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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 6964-21-2 with best quality

Cas:6964-21-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3-Thiopheneacetic acidCAS6964-21-2

Cas:6964-21-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 25.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Thiopheneacetic acid 6964-21-2

Cas:6964-21-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Thiopheneacetic acid CAS:6964-21-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

3-Thiopheneacetic acid CAS:6964-21-2

Cas:6964-21-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:6964-21-2

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-THIOPHENEACETIC ACID

Cas:6964-21-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

high quality 3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white to light yellow crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Int

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Thiopheneacetic Acid cas no. 6964-21-2 98%

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Thiopheneacetic Acid

Cas:6964-21-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

high purity, manufacturer Application:Intermediate

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Thiophene-3-acetic Acid 500g

Cas:6964-21-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Thiophene-3-acetic Acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

3-Thiopheneacetic acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as pri

3-Thienylacetic Acid

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-Thiopheneacetic acid cas 6964-21-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-Thiopheneacetic acid cas 6964-21-2

Cas:6964-21-2

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

carbon monoxide
201230-82-2

carbon monoxide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Stage #1: 3-Bromomethylthiophene; carbon monoxide With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide at 80℃; under 760 Torr; for 18h; Carbonylation; Hydrolysis;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
85%
carbon dioxide
124-38-9

carbon dioxide

[1-Thiophen-3-yl-meth-(E)-ylidene]-hydrazine

[1-Thiophen-3-yl-meth-(E)-ylidene]-hydrazine

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;47%
3-hydroxymethyl-thiophene
71637-34-8

3-hydroxymethyl-thiophene

carbon monoxide
201230-82-2

carbon monoxide

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

3-Methylthiophene
616-44-4

3-Methylthiophene

Conditions
ConditionsYield
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction;A 34%
B 11%
With tetrakis(triphenylphosphine) palladium(0); hydrogen iodide In acetone at 90℃; under 68400 Torr; for 42h;A 34 % Spectr.
B 11 % Spectr.
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

sodium cyanide
143-33-9

sodium cyanide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With ethanol Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
2-(thiophene-3-yl) acetamide
13781-66-3

2-(thiophene-3-yl) acetamide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With potassium hydroxide
ethyl-3 thiophene acetate
37784-63-7

ethyl-3 thiophene acetate

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With sodium hydroxide
3-thienyl iodide
10486-61-0

3-thienyl iodide

tert-butyl sodioacetate

tert-butyl sodioacetate

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

2-acetoacetic acid
541-50-4

2-acetoacetic acid

C

Di-thiophen-3-yl-acetic acid

Di-thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid; iron(II) sulfate 1.) NH3 (liquid), 45 min, 2.) H2O, reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
thiophen-3-yl-acetic acid i-propyl ester
53064-74-7

thiophen-3-yl-acetic acid i-propyl ester

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

propene
187737-37-7

propene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
Thiophen-3-yl-acetic acid tert-butyl ester
58416-26-5

Thiophen-3-yl-acetic acid tert-butyl ester

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

isobutene
115-11-7

isobutene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
1-diazo-2-(thiophen-3-yl)ethanone
124687-94-1

1-diazo-2-(thiophen-3-yl)ethanone

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With silver(l) oxide In 1,4-dioxane Rearrangement;
3-thiophene carboxylic acid chloride
41507-35-1

3-thiophene carboxylic acid chloride

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether / 0 °C
2: aq. Ag2O / dioxane
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether / Erwaermen des Reaktionsprodukts mit Silberoxid und Aethanol
2: ethanolic NaOH-solution
View Scheme
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (COCl)2; DMF / CH2Cl2
2: diethyl ether / 0 °C
3: aq. Ag2O / dioxane
View Scheme
methanol
67-56-1

methanol

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

thiophen-3-yl-acetic acid methyl ester
58414-52-1

thiophen-3-yl-acetic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;100%
With sulfuric acid for 24h; Reflux;100%
With acetyl chloride at 0 - 20℃;100%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-(2-chlorothiophen-3-yl)acetic acid
188718-23-2

2-(2-chlorothiophen-3-yl)acetic acid

Conditions
ConditionsYield
With N-chloro-succinimide; acetic acid In benzene at 80℃; for 1h; Inert atmosphere;100%
With N-chloro-succinimide; acetic acid
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h;
Stage #2: With water In tetrahydrofuran; ethyl acetate
99%
With lithium aluminium tetrahydride98%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere;98%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

5,6-dimethoxy-2-(N-propylamino)indan
162751-96-4

5,6-dimethoxy-2-(N-propylamino)indan

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide
745060-23-5

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h;99%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-(thiophen-3-yl)acetamide
940741-63-9

N-benzyl-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;99%
With tris(2,2,2-trifluoroethyl) borate In acetonitrile at 80℃; for 5h;91%
Stage #1: thiophen-3-yl-acetic acid With titanium(IV) isopropylate In tetrahydrofuran at 40 - 70℃; Molecular sieve; Inert atmosphere;
Stage #2: benzylamine In tetrahydrofuran at 70℃; Molecular sieve; Inert atmosphere;
88%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

ethanol
64-17-5

ethanol

ethyl-3 thiophene acetate
37784-63-7

ethyl-3 thiophene acetate

Conditions
ConditionsYield
With hydrogenchloride for 0.166667h;98%
With sulfuric acid for 24h; Reflux;97%
With sulfuric acid for 24h; Reflux;97%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester
786704-01-6

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester

2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester
786704-15-2

2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h;
Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester In tetrahydrofuran for 8h;
97%
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 1h;
Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester With 4 A molecular sieve In tetrahydrofuran for 9h;
97%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide
654682-77-6

N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 60h; Inert atmosphere;
96%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;95%
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 5h;
89%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

butan-1-ol
71-36-3

butan-1-ol

thiophen-3-yl-acetic acid n-butyl ester

thiophen-3-yl-acetic acid n-butyl ester

Conditions
ConditionsYield
With sulfuric acid In benzene for 24h; Reflux;96%
sulfuric acid for 6h; Heating;60%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

N-hydroxy-2-(thiophen-3-yl)acetamide
1013424-78-6

N-hydroxy-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With 4-(Methylamino)pyridine; diisopropyl-carbodiimide In dichloromethane at 20℃;
Stage #2: With hydroxylamine In dichloromethane; water at 20℃; Further stages.;
96%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-(thiophen-3-yl)acetyl chloride
13781-65-2

2-(thiophen-3-yl)acetyl chloride

Conditions
ConditionsYield
With thionyl chloride at 60℃; for 2h;95%
With sulfuryl dichloride at 60℃; for 3h;
With thionyl chloride for 3h; Heating;
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

(Z)-4-bromo-N′-hydroxybenzimidamide
19227-14-6

(Z)-4-bromo-N′-hydroxybenzimidamide

O- p-bromobenzamidoxime

O- p-bromobenzamidoxime

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;95%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

methyl chloroformate
79-22-1

methyl chloroformate

thiophen-3-yl-acetic acid methyl ester
58414-52-1

thiophen-3-yl-acetic acid methyl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;94%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2,3,4,5,6-pentafluorophenol
771-61-9

2,3,4,5,6-pentafluorophenol

Pentafluorophenyl (thiophen-3-yl)ethanoate
214832-32-3

Pentafluorophenyl (thiophen-3-yl)ethanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane92%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

N-(3',4'-dimethoxy-β-phenethyl)-3-thienylacetamide
70474-53-2

N-(3',4'-dimethoxy-β-phenethyl)-3-thienylacetamide

Conditions
ConditionsYield
at 170℃; Heating;92%
for 2h; Heating;92%
With triethylamine; HATU In dichloromethane at 20℃;
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-chloro-ethanol
107-07-3

2-chloro-ethanol

thiophen-3-yl-acetic acid 2-chloro-ethyl ester
477282-74-9

thiophen-3-yl-acetic acid 2-chloro-ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane92%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Ethyl 4-bromobenzoate
5798-75-4

Ethyl 4-bromobenzoate

methyl iodide
74-88-4

methyl iodide

C16H16O4S
1350637-88-5

C16H16O4S

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid; Ethyl 4-bromobenzoate With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere;
Stage #2: methyl iodide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; regioselective reaction;
92%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

methyl iodide
74-88-4

methyl iodide

C14H11NO2S
1350637-89-6

C14H11NO2S

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid; 4-bromobenzenecarbonitrile With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere;
Stage #2: methyl iodide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; regioselective reaction;
92%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-2-(thiophen-3-yl)acetate

methyl 2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-2-(thiophen-3-yl)acetate

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical With N4,N4,N7,N7-tetramethyl-1,10-phenanthroline-4,7-diamine; iron(II) acetate In tetrahydrofuran at 60℃; for 24h; Molecular sieve; Inert atmosphere; Schlenk technique;
Stage #2: diazomethyl-trimethyl-silane With methanol In tetrahydrofuran; hexane for 1h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran; hexane; ethyl acetate chemoselective reaction;
92%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

ethyl iodide
75-03-6

ethyl iodide

ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

C15H12O2S

C15H12O2S

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid; ortho-bromobenzaldehyde With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h;
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Temperature;
91%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

ethyl bromide
74-96-4

ethyl bromide

ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

C15H12O2S

C15H12O2S

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid; ortho-bromobenzaldehyde With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h;
Stage #2: ethyl bromide In N,N-dimethyl-formamide at 20℃;
91%
carbon dioxide
124-38-9

carbon dioxide

3-[(phenylsulfonyl)methyl]thiophene
129759-54-2

3-[(phenylsulfonyl)methyl]thiophene

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 30℃; for 6h; Electrolysis;99%
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

carbon monoxide
201230-82-2

carbon monoxide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Stage #1: 3-Bromomethylthiophene; carbon monoxide With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide at 80℃; under 760 Torr; for 18h; Carbonylation; Hydrolysis;
Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
85%
carbon dioxide
124-38-9

carbon dioxide

[1-Thiophen-3-yl-meth-(E)-ylidene]-hydrazine

[1-Thiophen-3-yl-meth-(E)-ylidene]-hydrazine

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;47%
3-hydroxymethyl-thiophene
71637-34-8

3-hydroxymethyl-thiophene

carbon monoxide
201230-82-2

carbon monoxide

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

3-Methylthiophene
616-44-4

3-Methylthiophene

Conditions
ConditionsYield
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction;A 34%
B 11%
With tetrakis(triphenylphosphine) palladium(0); hydrogen iodide In acetone at 90℃; under 68400 Torr; for 42h;A 34 % Spectr.
B 11 % Spectr.
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

sodium cyanide
143-33-9

sodium cyanide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With ethanol Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
2-(thiophene-3-yl) acetamide
13781-66-3

2-(thiophene-3-yl) acetamide

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With potassium hydroxide
ethyl-3 thiophene acetate
37784-63-7

ethyl-3 thiophene acetate

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With sodium hydroxide
3-thienyl iodide
10486-61-0

3-thienyl iodide

tert-butyl sodioacetate

tert-butyl sodioacetate

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

2-acetoacetic acid
541-50-4

2-acetoacetic acid

C

Di-thiophen-3-yl-acetic acid

Di-thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid; iron(II) sulfate 1.) NH3 (liquid), 45 min, 2.) H2O, reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
thiophen-3-yl-acetic acid i-propyl ester
53064-74-7

thiophen-3-yl-acetic acid i-propyl ester

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

propene
187737-37-7

propene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
Thiophen-3-yl-acetic acid tert-butyl ester
58416-26-5

Thiophen-3-yl-acetic acid tert-butyl ester

A

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

B

isobutene
115-11-7

isobutene

Conditions
ConditionsYield
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated;
1-diazo-2-(thiophen-3-yl)ethanone
124687-94-1

1-diazo-2-(thiophen-3-yl)ethanone

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
With silver(l) oxide In 1,4-dioxane Rearrangement;
3-thiophene carboxylic acid chloride
41507-35-1

3-thiophene carboxylic acid chloride

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether / 0 °C
2: aq. Ag2O / dioxane
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether / Erwaermen des Reaktionsprodukts mit Silberoxid und Aethanol
2: ethanolic NaOH-solution
View Scheme
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (COCl)2; DMF / CH2Cl2
2: diethyl ether / 0 °C
3: aq. Ag2O / dioxane
View Scheme
methanol
67-56-1

methanol

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

thiophen-3-yl-acetic acid methyl ester
58414-52-1

thiophen-3-yl-acetic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;100%
With sulfuric acid for 24h; Reflux;100%
With acetyl chloride at 0 - 20℃;100%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-(2-chlorothiophen-3-yl)acetic acid
188718-23-2

2-(2-chlorothiophen-3-yl)acetic acid

Conditions
ConditionsYield
With N-chloro-succinimide; acetic acid In benzene at 80℃; for 1h; Inert atmosphere;100%
With N-chloro-succinimide; acetic acid
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h;
Stage #2: With water In tetrahydrofuran; ethyl acetate
99%
With lithium aluminium tetrahydride98%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere;98%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

5,6-dimethoxy-2-(N-propylamino)indan
162751-96-4

5,6-dimethoxy-2-(N-propylamino)indan

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide
745060-23-5

N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h;99%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-(thiophen-3-yl)acetamide
940741-63-9

N-benzyl-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;99%
With tris(2,2,2-trifluoroethyl) borate In acetonitrile at 80℃; for 5h;91%
Stage #1: thiophen-3-yl-acetic acid With titanium(IV) isopropylate In tetrahydrofuran at 40 - 70℃; Molecular sieve; Inert atmosphere;
Stage #2: benzylamine In tetrahydrofuran at 70℃; Molecular sieve; Inert atmosphere;
88%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

ethanol
64-17-5

ethanol

ethyl-3 thiophene acetate
37784-63-7

ethyl-3 thiophene acetate

Conditions
ConditionsYield
With hydrogenchloride for 0.166667h;98%
With sulfuric acid for 24h; Reflux;97%
With sulfuric acid for 24h; Reflux;97%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester
786704-01-6

2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester

2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester
786704-15-2

2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h;
Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester In tetrahydrofuran for 8h;
97%
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 1h;
Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester With 4 A molecular sieve In tetrahydrofuran for 9h;
97%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide
654682-77-6

N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 60h; Inert atmosphere;
96%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;95%
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 5h;
89%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

butan-1-ol
71-36-3

butan-1-ol

thiophen-3-yl-acetic acid n-butyl ester

thiophen-3-yl-acetic acid n-butyl ester

Conditions
ConditionsYield
With sulfuric acid In benzene for 24h; Reflux;96%
sulfuric acid for 6h; Heating;60%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

N-hydroxy-2-(thiophen-3-yl)acetamide
1013424-78-6

N-hydroxy-2-(thiophen-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With 4-(Methylamino)pyridine; diisopropyl-carbodiimide In dichloromethane at 20℃;
Stage #2: With hydroxylamine In dichloromethane; water at 20℃; Further stages.;
96%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

2-(thiophen-3-yl)acetyl chloride
13781-65-2

2-(thiophen-3-yl)acetyl chloride

Conditions
ConditionsYield
With thionyl chloride at 60℃; for 2h;95%
With sulfuryl dichloride at 60℃; for 3h;
With thionyl chloride for 3h; Heating;
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

(Z)-4-bromo-N′-hydroxybenzimidamide
19227-14-6

(Z)-4-bromo-N′-hydroxybenzimidamide

O- p-bromobenzamidoxime

O- p-bromobenzamidoxime

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane Ambient temperature;95%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

naphtho[1,2-b]thiophene-4-carboxylic acid
50920-15-5

naphtho[1,2-b]thiophene-4-carboxylic acid

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h;95%
With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 110℃; for 12h; Inert atmosphere; regiospecific reaction;95%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

N-(2-(dimethylamino)ethyl)-2-(thiophene-3-yl)acetamide

N-(2-(dimethylamino)ethyl)-2-(thiophene-3-yl)acetamide

Conditions
ConditionsYield
With boric acid In toluene for 24h; Reflux;94.92%
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: N,N-dimethylethylenediamine In tetrahydrofuran at 20℃;
67%

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