Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryLuhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod
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inquiryUnique advantages for Tadalafil intermediate Cas 171489-59-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Off-white powder Storage:-20°C Freezer Package:1kg/foil bag;25kg/
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryName:(1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE CAS no:171489-59-1 Grade:Medical, scientific research, export Molecular formula:C22H19ClN2O5 Molecular weight:426.85 Produ
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName: (1R,3R)-methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-B]indole-3-carboxylate CAS:171489-59-1 MF: C22H19ClN2O5 Appearance:yellow-like powder Storage:Store in cool and dry place, away from sun light. Packag
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inquiry(1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE CAS: 171489-59-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and develo
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inquiryProduct Name: (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE Synonyms: (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(chloroacetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylic a
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:171489-59-1
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inquiryAppearance:White or off white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Pharmaceutical intermediates Transportation:Common products:Sea/Air/Courier D
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryProName: High quality (6R.12aR)-methyl-1,2,3,4-... CasNo: 171489-59-1 Molecular Formula: C22H19ClN2O5 Appearance: white-off solid or colorless liquid ( ... Application: Fine Intermediate DeliveryTime: Industrial Grade PackAge: 25kgs/fiber dru
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inquirychloroacetyl chloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 5 - 20℃; for 1.66667h; Product distribution / selectivity; | 97% |
Stage #1: (1R,3R)-1-benzo[1,3]dioxol-5-yl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester hydrochloride With triethylamine In tetrahydrofuran; water at 0 - 20℃; Stage #2: chloroacetyl chloride In tetrahydrofuran; water at 0 - 10℃; for 2h; | 95% |
With triethylamine In tetrahydrofuran; water at 0 - 10℃; for 2h; Inert atmosphere; | 93% |
chloroacetyl chloride
(1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: (1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate With triethylamine In dichloromethane at 20℃; for 0.166667h; Large scale; Stage #2: chloroacetyl chloride In dichloromethane at 20℃; for 1h; Large scale; | 95.2% |
With potassium carbonate In dichloromethane; ethyl acetate at 5 - 20℃; | 94% |
With sodium hydrogencarbonate In chloroform at 20℃; | 93% |
piperonal
(R)-(+)-tryptophan methyl ester hydrochloride
chloroacetyl chloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: piperonal; (R)-(+)-tryptophan methyl ester hydrochloride at 85℃; for 3h; Stage #2: chloroacetyl chloride With triethylamine In tetrahydrofuran; water at 0 - 10℃; for 1h; Product distribution / selectivity; | 86% |
chloroacetyl chloride
A
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
B
(1S,3R)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; for 2h; N-acyliminium Pictet-Spengler reaction; | A 43% B 34% |
piperonal
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 23 percent / trifluoroacetic acid / CH2Cl2 / 24 h / 20 °C 2: 83 percent / triethylamine / CHCl3 / -10 °C View Scheme |
(R)-(+)-tryptophan methyl ester hydrochloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 23 percent / trifluoroacetic acid / CH2Cl2 / 24 h / 20 °C 2: 83 percent / triethylamine / CHCl3 / -10 °C View Scheme | |
Multi-step reaction with 2 steps 1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C 2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / aq.HCl / methanol / 36 h / Heating 2: 78 percent / NaHCO3 / CH2Cl2; H2O View Scheme |
piperonal
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C 2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / aq.HCl / methanol / 36 h / Heating 2: 78 percent / NaHCO3 / CH2Cl2; H2O View Scheme | |
Multi-step reaction with 2 steps 1: 95 percent / Et3N; MgSO4 / CH2Cl2 / 24 h 2: 43 percent / DMAP / CH2Cl2 / 2 h / 20 °C View Scheme |
piperonal
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 42 percent / TFA / CH2Cl2 / 20 °C 2: 93 percent / NaHCO3 / CHCl3 / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene / Heating 2: TFA 3: Et3N View Scheme |
D-Tryptophan methyl ester
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 42 percent / TFA / CH2Cl2 / 20 °C 2: 93 percent / NaHCO3 / CHCl3 / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Molecular sieve 2: triethylamine / chloroform / -10 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water; toluene / 15 h / Reflux; Large scale 2.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Large scale 2.2: 1 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / 10 h / 70 - 80 °C / Large scale 2: triethylamine / chloroform / 2 h / 20 - 30 °C View Scheme |
(R)-2-{[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-amino}-3-(1H-indol-3-yl)-propionic acid methyl ester
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TFA 2: Et3N View Scheme |
chloroacetyl chloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran Reflux; |
piperonal
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Molecular sieve 2: triethylamine / chloroform / -10 °C View Scheme | |
Multi-step reaction with 2 steps 1: 0.25 h / 110 °C 2: triethylamine / water; tetrahydrofuran / 2 h / 0 - 10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: 0.25 h / 110 °C 2: triethylamine / tetrahydrofuran; water / 2 h / 0 - 10 °C / Inert atmosphere View Scheme |
(3R)-1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahidro-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
chloroacetyl chloride
A
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
B
(1S,3R)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane |
D-tryptophan
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / 4 h / 40 °C 2.1: carbonic acid dimethyl ester / 18 h / Reflux 3.1: triethylamine / 1 h / Ionic liquid 3.2: 0 °C / Ionic liquid View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride / 1.5 h / 0 - 68 °C 2.1: isopropyl alcohol / 66 - 70 °C 3.1: triethylamine / tetrahydrofuran / 0 °C 3.2: 1 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid / 2 h / Reflux; Large scale 2.1: hydrogenchloride / water; toluene / 15 h / Reflux; Large scale 3.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Large scale 3.2: 1 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / 2 h / 10 - 45 °C / Large scale 2: isopropyl alcohol / 10 h / 70 - 80 °C / Large scale 3: triethylamine / chloroform / 2 h / 20 - 30 °C View Scheme |
chloroacetyl chloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In water; acetonitrile at 5 - 10℃; Temperature; Solvent; | 13.4 g |
piperonol
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: manganese(IV) oxide / dichloromethane / 20 °C 2: isopropyl alcohol / Reflux 3: triethylamine / tetrahydrofuran / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C 2: isopropyl alcohol / 24 h / Reflux 3: triethylamine / dichloromethane / -10 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: aluminum isopropoxide / toluene / 110 °C 1.2: 2 h / Heating / reflux 2.1: isopropyl alcohol / 66 - 70 °C 3.1: triethylamine / tetrahydrofuran / 0 °C 3.2: 1 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: manganese(IV) oxide / dichloromethane / 20 °C 2: isopropyl alcohol / 80 - 100 °C 3: triethylamine / dichloromethane / 3 h / 0 - 20 °C View Scheme |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trifluorormethanesulfonic acid / dichloromethane / 3 h / 20 °C 2.1: dichloromethane / 5 h / 30 °C 2.2: 6 h / 75 - 80 °C / 22502.3 Torr 3.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: trifluorormethanesulfonic acid / dichloromethane / 3 h / 20 °C 2.1: ethyl acetate / 5 h / 30 °C 2.2: 6 h / 75 - 80 °C / 22502.3 Torr / Inert atmosphere 3.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C View Scheme |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ethyl acetate / 5 h / 30 °C 1.2: 6 h / 75 - 80 °C / 22502.3 Torr / Inert atmosphere 2.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C View Scheme |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20℃; | 95% |
In N,N-dimethyl-formamide at 20℃; for 10h; | 95% |
In methanol for 3h; Reflux; Large scale; | 95.3% |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In ethanol; water at 40℃; for 4h; | 95% |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate In tetrahydrofuran at 30 - 55℃; for 1h; Stage #2: methylamine In tetrahydrofuran at 5 - 55℃; for 1h; | 94.6% |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With methylamine In dichloromethane for 2h; | 93.5% |
With methylamine In water for 20h; Ionic liquid; | 355 mg |
benzyl-methyl-amine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(1R,3R)-methyl-1,2,3,4-tetrahydro-2-(2-(benzyl(methyl)amino)acetyl)-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In ISOPROPYLAMIDE at 20℃; for 2h; Product distribution / selectivity; | 90% |
4-(2-aminoethyl)benzenesulfonamide
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol at 45℃; for 22h; | 89.5% |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With hydrazine In tetrahydrofuran; methanol; water at 20℃; for 108h; | 82% |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With tert-butyl 4-(aminomethyl)piperidine-1-carboxylate In methanol at 80℃; | 79% |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With ammonia In methanol at 45℃; for 20h; | 70% |
With ammonia In methanol at 40℃; for 72h; | 68% |
With ammonia In methanol Reflux; | 60% |
With ammonia Heating; | 31% |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
In water; acetonitrile at 90℃; for 2h; Temperature; Solvent; | 69.88% |
isopropylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
In methanol Heating; | 69% |
4-(2-aminoethyl)-1-(phenylmethyl)piperidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 67% |
With triethylamine In methanol for 18h; Reflux; | 67% |
glyoxylic acid ethyl ester
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With C53H43O4PSi2 In diethyl ether; toluene at 0℃; for 48h; enantioselective reaction; | 67% |
hydroxylamine hydrochloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 45℃; for 24h; | 66% |
4-amino-1-benzylpiperidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 65% |
In ethanol Reflux; | 59% |
In ethanol at 50℃; |
4-(2-AMINOETHYL)MORPHOLINE
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 62% |
In ethanol Reflux; | 39% |
In ethanol at 50℃; |
tyrosamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-[2-(4-hydroxyphenyl)ethyl]-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido-[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In ethanol Reflux; | 62% |
1-Benzyl-3-aminopyrrolidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 59% |
4-aminomethyl-1-benzylpiperidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 58% |
N-butylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
In methanol Heating; | 57% |
In ethanol Reflux; | 44% |
4-morpholinobenzylamine hydrochloride
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-(4-morpholin-4-ylbenzyl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido-[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With triethylamine In methanol Microwave irradiation; | 57% |
(R)-1-benzyl-3-aminopyrrolidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-((R)-1-benzylpyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 56% |
Reflux; | 48% |
Stage #1: (R)-1-benzyl-3-aminopyrrolidine; methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate for 12 - 24h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate | 48% |
In ethanol at 50℃; |
2-(4-methylpiperazin-1-yl)ethylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 56% |
hydrazine hydrate
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
In ethanol Microwave irradiation; | 56% |
1-(2-aminoethyl)-4-benzylpiperidine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 56% |
5-((7-methoxynaphthalen-1-yl)methyl)-1H-tetrazole
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50 - 55℃; | 55% |
N-methyl-N-phenylethylenediamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 55% |
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