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Hunan Russell Chemicals Technology Co.,Ltd

low price and high purityAppearance:solid or liquid Storage:in sealed air resistant place Package:As customer require Application:Pharma;Industry;Agricultural Transportation:by sea or by airplane Port:any port in China

Chloroacetone, 95%, stabilized 78-95-5

Cas:78-95-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Pure Chemistry Scientific Inc.

78-95-5 Application:Chloroacetone

Chloroacetone

Cas:78-95-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

acetone
67-64-1

acetone

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With chlorine; calcium carbonate In water at 110℃; Reagent/catalyst; Temperature;95.6%
With methanol; sulfuryl dichloride In dichloromethane85%
With sulfuryl dichloride
(C4H9)3SnOCH(CH2Cl)2
35952-61-5

(C4H9)3SnOCH(CH2Cl)2

A

tributyltin chloride
1461-22-9

tributyltin chloride

B

chloroacetone
78-95-5

chloroacetone

C

epichlorohydrin
106-89-8

epichlorohydrin

Conditions
ConditionsYield
63% decompn. at 210°C (1 h);A n/a
B 5%
C 95%
acetone
67-64-1

acetone

A

1,1-Dichloroacetone
513-88-2

1,1-Dichloroacetone

B

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With trichloroisocyanuric acid; boron trifluoride diethyl etherate In acetic acid for 1h; Heating; Yields of byproduct given;A n/a
B 88%
With water; chlorine; calcium carbonate
methyl 2-chloroacetoacetate
4755-81-1

methyl 2-chloroacetoacetate

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With sulfuric acid for 3h; Heating;85%
1,3-Dichloro-2-propanol
96-23-1

1,3-Dichloro-2-propanol

A

chloroacetone
78-95-5

chloroacetone

B

epichlorohydrin
106-89-8

epichlorohydrin

Conditions
ConditionsYield
With HT4-c823 In water at 149.84℃; under 750.075 Torr; for 0.5h; Catalytic behavior; Reagent/catalyst; Temperature; Flow reactor; chemoselective reaction;A 18.9%
B 80.5%
diazoacetone
2684-62-0

diazoacetone

A

chloroacetone
78-95-5

chloroacetone

B

2-diazo-3-oxobutanal
177084-70-7

2-diazo-3-oxobutanal

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h; Ambient temperature;A 50%
B 14%
diazoacetone
2684-62-0

diazoacetone

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

A

chloroacetone
78-95-5

chloroacetone

B

2-diazo-3-oxobutanal
177084-70-7

2-diazo-3-oxobutanal

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 1h; Ambient temperature;A 50%
B 14%
diazoacetone
2684-62-0

diazoacetone

A

4,5-dimethylfuran-3(2H)-one

4,5-dimethylfuran-3(2H)-one

B

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

C

chloroacetone
78-95-5

chloroacetone

D

1,1'-oxydi(propan-2-one)
76089-31-1

1,1'-oxydi(propan-2-one)

Conditions
ConditionsYield
With hydrogenchloride; gallium(III) trichloride; water In dichloromethane at 20℃; for 0.0833333h;A 34%
B 8%
C 20%
D 31%
cis/trans-3,5-Bis-(chloromethyl)-3-fluoro-5-methyl-1,2,4-trioxolane
173063-66-6

cis/trans-3,5-Bis-(chloromethyl)-3-fluoro-5-methyl-1,2,4-trioxolane

A

chloroacetone
78-95-5

chloroacetone

B

chloroacetyl chloride
79-04-9

chloroacetyl chloride

C

Chloro-acetic acid 1,2-dichloro-1-methyl-ethyl ester

Chloro-acetic acid 1,2-dichloro-1-methyl-ethyl ester

Conditions
ConditionsYield
With triphenylphosphine In chloroform-d1A 28 % Spectr.
B 23 % Spectr.
C 33%
{Pd2(μ-H)(COCH3)2(μ-dppm)2}BPh4
115290-60-3

{Pd2(μ-H)(COCH3)2(μ-dppm)2}BPh4

Pd2(CH3)2(Cl)2(μdppm)2
98194-67-3

Pd2(CH3)2(Cl)2(μdppm)2

B

acetaldehyde
75-07-0

acetaldehyde

C

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
In dichloromethane warming of {Pd2(μ-H)(COCH3)2(dppm)2}BPh4 in CH2Cl2 (23°C, 24 h);A 32%
B n/a
C n/a
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With chlorine at 0 - 10℃; Kochen des Reaktionsprodukts mit Wasser;
2,3-Dichloroprop-1-ene
78-88-6

2,3-Dichloroprop-1-ene

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With sulfuric acid Destillieren der Loesung mit Wasser;
diazoacetone
2684-62-0

diazoacetone

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether
Stage #1: diazoacetone With ethylaluminum dichloride In hexane; dichloromethane at 20℃; for 0.0166667h;
Stage #2: With methanol In hexane; dichloromethane
1,2-propanediene
463-49-0

1,2-propanediene

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With water; chlorine
chloroform
67-66-3

chloroform

1,4-dichloro-2-methyl-2-butene
29843-58-1

1,4-dichloro-2-methyl-2-butene

A

2-chloroethanal
107-20-0

2-chloroethanal

B

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
beim Ozonisierung und Behandeln des Ozonids mit Wasser bei 75-80grad;
(E)-1,3-dichloro-2-methyl-2-butene
52842-49-6

(E)-1,3-dichloro-2-methyl-2-butene

A

acetic acid
64-19-7

acetic acid

B

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
bei der Ozonspaltung;
β-chloro-α-hydroxy-isobutyronitrile
33401-05-7

β-chloro-α-hydroxy-isobutyronitrile

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
beim Destillieren unter gewoehnlichem Druck;
ethyl hypochlorite
624-85-1

ethyl hypochlorite

acetone
67-64-1

acetone

chloroacetone
78-95-5

chloroacetone

bis(2-chloroethyl)selenium dichloride
106471-36-7

bis(2-chloroethyl)selenium dichloride

acetone
67-64-1

acetone

chloroacetone
78-95-5

chloroacetone

bis(2-bromoethyl)selenium dichloride
116008-96-9

bis(2-bromoethyl)selenium dichloride

acetone
67-64-1

acetone

chloroacetone
78-95-5

chloroacetone

chlorourea
3135-74-8

chlorourea

acetone
67-64-1

acetone

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With water
dibenzyl sulfide
538-74-9

dibenzyl sulfide

acetone
67-64-1

acetone

N-chlorobenzamide
1821-34-7

N-chlorobenzamide

A

N-benzoyl-S,S-dibenzyl-sulfimide

N-benzoyl-S,S-dibenzyl-sulfimide

B

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
at -20℃;
propenyl chloride
590-21-6

propenyl chloride

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With N-oxo-N-nitrosoamine at 280℃; under 367754 Torr;
1-Chloro-2-propanol
127-00-4

1-Chloro-2-propanol

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With chromic acid
With ruthenium(IV) oxide; sodium chloride In water; ethyl acetate electrooxidation;
With sodium hydroxide; N-bromoacetamide In water at 24.9℃; Mechanism; Kinetics; Thermodynamic data; var. of temp. (Tab. VI); ΔH(excit.), ΔS(excit.), ΔF(excit.);
methyloxirane
75-56-9, 16033-71-9

methyloxirane

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With chlorine at 0℃;
acetyl chloride
75-36-5

acetyl chloride

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
With hydrogenchloride 1.) ether, 2 h, -20 to 0 deg C, 2.) -20 deg C to room temp.; Multistep reaction;
2-chloro-1,2-epoxypropane
5950-21-0

2-chloro-1,2-epoxypropane

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
for 48h;
1,3-Dichloro-2-propanol
96-23-1

1,3-Dichloro-2-propanol

A

2,3-Dichloro-1-propanol
616-23-9

2,3-Dichloro-1-propanol

B

1,2,3-trichloropropane
96-18-4

1,2,3-trichloropropane

C

1-chloro-3-(2-chloro-1-chloromethyl-ethoxy)-propan-2-ol
23916-48-5

1-chloro-3-(2-chloro-1-chloromethyl-ethoxy)-propan-2-ol

D

chloroacetone
78-95-5

chloroacetone

Conditions
ConditionsYield
at 180℃; Product distribution; also in the presence of 1.5 percent HCl or 5percent epichlorhydrin;
4-pyridone
108-96-3

4-pyridone

chloroacetone
78-95-5

chloroacetone

1-(2-oxopropyl)-4-pyridone
153075-85-5

1-(2-oxopropyl)-4-pyridone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h;100%
Octanethiol
111-88-6

Octanethiol

chloroacetone
78-95-5

chloroacetone

3-Octylthiopropan-2-one
20233-08-3

3-Octylthiopropan-2-one

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 1h;100%
With potassium carbonate In tetrahydrofuran
O-benzylhydoxylamine hydrochloride
2687-43-6

O-benzylhydoxylamine hydrochloride

chloroacetone
78-95-5

chloroacetone

1-chloropropan-2-one O-benzyloxime
83200-26-4

1-chloropropan-2-one O-benzyloxime

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 20℃; for 5h;100%
With sodium hydroxide In methanol 2.) room temp., 5 h;91%
2,6-dimethyl-1,5-dihydroxynaphthalene
123979-29-3

2,6-dimethyl-1,5-dihydroxynaphthalene

chloroacetone
78-95-5

chloroacetone

2,6-Dimethyl-1,5-bis(2-oxopropoxy)naphthalene
137517-19-2

2,6-Dimethyl-1,5-bis(2-oxopropoxy)naphthalene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;100%
2,6-Dipropyl-1,5-naphthalenediol
137517-25-0

2,6-Dipropyl-1,5-naphthalenediol

chloroacetone
78-95-5

chloroacetone

2,6-Dipropyl-1,5-bis(2-oxopropoxy)naphthalene
137517-22-7

2,6-Dipropyl-1,5-bis(2-oxopropoxy)naphthalene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;100%
Diethyl 2-methyl-2-(4-thiocarbamoylphenyl)malonate
132483-78-4

Diethyl 2-methyl-2-(4-thiocarbamoylphenyl)malonate

chloroacetone
78-95-5

chloroacetone

Diethyl 2-methyl-2-<4-(4-methylthiozol-2-yl)phenyl>malonate
138569-11-6

Diethyl 2-methyl-2-<4-(4-methylthiozol-2-yl)phenyl>malonate

Conditions
ConditionsYield
In benzene for 3.25h; Heating;100%
chloroacetone
78-95-5

chloroacetone

1-trimethylsilylpyrazole
18156-75-7

1-trimethylsilylpyrazole

(chloro-1' trimethylsiloxy-2' isopropyl)-1 pyrazole

(chloro-1' trimethylsiloxy-2' isopropyl)-1 pyrazole

Conditions
ConditionsYield
at 80℃; for 1h;100%
chloroacetone
78-95-5

chloroacetone

1-trimethylsilyl-1,2,4-triazole
18293-54-4

1-trimethylsilyl-1,2,4-triazole

(chloro-1' trimethylsiloxy-2' isopropyl)-1 triazole-1,2,4

(chloro-1' trimethylsiloxy-2' isopropyl)-1 triazole-1,2,4

Conditions
ConditionsYield
at 100℃; for 1h;100%
chloroacetone
78-95-5

chloroacetone

1-(trimethylsilyl)-1H-benzotriazole
43183-36-4

1-(trimethylsilyl)-1H-benzotriazole

(chloro-1' trimethylsiloxy-2' isopropyl)-1 benzotriazole

(chloro-1' trimethylsiloxy-2' isopropyl)-1 benzotriazole

Conditions
ConditionsYield
at 100℃; for 1h;100%
chloroacetone
78-95-5

chloroacetone

5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol
15264-63-8

5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol

1-(5-Pyridin-4-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-2-one
81555-96-6

1-(5-Pyridin-4-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-2-one

Conditions
ConditionsYield
With sodium hydroxide for 12h; Ambient temperature;100%
8-Chloro-2-methyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
110766-90-0

8-Chloro-2-methyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

chloroacetone
78-95-5

chloroacetone

8-Chloro-2-methyl-5-(2-oxo-propyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

8-Chloro-2-methyl-5-(2-oxo-propyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran Ambient temperature;100%
chloroacetone
78-95-5

chloroacetone

6-Fluoro-4-methyl-2-phenyl-thieno[2,3-d]pyrimidin-5-ylamine
216776-76-0

6-Fluoro-4-methyl-2-phenyl-thieno[2,3-d]pyrimidin-5-ylamine

6-acetyl-5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine
115073-27-3

6-acetyl-5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine

Conditions
ConditionsYield
With potassium carbonate100%
2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

chloroacetone
78-95-5

chloroacetone

2-acetonylthiobenzimidazole hydrochloride

2-acetonylthiobenzimidazole hydrochloride

Conditions
ConditionsYield
at 60℃; for 12h; Solid phase reaction; substitution;100%
chloroacetone
78-95-5

chloroacetone

5-(2-chlorophenyl)-3-mercapto-2-cyclohexen-1-one
239131-42-1

5-(2-chlorophenyl)-3-mercapto-2-cyclohexen-1-one

5-(2-chlorophenyl)-3-[(2-oxopropyl)thio]-2-cyclohexen-1-one
239131-43-2

5-(2-chlorophenyl)-3-[(2-oxopropyl)thio]-2-cyclohexen-1-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 20℃; for 5h;100%
With sodium ethanolate In ethanol at 20℃; for 5h;
dibenzo[b,f]thiepin-10(11H)-one
1898-85-7

dibenzo[b,f]thiepin-10(11H)-one

chloroacetone
78-95-5

chloroacetone

1-(dibenzo[b,f]thiepin-10-yloxy)-propan-2-one

1-(dibenzo[b,f]thiepin-10-yloxy)-propan-2-one

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide100%
With sodium hydride In dimethyl sulfoxide at 20℃;23%
2-bromo-4-fluoro-phenol
496-69-5

2-bromo-4-fluoro-phenol

chloroacetone
78-95-5

chloroacetone

1-(2-bromo-4-fluorophenoxy)propan-2-one
286836-12-2

1-(2-bromo-4-fluorophenoxy)propan-2-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran for 4h; Heating / reflux;100%
With potassium carbonate; potassium iodide In tetrahydrofuran for 4h; Heating / reflux;100%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;59%
With potassium carbonate; potassium iodide In acetone at 55℃; for 2h;
With potassium iodide; potassium carbonate In tetrahydrofuran; ethyl acetate2.7 gm (100%)
2-hydroxy-4 methoxybenzonitrile
39835-11-5

2-hydroxy-4 methoxybenzonitrile

chloroacetone
78-95-5

chloroacetone

C11H11NO3
869789-23-1

C11H11NO3

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone at 0 - 20℃; for 1h; Heating / reflux;100%
N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]thiourea
872707-11-4

N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]thiourea

chloroacetone
78-95-5

chloroacetone

{2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-4-yl}methanol
872707-12-5

{2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-4-yl}methanol

Conditions
ConditionsYield
In ethanol for 16h; Heating / reflux;100%
In ethanol for 16h; Heating / reflux;100%
In ethanol for 16h; Heating / reflux; Under nitrogen;100%
2-Cyclopropylamino-4,6-difluoro-benzoic acid
1059686-59-7

2-Cyclopropylamino-4,6-difluoro-benzoic acid

chloroacetone
78-95-5

chloroacetone

2-Cyclopropylamino-4,6-difluoro-benzoic acid 2-oxo-propyl ester
1059686-60-0

2-Cyclopropylamino-4,6-difluoro-benzoic acid 2-oxo-propyl ester

Conditions
ConditionsYield
Stage #1: 2-Cyclopropylamino-4,6-difluoro-benzoic acid With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h;
Stage #2: chloroacetone In N,N-dimethyl-formamide at 20 - 55℃; for 1.5h;
100%
1-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea
953045-29-9

1-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea

chloroacetone
78-95-5

chloroacetone

N-(5-bromo-3-(phenylthio)pyridin-2-yl)-4-methylthiazol-2-amine
953040-73-8

N-(5-bromo-3-(phenylthio)pyridin-2-yl)-4-methylthiazol-2-amine

Conditions
ConditionsYield
With triethylamine In ethanol at 70℃; for 6h;100%
tert-butyl (S)-1-amino-3-(1H-indol-3-yl)-1-thioxopropan-2-yl carbamate
1189115-86-3

tert-butyl (S)-1-amino-3-(1H-indol-3-yl)-1-thioxopropan-2-yl carbamate

chloroacetone
78-95-5

chloroacetone

tert-butyl [(S)-1-(4-hydroxy-4-methyl-4,5-dihydro-thiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-carbamate
1189115-87-4

tert-butyl [(S)-1-(4-hydroxy-4-methyl-4,5-dihydro-thiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-carbamate

Conditions
ConditionsYield
With potassium hydrogencarbonate In 1,2-dimethoxyethane at 45 - 70℃;100%
C9H9ClOS
1186033-44-2

C9H9ClOS

chloroacetone
78-95-5

chloroacetone

1-(4-chloro-1H-benzo[b]thiophen-2-yl)ethanone
66490-34-4

1-(4-chloro-1H-benzo[b]thiophen-2-yl)ethanone

Conditions
ConditionsYield
With calcium oxide In acetone at 59℃;100%
With calcium oxide for 3h; Reflux;
2-(ethylsulfanyl)benzenecarbaldehyde
53606-33-0

2-(ethylsulfanyl)benzenecarbaldehyde

chloroacetone
78-95-5

chloroacetone

2-acetyl benzo[b]thiophene
22720-75-8

2-acetyl benzo[b]thiophene

Conditions
ConditionsYield
With calcium oxide In acetone at 59℃;100%
With calcium oxide for 3h; Reflux;
1,2,4-Triazole
288-88-0

1,2,4-Triazole

chloroacetone
78-95-5

chloroacetone

1-(1H-1,2,4-triazol-1-yl)propan-2-one
64882-52-6

1-(1H-1,2,4-triazol-1-yl)propan-2-one

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; for 20h;100%
With sodium hydrogencarbonate In toluene at 110 - 120℃; for 3h; Inert atmosphere;22.2%
coenzyme A disodium salt

coenzyme A disodium salt

chloroacetone
78-95-5

chloroacetone

acetonyl-CoA
75179-85-0

acetonyl-CoA

Conditions
ConditionsYield
With N,N-dimethyl-formamide In water at 0 - 5℃; Inert atmosphere;100%
chloroacetone
78-95-5

chloroacetone

(S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one
188115-27-7

(S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one

C15H16N2O2S
1271450-06-6

C15H16N2O2S

Conditions
ConditionsYield
Stage #1: (S)-11-thioxo-2,3,11,11a-tetrahydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(10H)-one With sodium hydride In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: chloroacetone In dimethyl sulfoxide at 20℃; for 0.666667h; Inert atmosphere;
100%
2-amino-3-chloro-4-iodopyridine
1152617-24-7

2-amino-3-chloro-4-iodopyridine

chloroacetone
78-95-5

chloroacetone

8-chloro-7-iodo-2-methylimidazo[1,2-a]pyridine
1416551-60-4

8-chloro-7-iodo-2-methylimidazo[1,2-a]pyridine

Conditions
ConditionsYield
In ethanol at 65℃;100%
2,3-dimethylbromobenzene
576-23-8

2,3-dimethylbromobenzene

chloroacetone
78-95-5

chloroacetone

2-(2,3-dimethylphenyl)-2-methyloxirane
42432-45-1

2-(2,3-dimethylphenyl)-2-methyloxirane

Conditions
ConditionsYield
Stage #1: 2,3-dimethylbromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: chloroacetone In tetrahydrofuran; hexane; toluene at -78 - 20℃; for 1.33333h; Product distribution / selectivity;
100%
Stage #1: 2,3-dimethylbromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: chloroacetone In tetrahydrofuran; hexane; toluene at -78 - 20℃; Product distribution / selectivity;
100%
1H-indole-3-carbothioamide
59108-90-6

1H-indole-3-carbothioamide

chloroacetone
78-95-5

chloroacetone

4-methyl-2-(3-indolyl)thiazole
93588-10-4

4-methyl-2-(3-indolyl)thiazole

Conditions
ConditionsYield
In ethanol at 80℃; for 1.5h; Reflux;100%
C21H22N4O

C21H22N4O

chloroacetone
78-95-5

chloroacetone

C24H26N4O2

C24H26N4O2

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; acetonitrile at 20℃; for 8h; Reflux;100%
With potassium carbonate In dichloromethane; acetonitrile for 8h; Reflux;100%
With potassium carbonate In dichloromethane; acetonitrile for 8h; Reflux;

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