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LEAP CHEM Co., Ltd.

LEAPChem is a specialized fine chemical supplier for research, development and production. LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing act

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0 Metric Ton

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Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Thiophene-3-ethanol Manufacturer/High quality/Best price/In stock

Cas:13781-67-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Thiopheneethanol supplier in China

Cas:13781-67-4

Min.Order:0 Metric Ton

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply Thiophene-3-ethanol CAS 13781-67-4 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Factory supply Thiophene-3-ethanol CAS 13781-67-4 with fast delivery

Cas:13781-67-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Thiopheneethanol

Cas:13781-67-4

Min.Order:1

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Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(3-Thienyl)-1-ethanol

Cas:13781-67-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

HotCAS 13781-67-4 with high quality products

Cas:13781-67-4

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Thiophene-3-ethanol 13781-67-4

Cas:13781-67-4

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Thiophene-3-ethanol CAS: 13781-67-4 MF: C6H8OS MW: 128.19 EINECS: 237-434-7 Mol File: 13781-67-4.mol Thiophene-3-ethanol Structure Thiophene-3-ethanol Chemical Properties Boiling point 110-111 °C14 mm Hg(lit.

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Organic Intermediate, Thiophene-3-ethanol CAS:13781-67-4

Cas:13781-67-4

Min.Order:1 Kilogram

FOB Price: $42.1 / 48.6

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Thiophene-3-ethanol CAS:13781-67-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

Thiophene-3-ethanol CAS:13781-67-4

Cas:13781-67-4

Min.Order:1 Gram

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Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0

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Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

thiophene-3-ethanol

Cas:13781-67-4

Min.Order:100 Metric Ton

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Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-Thiopheneethanol

Cas:13781-67-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Thiophene-3-Ethanol CAS No.:13781-67-4 Molecule Formula:C5H6OS Molecule Weight:114.17 Purity: 98.0% Package: 200kg/drum Description:Light yellow transparent liquid Manufacture Standards:Enterprise Standard TESTING I

Best Quality Thiophene-3-Ethanol with good supplier

Cas:13781-67-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Thiophene-3-ethanol,13781-67-4

Cas:13781-67-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2-(Thiophen-3-yl)ethanol

Cas:13781-67-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-(3-Thienyl)ethanol cas no. 13781-67-4 98%

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-(Thiophen-3-yl)ethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Thiopheneethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Thiophene-3-Ethanol

Cas:13781-67-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

Thiophene-3-ethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Thiophene-3-ethanol 500g

Cas:13781-67-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3-Thiopheneethanol

Cas:13781-67-4

Min.Order:0

Negotiable

Type:Manufacturers

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Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-Thiopheneethanol

Cas:13781-67-4

Min.Order:0

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Type:Manufacturers

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Synthetic route

thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 2h;
Stage #2: With water In tetrahydrofuran; ethyl acetate
99%
With lithium aluminium tetrahydride98%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere;98%
thiophen-3-yl-acetic acid methyl ester
58414-52-1

thiophen-3-yl-acetic acid methyl ester

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
Stage #1: thiophen-3-yl-acetic acid methyl ester With 1,1,3,3-Tetramethyldisiloxane; vanadium(V) oxytriisopropoxide In toluene at 100℃; for 26h; Inert atmosphere; Sealed tube;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran; toluene for 2h; Inert atmosphere;
74%
In tetrahydrofuran; water; ethyl acetate
3-Bromothiophene
872-31-1

3-Bromothiophene

ethyleneglycol sulfate
1072-53-3

ethyleneglycol sulfate

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
Stage #1: 3-Bromothiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h;
Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexane at -78 - 20℃;
Stage #3: With sulfuric acid In tetrahydrofuran; hexane for 4h; Heating; Further stages.;
53%
oxirane
75-21-8

oxirane

3-thienyl lithium
1192-06-9

3-thienyl lithium

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
With diethyl ether at -70℃;
In tetrahydrofuran; diethyl ether at -70 - 20℃; for 1h;
oxirane
75-21-8

oxirane

3-Bromothiophene
872-31-1

3-Bromothiophene

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

3-thiopheneethanol methanesulfonate (ester)
114896-64-9

3-thiopheneethanol methanesulfonate (ester)

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 0.5h;100%
With triethylamine In dichloromethane at 0℃; for 0.25h;99%
With triethylamine In dichloromethane at 0℃; for 0.25h;99%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-(thiophen-3-yl)ethyl 4-methylbenzenesulfonate
40412-09-7

2-(thiophen-3-yl)ethyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In toluene at 0 - 35℃; for 12h;93%
With triethylamine In dichloromethane at 0 - 20℃; for 5h;90%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

1-Iodonaphthalene
90-14-2

1-Iodonaphthalene

3-(2-(naphthalen-1-yloxy)ethyl)thiophene
960395-49-7

3-(2-(naphthalen-1-yloxy)ethyl)thiophene

Conditions
ConditionsYield
With copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate In toluene at 110℃; for 24h;99%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

5,7-dihydro-7-(4-nitrophenyl)-4H-thieno[2,3-c]pyran
1220970-39-7

5,7-dihydro-7-(4-nitrophenyl)-4H-thieno[2,3-c]pyran

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;99%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

4-(5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl)benzonitrile
1220970-41-1

4-(5,7-dihydro-4H-thieno[2,3-c]pyran-7-yl)benzonitrile

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;99%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

diethylphosphonoacetic acid
3095-95-2

diethylphosphonoacetic acid

2-(thiophen-3-yl)ethyl 2-(diethoxyphosphoryl)acetate

2-(thiophen-3-yl)ethyl 2-(diethoxyphosphoryl)acetate

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;99%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

3-(2'-iodoethyl) thiophene
114896-65-0

3-(2'-iodoethyl) thiophene

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane for 3h; Ambient temperature;98%
With 1H-imidazole; triphenylphosphine diiodide In dichloromethane Ambient temperature;
Multi-step reaction with 2 steps
1: 53 percent / PBr3 / benzene / 5 h / Ambient temperature
2: 92 percent / NaI / acetone / 96 h / 50 °C
View Scheme
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

methyl 2-(2-bromothiophen-3-yl)ethan-1-ol
111881-86-8

methyl 2-(2-bromothiophen-3-yl)ethan-1-ol

Conditions
ConditionsYield
With N-Bromosuccinimide In fluorobenzene at 20℃; for 24h; Darkness;98%
With N-Bromosuccinimide In dichloromethane at 20℃; for 0.25h;95%
With N-Bromosuccinimide; acetic acid In dichloromethane for 0.5h;91%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

5,7-dihydro-7-(4-methoxyphenyl)-4H-thieno[2,3-c]pyran
1220970-40-0

5,7-dihydro-7-(4-methoxyphenyl)-4H-thieno[2,3-c]pyran

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;98%
With bismuth(lll) trifluoromethanesulfonate In toluene at 20 - 80℃; for 1h; oxa-Pictet-Spengler cyclisation;98%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

2-(thiophene-2-yl) ethyl 4-nitrobenzoate

2-(thiophene-2-yl) ethyl 4-nitrobenzoate

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)thiophene; 4-nitro-benzoic acid With ethyl 2-(3,4-dichlorophenyl)azocarboxylate; triphenylphosphine In toluene at 20℃; for 3h; Mitsunobu Displacement; Inert atmosphere;
Stage #2: With iron(II) phthalocyanine In toluene at 20℃; for 12h; Inert atmosphere;
98%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

1-methylindole
603-76-9

1-methylindole

1-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)ethane-1,2-dione

1-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)ethane-1,2-dione

Conditions
ConditionsYield
With 1-methyl-piperazine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; zinc trifluoromethanesulfonate In toluene at 110℃; for 6h; Inert atmosphere;96.2%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

carbon monoxide
201230-82-2

carbon monoxide

1,4-diphenyl-1,3-butadiyne
886-66-8

1,4-diphenyl-1,3-butadiyne

2-(thiophen-3-yl)ethyl (E)-2-benzylidene-4-phenylbut-3-ynoate

2-(thiophen-3-yl)ethyl (E)-2-benzylidene-4-phenylbut-3-ynoate

Conditions
ConditionsYield
With (1S)-10-camphorsulfonic acid; palladium diacetate; 2,2'-bis(tert-butyl(pyridin-2-yl)phosphaneyl)-1,1'-binaphthalene In toluene at 40℃; for 20h; Inert atmosphere; Autoclave; High pressure; chemoselective reaction;96%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

diethyl 2-(3-thienyl) ethyl phosphate

diethyl 2-(3-thienyl) ethyl phosphate

Conditions
ConditionsYield
With triethylamine In tetrachloromethane for 1.5h; ultrasonic irradiation;95%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

2-(3'-thiophenyl)-1-bromoethane
57070-76-5

2-(3'-thiophenyl)-1-bromoethane

Conditions
ConditionsYield
With triphenylphosphine dibromide 1:1 addition complex In acetonitrile Bromination; Heating;95%
With 2,6-dimethylpyridine; bromine; triphenylphosphine In dichloromethane at 0℃; for 5h;95%
With carbon tetrabromide; triphenylphosphine In tetrahydrofuran at 70℃; for 3h;86%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

3-bromo-4-hydroxybenzonitrile
2315-86-8

3-bromo-4-hydroxybenzonitrile

3-bromo-4-(2-thiophen-3-ylethoxy)benzonitrile
1189815-96-0

3-bromo-4-(2-thiophen-3-ylethoxy)benzonitrile

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃;95%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃;
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

trifluoroacetic acid
76-05-1

trifluoroacetic acid

4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate
1307248-40-3

4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)thiophene; N-tert-butyloxycarbonylpiperidin-4-one In dichloromethane at 20℃;
Stage #2: trifluoroacetic acid In dichloromethane at 14 - 30℃; for 20.0833h;
95%
In dichloromethane at 14 - 30℃; for 20.0833h;95%
Stage #1: 3-(2-hydroxyethyl)thiophene; N-tert-butyloxycarbonylpiperidin-4-one In dichloromethane at 20℃; for 0.166667h;
Stage #2: trifluoroacetic acid In dichloromethane at 0 - 20℃; for 16.5h;
91%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]
1283095-47-5

4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 20.5h;95%
In tetrahydrofuran; dichloromethane at 25℃;95%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

1-methyl-1H-indole-2,3-dione
2058-74-4

1-methyl-1H-indole-2,3-dione

1-methyl-4',5'-dihydrospiro[indoline-3,7'-thieno[2,3-c]pyran]-2-one

1-methyl-4',5'-dihydrospiro[indoline-3,7'-thieno[2,3-c]pyran]-2-one

Conditions
ConditionsYield
With iron perchlorate hexahydrate In tetrahydrofuran at 80℃; for 72h; Friedel-Crafts Alkylation; Inert atmosphere;95%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

ethyl 5-allyloxyindole-2-carboxylate
51086-05-6

ethyl 5-allyloxyindole-2-carboxylate

5-allyloxy-1-[(2-thiophen-3-yl)ethyl]-1H-indole-2-carboxylic acid ethyl ester
385785-67-1

5-allyloxy-1-[(2-thiophen-3-yl)ethyl]-1H-indole-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With tributylphosphine; diamide In tetrahydrofuran at 20℃; for 18.3h; Stirring;94%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

5,7-dihydro-7,7-dimethyl-4H-thieno[2,3-c]pyran
1220970-47-7

5,7-dihydro-7,7-dimethyl-4H-thieno[2,3-c]pyran

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate; water In toluene at 80℃; oxa Pictet-Spengler reaction;94%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

1-Bromopentane
110-53-2

1-Bromopentane

3-[2-(pentyloxy)ethyl]thiophene

3-[2-(pentyloxy)ethyl]thiophene

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)thiophene With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.5h;
Stage #2: 1-Bromopentane In dimethyl sulfoxide; mineral oil at 20℃; for 8h;
94%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

methyl 5-hydroxy-6-iodopyridine-3-carboxylate
1189816-87-2

methyl 5-hydroxy-6-iodopyridine-3-carboxylate

methyl 6-iodo-5-(2-(thiophen-3-yl)ethoxy)nicotinate
1189816-88-3

methyl 6-iodo-5-(2-(thiophen-3-yl)ethoxy)nicotinate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;93.2%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

tert-butylphenylphosphinic acid chloride
4923-85-7

tert-butylphenylphosphinic acid chloride

O-2-(3-thienyl)ethyltert-butylphenylphosphinate

O-2-(3-thienyl)ethyltert-butylphenylphosphinate

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxyethyl)thiophene With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 2h; Inert atmosphere;
Stage #2: tert-butylphenylphosphinic acid chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 6h;
93%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

trityl chloride
76-83-5

trityl chloride

3-(2-trityloxy-ethyl)-thiophene
198278-17-0

3-(2-trityloxy-ethyl)-thiophene

Conditions
ConditionsYield
With iron(III) chloride; 1-(n-butyl)-3-methylimidazolium triflate at 20℃; for 3.25h; Ionic liquid;92%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

allyl bromide
106-95-6

allyl bromide

3-(2-(allyloxy)ethyl)thiophene
136473-37-5

3-(2-(allyloxy)ethyl)thiophene

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 50℃; Inert atmosphere;92%
Stage #1: 3-(2-hydroxyethyl)thiophene With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 1h;
Stage #2: allyl bromide In tetrahydrofuran; mineral oil at 0 - 20℃;
52%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

2,5-dibromo-3-(2-hydroxyethyl)thiophene
207733-28-6

2,5-dibromo-3-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
With tetrabutylammomium bromide; bromine In methanol; dichloromethane at 20℃; for 1h;91.2%
With N-Bromosuccinimide In toluene at -20 - 20℃;86%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 40℃; for 3h;85%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

methyl 3-hydroxy-5-isopropoxybenzoate
752242-26-5

methyl 3-hydroxy-5-isopropoxybenzoate

Methyl 3-isopropoxy-5-(2-(3-thienyl)ethoxy)benzoate
852520-41-3

Methyl 3-isopropoxy-5-(2-(3-thienyl)ethoxy)benzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h;91%
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃;67%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 20h;41%
3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

2-(3'-thienyl)ethyl chloride
7136-58-5

2-(3'-thienyl)ethyl chloride

Conditions
ConditionsYield
With pyridine; thionyl chloride In diethyl ether90%
With tetrachloromethane; tributylphosphine In acetonitrile for 18h; Heating;84%
With thionyl chloride In chloroform81.5%
With methanesulfonyl chloride; triethylamine In dichloromethane
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

3-(2-hydroxyethyl)thiophene
13781-67-4

3-(2-hydroxyethyl)thiophene

3-<2-(tetrahydropyranyloxy)ethyl>thiophene
160557-19-7

3-<2-(tetrahydropyranyloxy)ethyl>thiophene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In diethyl ether for 3h; Ambient temperature;90%
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃;73%
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃;73%

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