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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (-)-4-Chlorobenzhydrylamine supplier in China

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(αR)-4-Chloro-α-phenylbenzenemethanamine

Cas:163837-57-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(-)-4-Chlorobenzhydrylamine 163837-57-8

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

(-)-4-Chlorobenzhydrylamine/ LIDE PHARMA- Factory supply / Best price

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(-)-4-Chlorobenzhydrylamine CAS:163837-57-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

(-)-4-Chlorobenzhydrylamine CAS:163837-57-8

Cas:163837-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality, moderate price & quick delivery Appearance:detailed see specifications Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:according to the clients requirements Application:intermediates of Drug

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(R)-1-(4-CHLOROPHENYL)-1-PHENYLMETHYLAMINE

Cas:163837-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

(-) - ALPHA- (4-CHLOROPHENYL) BENZYLAMINE (+) - TARTRATE SALT; (+) - Tartrate Sa

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT, 99%

Cas:163837-57-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(-)-alpha-(4-Chlorophenyl)benzylamine (+)-tartrate salt

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

(-)-Alpha-(4-Chlorophenyl)Benzylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(-)-4-Chlorobenzhydrylamine

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

(-)-alpha-(4-chlorophenyl)benzylamine (+)-tartrate salt

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

stocks,competitive price,superior product If you nee, pls feel free to contact me. Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:pharmaceutical interm

(R)-(4-chlorophenyl)(phenyl)methanamine

Cas:163837-57-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

(-)-4-Chlorobenzhydrylamine cas 163837-57-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(-)-4-Chlorobenzhydrylamine cas 163837-57-8

Cas:163837-57-8

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

(-)-(R)-Phenyl N-(4-chlorobenzhydryl)carbamate

(-)-(R)-Phenyl N-(4-chlorobenzhydryl)carbamate

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With lithium hydroxide; water In acetonitrile at 50℃; for 3h; Hydrolysis;100%
(R)-N-((4-chlorophenyl)(phenyl)methyl)-N’,N’-dimethylsulfamide
898231-59-9

(R)-N-((4-chlorophenyl)(phenyl)methyl)-N’,N’-dimethylsulfamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With Trimethylenediamine for 0.5h; Microwave irradiation; enantioselective reaction;99%
With Trimethylenediamine for 2h; microwave irradiation;96%
(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine
1000693-79-7

(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With hydrogenchloride In methanol; dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;95%
With hydrogenchloride In dichloromethane; ethyl acetate at 0℃; Schlenk technique;88%
(R)-N-((4-chlorophenyl)(phenyl)methyl)benzamide
1174154-53-0

(R)-N-((4-chlorophenyl)(phenyl)methyl)benzamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Stage #1: (R)-N-((4-chlorophenyl)(phenyl)methyl)benzamide With triphenyl phosphite; chlorine; triethylamine In chloroform at -30℃; for 3h; Inert atmosphere;
Stage #2: With propan-1-ol In chloroform at -30 - 20℃; for 3h; Inert atmosphere;
Stage #3: With water In methanol at 20℃; for 12h; optical yield given as %ee;
80%
p-chlorobenzhydrylamine
28022-43-7

p-chlorobenzhydrylamine

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With L-Tartaric acid at 30 - 90℃; Inert atmosphere;70%
With sodium tetrahydroborate; porcine kidney D-amino acid oxidase variant I230A/R283G In aq. buffer at 30℃; for 1h; pH=9; Enzymatic reaction; stereoselective reaction;46.2%
triphenylborane
960-71-4

triphenylborane

(1S,3S,4R)-2-(4-chlorophenylmethyl)-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate

(1S,3S,4R)-2-(4-chlorophenylmethyl)-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Stage #1: triphenylborane; (1S,3S,4R)-2-(4-chlorophenylmethyl)-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate With lithium hexamethyldisilazane In tetrahydrofuran; 1,4-dioxane at 5℃; for 5h;
Stage #2: With hydroxylamine-O-sulfonic acid
68%
p-chlorobenzhydrylamine
28022-43-7

p-chlorobenzhydrylamine

A

(4-chlorophenyl)phenylmethanol
119-56-2

(4-chlorophenyl)phenylmethanol

B

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

C

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With hydrogenchloride; borane-ammonia complex In aq. phosphate buffer at 37℃; pH=7.8;A n/a
B n/a
C 45%
phenylmagnesium bromide

phenylmagnesium bromide

(R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide
336105-23-8

(R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide In diethyl ether at -20℃;
Stage #2: With hydrogenchloride In methanol at 22℃;
Stage #1: phenylmagnesium bromide; (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide In toluene
Stage #2: With hydrogenchloride In methanol
(R)-(+)-N-[(4-chlorophenyl)(phenyl)methyl]formamide
474654-18-7

(R)-(+)-N-[(4-chlorophenyl)(phenyl)methyl]formamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 4h;
phenylmagnesium bromide

phenylmagnesium bromide

2-Methyl-butane-2-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

2-Methyl-butane-2-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; 2-Methyl-butane-2-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide In toluene
Stage #2: With hydrogenchloride In methanol
phenylmagnesium bromide

phenylmagnesium bromide

3-Ethyl-pentane-3-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

3-Ethyl-pentane-3-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; 3-Ethyl-pentane-3-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide In toluene
Stage #2: With hydrogenchloride In methanol
phenylmagnesium bromide

phenylmagnesium bromide

Adamantane-1-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

Adamantane-1-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; Adamantane-1-sulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide In toluene
Stage #2: With hydrogenchloride In methanol
phenylmagnesium bromide

phenylmagnesium bromide

2,4,6-Triisopropyl-benzenesulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

2,4,6-Triisopropyl-benzenesulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; 2,4,6-Triisopropyl-benzenesulfinic acid 1-(4-chloro-phenyl)-meth-(E)-ylideneamide In toluene at -20 - 0℃;
Stage #2: With hydrogenchloride In methanol
A n/a
B 80 % Chromat.
phenyltriisopropoxytitanium(IV)
16635-23-7

phenyltriisopropoxytitanium(IV)

N-(4-chlorophenyl)methylidene-2,4,6-triisopropylbenzenesulfonamide

N-(4-chlorophenyl)methylidene-2,4,6-triisopropylbenzenesulfonamide

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
Stage #1: phenyltriisopropoxytitanium(IV); N-(4-chlorophenyl)methylidene-2,4,6-triisopropylbenzenesulfonamide With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); bis(ethylene)rhodium(I) chloride dimer In tetrahydrofuran at 20℃; for 1h;
Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran for 1h; Heating; Title compound not separated from byproducts;
(E)-N-(4-chlorobenzylidene)-N’,N’-dimethylsulfamide
940939-32-2

(E)-N-(4-chlorobenzylidene)-N’,N’-dimethylsulfamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (R)-1,1'-binaphthyl-2,2'-diyl 4-methoxyphenylamidophosphite / Rh(acac)(C2H4)2 / acetone / 4 h / 40 °C
2: 96 percent / 1,3-diaminopropane / 2 h / microwave irradiation
View Scheme
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

substututed benzylbromide phosphonium salt

substututed benzylbromide phosphonium salt

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 70 percent / toluene / 16 h / Heating
2: (R)-1,1'-binaphthyl-2,2'-diyl 4-methoxyphenylamidophosphite / Rh(acac)(C2H4)2 / acetone / 4 h / 40 °C
3: 96 percent / 1,3-diaminopropane / 2 h / microwave irradiation
View Scheme
phenylboronic acid
98-80-6

phenylboronic acid

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (R)-1,1'-binaphthyl-2,2'-diyl 4-methoxyphenylamidophosphite / Rh(acac)(C2H4)2 / acetone / 4 h / 40 °C
2: 96 percent / 1,3-diaminopropane / 2 h / microwave irradiation
View Scheme
4-chlorobenzyl bromide
622-95-7

4-chlorobenzyl bromide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: AgBF4 / CH2Cl2 / 48 h / 20 °C
2.1: LiHMDS / tetrahydrofuran; dioxane / 5 h / 5 °C
2.2: 68 percent / H2NOSO3H
View Scheme
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 95 percent / Ti(OEt)4 / tetrahydrofuran / 20 °C
2.1: toluene
2.2: HCl / methanol
View Scheme
Multi-step reaction with 2 steps
1.1: 95 percent / Ti(OEt)4 / tetrahydrofuran / 20 °C
2.1: toluene
2.2: HCl / methanol
View Scheme
Multi-step reaction with 2 steps
1.1: 95 percent / Ti(OEt)4 / tetrahydrofuran / 20 °C
2.1: toluene
2.2: HCl / methanol
View Scheme
Multi-step reaction with 2 steps
1.1: 95 percent / Ti(OEt)4 / tetrahydrofuran / 20 °C
2.1: toluene
2.2: HCl / methanol
View Scheme
Multi-step reaction with 3 steps
1: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
2: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
3: pyridine; water / 16 h / Reflux
View Scheme
diphenylzinc
1078-58-6

diphenylzinc

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (Rp,S)-C31H29NO; Et2Zn / toluene / 12 h / -20 °C
2: HCl / methanol / 4 h / 50 °C
View Scheme
N-{(4-chlorophenyl)[(4-methylphenyl)sulfonyl]methyl}formamide

N-{(4-chlorophenyl)[(4-methylphenyl)sulfonyl]methyl}formamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (Rp,S)-C31H29NO; Et2Zn / toluene / 12 h / -20 °C
2: HCl / methanol / 4 h / 50 °C
View Scheme
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

resin-bound p-methylphenylboronic acid

resin-bound p-methylphenylboronic acid

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 90 percent / Ti(OEt)4 / tetrahydrofuran / 22 °C
2.1: diethyl ether / -20 °C
2.2: HCl / methanol / 22 °C
View Scheme
N,N'-sulfonyl bis-[(4-chlorophenyl)(phenyl)methanamine]
1309582-68-0

N,N'-sulfonyl bis-[(4-chlorophenyl)(phenyl)methanamine]

A

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

B

(S)-4-chloro-α-phenyl-benzenemethanamine
163837-32-9

(S)-4-chloro-α-phenyl-benzenemethanamine

Conditions
ConditionsYield
With pyridine; water Reflux; optical yield given as %ee;
C14H11ClF3NO3S

C14H11ClF3NO3S

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
With formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In N,N-dimethyl-formamide at 50℃; for 2h;145 mg
2-((4-chlorophenyl)(imino)methyl)phenol
1334334-91-6

2-((4-chlorophenyl)(imino)methyl)phenol

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate / benzene / 72 h / 50 °C / Inert atmosphere; Sealed tube
2: triethylamine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
3: formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
View Scheme
(S)-2-(amino(4-chlorophenyl)methyl)phenol
1334247-23-2

(S)-2-(amino(4-chlorophenyl)methyl)phenol

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2: formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere
1.2: 12 h / 0 - 20 °C / Inert atmosphere
2.1: palladium diacetate; triethylamine; formic acid; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 20 h / 50 °C / Inert atmosphere; Sealed tube
3.1: hydrogenchloride / dichloromethane; methanol / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
4'-chloro-2-hydroxybenzophenone
2985-79-7

4'-chloro-2-hydroxybenzophenone

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ammonia / methanol / 16 h / 20 °C / Cooling with ice
2: (R)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate / benzene / 72 h / 50 °C / Inert atmosphere; Sealed tube
3: triethylamine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
4: formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium acetate; hydrogen; titanium(IV) isopropylate; Ru[(S)-SegPhos](OAc)2 / methanol / 24 h / 80 °C / 38002.6 Torr / Autoclave
2.1: dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: palladium diacetate; triethylamine; formic acid; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 20 h / 50 °C / Inert atmosphere; Sealed tube
4.1: hydrogenchloride / dichloromethane; methanol / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
N-methyl-N'-[4-chlorophenylmethylidene]sulfamide
1438244-01-9

N-methyl-N'-[4-chlorophenylmethylidene]sulfamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water; potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; phenylboronic acid; (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene / dichloromethane / 16 h / 35 °C / Inert atmosphere; Schlenk technique
2: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
3: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
4: pyridine; water / 16 h / Reflux
View Scheme
benzaldehyde
100-52-7

benzaldehyde

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
2: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
3: pyridine; water / 16 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
2: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
3: pyridine; water / 16 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: formic acid / methanol; water / 24 h / 20 °C
2: potassium carbonate; sodium sulfate / tetrahydrofuran / 18 h / Inert atmosphere; Reflux
3: sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; sodium t-butanolate; copper(l) chloride; (R)-(6-(tert-butylsulfinyl)-2,3-dimethoxyphenyl)diisopropylphosphine / toluene / 12 h / 20 °C
4: potassium carbonate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; XPhos; water / toluene / 14 h / 80 °C / Schlenk technique
5: hydrogenchloride / dichloromethane; ethyl acetate / 0 °C / Schlenk technique
View Scheme
N-methyl-N'-[phenylmethylidene]sulfamide
1438244-02-0

N-methyl-N'-[phenylmethylidene]sulfamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water; potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / dichloromethane / 16 h / 35 °C / Inert atmosphere; Schlenk technique
2: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
3: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
4: pyridine; water / 16 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: water; potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / dichloromethane / 16 h / 35 °C / Inert atmosphere; Schlenk technique
2: titanium(IV) tetraethanolate / tetrahydrofuran / 7 h / Reflux
3: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (1R,4R,7R)-naphthalen-2-yl 7-isopropyl-5-methylbicyclo[2.2.2]octa-2,5-diene-2-carboxylate / toluene; water / 16 h / 35 °C / Inert atmosphere; Schlenk technique
4: pyridine; water / 16 h / Reflux
View Scheme
acetic anhydride
108-24-7

acetic anhydride

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

N-[(R)-(4-chlorophenyl)(phenyl)methyl]acetamide

N-[(R)-(4-chlorophenyl)(phenyl)methyl]acetamide

Conditions
ConditionsYield
With triethylamine In toluene at 20℃;96%
In diethyl ether Inert atmosphere;
In water at 20℃; for 7h;
4-methoxy-benzenesulfonic acid-[bis-(2-chloro-ethyl)-amide]
86357-59-7

4-methoxy-benzenesulfonic acid-[bis-(2-chloro-ethyl)-amide]

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine
943987-59-5

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 125 - 130℃; for 10h; Heating / reflux; Industry scale;90.83%
With tributyl-amine for 4h; Reflux;
N,N-bis(2-chloroethyl)-p-toluenesulfonamide
42137-88-2

N,N-bis(2-chloroethyl)-p-toluenesulfonamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine
942283-97-8

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 127℃; for 4h; Heating / reflux;87.2%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine
1000693-79-7

(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; enantioselective reaction;86%
N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide
1150310-73-8

N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

levocetirizine N-benzyl amide
1150310-68-1

levocetirizine N-benzyl amide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 130℃; for 4h; Inert atmosphere;75%
With N-ethyl-N,N-diisopropylamine at 120 - 125℃; for 6h;n/a
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(R)-(+)-α-(4-chlorophenyl)-N-(2,2-dimethoxyethyl)benzylamine
292066-74-1

(R)-(+)-α-(4-chlorophenyl)-N-(2,2-dimethoxyethyl)benzylamine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; Alkylation;70%
tris-(2-chloro-ethyl)-amine
555-77-1

tris-(2-chloro-ethyl)-amine

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

C19H22Cl2N2

C19H22Cl2N2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine at 120℃; for 3h;70%
N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride
10429-82-0

N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

A

1-benzyl-4-(4-chloro-benzhydryl)-piperazine
80476-91-1

1-benzyl-4-(4-chloro-benzhydryl)-piperazine

B

sodium chloride
7647-14-5

sodium chloride

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium iodide In butan-1-ol at 0 - 110℃; for 4h;

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