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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-, ethyl ester Manufacturer/High quality/Best price/In stock

Cas:2199-51-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 2,4-Dimethyl-1H-Pyrrole-3-Carboxylate supplier in China

Cas:2199-51-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:2199-51-1/High quality/Factory supply

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Dimethyl-3-pyrrolecarboxylic acid ethyl ester

Cas:2199-51-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate CAS No. 2199-

2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethylester

Cas:2199-51-1

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2,4-Dimethyl-1H-Pyrrole-3-carboxylic acid ethyl ester)

Cas:2199-51-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM -Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Pure CAS 2199-51-1 with high quality products

Cas:2199-51-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-, ethyl ester 2199-51-1

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate CAS:2199-51-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hi

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate CAS:2199-51-1

Cas:2199-51-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2199-51-1

Cas:2199-51-1

Min.Order:0

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 2,4-Dimethyl-1H-Pyrrole-3-Carboxylate

Cas:2199-51-1

Min.Order:0

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Type:Manufacturers

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER

Cas:2199-51-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-Dimethyl-1H-Pyrrole-3-carboxylic acid ethyl ester

Cas:2199-51-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 2,4-dimethylpyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,4-Dimethyl-1H-pyrrole-3-carboxylicacidethylester CAS NO.2199-51-1

Cas:2199-51-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylateAppearance:White to light brown crystalline Storage:2-8 ℃ or Others Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect.

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:2,4-Dimethyl-1H-pyrr

1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-, ethyl ester

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Ethyl 2,4-Dimethyl-1H-Pyrrole-3-Carboxylate CAS No.:2199-51-1 Molecule Formula:C9H13NO2 Molecule Weight:167.21 Purity: 98.0% Package: 25kg/drum Description:Red to brown powder Manufacture Standards:Enterprise Standard

High Quality Ethyl 2,4-Dimethyl-1H-Pyrrole-3-Carboxylate

Cas:2199-51-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-, ethyl ester

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Manufacturers

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JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1

Cas:2199-51-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Ethyl 2,4-dimethyl-1h-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,4-Dimethyl-1H-Pyrrole-3-carboxylic acid ethyl ester cas no. 2199-51-1 98%

Cas:2199-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
86770-31-2

2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol at 65℃; for 4h; Inert atmosphere;99%
With hydrogenchloride; water In ethanol at 70℃; for 3h;91%
With hydrogenchloride In ethanol; water at 65℃; for 1h;89%
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester
5442-91-1

3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Temperature; Inert atmosphere;98.5%
at 200℃; for 0.0833333h; Temperature; Inert atmosphere;98.5%
Heating;80%
(E)-ethyl 3-((tert-butoxycarbonyl)(prop-2-yn-1-yl)amino)but-2-enoate

(E)-ethyl 3-((tert-butoxycarbonyl)(prop-2-yn-1-yl)amino)but-2-enoate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h; Inert atmosphere;89%
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
2: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
2: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
2,4-dimethylpyrrole-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl ester
817162-41-7

2,4-dimethylpyrrole-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl ester

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 0.0833333h; Reflux;87%
(E)-3-(2-Hydroxy-propylamino)-but-2-enoic acid ethyl ester

(E)-3-(2-Hydroxy-propylamino)-but-2-enoic acid ethyl ester

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); 2,4,6-trimethylphenyl bromide; potassium carbonate In N,N-dimethyl-formamide at 150℃; for 3h;76%
With tetrakis(triphenylphosphine) palladium(0); 2,4,6-trimethylphenyl bromide; potassium carbonate In N,N-dimethyl-formamide at 150℃; for 3h;76%
C14H21NO4

C14H21NO4

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran for 0.0833333h; Reflux;73%
methyllithium
917-54-4

methyllithium

ethyl 3-((N-methoxy-N-methylcarbamoyl)methylamino)crotonate
231609-63-5

ethyl 3-((N-methoxy-N-methylcarbamoyl)methylamino)crotonate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
In tetrahydrofuran at -10℃; for 1h;62%
(E)-4-diazo-3-methylbut-2-enoic acid ethyl ester
1426858-39-0

(E)-4-diazo-3-methylbut-2-enoic acid ethyl ester

acetonitrile
75-05-8

acetonitrile

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With silver hexafluoroantimonate In dichloromethane at 20℃; for 1h; Inert atmosphere;15%
diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate
2436-79-5

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With piperidine at 250℃; unter Wasserstoff;
With sodium hydroxide Erhitzen des bei 100grad getrockneten Reaktionsprodukts mit Glycerin;
Multi-step reaction with 2 steps
1: water; potassium hydroxide / ethanol / 10 h / 50 - 60 °C
2: Inert atmosphere
View Scheme
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester
68999-91-7

3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-benzyl ester 4-ethyl ester

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With methanol; nickel at 110 - 120℃; under 73550.8 Torr; Hydrogenation;
2,4-dimethyl-5-(trimethyl-pyrrol-2-ylidenemethyl)-pyrrole-3-carboxylic acid ethyl ester

2,4-dimethyl-5-(trimethyl-pyrrol-2-ylidenemethyl)-pyrrole-3-carboxylic acid ethyl ester

A

2,3,4-trimethyl-1H-pyrrole
3855-78-5

2,3,4-trimethyl-1H-pyrrole

B

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
bei der trockenen Destillation;
(Z)-2-oxopropanal oxime
31915-82-9

(Z)-2-oxopropanal oxime

ethyl acetoacetate
141-97-9

ethyl acetoacetate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide; sodium dithionite
ethyl acetoacetate
141-97-9

ethyl acetoacetate

propanone 1-oxime
306-44-5

propanone 1-oxime

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With acetic acid; zinc
Behandlung mit Zinkstaub in verd. Essigsaeure;
3.5-dimethyl-pyrrole-dicarboxylic acid-(2.4)-monoethyl ester-(4)

3.5-dimethyl-pyrrole-dicarboxylic acid-(2.4)-monoethyl ester-(4)

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
beim Erhitzen ueber den Schmelzpunkt;
ethyl acetoacetate
141-97-9

ethyl acetoacetate

hydrochloride of aminoacetone

hydrochloride of aminoacetone

A

2,4-dimethyl-1H-pyrrole-3-carboxylic acid
17106-13-7

2,4-dimethyl-1H-pyrrole-3-carboxylic acid

B

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide
ammonia
7664-41-7

ammonia

ethyl acetoacetate
141-97-9

ethyl acetoacetate

chloroacetone
78-95-5

chloroacetone

A

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

B

2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-52-2

2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

ethyl acetoacetate
141-97-9

ethyl acetoacetate

Ba(CN)2

Ba(CN)2

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 168 h / 20 °C
2: 76 percent / Pd(PPh3)4; K2CO3; mesityl bromide / dimethylformamide / 3 h / 150 °C
View Scheme
ethyl acetoacetate
141-97-9

ethyl acetoacetate

diazonium-salt from 2-amino-phenylarsonic acid

diazonium-salt from 2-amino-phenylarsonic acid

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / 4 Angstroem molecular sieves / tetrahydrofuran / 168 h / Ambient temperature
2: 76 percent / 2 molpercent Pd(PPh3)4, mesityl bromide, potassium carbonate / dimethylformamide / 3 h / 150 °C
View Scheme
butyl acetoacetate
591-60-6

butyl acetoacetate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; aqueous NaNO2 / Erwaermen des Reaktionsgemisches mit Acetessigsaeure-aethylester, Zink-Pulver und Essigsaeure
2: Raney nickel; methanol / 110 - 120 °C / 73550.8 Torr / Hydrogenation
View Scheme
ethyl (E)-3-formyl-2-butenoate
62054-49-3

ethyl (E)-3-formyl-2-butenoate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 0 °C / Inert atmosphere
2: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
3: silver hexafluoroantimonate / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
C14H18N2O4S

C14H18N2O4S

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2: silver hexafluoroantimonate / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid; sodium nitrite / 3.5 h / 10 - 25 °C
1.2: 2 h / 75 °C
2.1: hydrogenchloride / ethanol; water / 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sodium nitrite; acetic acid / 3.5 h / 8 - 20 °C
1.2: 2 h / Heating
2.1: hydrogenchloride; water / 4 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: neat (no solvent) / 2 h / 20 °C
2: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 0.08 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: neat (no solvent) / 2 h / 20 °C
2: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
4: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: neat (no solvent) / 2 h / 20 °C
2: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
4: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-amino-2-propanol
78-96-6, 1674-56-2

3-amino-2-propanol

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl acetoacetate; 3-amino-2-propanol In tetrahydrofuran at 20℃; for 168h; Molecular sieve; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0); 2,4,6-trimethylphenyl bromide; potassium carbonate In N,N-dimethyl-formamide at 150℃; Inert atmosphere;
C9H13NO2
1379398-74-9

C9H13NO2

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 0.08 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
3: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: dmap / acetonitrile / 3 h / 50 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C
3: potassium tert-butylate / tetrahydrofuran / 0.08 h / Reflux
View Scheme
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

Conditions
ConditionsYield
With hydrogenchloride In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; trichlorophosphate100%
With hydrogenchloride In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; trichlorophosphate100%
With hydrogenchloride In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; trichlorophosphate100%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester; N,N-dimethyl-formamide With trichlorophosphate In dichloromethane for 1.5h; Vilsmeier-Haack Formylation; Reflux;
Stage #2: With sodium hydroxide In dichloromethane; water for 0.5h; Vilsmeier-Haack Formylation; Reflux;
100%
Stage #1: 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester; N,N-dimethyl-formamide With trichlorophosphate In dichloromethane Vilsmeier formylation; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In water
99%
Stage #1: 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester; N,N-dimethyl-formamide With trichlorophosphate In dichloromethane at 4℃; for 1.25h; Reflux;
Stage #2: With hydrogenchloride In dichloromethane; water at 10℃;
97%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N,N-dimethyl-4-nitrobenzamide
7291-01-2

N,N-dimethyl-4-nitrobenzamide

2,4-dimethyl-5-(4-nitro-benzoyl)-pyrrole-3-carboxylic acid ethyl ester
63833-38-5

2,4-dimethyl-5-(4-nitro-benzoyl)-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane at 35℃; Rate constant; measurement of the rate and half reaction time of the Vilsmeier-Haak reaction; investigation of the influence of POCl3 molar quantity on the reaction rate;96%
With hydrogenchloride; sodium carbonate; trichlorophosphate at 35℃;96%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Trimethyl-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-ammonium; iodide

Trimethyl-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-ammonium; iodide

2,4-Dimethyl-5-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester

2,4-Dimethyl-5-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
In dichloromethane at 20 - 40℃;94%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Dimethyl-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-amine

Dimethyl-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-amine

2,4-Dimethyl-5-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester

2,4-Dimethyl-5-((1Z,4Z,9Z,15Z)-3,8,13,18-tetraethyl-2,7,12,17-tetramethyl-porphyrin-5-ylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With methyl iodide In dichloromethane at 40℃; Substitution;94%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

3-Benzyl-2-chloro-5,6-dihydro-4H-[1,3]thiazin-3-ium; chloride
117450-55-2

3-Benzyl-2-chloro-5,6-dihydro-4H-[1,3]thiazin-3-ium; chloride

3-Benzyl-2-(3-ethoxycarbonyl-2,4-dimethylpyrrol-5-yl)-5,6-dihydro-4H-1,3-thiazinium-chlorid

3-Benzyl-2-(3-ethoxycarbonyl-2,4-dimethylpyrrol-5-yl)-5,6-dihydro-4H-1,3-thiazinium-chlorid

Conditions
ConditionsYield
In benzene for 3h; Heating;93%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

salicylaldehyde
90-02-8

salicylaldehyde

5,5'-(2-Hydroxyphenylmethylen)bis<2,4-dimethyl-3-pyrrolcarbonsaeure-ethylester>
77476-68-7

5,5'-(2-Hydroxyphenylmethylen)bis<2,4-dimethyl-3-pyrrolcarbonsaeure-ethylester>

Conditions
ConditionsYield
With hydrogen bromide In acetic acid93%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

2,4-dimethyl-1H-pyrrole-3-carboxylic acid
17106-13-7

2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions
ConditionsYield
With water; potassium hydroxide In methanol Reflux;92%
Stage #1: 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester With water; potassium hydroxide In methanol Reflux;
Stage #2: With hydrogenchloride In water pH=3 - 4;
76%
With alkaline solution
With lithium hydroxide monohydrate In 1,4-dioxane; water at 100℃; for 24h;7.4 mg
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

4-benzoylmorpholine
1468-28-6

4-benzoylmorpholine

ethyl 5-benzoyl-2,4-dimethylpyrrole-3-carboxylate
63833-46-5

ethyl 5-benzoyl-2,4-dimethylpyrrole-3-carboxylate

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane at 35℃; Rate constant; measurement of the rate and half reaction time of the Vilsmeier-Haak reaction;92%
With hydrogenchloride; sodium carbonate; trichlorophosphate at 35℃;92%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

ethyl 5-benzoyl-2,4-dimethylpyrrole-3-carboxylate
63833-46-5

ethyl 5-benzoyl-2,4-dimethylpyrrole-3-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; sodium carbonate; trichlorophosphate at 35℃;92%
With trichlorophosphate In 1,2-dichloro-ethane at 35℃; Rate constant; measurement of the rate and half reaction time of the Vilsmeier-Haak reaction;92%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

2,4-Dihydroxybenzaldehyde
95-01-2

2,4-Dihydroxybenzaldehyde

2-(2,4-Dihydroxyphenylmethylen)-4-ethoxycarbonyl-3,5-dimethylpyrroliumbromid
77476-61-0

2-(2,4-Dihydroxyphenylmethylen)-4-ethoxycarbonyl-3,5-dimethylpyrroliumbromid

Conditions
ConditionsYield
With hydrogen bromide In acetic acid92%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N,N-dimethylform-13C-amide
32488-43-0

N,N-dimethylform-13C-amide

ethyl 5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
1194048-24-2

ethyl 5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester; N,N-dimethylform-13C-amide With trichlorophosphate In dichloromethane at 4℃; for 1.25h; Reflux;
Stage #2: With hydrogenchloride In dichloromethane; water at 10℃;
91%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

2-((trifluoromethyl)thio)isoindoline-1,3-dione
719-98-2

2-((trifluoromethyl)thio)isoindoline-1,3-dione

ethyl 2,4-dimethyl-5-((trifluoromethyl)thio)-1H-pyrrole-3-carboxylate

ethyl 2,4-dimethyl-5-((trifluoromethyl)thio)-1H-pyrrole-3-carboxylate

Conditions
ConditionsYield
With sodium chloride In N,N-dimethyl-formamide at 90℃; for 14h; Inert atmosphere; Schlenk technique;91%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N-(4-methoxybenzoyl)morpholine
7504-58-7

N-(4-methoxybenzoyl)morpholine

5-(4-Methoxy-benzoyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
63833-34-1

5-(4-Methoxy-benzoyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride; sodium carbonate; trichlorophosphate at 35℃;90%
With trichlorophosphate In 1,2-dichloro-ethane at 35℃; Rate constant; measurement of the rate and half reaction time of the Vilsmeier-Haak reaction;90%
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

3-nitro-N,N-dimethylbenzamide
7291-02-3

3-nitro-N,N-dimethylbenzamide

2,4-dimethyl-5-(3-nitro-benzoyl)-pyrrole-3-carboxylic acid ethyl ester
63833-39-6

2,4-dimethyl-5-(3-nitro-benzoyl)-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride; sodium carbonate; trichlorophosphate at 35℃;90%
With trichlorophosphate In 1,2-dichloro-ethane at 35℃; Rate constant; measurement of the rate and half reaction time of the Vilsmeier-Haak reaction;90%

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