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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

1-(((4-NITROPHENOXY)CARBONYL)OXY)ETHYL ISOBUTYRATE

Cas:194995-47-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Propanoic acid, 2-Methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester/ LIDE PHARMA- Factory supply / Best price

Cas:194995-47-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

1-(((4-Nitrophenoxy)carbonyl)oxy)ethyl isobutyrate

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

194995-47-6

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Propanoic acid, 2-Methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

1-(((4-Nitrophenoxy)carbonyl)oxy)ethyl isobutyrate

Cas:194995-47-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

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Zouping Mingxing Chemical Co.,Ltd.

Productnumber:gabapentinintermediates Productname:acrylicacid,2-methyl-1-[[(4-nitrobenzeneoxygenradicals)carbonyl]foxy]ethylester CasNo.…

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Trading Company

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Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemical Co.Ltd

Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en

Propanoic acid, 2-methyl-, 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl ester

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Alchemist-pharm chemical Technology Co. Ltd.

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

194995-47-6

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

1-((4-nitro-phenoxy)carbonyloxy)ethyl isobutyrate

Cas:194995-47-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(1-chloroethyl)-(4-nitrophenyl)carbonate
101623-69-2

(1-chloroethyl)-(4-nitrophenyl)carbonate

mercuric dimethyl acetate
19348-33-5

mercuric dimethyl acetate

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

Conditions
ConditionsYield
With acetic acid Heating;85%
In dichloromethane at 45℃; for 24h;52%
isobutyric Acid
79-31-2

isobutyric Acid

(1-chloroethyl)-(4-nitrophenyl)carbonate
101623-69-2

(1-chloroethyl)-(4-nitrophenyl)carbonate

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: isobutyric Acid With zinc(II) oxide In toluene at 105℃; for 1h;
Stage #2: (1-chloroethyl)-(4-nitrophenyl)carbonate; sodium iodide In toluene at 60℃; for 24h; Product distribution / selectivity;
75%
With sodium iodide; zinc(II) oxide at 60 - 70℃; for 24h;40 mg
4-nitro-phenol
100-02-7

4-nitro-phenol

carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

isobutyric Acid
79-31-2

isobutyric Acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 4-nitro-phenol; carbonochloridic acid 1-chloro-ethyl ester With tributyl-amine In toluene at 20℃;
Stage #2: isobutyric Acid With zinc(II) oxide; sodium iodide In toluene at 75℃; for 10h; Product distribution / selectivity;
60%
4-nitro-phenol
100-02-7

4-nitro-phenol

thiophosphoric acid-chloride O,O'-diisobutyl ester

thiophosphoric acid-chloride O,O'-diisobutyl ester

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / TEA / Ambient temperature
2: 85 percent / MeCO2H / Heating
View Scheme
4-nitro-phenol
100-02-7

4-nitro-phenol

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridine / dichloromethane / 0.17 h / 0 - 4 °C
1.2: 20 °C
2.1: zinc(II) oxide; sodium iodide / 24 h / 60 - 70 °C
View Scheme
H-Gpn-OH
60142-96-3

H-Gpn-OH

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

gabapentin enacarbil
478296-72-9

gabapentin enacarbil

Conditions
ConditionsYield
With chloro-trimethyl-silane; tributyl-amine In toluene at 20℃; for 24h; Product distribution / selectivity;100%
1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl isobutyrate

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl isobutyrate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 5℃; for 4h;88.2%
(7S)-4,7,8-trimethyl-2-[[1-[[6-(trifluoromethyl)-3-pyridyl]methyl]pyrazol-4-yl]methylamino]-5,7-dihydropteridin-6-one

(7S)-4,7,8-trimethyl-2-[[1-[[6-(trifluoromethyl)-3-pyridyl]methyl]pyrazol-4-yl]methylamino]-5,7-dihydropteridin-6-one

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-((((1-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazol-4-yl)methyl)((7S)-4,7,8-trimethyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)carbamoyl)oxy)ethyl isobutyrate

1-((((1-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazol-4-yl)methyl)((7S)-4,7,8-trimethyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)carbamoyl)oxy)ethyl isobutyrate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 100℃; for 24h; Sealed tube;85.16%
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

C17H22ClNO6

C17H22ClNO6

Conditions
ConditionsYield
Stage #1: (R)-(-)-baclofen hydrochloride With chloro-trimethyl-silane; triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: 1-{[(4-nitrophenoxy)carbonyl]oxy}ethyl 2-methylpropanoate In dichloromethane at 20℃; for 3h;
73%
methyl (2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-2-carboxylate

methyl (2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-2-carboxylate

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-(1-(isobutyryloxy)ethyl) 2-methyl (2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-1,2-dicarboxylate

1-(1-(isobutyryloxy)ethyl) 2-methyl (2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;67%
CH2O2*C24H32N2O4S3

CH2O2*C24H32N2O4S3

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

isobutyric acid 1-{1-[2-(benzyloxycarbonylmethylcarbamoyl)-3-phenylpropyldisulfanylmethyl]-3-methanesulfinylpropylcarbamoyloxy}ethyl ester

isobutyric acid 1-{1-[2-(benzyloxycarbonylmethylcarbamoyl)-3-phenylpropyldisulfanylmethyl]-3-methanesulfinylpropylcarbamoyloxy}ethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 72h;59%
(2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-2-carboxylic acid

(2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)pyrrolidine-2-carboxylic acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)-1-((1-(isobutyryloxy)ethoxy)carbonyl)pyrrolidine-2-carboxylic acid

(2S,4S)-4-(3-((4-(dimethylamino)-4-phenylcyclohexyl)methyl)phenoxy)-1-((1-(isobutyryloxy)ethoxy)carbonyl)pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;47%
C22H28NO6P

C22H28NO6P

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

{4-ethoxy-1-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]-4-oxobutyl}(2-phenylethyl)phosphinic acid

{4-ethoxy-1-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]-4-oxobutyl}(2-phenylethyl)phosphinic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 0 - 20℃;40%
C32H45N7O3

C32H45N7O3

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

C39H55N7O7

C39H55N7O7

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 2h; Inert atmosphere;30.91%
C30H43N7O2

C30H43N7O2

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

C37H53N7O6

C37H53N7O6

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0℃; for 2h; Inert atmosphere;30.91%
C2HF3O2*C17H26N2O4S3

C2HF3O2*C17H26N2O4S3

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

isobutyric acid 1-{1-2-[2-(carboxymethylcarbamoyl)-3-phenylpropyldisulfanylmethyl]-3-methanesulfinylpropylcarbamoyloxy}ethyl ester

isobutyric acid 1-{1-2-[2-(carboxymethylcarbamoyl)-3-phenylpropyldisulfanylmethyl]-3-methanesulfinylpropylcarbamoyloxy}ethyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 21h;28.1%
CL191,121
161855-50-1

CL191,121

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(2R,3R)-2-[(1-isobutyryloxy-ethoxycarbonylamino)-methyl]-tetrahydro-furan-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid

(4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(2R,3R)-2-[(1-isobutyryloxy-ethoxycarbonylamino)-methyl]-tetrahydro-furan-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(2R,3R)-2-[(1-isobutyryloxy-ethoxycarbonylamino)-methyl]-tetrahydro-furan-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid ethoxycarbonyloxymethyl ester

(4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(2R,3R)-2-[(1-isobutyryloxy-ethoxycarbonylamino)-methyl]-tetrahydro-furan-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid ethoxycarbonyloxymethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 77 percent / K2CO3 / acetonitrile / Ambient temperature
View Scheme
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

pregabilin
148553-50-8

pregabilin

A

3-{[(α-(R)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid
1174748-30-1

3-{[(α-(R)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid

B

3-{[(α-(S)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid

3-{[(α-(S)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid

Conditions
ConditionsYield
Stage #1: pregabilin With chloro-trimethyl-silane; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: 1-{[(4-nitrophenoxy)carbonyl]oxy}ethyl 2-methylpropanoate In dichloromethane at 20℃; for 1.5h;
1-{(4-bromophenylalaninyl)aminomethyl}-1-cyclohexane-acetic acid
478296-99-0

1-{(4-bromophenylalaninyl)aminomethyl}-1-cyclohexane-acetic acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-{[N-[(α-isobutanoyloxyethoxy)carbonyl]-4-bromophenylalaninyl]-aminomethyl}-1-cyclohexaneacetic acid
478296-98-9

1-{[N-[(α-isobutanoyloxyethoxy)carbonyl]-4-bromophenylalaninyl]-aminomethyl}-1-cyclohexaneacetic acid

Conditions
ConditionsYield
Stage #1: 1-{(4-bromophenylalaninyl)aminomethyl}-1-cyclohexane-acetic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: 1-{[(4-nitrophenoxy)carbonyl]oxy}ethyl 2-methylpropanoate In dichloromethane at 0 - 20℃; for 7h;
(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl (2S)-2-[(3S)-3-aminopyrrolidin-1-yl]-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate trihydrochloride

(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl (2S)-2-[(3S)-3-aminopyrrolidin-1-yl]-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate trihydrochloride

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl (2S)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-{(3S)-3-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pyrrolidin-1-yl}propanoate
1277173-49-5

(5-tert-butyl-2-oxo-1,3-dioxol-4-yl)methyl (2S)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-{(3S)-3-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pyrrolidin-1-yl}propanoate

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 11h; Cooling with ice;
(2S)-2-[(3S)-3-aminopyrrolidin-1-yl]-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoic acid
1277173-20-2

(2S)-2-[(3S)-3-aminopyrrolidin-1-yl]-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoic acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(2S)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-{(3S)-3-[({1[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pyrrolidin-1-yl}propanoic acid
1277173-19-9

(2S)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-{(3S)-3-[({1[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pyrrolidin-1-yl}propanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃;
(2S)-5-amino-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid
1224846-59-6

(2S)-5-amino-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(2S)-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)-5-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pentanoic acid
1224847-42-0

(2S)-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)-5-[({1-[(2-methylpropanoyl)oxy]ethoxy}carbonyl)amino]pentanoic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 15h;
C29H32ClFN2O4

C29H32ClFN2O4

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

C36H42ClFN2O8

C36H42ClFN2O8

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20 - 25℃; Inert atmosphere;555 mg
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 25℃; Inert atmosphere;555 mg
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride salt

1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride salt

(E)-1-(((amino(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)phenyl)methylene)carbamoyl)oxy)ethyl isobutyrate

(E)-1-(((amino(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)phenyl)methylene)carbamoyl)oxy)ethyl isobutyrate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 48h;0.15 g
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(2S)-5-({[(1R)-1-(isobutyryloxy)ethoxy]carbonyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid
1335138-79-8

(2S)-5-({[(1R)-1-(isobutyryloxy)ethoxy]carbonyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / -5 - 0 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRALCEL OJ-H / hexane; isopropyl alcohol / Resolution of racemate
3: triethylamine; sodium hydroxide / acetonitrile; water / 20 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRAZYME L-2,C4 / aq. phosphate buffer; tert-butyl methyl ether / 38 h / 20 °C / Enzymatic reaction
3: triethylamine; sodium hydroxide / acetonitrile; water / 20 h / 0 °C
View Scheme
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

(2S)-5-({[(1S)-1-(isobutyryloxy)ethoxy]carbonyl}amino)2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

(2S)-5-({[(1S)-1-(isobutyryloxy)ethoxy]carbonyl}amino)2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRALCEL OJ-H / hexane; isopropyl alcohol / Resolution of racemate
3: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 4 h / 0 °C
View Scheme
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl (R)-isobutyrate

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl (R)-isobutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRALCEL OJ-H / hexane; isopropyl alcohol / Resolution of racemate
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRAZYME L-2,C4 / aq. phosphate buffer; tert-butyl methyl ether / 38 h / 20 °C / Enzymatic reaction
View Scheme
1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester
194995-47-6

1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl (S)-isobutyrate

1-{[(1,1,1,3,3,3-hexafluoro-2-propoxy)carbonyl]oxy}ethyl (S)-isobutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 0 - 5 °C
2: CHIRALCEL OJ-H / hexane; isopropyl alcohol / Resolution of racemate
View Scheme

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