.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
2.2: 2 h / 70 °C / Inert atmosphere
3.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / -60 °C
2: methanol / 6 h / 64 - 65 °C
3: acetic acid / water / 1 h / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C
2: methanol / 6 h / 64 - 65 °C
3: acetic acid / water / 1 h / 25 °C
View Scheme
11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one

11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
1.2: 2 h / 70 °C / Inert atmosphere
2.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: methanol / 6 h / 64 - 65 °C
2: acetic acid / water / 1 h / 25 °C
View Scheme
3-(ethylenedioxy)estra-5,10-epoxy-9(11)-ene-17-one
786698-67-7

3-(ethylenedioxy)estra-5,10-epoxy-9(11)-ene-17-one

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: triethylamine; acetic acid / Inert atmosphere
4.1: sodium methylate / methanol
5.1: Acidic conditions
View Scheme
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
4.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
5.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
5.2: 2 h / 70 °C / Inert atmosphere
6.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
(8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol
5490-76-6

(8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere
2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: triethylamine; acetic acid / Inert atmosphere
4.1: sodium methylate / methanol
5.1: Acidic conditions
View Scheme
Multi-step reaction with 6 steps
1.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere
2.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
4.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
5.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
5.2: 2 h / 70 °C / Inert atmosphere
6.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: disodium hydrogenphosphate; dihydrogen peroxide / dichloromethane / 18 h / 20 °C / Industrial scale
2.1: magnesium / tetrahydrofuran; ethylene dibromide / 3 h / 45 °C / Industrial scale
2.2: 0 °C / Industrial scale
3.1: triethylamine / dichloromethane / 0.08 h / 0 °C / Industrial scale
3.2: 2 h / -5 - 0 °C / Industrial scale
4.1: methanol / 2.5 h / 70 °C / Industrial scale
4.2: 5 h / 70 °C / Industrial scale
5.1: hydrogenchloride / methanol; water / 1 h / 20 °C / Industrial scale
View Scheme
C36H43NO4S

C36H43NO4S

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methylate / methanol
2: Acidic conditions
View Scheme
C31H43NO5

C31H43NO5

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Acidic conditions;
ethylene deltenone
5571-36-8

ethylene deltenone

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 0 °C
2.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere
3.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
4.1: triethylamine; acetic acid / Inert atmosphere
5.1: sodium methylate / methanol
6.1: Acidic conditions
View Scheme
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 0 °C
2.1: Hexafluoroacetone; dihydrogen peroxide; sodium phosphate dibasic dodecahydrate / water; dichloromethane / Inert atmosphere
3.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
4.1: sulfuric acid / water; ethanol / 2 h / 70 °C / Inert atmosphere
5.1: triethylamine / tetrahydrofuran / 2 h / -78 - -70 °C / Inert atmosphere
6.1: sodium methylate / methanol / 1 h / 70 °C / Inert atmosphere
6.2: 2 h / 70 °C / Inert atmosphere
7.1: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: acetic acid / methanol / 20 °C
2.1: toluene-4-sulfonic acid / tetrahydrofuran / 3 h / 20 °C / Cooling; Large scale
3.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
4.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
5.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
6.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
6.2: 2 h / 10 - 20 °C / Large scale
7.1: hydrogenchloride / 2 h / 25 °C
View Scheme
3,3,20,20-bis(ethylene-dioxy)-17α-hydroxy-5β,10β-epoxy-19-norpregna-9(11)-ene

3,3,20,20-bis(ethylene-dioxy)-17α-hydroxy-5β,10β-epoxy-19-norpregna-9(11)-ene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium / tetrahydrofuran; dichloromethane / 3 h / 40 - 50 °C / Large scale
1.2: 2 h / 10 - 20 °C / Cooling with ice; Large scale
2.1: hydrogenchloride; water / 2 h / 25 °C
View Scheme
17α-[(±)1-(1-n-propyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-n-propyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
4.2: 2 h / 10 - 20 °C / Large scale
5.1: hydrogenchloride / 2 h / 25 °C
View Scheme
17α-[(±)1-(1-isobutyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-isobutyloxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
4.2: 2 h / 10 - 20 °C / Large scale
5.1: hydrogenchloride / 2 h / 25 °C
View Scheme
17α-[(±)1-(1-tetrahydropyran)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-tetrahydropyran)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
4.2: 2 h / 10 - 20 °C / Large scale
5.1: hydrogenchloride / 2 h / 25 °C
View Scheme
17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
2.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
3.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
3.2: 2 h / 10 - 20 °C / Large scale
4.1: hydrogenchloride / 2 h / 25 °C
View Scheme
3,3,20,20-bis(ethylenedioxy)-5α,17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl]-19-norgestrel-9(11)-ene

3,3,20,20-bis(ethylenedioxy)-5α,17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl]-19-norgestrel-9(11)-ene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
With hydrogenchloride at 25℃; for 2h;
C25H35NO4

C25H35NO4

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C / Cooling; Large scale
2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
4.2: 2 h / 10 - 20 °C / Large scale
5.1: hydrogenchloride / 2 h / 25 °C
View Scheme
17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

17α-[(±)1-(1-ethoxyl)ethyl]oxyl-17β-cyano-3,3-(ethylene-dioxy)-19-norpregna-5(10),9(11)-diene

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; 2-methyltetrahydrofuran / 0 - 10 °C
2.1: trimethyl orthoformate; toluene-4-sulfonic acid / dichloromethane / 5 h / 20 - 25 °C / Large scale
3.1: Hexafluoroacetone; dihydrogen peroxide / dichloromethane; pyridine / -5 - 5 °C / Large scale
4.1: magnesium; copper(l) chloride / tetrahydrofuran / 3 h / 25 - 50 °C / Large scale
4.2: 2 h / 10 - 20 °C / Large scale
5.1: hydrogenchloride / 2 h / 25 °C
View Scheme
11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one

11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one

A

11β-(4-(N,N-dimethylamino)phenyl)-17β-hydroxy-19-norpregna-4,9-diene-3,20-dione

11β-(4-(N,N-dimethylamino)phenyl)-17β-hydroxy-19-norpregna-4,9-diene-3,20-dione

B

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Stage #1: 11β-(4-N,N-dimethylaminophenyl)-21-(phenyl-sulfinyl)-19-norpregna-4,9,17(20),20-tetraene-3-one With sodium methylate; phosphorous acid trimethyl ester
Stage #2: With hydrogenchloride
C24H34O6

C24H34O6

CDB-3236
159811-51-5

CDB-3236

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: magnesium; copper dichloride / tetrahydrofuran; ethylene dibromide / 2.5 h / 10 - 25 °C
2: hydrogenchloride / water / 2 h / 25 °C
View Scheme
acetic anhydride
108-24-7

acetic anhydride

CDB-3236
159811-51-5

CDB-3236

ulipristal acetate
126784-99-4

ulipristal acetate

Conditions
ConditionsYield
Stage #1: acetic anhydride With perchloric acid at -10℃; Inert atmosphere;
Stage #2: CDB-3236 In dichloromethane at -30 - -20℃; for 2h; Inert atmosphere;
93.4%
Stage #1: acetic anhydride; CDB-3236 With perchloric acid In dichloromethane at -10℃; for 3h; Industrial scale;
Stage #2: With pyrographite In isopropyl alcohol for 0.5h; Industrial scale;
90.9%
With perchloric acid In dichloromethane at -25 - -20℃; for 0.833333h;85%
trifluoroacetic anhydride
96-63-9

trifluoroacetic anhydride

CDB-3236
159811-51-5

CDB-3236

ulipristal acetate
126784-99-4

ulipristal acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.333333h;68%
CDB-3236
159811-51-5

CDB-3236

11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione
159681-67-1

11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
With iodine; calcium oxide In tetrahydrofuran; methanol

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