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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

acetoacetic acid

Cas:541-50-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Acetoacetic acid

Cas:541-50-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Acetoacetic Acid CAS 541-50-4

Cas:541-50-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Butanoic acid, 3-oxo- 541-50-4

Cas:541-50-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Acetoacetic Acid

Cas:541-50-4

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Acetoacetic Acid

Cas:541-50-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Acetoacetic Acid

Cas:541-50-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

English name: Acetoacetic Acid English synonyms: Acetoacetic Acid;3-oxobutanoic acid;acetoncarboxylic acid;3-ketobutanoic acid 3-oxobutanoic acid;acetylacetic acid;diacetic acid;ACETOACETATE;3-ketobutyric acid CAS Number

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity Acetoacetic Acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Acetoacetic Acid

Cas:541-50-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Acetoacetic Acid

Cas:541-50-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Acetoacetic Acid

Cas:541-50-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

high purity Storage:normal temperature Package:DRUM Application:mainly for medical use for R&Dpurpose use only Transportation:AIR,SEA Port:BEIJING,SHANGHAI,TIANJIN,SHENZHEN

3-Oxobutanoic acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Acetoacetic Acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

Acetoacetic Acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

Acetoacetic Acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Butanoic acid, 3-oxo-

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

TIANFUCHEM--High purity Acetoacetic Acid factory price

Cas:541-50-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:intermediate

Acetoacetic Acid

Cas:541-50-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2S,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid

(2S,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid

A

L-Cysteine
52-90-4

L-Cysteine

B

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With water at 90℃; Column which a srtongly acidic cation exchanger in the H+ form;A n/a
B 99.6%
tert-butyl acetoacetate
1694-31-1

tert-butyl acetoacetate

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃;87%
With trifluoroacetic acid63%
With trifluoroacetic acid Ambient temperature;
With water
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 60℃; for 3h;80%
With potassium hydroxide In water at 20℃; Inert atmosphere;22%
With sodium hydroxide
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
Stage #1: acetoacetic acid methyl ester With sodium hydroxide; water at 20℃; for 18h;
Stage #2: With ammonium sulfate
Stage #3: With hydrogenchloride In water at 0℃;
60%
Stage #1: acetoacetic acid methyl ester With sodium hydroxide; water at 20℃; for 18.3333h;
Stage #2: With hydrogenchloride; water at 0℃;
60%
With hydrogenchloride; sodium methylate 1.) MeOH, H2O, 8 h; Yield given; Multistep reaction;
With water; sodium hydroxide for 6h; Cooling;
4-hydroxy-3,5-di-tert-butylthiophenol
950-59-4

4-hydroxy-3,5-di-tert-butylthiophenol

ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
In ethanol; benzene43%
3-methylbutyric acid
503-74-2

3-methylbutyric acid

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

acetone
67-64-1

acetone

Conditions
ConditionsYield
beim Abbau durch Leberschnitte;
acetonedicarboxylic acid
542-05-2

acetonedicarboxylic acid

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

C

acetone
67-64-1

acetone

Conditions
ConditionsYield
at 42℃; Rate constant; durch H+ sowie durch Kupfer(2+) und andere Metall-Ionen in wss. Loesung katalysierte Zersetzung;
at 22 - 45℃; Rate constant; durch Eisen(3+) katalysierte Zersetzung in wss. Loesung;
at 37 - 50℃; Rate constant; durch Eisen(3+) katalysierte Zersetzung in wss. Loesung;
α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

(Z)-but-2-enoic acid
503-64-0

(Z)-but-2-enoic acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
in Gegenwart von Nieren- und von Leber-Enzympraeparaten;
ethanol
64-17-5

ethanol

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
in der Leber von Ratten;
1.3-butanediol
18826-95-4, 107-88-0

1.3-butanediol

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

crotonaldehyde
123-73-9

crotonaldehyde

Conditions
ConditionsYield
With ammonium iron (II) sulfate; sulfuric acid; dihydrogen peroxide at 25℃;
(Z)-but-2-enoic acid
503-64-0

(Z)-but-2-enoic acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
in Gegenwart von Lebergewebe;
(R)-3-hydroxybutyric acid
625-72-9

(R)-3-hydroxybutyric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
bei der Durchstroemung der ueberlebenden Hundeleber;
findet sich im Organismus des Frosches auch nach Entfernung der Leber statt;
Einw. von Bac. megatherium;
L-leucine
61-90-5

L-leucine

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

acetone
67-64-1

acetone

Conditions
ConditionsYield
im tierischen Organismus und durch tierische Gewebe;
2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
Oxydation in Gegenwart von Kaninchenleber-cyclophorase;
L-Tartaric acid
87-69-4

L-Tartaric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
bei Durchstroemung der isolierten Hundeleber; das Ammoniumsalz reagiert;
DL-tartaric acid
133-37-9

DL-tartaric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
Reaktion des Ammoniumracemats bei Durchstroemung der isolierten Hundeleber;
D-glucaric acid
87-73-0

D-glucaric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
bei der Durchblutung der ueberlebenden Leber;
meso-galactaric acid
526-99-8, 1213827-87-2

meso-galactaric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
bei der Durchblutung der isolierten ueberlebenden Leber;
cyclobutane-1,3-dione
15506-53-3

cyclobutane-1,3-dione

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With water
butyric acid ; calcium butyrate
5892-23-9, 99283-81-5

butyric acid ; calcium butyrate

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

succinic acid
110-15-6

succinic acid

C

acetone
67-64-1

acetone

D

3-Hydroxybutyric acid
300-85-6, 625-71-8

3-Hydroxybutyric acid

Conditions
ConditionsYield
at 28℃; bei der Vergaerung durch Aspergillus niger;
at 32℃; bei der Vergaerung durch Aspergillus niger;
maleic acid
110-16-7

maleic acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
im Blut geloest, bei Durchstroemung der isolierten Hundeleber;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

3-Hydroxybutyric acid
300-85-6, 625-71-8

3-Hydroxybutyric acid

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

succinic acid
110-15-6

succinic acid

Conditions
ConditionsYield
in Gegenwart des Muskelenzym-Praeparats und von Coenzym I;
3-Hydroxybutyric acid
300-85-6, 625-71-8

3-Hydroxybutyric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
die aerobe Oxydation von Cystein wirkt induzierend auf die Oxydation; Milchperoxydase beschleunigt diese Reaktion; inactive β-oxy-butyric acid;
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium carbonate at 20℃; Electrochemical reaction;
L-histidine
71-00-1

L-histidine

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
in der kuenstlich durchbluteten Hundeleber;
valeric acid
109-52-4

valeric acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
durch Lebergewebeschnitte;
valeric acid
109-52-4

valeric acid

A

2-acetoacetic acid
541-50-4

2-acetoacetic acid

B

propionic acid
802294-64-0

propionic acid

Conditions
ConditionsYield
durch das 'Cyclophorase-System';
3-methyl-5-oxo-hex-2-enoic acid
23280-40-2

3-methyl-5-oxo-hex-2-enoic acid

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With sodium hydroxide
benzyl acetoacetate
5396-89-4

benzyl acetoacetate

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With hydrogen; palladium
With water
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With hydrogenchloride; water 1.) CCl4, 0-5 deg C, 2.) 0-5 deg C, 3 h; Yield given. Multistep reaction;
With water; sodium hydroxide at 25℃; pH=6; Kinetics; Solvent; Temperature;
3-thienyl iodide
10486-61-0

3-thienyl iodide

tert-butyl sodioacetate

tert-butyl sodioacetate

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

2-acetoacetic acid
541-50-4

2-acetoacetic acid

C

Di-thiophen-3-yl-acetic acid

Di-thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid; iron(II) sulfate 1.) NH3 (liquid), 45 min, 2.) H2O, reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

2-acetoacetic acid
541-50-4

2-acetoacetic acid

2,2-dimethyl-5-(3-oxobutanoyl)-1,3-dioxane-4,6-dione
143456-22-8

2,2-dimethyl-5-(3-oxobutanoyl)-1,3-dioxane-4,6-dione

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 6h; Ambient temperature;99%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(R)-N-(4-bromobenzylidene)-2-methylpropane-2-sulfinamide

(R)-N-(4-bromobenzylidene)-2-methylpropane-2-sulfinamide

(4S,RS)-4-amino-4-(4-bromophenyl)-N-(tert-butanesulfinyl)butan-2-one

(4S,RS)-4-amino-4-(4-bromophenyl)-N-(tert-butanesulfinyl)butan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;99%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(Rs)-N-(tert-butanesulfinyl)-5-bromopentan-1-imine

(Rs)-N-(tert-butanesulfinyl)-5-bromopentan-1-imine

(4R,RS)-4-amino-8-bromo-N-(tert-butanesulfinyl)octan-2-one

(4R,RS)-4-amino-8-bromo-N-(tert-butanesulfinyl)octan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;99%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one
497235-37-7

6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one

(R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
1126895-95-1

(R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Conditions
ConditionsYield
With C25H39N3O9S In tetrahydrofuran at -20℃; Schlenk technique; enantioselective reaction;98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(RS,E)-(-)-N-(3-phenylpropyl)idene-tert-butanesulfinamide
336105-29-4

(RS,E)-(-)-N-(3-phenylpropyl)idene-tert-butanesulfinamide

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-phenylhexan-2-one

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-phenylhexan-2-one

Conditions
ConditionsYield
Stage #1: 2-acetoacetic acid With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃; Mannich Aminomethylation;
Stage #2: (RS,E)-(-)-N-(3-phenylpropyl)idene-tert-butanesulfinamide In tetrahydrofuran; methanol at 23℃; for 1h; Mannich Aminomethylation; diastereoselective reaction;
98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

2-Methyl-propane-2-sulfinic acid (R)-non-(E)-ylideneamide

2-Methyl-propane-2-sulfinic acid (R)-non-(E)-ylideneamide

(4R,RS)-4-amino-N-(tert-butanesulfinyl)dodecan-2-one

(4R,RS)-4-amino-N-(tert-butanesulfinyl)dodecan-2-one

Conditions
ConditionsYield
Stage #1: 2-acetoacetic acid With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃; Mannich Aminomethylation;
Stage #2: 2-Methyl-propane-2-sulfinic acid (R)-non-(E)-ylideneamide In tetrahydrofuran; methanol at 23℃; for 1h; Mannich Aminomethylation; diastereoselective reaction;
98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide
220315-20-8

(R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-methylheptan-2-one

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-methylheptan-2-one

Conditions
ConditionsYield
Stage #1: 2-acetoacetic acid With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃; Mannich Aminomethylation;
Stage #2: (R,E)-2-methyl-N-(3-methylbutylidene)-2-propanesulfinamide In tetrahydrofuran; methanol at 23℃; for 1h; Mannich Aminomethylation; diastereoselective reaction;
98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

C9H18BrNOS

C9H18BrNOS

(4R,RS)-4-amino-8-bromo-N-(tert-butanesulfinyl)octan-2-one

(4R,RS)-4-amino-8-bromo-N-(tert-butanesulfinyl)octan-2-one

Conditions
ConditionsYield
Stage #1: 2-acetoacetic acid With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃; Mannich Aminomethylation;
Stage #2: C9H18BrNOS In tetrahydrofuran; methanol at 23℃; for 1h; Mannich Aminomethylation; diastereoselective reaction;
98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide
336105-24-9

(R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide

(4S,RS)-4-amino-4-(4-bromophenyl)-N-(tert-butanesulfinyl)butan-2-one

(4S,RS)-4-amino-4-(4-bromophenyl)-N-(tert-butanesulfinyl)butan-2-one

Conditions
ConditionsYield
Stage #1: 2-acetoacetic acid With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃; Mannich Aminomethylation;
Stage #2: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide In tetrahydrofuran; methanol at 23℃; for 5h; Mannich Aminomethylation; diastereoselective reaction;
98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(R)-N-(tert-butanesulfinyl)-N-(3-phenylpropyliden)amine
508225-73-8

(R)-N-(tert-butanesulfinyl)-N-(3-phenylpropyliden)amine

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-phenylhexan-2-one

(4R,RS)-4-amino-N-(tert-butanesulfinyl)-6-phenylhexan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

C10H20ClNOS

C10H20ClNOS

(4S,SS)-4-amino-8-chloro-N-(tert-butanesulfinyl)octan-2-one

(4S,SS)-4-amino-8-chloro-N-(tert-butanesulfinyl)octan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;98%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

C68H78O18

C68H78O18

C72H82O20

C72H82O20

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;94%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

benzyl 4-(hydroxymethyl)piperidine-N-carboxylate
122860-33-7

benzyl 4-(hydroxymethyl)piperidine-N-carboxylate

C18H23NO5
1224680-81-2

C18H23NO5

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 12h;93%
(R)-N-benzylidene-2-methylpropane-2-sulfinamide
196929-85-8

(R)-N-benzylidene-2-methylpropane-2-sulfinamide

2-acetoacetic acid
541-50-4

2-acetoacetic acid

(4S,RS)-4-amino-N-(tert-butanesulfinyl)-4-phenylbutan-2-one

(4S,RS)-4-amino-N-(tert-butanesulfinyl)-4-phenylbutan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;92%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

ethyl 5-methylbenzo[d]isothiazole-3-carboxylate 1,1-dioxide
1418632-92-4

ethyl 5-methylbenzo[d]isothiazole-3-carboxylate 1,1-dioxide

C14H17NO5S

C14H17NO5S

Conditions
ConditionsYield
With C25H35N2O3P; diethyl allene-1,3-dicarboxylate In diethyl ether at -30℃; for 36h; enantioselective reaction;92%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

indole-2,3-dione
91-56-5

indole-2,3-dione

3-hydroxy-3-(2-oxopropyl)indolin-2-one
33417-17-3

3-hydroxy-3-(2-oxopropyl)indolin-2-one

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 2h; Aldol Addition; Molecular sieve; Sealed tube;91%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

2-(1-allyl-2-oxoindolin-3-ylidene)malononitrile
519168-62-8

2-(1-allyl-2-oxoindolin-3-ylidene)malononitrile

2-(1-allyl-2-oxo-3-(2-oxopropyl)indolin-3-yl)malononitrile

2-(1-allyl-2-oxo-3-(2-oxopropyl)indolin-3-yl)malononitrile

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In neat (no solvent) for 0.333333h; Michael Addition; Milling; Green chemistry;91%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(-/-)-2-ethoxy-2H-1-benzopyran

(-/-)-2-ethoxy-2H-1-benzopyran

1-(2H-chromen-2-yl)propan-2-one

1-(2H-chromen-2-yl)propan-2-one

Conditions
ConditionsYield
In water at 20℃; for 12h;91%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

benzaldehyde
100-52-7

benzaldehyde

(E)-2-acetyl-3-phenylpropenoic acid

(E)-2-acetyl-3-phenylpropenoic acid

Conditions
ConditionsYield
ytterbium(III) perfluorooctanesulfonate In toluene at 80℃; for 12h; Knoevenagel condensation;90%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

(E)-1,3-diphenyl-2-propen-1-ol
62668-02-4

(E)-1,3-diphenyl-2-propen-1-ol

(+)-(R)-1,3-diphenyl-1-hexen-5-one
104637-14-1

(+)-(R)-1,3-diphenyl-1-hexen-5-one

Conditions
ConditionsYield
With iodine In nitromethane at 20℃; for 2h; Schlenk technique;90%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

urea
57-13-6

urea

C13H14N2O4
1250832-29-1

C13H14N2O4

Conditions
ConditionsYield
With silicon-supported ionic liquid catalyst In ethanol at 20 - 30℃; for 0.166667h;90%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

urea
57-13-6

urea

6-methyl-4-(3-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

6-methyl-4-(3-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

Conditions
ConditionsYield
With silicon-supported ionic liquid catalyst In ethanol at 20 - 30℃; for 0.5h;90%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

1-methyl-4-(trifluoromethyl)-1H-pyrimidin-2-one
136547-21-2

1-methyl-4-(trifluoromethyl)-1H-pyrimidin-2-one

3-methyl-4-(2-oxopropyl)-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidin-2-one
1597414-23-7

3-methyl-4-(2-oxopropyl)-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidin-2-one

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 14h; regioselective reaction;90%
(RS)-N-ethylidene-tert-butanesulfinamide
439117-21-2

(RS)-N-ethylidene-tert-butanesulfinamide

2-acetoacetic acid
541-50-4

2-acetoacetic acid

(4R,RS)-4-amino-N-(tert-butanesulfinyl)pentan-2-one

(4R,RS)-4-amino-N-(tert-butanesulfinyl)pentan-2-one

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol at 0 - 23℃;90%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

2-(1-Methyl-2-oxo-1,2-dihydro-indol-3-ylidene)-malononitrile
39081-26-0

2-(1-Methyl-2-oxo-1,2-dihydro-indol-3-ylidene)-malononitrile

2-(1-methyl-2-oxo-3-(2-oxopropyl)indolin-3-yl)malononitrile

2-(1-methyl-2-oxo-3-(2-oxopropyl)indolin-3-yl)malononitrile

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In neat (no solvent) for 0.333333h; Michael Addition; Milling; Green chemistry;89%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile
59762-59-3

2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile

2-[1'-benzyl-2'-oxo-3'-(2''-oxoprop-1''-yl)indolin-3'-yl]malononitrile

2-[1'-benzyl-2'-oxo-3'-(2''-oxoprop-1''-yl)indolin-3'-yl]malononitrile

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In neat (no solvent) for 0.416667h; Michael Addition; Milling; Green chemistry;89%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

benzaldehyde
100-52-7

benzaldehyde

urea
57-13-6

urea

1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid
60750-37-0

1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

Conditions
ConditionsYield
With silicon-supported ionic liquid catalyst In ethanol at 20 - 30℃; for 0.333333h;89%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

1-phenylpropadiene
2327-99-3

1-phenylpropadiene

4-phenyl-5-hexen-2-one
50552-30-2

4-phenyl-5-hexen-2-one

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,2-dichloro-ethane at 20℃; for 5h; Schlenk technique; Inert atmosphere; regioselective reaction;88%
2-acetoacetic acid
541-50-4

2-acetoacetic acid

2-<3,4-bis(benzyloxy)phenyl>ethanol
96826-11-8

2-<3,4-bis(benzyloxy)phenyl>ethanol

3,4-bis(benzyloxy)phenethyl 3-oxobutanoate

3,4-bis(benzyloxy)phenethyl 3-oxobutanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 1h;88%

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