Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical
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inquiryTadalafil CAS 171596-29-5 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Pr
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct advantage: Guaranteed quality Good pice Well packed Service advantage: Pre-sale service 1. Technical consultancy, to help customer know about the properties, features, quality, production and supply of the product they wa
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryOur Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual
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inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
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inquiryTadalafil cas 171596-29-5 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste
Cas:171596-29-5
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inquiryOur service: 1.We have experience in exporting Pharmaceutical intermediates . 2.Professional packing with professional materials 3. We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the trackin
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryhebeikunsui Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical inter
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryProName: Hubei DiBo chemical co., LTD CasNo: 171596-29-5 Molecular Formula: Unspecified Appearance: Solid powder Application: Applied in dietary supplements,pharmac... DeliveryTime: 3 DAYS AFETR PAYMENT PackAge: aluminum foil bag,carton drum
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:171596-29-5
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
Cas:171596-29-5
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
ProName:High quality Tadalafil CasNo:171596-29-5 Molecular Formula:C22H19N3O4 Appearance:White powder Application:pharmaceutical intermediates DeliveryTime:WIthin 2 days PackAge:25KG/DRUM Port:Qingdao Port Product
Factory direct sales, accept customization. Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical Ingredient), p
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
GuangZhou Medcan Pharmatech LTD is a high-tech company engaged in new biopharmaceutical product development, sales, genetic engineering, bioinformatics and other areas of research and development, registered capital of 16660,000 RMB, the company ha
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:171596-29-5
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inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
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inquiry1. DMF is available. 2. Registerred in Iran MOH already. 3. Under registerring in Japan and Korea Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediate
Product Name: Tadalafil Synonyms: TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;(6R,12A
Cas:171596-29-5
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryProduct Description Advantage: High quality and competitive price. 1. We can provide samples for testing. 2. All purity >99%. As a manufacturer, we can supply high quality products at ex-factory prices. Fast and safe delivery. 1. The package c
Cas:171596-29-5
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Type:Trading Company
inquiryItems Standard Result Appearance White or off-white powder Off-white powder Identification H
Cas:171596-29-5
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquirymethylamine
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In dichloromethane at 0 - 5℃; for 3h; Temperature; Solvent; | 99.3% |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20℃; | 95% |
In N,N-dimethyl-formamide at 20℃; for 10h; | 95% |
In methanol for 3h; Reflux; Large scale; | 95.3% |
1,2-dibromomethane
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With sodium hydroxide In N,N-dimethyl-formamide at 60℃; for 6h; | 95% |
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 93% |
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 93% |
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 93% |
(1R,3R)-methyl-1,2,3,4-tetrahydro-2-(2-(benzyl(methyl)amino)acetyl)-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With hydrogen; Raney Ni In ISOPROPYLAMIDE at 80℃; under 2280.15 Torr; for 22h; Product distribution / selectivity; | 94% |
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With methylamine In dichloromethane for 2h; | 93.5% |
With methylamine In water for 20h; Ionic liquid; | 355 mg |
sarcosine ethyl ester hydrochloride
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With potassium carbonate In ethylene glycol at 110℃; Solvent; Reagent/catalyst; Temperature; Green chemistry; | 92.7% |
1-benzo[1,3]dioxol-5-yl-2-{[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetyl}-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With piperidine In N,N-dimethyl-formamide at 20℃; for 1h; | 92% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Stage #1: C22H20N4O3 With sulfuric acid In isopropyl alcohol for 12h; Reflux; Stage #2: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 8h; Temperature; | 91.2% |
methylamine
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 50℃; Solvent; Temperature; | 91% |
sarcosine
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Stage #1: sarcosine; (1R,3R)-1-benzo[1,3]dioxol-5-yl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester hydrochloride With triethylamine In tetrahydrofuran at 30℃; for 0.333333h; Stage #2: With dicyclohexyl-carbodiimide In tetrahydrofuran for 0.5h; Solvent; Reagent/catalyst; Temperature; Further stages; | 90.54% |
piperonal
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In isopropyl alcohol at 80℃; for 16h; Solvent; Temperature; | 58.2% |
methylamine
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
A
(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
B
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In methanol at 50℃; for 16h; | A 1.1% B 54% |
(1R,3R)-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride
sarcosine ethyl ester hydrochloride
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 50 - 55℃; for 10h; Large scale reaction; | 52.6% |
(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Stage #1: (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -50 - -35℃; for 2 - 6h; Stage #2: With ammonium chloride In tetrahydrofuran; hexane; water; ethyl acetate at -40 - 30℃; Product distribution / selectivity; | 48% |
Stage #1: (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide With n-butyllithium In tetrahydrofuran; hexane at -40 - -35℃; for 2.5h; Stage #2: With ammonium chloride In tetrahydrofuran; hexane; water; ethyl acetate at -40 - 30℃; Product distribution / selectivity; |
piperonal
Boc-D-Trp-OH
chloroacetyl chloride
methylamine
A
(6S,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1',2':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione
B
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Stage #1: Boc-D-Trp-OH With dmap; dicyclohexyl-carbodiimide In dichloromethane for 0.166667h; Microwave irradiation; Stage #2: piperonal With trifluoroacetic acid In chloroform for 0.5h; Pictet-Spengler cyclisation; Microwave irradiation; Stage #3: chloroacetyl chloride; methylamine Further stages; | A 45% B 32% |
piperonal
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C 2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C 3: 54 percent / methanol / 16 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: 85 percent / aq.HCl / methanol / 36 h / Heating 2: 78 percent / NaHCO3 / CH2Cl2; H2O 3: 88 percent / CHCl3; ethanol / 7 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 95 percent / Et3N; MgSO4 / CH2Cl2 / 24 h 2: 43 percent / DMAP / CH2Cl2 / 2 h / 20 °C 3: 92 percent / methanol / 16 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: 95 percent / Et3N; MgSO4 / CH2Cl2 / 24 h 2: DMAP; basic alumina / CH2Cl2 / 2 h / -25 - 20 °C 3: 92 percent / piperidine / dimethylformamide / 1 h / 20 °C View Scheme |
(R)-(+)-tryptophan methyl ester hydrochloride
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 25 percent / TFA / methanol; CH2Cl2 / 60 h / 20 °C 2: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C 3: 54 percent / methanol / 16 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: 85 percent / aq.HCl / methanol / 36 h / Heating 2: 78 percent / NaHCO3 / CH2Cl2; H2O 3: 88 percent / CHCl3; ethanol / 7 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 95 percent / Et3N; MgSO4 / CH2Cl2 / 24 h 2: 43 percent / DMAP / CH2Cl2 / 2 h / 20 °C 3: 92 percent / methanol / 16 h / 50 °C View Scheme |
(1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C 2: 54 percent / methanol / 16 h / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: 93 percent / NaHCO3 / CHCl3 / 20 °C 2: 77 percent / ethanol / Heating View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 78 percent / NaHCO3 / CH2Cl2; H2O 2: 88 percent / CHCl3; ethanol / 7 h / Heating View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 43 percent / DMAP / CH2Cl2 / 2 h / 20 °C 2: 92 percent / methanol / 16 h / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: DMAP; basic alumina / CH2Cl2 / 2 h / -25 - 20 °C 2: 92 percent / piperidine / dimethylformamide / 1 h / 20 °C View Scheme |
piperonal
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 42 percent / TFA / CH2Cl2 / 20 °C 2: 93 percent / NaHCO3 / CHCl3 / 20 °C 3: 77 percent / ethanol / Heating View Scheme |
D-Tryptophan methyl ester
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 42 percent / TFA / CH2Cl2 / 20 °C 2: 93 percent / NaHCO3 / CHCl3 / 20 °C 3: 77 percent / ethanol / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water; toluene / 15 h / Reflux; Large scale 2.1: triethylamine / dichloromethane / 0.17 h / 20 °C / Large scale 2.2: 1 h / 20 °C / Large scale 3.1: methanol / 3 h / Reflux; Large scale View Scheme | |
Multi-step reaction with 3 steps 1: isopropyl alcohol / 10 h / 70 - 80 °C / Large scale 2: triethylamine / chloroform / 2 h / 20 - 30 °C 3: methylamine / dichloromethane / 2 h View Scheme |
methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
methylamine hydrochloride
A
(6S,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1',2':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione
B
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; |
piperonal
(R)-(+)-tryptophan methyl ester hydrochloride
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 3 h / 85 °C 1.2: 1 h / 0 - 10 °C 2.1: water; tetrahydrofuran / 1 h / 55 °C / Inert atmosphere View Scheme |
piperonal
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 0.25 h / 110 °C 2: triethylamine / water; tetrahydrofuran / 2 h / 0 - 10 °C / Inert atmosphere 3: water; tetrahydrofuran / 1 h / 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: 0.25 h / 110 °C 2: triethylamine / tetrahydrofuran; water / 2 h / 0 - 10 °C / Inert atmosphere 3: tetrahydrofuran; water / 1 h / 55 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 105 °C / Autoclave 2: sodium carbonate / acetonitrile; water / 5 - 10 °C 3: water; isopropyl alcohol / 110 - 120 °C View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 4-methyl-morpholine / tetrahydrofuran / Inert atmosphere 1.2: 1 h / -20 - 20 °C / Inert atmosphere 2.1: trifluoroacetic acid / toluene / 15 h / 45 - 50 °C 3.1: toluene / 8 h / 110 °C View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In toluene at 110℃; for 8h; | 0.39 g |
piperonal
(R)-ethyl 2-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)-N-methylpropanamido)acetate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / toluene / 15 h / 45 - 50 °C 2: toluene / 8 h / 110 °C View Scheme |
Boc-D-Trp-OH
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere 1.2: 0.5 h / -20 °C / Inert atmosphere 2.1: 4-methyl-morpholine / tetrahydrofuran / Inert atmosphere 2.2: 1 h / -20 - 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / toluene / 15 h / 45 - 50 °C 4.1: toluene / 8 h / 110 °C View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide; isopropyl alcohol at 83℃; for 5h; | 98% |
naphthalene-1,5-disulfonate
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In Isopropyl acetate at 45℃; for 48h; pH=2 - 3; Solvent; | 95.4% |
salicylic acid
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In Isopropyl acetate at 45℃; for 48h; pH=2 - 3; Solvent; | 94.81% |
(S)-Mandelic acid
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
In Isopropyl acetate at 45℃; for 48h; pH=2 - 3; Solvent; | 94.25% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-3,3,12a-trideuterio-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With water-d2; potassium carbonate In tetrahydrofuran; dimethylsulfoxide-d6 at 65℃; for 16h; | 94% |
malonic acid
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
C3H4O4*C22H19N3O4
Conditions | Yield |
---|---|
In ethyl acetate for 5h; | 85% |
In acetonitrile Product distribution / selectivity; | |
In acetonitrile at 25℃; for 0.5h; |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
3-((2-(benzo[d][1,3]dioxole-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; water; tetramethlyammonium chloride In dimethyl sulfoxide at 40℃; for 7h; | 79% |
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; water at 20℃; for 8h; Product distribution / selectivity; |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With N-Bromosuccinimide; acetic acid at 50℃; for 5h; Reagent/catalyst; | 78% |
4-Methoxybenzenethiol
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With tetrabutylammonium tetrafluoroborate for 4.5h; Electrolysis; Inert atmosphere; Sealed tube; regioselective reaction; | 65% |
2-Fluoro-5-nitropyridine
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 23℃; for 40h; Inert atmosphere; | 61% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; deuterium In tetrahydrofuran at 55℃; under 750.075 Torr; for 22h; Inert atmosphere; | 46% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With [(Tp)NiIV(CF3)3] In dimethyl sulfoxide at 25℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 43% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With tert.-butylnitrite; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20℃; for 15h; Irradiation; | 42% |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Conditions | Yield |
---|---|
With potassium superoxide; 18-crown-6 ether In N,N-dimethyl-formamide at 25℃; for 6h; Winterfeldt oxidation; | 38% |
Multi-step reaction with 2 steps 1: O2; KOtBu / dimethylformamide; tetrahydrofuran / 4 h 2: 16.2 mg / PyBrOP; di-isopropylethylamine / dimethylformamide; tetrahydrofuran / 16 h / 25 °C View Scheme |
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
(6R,12aR)-6-benzo[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dithione
Conditions | Yield |
---|---|
With Lawessons reagent In tetrahydrofuran at 20℃; for 72h; | 25% |
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