As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:6964-21-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:6964-21-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:6964-21-2
Min.Order:1 Gram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:6964-21-2
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Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:6964-21-2
Min.Order:1 Kilogram
FOB Price: $20.0 / 25.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:6964-21-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry3-Thiopheneacetic acid CAS:6964-21-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int
Cas:6964-21-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:6964-21-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:6964-21-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:6964-21-2
Min.Order:0 Metric Ton
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Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:6964-21-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white to light yellow crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Int
We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an
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Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:6964-21-2
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:6964-21-2
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAcmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
Cas:6964-21-2
Min.Order:1 bottle
Negotiable
Type:Lab/Research institutions
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as pri
3-Thiopheneacetic acid cas 6964-21-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Conditions | Yield |
---|---|
Stage #1: 3-Bromomethylthiophene; carbon monoxide With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide at 80℃; under 760 Torr; for 18h; Carbonylation; Hydrolysis; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; | 85% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction; | 47% |
3-hydroxymethyl-thiophene
carbon monoxide
A
thiophen-3-yl-acetic acid
B
3-Methylthiophene
Conditions | Yield |
---|---|
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction; | A 34% B 11% |
With tetrakis(triphenylphosphine) palladium(0); hydrogen iodide In acetone at 90℃; under 68400 Torr; for 42h; | A 34 % Spectr. B 11 % Spectr. |
Conditions | Yield |
---|---|
With ethanol Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge; |
2-(thiophene-3-yl) acetamide
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With potassium hydroxide |
ethyl-3 thiophene acetate
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; iron(II) sulfate 1.) NH3 (liquid), 45 min, 2.) H2O, reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given; |
thiophen-3-yl-acetic acid i-propyl ester
A
thiophen-3-yl-acetic acid
B
propene
Conditions | Yield |
---|---|
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated; |
Thiophen-3-yl-acetic acid tert-butyl ester
A
thiophen-3-yl-acetic acid
B
isobutene
Conditions | Yield |
---|---|
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated; |
1-diazo-2-(thiophen-3-yl)ethanone
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With silver(l) oxide In 1,4-dioxane Rearrangement; |
3-thiophene carboxylic acid chloride
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether / Erwaermen des Reaktionsprodukts mit Silberoxid und Aethanol 2: ethanolic NaOH-solution View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane View Scheme |
methanol
thiophen-3-yl-acetic acid
thiophen-3-yl-acetic acid methyl ester
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; | 100% |
With sulfuric acid for 24h; Reflux; | 100% |
With acetyl chloride at 0 - 20℃; | 100% |
thiophen-3-yl-acetic acid
2-(2-chlorothiophen-3-yl)acetic acid
Conditions | Yield |
---|---|
With N-chloro-succinimide; acetic acid In benzene at 80℃; for 1h; Inert atmosphere; | 100% |
With N-chloro-succinimide; acetic acid |
thiophen-3-yl-acetic acid
3-(2-hydroxyethyl)thiophene
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h; Stage #2: With water In tetrahydrofuran; ethyl acetate | 99% |
With lithium aluminium tetrahydride | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere; | 98% |
thiophen-3-yl-acetic acid
5,6-dimethoxy-2-(N-propylamino)indan
N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide
Conditions | Yield |
---|---|
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h; | 99% |
thiophen-3-yl-acetic acid
benzylamine
N-benzyl-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere; | 99% |
With tris(2,2,2-trifluoroethyl) borate In acetonitrile at 80℃; for 5h; | 91% |
Stage #1: thiophen-3-yl-acetic acid With titanium(IV) isopropylate In tetrahydrofuran at 40 - 70℃; Molecular sieve; Inert atmosphere; Stage #2: benzylamine In tetrahydrofuran at 70℃; Molecular sieve; Inert atmosphere; | 88% |
Conditions | Yield |
---|---|
With hydrogenchloride for 0.166667h; | 98% |
With sulfuric acid for 24h; Reflux; | 97% |
With sulfuric acid for 24h; Reflux; | 97% |
thiophen-3-yl-acetic acid
2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester
2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h; Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester In tetrahydrofuran for 8h; | 97% |
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 1h; Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester With 4 A molecular sieve In tetrahydrofuran for 9h; | 97% |
thiophen-3-yl-acetic acid
N,O-dimethylhydroxylamine*hydrochloride
N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 60h; Inert atmosphere; | 96% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 95% |
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 5h; | 89% |
Conditions | Yield |
---|---|
With sulfuric acid In benzene for 24h; Reflux; | 96% |
sulfuric acid for 6h; Heating; | 60% |
thiophen-3-yl-acetic acid
N-hydroxy-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With 4-(Methylamino)pyridine; diisopropyl-carbodiimide In dichloromethane at 20℃; Stage #2: With hydroxylamine In dichloromethane; water at 20℃; Further stages.; | 96% |
thiophen-3-yl-acetic acid
2-(thiophen-3-yl)acetyl chloride
Conditions | Yield |
---|---|
With thionyl chloride at 60℃; for 2h; | 95% |
With sulfuryl dichloride at 60℃; for 3h; | |
With thionyl chloride for 3h; Heating; |
thiophen-3-yl-acetic acid
(Z)-4-bromo-N′-hydroxybenzimidamide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 95% |
thiophen-3-yl-acetic acid
methyl chloroformate
thiophen-3-yl-acetic acid methyl ester
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h; | 94% |
thiophen-3-yl-acetic acid
2,3,4,5,6-pentafluorophenol
Pentafluorophenyl (thiophen-3-yl)ethanoate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In 1,4-dioxane | 92% |
thiophen-3-yl-acetic acid
2-(3,4-dimethoxyphenyl)-ethylamine
N-(3',4'-dimethoxy-β-phenethyl)-3-thienylacetamide
Conditions | Yield |
---|---|
at 170℃; Heating; | 92% |
for 2h; Heating; | 92% |
With triethylamine; HATU In dichloromethane at 20℃; |
thiophen-3-yl-acetic acid
2-chloro-ethanol
thiophen-3-yl-acetic acid 2-chloro-ethyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane | 92% |
thiophen-3-yl-acetic acid
Ethyl 4-bromobenzoate
methyl iodide
C16H16O4S
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid; Ethyl 4-bromobenzoate With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere; Stage #2: methyl iodide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; regioselective reaction; | 92% |
thiophen-3-yl-acetic acid
4-bromobenzenecarbonitrile
methyl iodide
C14H11NO2S
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid; 4-bromobenzenecarbonitrile With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere; Stage #2: methyl iodide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; regioselective reaction; | 92% |
thiophen-3-yl-acetic acid
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
diazomethyl-trimethyl-silane
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical With N4,N4,N7,N7-tetramethyl-1,10-phenanthroline-4,7-diamine; iron(II) acetate In tetrahydrofuran at 60℃; for 24h; Molecular sieve; Inert atmosphere; Schlenk technique; Stage #2: diazomethyl-trimethyl-silane With methanol In tetrahydrofuran; hexane for 1h; Inert atmosphere; Stage #3: With acetic acid In tetrahydrofuran; hexane; ethyl acetate chemoselective reaction; | 92% |
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid; ortho-bromobenzaldehyde With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h; Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Temperature; | 91% |
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid; ortho-bromobenzaldehyde With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h; Stage #2: ethyl bromide In N,N-dimethyl-formamide at 20℃; | 91% |
carbon dioxide
3-[(phenylsulfonyl)methyl]thiophene
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 30℃; for 6h; Electrolysis; | 99% |
Conditions | Yield |
---|---|
Stage #1: 3-Bromomethylthiophene; carbon monoxide With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide at 80℃; under 760 Torr; for 18h; Carbonylation; Hydrolysis; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; | 85% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction; | 47% |
3-hydroxymethyl-thiophene
carbon monoxide
A
thiophen-3-yl-acetic acid
B
3-Methylthiophene
Conditions | Yield |
---|---|
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction; | A 34% B 11% |
With tetrakis(triphenylphosphine) palladium(0); hydrogen iodide In acetone at 90℃; under 68400 Torr; for 42h; | A 34 % Spectr. B 11 % Spectr. |
Conditions | Yield |
---|---|
With ethanol Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge; |
2-(thiophene-3-yl) acetamide
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With potassium hydroxide |
ethyl-3 thiophene acetate
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; iron(II) sulfate 1.) NH3 (liquid), 45 min, 2.) H2O, reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given; |
thiophen-3-yl-acetic acid i-propyl ester
A
thiophen-3-yl-acetic acid
B
propene
Conditions | Yield |
---|---|
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated; |
Thiophen-3-yl-acetic acid tert-butyl ester
A
thiophen-3-yl-acetic acid
B
isobutene
Conditions | Yield |
---|---|
In gaseous matrix at 326.9℃; gas-phase Hammett replacement ς0 substituent constant was investigated; |
1-diazo-2-(thiophen-3-yl)ethanone
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
With silver(l) oxide In 1,4-dioxane Rearrangement; |
3-thiophene carboxylic acid chloride
thiophen-3-yl-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether / Erwaermen des Reaktionsprodukts mit Silberoxid und Aethanol 2: ethanolic NaOH-solution View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane View Scheme |
methanol
thiophen-3-yl-acetic acid
thiophen-3-yl-acetic acid methyl ester
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; | 100% |
With sulfuric acid for 24h; Reflux; | 100% |
With acetyl chloride at 0 - 20℃; | 100% |
thiophen-3-yl-acetic acid
2-(2-chlorothiophen-3-yl)acetic acid
Conditions | Yield |
---|---|
With N-chloro-succinimide; acetic acid In benzene at 80℃; for 1h; Inert atmosphere; | 100% |
With N-chloro-succinimide; acetic acid |
thiophen-3-yl-acetic acid
3-(2-hydroxyethyl)thiophene
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h; Stage #2: With water In tetrahydrofuran; ethyl acetate | 99% |
With lithium aluminium tetrahydride | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere; | 98% |
thiophen-3-yl-acetic acid
5,6-dimethoxy-2-(N-propylamino)indan
N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-thiophen-3-yl-acetamide
Conditions | Yield |
---|---|
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h; | 99% |
thiophen-3-yl-acetic acid
benzylamine
N-benzyl-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere; | 99% |
With tris(2,2,2-trifluoroethyl) borate In acetonitrile at 80℃; for 5h; | 91% |
Stage #1: thiophen-3-yl-acetic acid With titanium(IV) isopropylate In tetrahydrofuran at 40 - 70℃; Molecular sieve; Inert atmosphere; Stage #2: benzylamine In tetrahydrofuran at 70℃; Molecular sieve; Inert atmosphere; | 88% |
Conditions | Yield |
---|---|
With hydrogenchloride for 0.166667h; | 98% |
With sulfuric acid for 24h; Reflux; | 97% |
With sulfuric acid for 24h; Reflux; | 97% |
thiophen-3-yl-acetic acid
2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester
2-diazo-3-[3-ethyl-2-oxo-1-(2-thiophen-3-yl-acetyl)-piperidin-3-yl]-3-oxo-propionic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h; Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester In tetrahydrofuran for 8h; | 97% |
Stage #1: thiophen-3-yl-acetic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 1h; Stage #2: 2-diazo-3-(3-ethyl-2-oxo-piperidin-3-yl)-3-oxo-propionic acid ethyl ester With 4 A molecular sieve In tetrahydrofuran for 9h; | 97% |
thiophen-3-yl-acetic acid
N,O-dimethylhydroxylamine*hydrochloride
N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 60h; Inert atmosphere; | 96% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 95% |
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 5h; | 89% |
Conditions | Yield |
---|---|
With sulfuric acid In benzene for 24h; Reflux; | 96% |
sulfuric acid for 6h; Heating; | 60% |
thiophen-3-yl-acetic acid
N-hydroxy-2-(thiophen-3-yl)acetamide
Conditions | Yield |
---|---|
Stage #1: thiophen-3-yl-acetic acid With 4-(Methylamino)pyridine; diisopropyl-carbodiimide In dichloromethane at 20℃; Stage #2: With hydroxylamine In dichloromethane; water at 20℃; Further stages.; | 96% |
thiophen-3-yl-acetic acid
2-(thiophen-3-yl)acetyl chloride
Conditions | Yield |
---|---|
With thionyl chloride at 60℃; for 2h; | 95% |
With sulfuryl dichloride at 60℃; for 3h; | |
With thionyl chloride for 3h; Heating; |
thiophen-3-yl-acetic acid
(Z)-4-bromo-N′-hydroxybenzimidamide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 95% |
thiophen-3-yl-acetic acid
ortho-bromobenzaldehyde
naphtho[1,2-b]thiophene-4-carboxylic acid
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl acetamide at 110℃; for 12h; | 95% |
With palladium diacetate; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 110℃; for 12h; Inert atmosphere; regiospecific reaction; | 95% |
Conditions | Yield |
---|---|
With boric acid In toluene for 24h; Reflux; | 94.92% |
Stage #1: thiophen-3-yl-acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: N,N-dimethylethylenediamine In tetrahydrofuran at 20℃; | 67% |
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