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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-[4-(Trifluoromethyl)-phenyl]-propan-1-ol

Cas:180635-74-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

180635-74-9 CAS NO.180635-74-9

Cas:180635-74-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-(Trifluoromethyl)benzenepropanol

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL cas no. 180635-74-9 98%

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-(4-(trifluoroMethyl)phenyl)propan-1-ol

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

180635-74-9

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OLAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

HENAN SUNLAKE ENTERPRISE CORPORATION Our company advantages: 1、The highest quality with the competitive price. 2、Professional human services. 3、The fastest and safest delivery service. 4、The faster and safest delivery service. 5、The hig

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

180635-74-9 CAS NO.180635-74-9

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GZ HONESTCHEM CO., LTD

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-(4-(trifluoroMethyl)phenyl)propan-1-ol

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Nanjing Raymon Biotech Co., Ltd.

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OLAppearance:yellow to white solid Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier li

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synova( Tianjin ) Chemical Technology Co,.Ltd

The company have effective management team, professional technical R & D personnel, the service spirit of customer oriented. We have long-term cooperation with famous domestic manufacturer, and excellent customer resources overseas. We are skilled in

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Run-chem Biological Co.,ltd

3-(4-(trifluoromethyl)phenyl)propan-1-ol 180635-74-9 98%+ Storage:dry and ventilated place Package:suitable for shipping Application:3-(4-(trifluoromethyl)phenyl)propan-1-ol 180635-74-9 98%+ Transportation:air shipping Port:shanghai

3-(4-(trifluoromethyl)phenyl)propan-1-ol 180635-74-9 98%+

Cas:180635-74-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

coolpharm Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Other

inquiry

Shenzhen Sumshine Biotech Co., Ltd.

1. Our staff are all biomedical related majors with rich experience in the pharmaceutical industry, and can provide you with more professional services.2. Our supplier has a good quality management system, and the quality of products is reliable and

Cinacalcet Impurity 29

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemical Co.Ltd

Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en

Benzenepropanol,4-(trifluoromethyl)-

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

High purity Application:Pharmaceutical intermediates, Material synthesis and analyzing the expectant ingredients

Cinacalcet Impurity 29

Cas:180635-74-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

3-(4-trifluoromethylphenyl)propionic acid
53473-36-2

3-(4-trifluoromethylphenyl)propionic acid

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Stage #1: 3-(4-trifluoromethylphenyl)propionic acid With borane-THF In tetrahydrofuran at 0 - 20℃; for 15.3h;
Stage #2: With methanol In tetrahydrofuran at 0℃;
100%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;100%
With sodium tetrahydroborate; iodine In tetrahydrofuran at 70℃; for 16h; Cooling with ice;100%
3-(4-tert-butylphenyl)propionic acid
1208-64-6

3-(4-tert-butylphenyl)propionic acid

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine In tetrahydrofuran at 20 - 70℃; for 16.5h; Cooling with ice;100%
4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

allyl alcohol
107-18-6

allyl alcohol

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tetramethylammonium formiate; triphenylphosphine In water; N,N-dimethyl-formamide at 80℃; for 4h; Heck Reaction; regioselective reaction;67%
4-(trifluoromethyl)benzylic alcohol
349-95-1

4-(trifluoromethyl)benzylic alcohol

ethanol
64-17-5

ethanol

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium tert-butylate In tetrahydrofuran at 100℃; for 24h; Inert atmosphere;37%
methyl 3-(4-(trifluoromethyl)phenyl)propanoate
849442-21-3

methyl 3-(4-(trifluoromethyl)phenyl)propanoate

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Heating;
With lithium aluminium tetrahydride In diethyl ether at 0℃;
With sodium tetrahydroborate In tetrahydrofuran; methanol Reflux;
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / Heating
2: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr
3: LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate
20754-22-7

methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr
2: LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate; lithium chloride; tetrabutylammomium bromide; lithium acetate dihydrate / N,N-dimethyl-formamide / 48 h / 20 °C
2: sodium tetrahydroborate / methanol / 0.17 h / 20 °C
View Scheme
3-(4-trifluoromethylphenyl)propanal
166947-09-7

3-(4-trifluoromethylphenyl)propanal

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 20℃; for 0.166667h;253 mg
3-(4-trifluoromethylphenyl)prop-2-yn-1-ol
173546-21-9

3-(4-trifluoromethylphenyl)prop-2-yn-1-ol

A

(Z)-3-(4-(trifluoromethyl)phenyl)-2-propene-1-ol
826994-11-0

(Z)-3-(4-(trifluoromethyl)phenyl)-2-propene-1-ol

B

3-(4-trifluoromethylphenyl)-2-propen-1-ol
125617-18-7

3-(4-trifluoromethylphenyl)-2-propen-1-ol

C

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate; hydrogen; cobalt(II) diacetate tetrahydrate; ethylenediamine In tetrahydrofuran; ethanol; water at 20℃; under 2250.23 Torr; for 12h; Autoclave; Glovebox; diastereoselective reaction;A n/a
B n/a
C n/a
4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

A

(Z)-3-(4-(trifluoromethyl)phenyl)-2-propene-1-ol
826994-11-0

(Z)-3-(4-(trifluoromethyl)phenyl)-2-propene-1-ol

B

3-(4-trifluoromethylphenyl)-2-propen-1-ol
125617-18-7

3-(4-trifluoromethylphenyl)-2-propen-1-ol

C

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere; Schlenk technique
2: ethylenediamine; sodium tetrahydroborate; hydrogen; cobalt(II) diacetate tetrahydrate / tetrahydrofuran; water; ethanol / 12 h / 20 °C / 2250.23 Torr / Autoclave; Glovebox
View Scheme
methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate
20754-22-7

methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate

A

3-(4-trifluoromethylphenyl)-2-propen-1-ol
125617-18-7

3-(4-trifluoromethylphenyl)-2-propen-1-ol

B

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With [Ru(2-(methylthio)-N-[(pyridin-2-yl)methyl]ethan-1-amine)(triphenylphosphine)Cl2]; potassium tert-butylate; hydrogen In toluene at 40℃; under 22502.3 Torr; for 4h; Overall yield = 63 %; Overall yield = 1.27 g;
4-trifluoromethylphenylacetylene
705-31-7

4-trifluoromethylphenylacetylene

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) chloride; bathophenanthroline / dimethyl sulfoxide / 12 h / 20 °C / 11251.1 Torr / Inert atmosphere; Autoclave
2: hydrogen / methanol / 18 h / 20 °C / 7500.75 Torr / Autoclave
3: hydrogen; molybdenum hexacarbonyl / 1-methyl-pyrrolidin-2-one / 14 h / 180 °C / 52505.3 Torr / Autoclave
View Scheme
C10H5F3O2*C9H19N

C10H5F3O2*C9H19N

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / methanol / 18 h / 20 °C / 7500.75 Torr / Autoclave
2: hydrogen; molybdenum hexacarbonyl / 1-methyl-pyrrolidin-2-one / 14 h / 180 °C / 52505.3 Torr / Autoclave
View Scheme
C10H9F3O2*C9H19N

C10H9F3O2*C9H19N

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

Conditions
ConditionsYield
With hydrogen; molybdenum hexacarbonyl In 1-methyl-pyrrolidin-2-one at 180℃; under 52505.3 Torr; for 14h; Autoclave;280 mg
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethylphenyl)-1-propyl trifluoromethanesulfonate

3-(4-trifluoromethylphenyl)-1-propyl trifluoromethanesulfonate

Conditions
ConditionsYield
With 2,4-lutidine In dichloromethane at -78℃; for 0.5h; Inert atmosphere;95%
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

(2E)-3-(4-trifluoromethylphenyl)prop-2-enal
95123-61-8

(2E)-3-(4-trifluoromethylphenyl)prop-2-enal

Conditions
ConditionsYield
With (S)-diphenylprolinol; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide; acetonitrile at 20℃; for 6h; stereoselective reaction;92%
[bromo(difluoro)methyl](trimethyl)silane
115262-01-6

[bromo(difluoro)methyl](trimethyl)silane

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

1-(3-(difluoromethoxy)propyl)-4-(trifluoromethyl)benzene

1-(3-(difluoromethoxy)propyl)-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium hydrogenfluoride In water at 20℃; for 12h;90%
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethylphenyl)propanal
166947-09-7

3-(4-trifluoromethylphenyl)propanal

Conditions
ConditionsYield
With pyridinium chlorochromate In dichloromethane at 0 - 20℃; for 3h;86.5%
Stage #1: 3-(4-(trifluoromethyl)phenyl)propan-1-ol With oxalyl dichloride In dichloromethane at -78℃; for 1h;
Stage #2: With triethylamine In dichloromethane at -78℃; for 2.5h;
79.31%
With pyridinium chlorochromate In dichloromethane at 20℃; for 4h;
benzoyl chloride
98-88-4

benzoyl chloride

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethylphenyl)propyl benzoate

3-(4-trifluoromethylphenyl)propyl benzoate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 5h;86%
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

1-(3-iodopropyl)-4-(trifluoromethyl)benzene

1-(3-iodopropyl)-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 1h; Appel Halogenation; Sealed tube;82%
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethylphenyl)propan-1-ol sulfamate ester
1042906-15-9

3-(4-trifluoromethylphenyl)propan-1-ol sulfamate ester

Conditions
ConditionsYield
With formic acid; isocyanate de chlorosulfonyle; triethylamine In dichloromethane at 0 - 25℃; Schlenk technique; Inert atmosphere;66%
With pyridine; formic acid; isocyanate de chlorosulfonyle In dichloromethane63%
1,2-bis(t-butyloxycarbonyl)hydrazine
16466-61-8

1,2-bis(t-butyloxycarbonyl)hydrazine

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

(S)-di-tert-butyl 1-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazine-1,2-dicarboxylate

(S)-di-tert-butyl 1-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)hydrazine-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: 1,2-bis(t-butyloxycarbonyl)hydrazine; 3-(4-(trifluoromethyl)phenyl)propan-1-ol With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 2,6-dimethylpyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(I) bromide In acetonitrile at 20℃; for 72h;
Stage #2: In methanol; acetonitrile at 0℃; enantioselective reaction;
59%
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethyl-phenyl)-propane-1-thiol

3-(4-trifluoromethyl-phenyl)-propane-1-thiol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C
2: ethanol / 24 h / Heating
3: NaOH / ethanol / 2 h / Heating
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

2-[3-(4-trifluoromethyl-phenyl)-propyl]-isothiourea; hydrobromide

2-[3-(4-trifluoromethyl-phenyl)-propyl]-isothiourea; hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C
2: ethanol / 24 h / Heating
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-[4-(Trifluoromethyl)phenyl]propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-pyrrolidinecarbothioate

3-[4-(Trifluoromethyl)phenyl]propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-2-pyrrolidinecarbothioate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C
2: ethanol / 24 h / Heating
3: NaOH / ethanol / 2 h / Heating
4: DCC; DMAP / CH2Cl2 / 24 h / 20 °C
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

2-{1-ethyl-3-methyl-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-N-methyl-2-phenyl-acetamide

2-{1-ethyl-3-methyl-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-N-methyl-2-phenyl-acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere
2: acetic acid / ethanol / 0.1 h / 130 °C / 10501.1 Torr / microwave irradiation
3: N-ethyl-N,N-diisopropylamine / 3-methyl-2-butyl-ketone / 24 h / 90 °C / Inert atmosphere
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

1-ethyl-3-methyl-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
955403-67-5

1-ethyl-3-methyl-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere
2: acetic acid / ethanol / 0.1 h / 130 °C / 10501.1 Torr / microwave irradiation
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

C18H18F3NO2

C18H18F3NO2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / ethyl acetate; water / 1.5 h / 0 °C
2: recombinant norcoclaurine synthase from Coptis japonica, first 29 amino acid residues removed / dimethyl sulfoxide / 0.25 h / 30 °C / pH 7 / Enzymatic reaction
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

(R)-3-(4-trifluoromethylbenzyl)-4-oxobutyronitrile

(R)-3-(4-trifluoromethylbenzyl)-4-oxobutyronitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 0.25 h / 0 °C
2: (2R,5S)-2-tert-butyl-3,5-dimethylimidazolidin-4-one trifluoromethanesulfonate; tris(bipyridine)ruthenium(II) dichloride hexahydrate; 2,6-dimethylpyridine / dimethyl sulfoxide / 8 h / 23 °C / Inert atmosphere; Sealed tube; Irradiation
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-(4-trifluoromethylbenzyl)-4-oxobutyronitrile

3-(4-trifluoromethylbenzyl)-4-oxobutyronitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 0.25 h / 0 °C
2: C9H18N2O*CHF3O3S; tris(bipyridine)ruthenium(II) dichloride hexahydrate; 2,6-dimethylpyridine / dimethyl sulfoxide / 8 h / 23 °C / Inert atmosphere; Sealed tube; Irradiation
View Scheme
3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

C12H12F3NO

C12H12F3NO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridinium chlorochromate / dichloromethane / 0.25 h / 0 °C
2: (2R,5S)-2-tert-butyl-3,5-dimethylimidazolidin-4-one trifluoromethanesulfonate; tris(bipyridine)ruthenium(II) dichloride hexahydrate; 2,6-dimethylpyridine / dimethyl sulfoxide / 8 h / 23 °C / Inert atmosphere; Sealed tube; Irradiation
3: sodium tetrahydroborate / dichloromethane; methanol / 3 h / 0 °C
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

3-oxo-3-(4-trifluoromethylphenyl)propyl benzoate

3-oxo-3-(4-trifluoromethylphenyl)propyl benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 5 h / 0 - 20 °C
2: cobalt(II) acetate; manganese(III) triacetate dihydrate; oxygen; 4,5,6,7-tetrafluoro-2-hydroxy-3-(2,2,2-trifluoroethoxy)-3-trifluoromethylisoindolin-1-one / 2,2,2-trifluoroethanol / 48 h / 60 °C / 760.05 Torr
View Scheme
1,2-bis(t-butyloxycarbonyl)hydrazine
16466-61-8

1,2-bis(t-butyloxycarbonyl)hydrazine

3-(4-(trifluoromethyl)phenyl)propan-1-ol
180635-74-9

3-(4-(trifluoromethyl)phenyl)propan-1-ol

C27H32F3N3O8

C27H32F3N3O8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(I) bromide; 2,6-dimethylpyridine; (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 72 h / 20 °C
1.2: 0 °C
2.1: pyridine / dichloromethane
View Scheme

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