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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-Chloro-2-fluoroaniline 2106-04-9 Manufacturer/High quality/Best price/In stock

Cas:2106-04-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Chloro-2-fluoroaniline Manufacturer/High quality/Best price/In stock

Cas:2106-04-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3-Chloro-2-Fluoroaniline

Cas:2106-04-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - 3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

3-Chloro-2-fluoroaniline CAS:2106-04-9

Cas:2106-04-9

Min.Order:1 Kilogram

FOB Price: $160.0 / 180.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 2106-04-9 with best quality

Cas:2106-04-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzenamine,3-chloro-2-fluoro-

Cas:2106-04-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2106-04-9

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Chloro-2-Fluoroaniline

Cas:2106-04-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 3-Chloro-2-Fluoroaniline CAS No.:2106-04-9 Molecule Formula:C6H5ClFN Molecule Weight:145.56 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITE

High Quality 3-Chloro-2-Fluoroaniline in stock

Cas:2106-04-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

3-Chloro-2-fluoroaniline Basic information Product Name: 3-Chloro-2-fluoroaniline Synonyms: BUTTPARK 29\01-51;TIMTEC-BB SBB004108;3-CHLORO-2-FLUOROANILINE;3-Chloro-2-fluoroaniline 97%;3-Chloro-2-fluoroaniline97%;3-chloro-2-fluoro-benzenamin;3-

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Colorless or light yellow liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmac

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Chloro-2-fluoroaniline cas no. 2106-04-9 97%

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Chloro-2-Fluoroaniline

Cas:2106-04-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Chloro-2-Fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3-Chloro-2-fluoroaniline CAS No.2106-04-9

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:intermediate

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:clear light yellow liquid Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use

3-Chloro-2-fluoroaniline

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-Chloro-2-fluoroaniline cas 2106-04-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-Chloro-2-fluoroaniline cas 2106-04-9

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

2106-04-9 Application:intermediate

Benzenamine, 3-chloro-2-fluoro-

Cas:2106-04-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-chloro-2-fluoro-3-nitrobenzene
2106-49-2

1-chloro-2-fluoro-3-nitrobenzene

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

Conditions
ConditionsYield
With iron
1,2-Dichloro-3-nitrobenzene
3209-22-1

1,2-Dichloro-3-nitrobenzene

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide; potassium fluoride / 150 °C
2: iron
View Scheme
4-chloro-7-methoxy-6-{[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]methoxy}quinazoline

4-chloro-7-methoxy-6-{[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]methoxy}quinazoline

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[(2S)-pyrrolidin-2-yl]methoxy}quinazoline hydrochloride

4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[(2S)-pyrrolidin-2-yl]methoxy}quinazoline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 1h; Heating / reflux;100%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

acetic anhydride
108-24-7

acetic anhydride

N-(3-chloro-2-fluorophenyl)acetamide
395-36-8

N-(3-chloro-2-fluorophenyl)acetamide

Conditions
ConditionsYield
for 2h; Reflux;100%
With sodium hydroxide; acetic acid
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

6-acetoxy-4-chloro-7-methoxyquinazoline
230955-75-6

6-acetoxy-4-chloro-7-methoxyquinazoline

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
740081-22-5

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Conditions
ConditionsYield
In acetonitrile at 80℃;99%
In isopropyl alcohol Heating;98%
In isopropyl alcohol for 3h; Reflux;93%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4-chloro-6-nitro-7-methoxyquinazoline
55496-69-0

4-chloro-6-nitro-7-methoxyquinazoline

4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-nitroquinazoline

4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-nitroquinazoline

Conditions
ConditionsYield
In acetonitrile at 80℃; for 0.5h;99%
With acetic acid; triethylamine for 48h;94%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-((3-chloro-2-fluorophenyl)amino)-2-oxoacetate

ethyl 2-((3-chloro-2-fluorophenyl)amino)-2-oxoacetate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h;98%
4-chloro-7-fluoro-6-nitroquinazoline hydrochloride
1000397-30-7

4-chloro-7-fluoro-6-nitroquinazoline hydrochloride

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine hydrochloride
1000397-23-8

N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 3h;97%
In isopropyl alcohol Reflux;
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

N,N'-bis(3-chloro-2-fluoro-phenyl)formamidine
1252041-51-2

N,N'-bis(3-chloro-2-fluoro-phenyl)formamidine

Conditions
ConditionsYield
With acetic acid In cyclohexane at 48℃; for 6h; Inert atmosphere; Industrial scale;96.2%
With acetic acid In cyclohexane at 48℃; for 12h;93%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

7-benzyloxy-4-chloro-6-methoxyquinazoline
162364-72-9

7-benzyloxy-4-chloro-6-methoxyquinazoline

7-(benzyloxy)-N-(3-chloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride
848415-65-6

7-(benzyloxy)-N-(3-chloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 80℃;96%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

6-bromo-4-chloro-7-fluoropyrido[3,2-d]pyrimidine

6-bromo-4-chloro-7-fluoropyrido[3,2-d]pyrimidine

6-bromo-N-(3-chloro-2-fluorophenyl)-7-fluoropyrido[3,2-d]pyrimidin-4-amine

6-bromo-N-(3-chloro-2-fluorophenyl)-7-fluoropyrido[3,2-d]pyrimidin-4-amine

Conditions
ConditionsYield
In acetonitrile at 25℃; for 1h;96%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

6-acetoxy-4-chloro-7-methoxyquinazoline
230955-75-6

6-acetoxy-4-chloro-7-methoxyquinazoline

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
612501-52-7

4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity; Heating / reflux;95%
4-chloro-6-iodoquinazoline
98556-31-1

4-chloro-6-iodoquinazoline

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

N-(3-chloro-2-fluorophenyl)-6-iodoquinazolin-4-amine

N-(3-chloro-2-fluorophenyl)-6-iodoquinazolin-4-amine

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 2h;95%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

N'-(3-chloro-2-fluoro-phenyl)-N,N-dimethyl-formamidine
1252041-52-3

N'-(3-chloro-2-fluoro-phenyl)-N,N-dimethyl-formamidine

Conditions
ConditionsYield
With acetic acid In 2-methyltetrahydrofuran at 76℃; for 3h;93%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

6-acetoxy-4-chloro-7-methoxyquinazoline
230955-75-6

6-acetoxy-4-chloro-7-methoxyquinazoline

4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate monohydrochloride
612501-80-1

4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate monohydrochloride

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 3h; Heating / reflux;92%
In isopropyl alcohol at 80℃; for 3h;92%
In isopropyl alcohol at 80℃; for 3h; Inert atmosphere;92%
6-[1-(tert-butoxycarbonyl)piperidin-3-yloxy]-4-chloro-7-methoxyquinazoline
612501-69-6

6-[1-(tert-butoxycarbonyl)piperidin-3-yloxy]-4-chloro-7-methoxyquinazoline

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4-(3-chloro-2-fluoroanilino)-7-methoxy-6-(piperidin-3-yloxy)quinazoline dihydrochloride

4-(3-chloro-2-fluoroanilino)-7-methoxy-6-(piperidin-3-yloxy)quinazoline dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; acetonitrile for 1h; Heating / reflux;91%
ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre
1041853-11-5

ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate
1041853-33-1

ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

Conditions
ConditionsYield
With acetic acid In ethanol at 75℃;88%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

benzoyl chloride
98-88-4

benzoyl chloride

N-(3-chloro-2-fluorophenyl)benzamide

N-(3-chloro-2-fluorophenyl)benzamide

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 60℃; for 2h; pH=8;87%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

2-mercapto-7-chlorobenzothiazole
1849-73-6

2-mercapto-7-chlorobenzothiazole

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120 - 130℃; Inert atmosphere;87%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

ethyl 5-chloro-1-(3,5-difluorobenzyl)-4-(2-oxoethyl)-1H-pyrazole-3-carboxylate

ethyl 5-chloro-1-(3,5-difluorobenzyl)-4-(2-oxoethyl)-1H-pyrazole-3-carboxylate

ethyl 5-chloro-4-(2-((3-chloro-2-fluorophenyl)amino)ethyl)-1-(3,5-difluorobenzyl)-1H-pyrazole-3-carboxylate

ethyl 5-chloro-4-(2-((3-chloro-2-fluorophenyl)amino)ethyl)-1-(3,5-difluorobenzyl)-1H-pyrazole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 3-chloro-2-fluoroaniline; ethyl 5-chloro-1-(3,5-difluorobenzyl)-4-(2-oxoethyl)-1H-pyrazole-3-carboxylate With acetic acid In 1,2-dichloro-ethane for 0.166667h;
Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 30℃; for 3h;
86%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4-chloro-7,8-dihydro[1,4]-dioxino[2,3-g]quinazoline
52791-05-6

4-chloro-7,8-dihydro[1,4]-dioxino[2,3-g]quinazoline

N-(3-chloro-2-fluorophenyl)-7,8-dihydro[1,4]dioxino[2,3-g]quinazolin-4-amine

N-(3-chloro-2-fluorophenyl)-7,8-dihydro[1,4]dioxino[2,3-g]quinazolin-4-amine

Conditions
ConditionsYield
Stage #1: 3-chloro-2-fluoroaniline; 4-chloro-7,8-dihydro[1,4]-dioxino[2,3-g]quinazoline In isopropyl alcohol at 80℃; Microwave irradiation;
Stage #2: With sodium hydrogencarbonate In water
85%
In N,N-dimethyl-formamide for 24h; Inert atmosphere; Heating;82%
In N,N-dimethyl-formamide at 60℃; for 24h;82%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid
88495-54-9

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

C12H14ClFN2O

C12H14ClFN2O

Conditions
ConditionsYield
Stage #1: 3-chloro-2-fluoroaniline; (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 13h; Inert atmosphere;
Stage #2: With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 22h; Inert atmosphere;
85%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

(1-adamantyl)methyl isocyanate
69887-12-3

(1-adamantyl)methyl isocyanate

1-(adamantan-1-ylmethyl)-3-(3-chloro-2-fluorophenyl)urea

1-(adamantan-1-ylmethyl)-3-(3-chloro-2-fluorophenyl)urea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 12h;85%
3-(4-chloro-3-nitrophenyl)-3-fluoro-2-benzofuran-1(3H)-one

3-(4-chloro-3-nitrophenyl)-3-fluoro-2-benzofuran-1(3H)-one

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

(3-chloro-2-fluorophenyl)-3-(4-chloro-3-nitrophenyl)-3-hydroxy-2,3-dihydro-1H-isoindol-1-one
870605-90-6

(3-chloro-2-fluorophenyl)-3-(4-chloro-3-nitrophenyl)-3-hydroxy-2,3-dihydro-1H-isoindol-1-one

Conditions
ConditionsYield
With N,N-dimethyl-aniline In 1,2-dichloro-ethane at 70℃; for 20h;84%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

(R)-4-chloro-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

(R)-4-chloro-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl-2,4-dimethylpiperazinyl-1-carboxylic acid ester

(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl-2,4-dimethylpiperazinyl-1-carboxylic acid ester

Conditions
ConditionsYield
In isopropyl alcohol for 3h; Reflux;83.1%
In isopropyl alcohol for 3h; Reflux;83.6%
methyl 8-(1-bromoethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate
1296271-41-4

methyl 8-(1-bromoethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

methyl 8-(1-(3-chloro-2-fluorophenylamino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate
1296271-42-5

methyl 8-(1-(3-chloro-2-fluorophenylamino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate

Conditions
ConditionsYield
In dichloromethane at 20 - 50℃; for 32h;82%
In dichloromethane at 20 - 50℃; for 32h;82%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4(5)formylimidazole
3034-50-2

4(5)formylimidazole

(3-chloro-2-fluoro-phenyl)-(3H-imidazol-4-ylmethyl)-amine
1020818-01-2

(3-chloro-2-fluoro-phenyl)-(3H-imidazol-4-ylmethyl)-amine

Conditions
ConditionsYield
Stage #1: 3-chloro-2-fluoroaniline; 4(5)formylimidazole In methanol at 60℃;
Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 4h;
Stage #3: With water In methanol
81%
3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline
1046452-66-7

3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

4-[(3-chloro-2-fluoro-phenyl)amino]-6-(4-oxo-cyclohexyloxy)-7-methoxy-quinazoline
1046137-42-1

4-[(3-chloro-2-fluoro-phenyl)amino]-6-(4-oxo-cyclohexyloxy)-7-methoxy-quinazoline

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline With triethylamine; trichlorophosphate In acetonitrile at 40℃; for 2h; Reflux;
Stage #2: 3-chloro-2-fluoroaniline With triethylamine at 20 - 40℃; for 5h; Reflux;
Stage #3: With hydrogenchloride; sodium hydroxide In dichloromethane; water; isopropyl alcohol
80%
Stage #1: 3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline With triethylamine; trichlorophosphate In acetonitrile at 40℃; for 2h; Inert atmosphere; Reflux;
Stage #2: 3-chloro-2-fluoroaniline With triethylamine In acetonitrile at 20 - 40℃; Inert atmosphere;
Stage #3: With hydrogenchloride In water; isopropyl alcohol at 20℃;
73%
(2S,4S)-4-(4-chloro-quinazolin-7-yloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
849345-43-3

(2S,4S)-4-(4-chloro-quinazolin-7-yloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

methyl (4S)-4-({4-[(3-chloro-2-fluorophenyl)amino]quinazolin-7-yl}oxy)-L-prolinate
849345-44-4

methyl (4S)-4-({4-[(3-chloro-2-fluorophenyl)amino]quinazolin-7-yl}oxy)-L-prolinate

Conditions
ConditionsYield
Stage #1: (2S,4S)-4-(4-chloro-quinazolin-7-yloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; 3-chloro-2-fluoroaniline With hydrogenchloride In 1,4-dioxane; acetonitrile for 2h; Heating / reflux;
Stage #2: With ammonia In methanol
79%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

potassium thioacyanate
333-20-0

potassium thioacyanate

3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

3-chloropentane-2,4-dione
1694-29-7

3-chloropentane-2,4-dione

2-(3,4,5-trimethoxybenzoylimino)-3-(3-chloro-2-fluorophenyl)-4-methyl-5-acetyl-1,3-thiazoline

2-(3,4,5-trimethoxybenzoylimino)-3-(3-chloro-2-fluorophenyl)-4-methyl-5-acetyl-1,3-thiazoline

Conditions
ConditionsYield
Stage #1: potassium thioacyanate; 3,4,5-Trimethoxybenzoyl chloride In acetonitrile
Stage #2: 3-chloro-2-fluoroaniline; 3-chloropentane-2,4-dione With 1-methyl-1H-imidazole In acetonitrile at 70 - 80℃; for 1h;
76%
2-hydroxy-4-(2-methoxyethoxy)benzoic acid
761455-13-4

2-hydroxy-4-(2-methoxyethoxy)benzoic acid

3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(3-chloro-2-fluorobenzyl)-2-hydroxy-4-(2-methoxyethoxy)benzamide

N-(3-chloro-2-fluorobenzyl)-2-hydroxy-4-(2-methoxyethoxy)benzamide

Conditions
ConditionsYield
Stage #1: 2-hydroxy-4-(2-methoxyethoxy)benzoic acid; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 3-chloro-2-fluoroaniline In tetrahydrofuran at 80℃; Inert atmosphere;
76%
3-chloro-2-fluoroaniline
2106-04-9

3-chloro-2-fluoroaniline

(E)-N'-(2-cyano-4-nitrophenyl)-N,N'-dimethylformimidamide

(E)-N'-(2-cyano-4-nitrophenyl)-N,N'-dimethylformimidamide

N-(2-fluoro-3-chlorophenyl)-6-nitroquinazolin-4-amine
1290545-22-0

N-(2-fluoro-3-chlorophenyl)-6-nitroquinazolin-4-amine

Conditions
ConditionsYield
With acetic acid for 1h; Reflux;75%

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