Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
3-Bromothiophene CAS No.:872-31-1 Name: 3-Bromothiophene Synonyms: 3-Thienyl bromide Molecular Structure Molecular Formula: C4H3BrS Molecular Weight: 163.03 CAS Registry Number:
Cas:872-31-1
Min.Order:1 Kilogram
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inquiryGood price Good quality Appearance:powder Storage:dry condition Package:According to the demand of customer Application:intermediate Transportation:by sea or by air Port:Shanghai Port
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:872-31-1
Min.Order:1 Gram
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:872-31-1
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Description Name 3-Bromothiophene CAS 872-31-1 Assay 99% Appearance
Cas:872-31-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 3-Bromothiophene Synonyms: 3-bromo-thiophen;beta-Bromothiophene;thiophene,3-bromo-;β-bromothiophene;TIMTEC-BB SBB003930;TIMTEC-BB SBB003931;ALPHA-THIENYL BROMIDE;3-THIENYL BROMIDE
Cas:872-31-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:872-31-1
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:872-31-1
Min.Order:10 Gram
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inquiryProduct name: 3-Bromothiophene CAS : 872-31-1 Appearance: Colorless transparent liquid Content: 99% Appearance:Colorless transparent liquid Storage:Preserve in well-closed, light-resistant and airtight containers. Package:25kg/drum Application:Organ
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:liquid Storage:Store in sealed containers at cool & dry pla
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Cas:872-31-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry3-Bromothiophene Chemical Properties Melting point <-10°C Boiling point 150 °C (lit.) density 1.74 g/mL at 25 °C (lit.) refractive index n20/D 1.591(lit.) Fp 140 °F storage temp. Keep in dark place,Sealed in
3-Bromothiophene CAS:872-31-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
Cas:872-31-1
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:872-31-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:872-31-1
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c
Cas:872-31-1
Min.Order:100 Metric Ton
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Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:872-31-1
Min.Order:0 Metric Ton
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:872-31-1
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:872-31-1
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:872-31-1
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry3-BromothiopheneAppearance:detailed see specifications Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:APIs & Intermediate;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridi
Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Used for synthetic drugs and
Product name: 3-Bromothiophene CAS No.:872-31-1 Molecule Formula:C4H3SBr Molecule Weight:163.04 Purity: 99.0% Package: 200kg/drum Description:Colorless to light yellow liquid Manufacture Standards:Enterprise Standard TESTING ITEM
Cas:872-31-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With dibutylbis(cyclopentadienyl)zirconium at 0℃; for 3h; | 98% |
With ethyl bromide; diethyl ether; magnesium erhitzen des Reaktionsprodukts mit Wasser; |
Conditions | Yield |
---|---|
With acetic acid; zinc In water for 3h; Reflux; | 90% |
With acetic acid; zinc In water at 0℃; for 5h; Reflux; | 70% |
64% |
Conditions | Yield |
---|---|
With hydrogen bromide; lead acetate In methanol electrolysis; | 82% |
In methanol at 35℃; for 5h; Product distribution; electrolysis in presence of Pb(OAc)2*2H2O, MeN+(C8H17)3Cl-, and HBr at 50 mA/cm2, anolyt : 10percent NH3 in MeOH; other conditions and other bromothiophenes investigated; | 82% |
In N,N-dimethyl-formamide divided cell electrolysis at constant potential (-1.70 V); 0.1 M tetraethylammonium bromide, mercury electrode; | 38% |
With quinoline; copper |
thiophene
3-Bromothiophene
Conditions | Yield |
---|---|
Stage #1: thiophene With bromine In chloroform at 0℃; Reflux; Stage #2: With sodium hydroxide In chloroform Stage #3: With acetic acid; zinc In water for 8h; Reflux; | 80.8% |
Stage #1: thiophene With hydrogen bromide; bromine In diethyl ether; water at 22℃; for 22.5h; Inert atmosphere; Stage #2: With acetic acid; zinc In water for 7h; Reflux; Inert atmosphere; | 48% |
With bromine; sodium acetate; zinc 1) water, reflux, 8 h; 2) reflux, 3 h, water; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide divided cell electrolysis at constant potential (-1.70 V); 0.1 M tetraethylammonium bromide, mercury electrode; | A 74% B 3% |
Conditions | Yield |
---|---|
With sodium amide; ferric nitrate In ammonia | A 72% B n/a |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide divided cell electrolysis at constant potential (-1.70 V); 0.1 M tetraethylammonium bromide, mercury electrode; | 60% |
Conditions | Yield |
---|---|
Stage #1: thiophene With bromine In chloroform for 4h; Heating; Stage #2: With acetic acid; zinc In water Heating; | A 23% B 51% |
3-Bromo-2-iodothiophene
sodium methylate
A
3-Bromothiophene
B
4-bromo-2-methoxythiophene
Conditions | Yield |
---|---|
With copper(II) oxide In methanol for 30h; Heating; | A n/a B 25% |
sodium methylate
3-bromo-4-iodothiophene
A
3-Bromothiophene
B
4-bromo-2-methoxythiophene
Conditions | Yield |
---|---|
With copper(II) oxide In methanol for 72h; Heating; | A n/a B 15% |
2,3,5-tribromothiophene
n-butyllithium
diethyl ether
3-Bromothiophene
Conditions | Yield |
---|---|
anschliessend mit Wasser behandeln; |
4-bromo-thiophene-2-carboxylic acid
3-Bromothiophene
Conditions | Yield |
---|---|
With quinoline; copper at 220℃; |
Conditions | Yield |
---|---|
With quinoline; copper |
Conditions | Yield |
---|---|
zeolithe at 100℃; |
Conditions | Yield |
---|---|
With copper(II) oxide In methanol for 30h; Product distribution; Heating; | A n/a B 25 % Chromat. |
3-Bromo-2-iodothiophene
A
3-Bromothiophene
C
3-bromo-4-iodothiophene
D
4-bromo-2-iodothiophene
Conditions | Yield |
---|---|
With sodium methylate In methanol for 72h; Product distribution; Heating; another solvents; | A 32 % Chromat. B 4 % Chromat. C 32 % Chromat. D 5 % Chromat. |
Conditions | Yield |
---|---|
With copper(II) oxide In methanol for 72h; Product distribution; Heating; | A n/a B 15 % Chromat. |
Conditions | Yield |
---|---|
With copper(II) oxide In methanol Product distribution; Heating; different reaction times; |
2-(trimethylsilyl)-3-bromothiophene
3-Bromothiophene
Conditions | Yield |
---|---|
In methanol; perchloric acid at 50℃; | |
In methanol; perchloric acid at 50℃; Rate constant; 1.) other solvents, 2.) k (excit.); | |
With sodium methylate In methanol at 50℃; Rate constant; deuterium isotope effect; |
3-bromo-4-iodothiophene
A
3-Bromothiophene
C
3-Bromo-2-iodothiophene
D
4-bromo-2-iodothiophene
Conditions | Yield |
---|---|
With sodium methylate In pyridine at 60℃; for 72h; Product distribution; | A 32 % Chromat. B 4 % Chromat. C 8 % Chromat. D 5 % Chromat. |
4-bromo-2-iodothiophene
A
3-Bromothiophene
C
3-Bromo-2-iodothiophene
D
3-bromo-4-iodothiophene
Conditions | Yield |
---|---|
With sodium methylate In pyridine for 72h; Product distribution; Ambient temperature; different reaction times; | A 32 % Chromat. B 4 % Chromat. C 8 % Chromat. D 32 % Chromat. |
(4-bromo-thiophen-2-yl)trimethylsilane
3-Bromothiophene
Conditions | Yield |
---|---|
In sulfuric acid; acetic acid at 50℃; | |
In methanol; perchloric acid at 50℃; Rate constant; 1.) other solvents, 2.) k (excit.); | |
With sodium methylate In methanol at 50℃; Rate constant; deuterium isotope effect; |
2,5-dibromothiophen
A
thiophene
B
2-bromothiophene
C
3-Bromothiophene
D
3,4-dibromothiophene
Conditions | Yield |
---|---|
With tetramethylammonium perchlorate In N,N-dimethyl-formamide Product distribution; Mechanism; controlled-potential electrolysis at reticulated vitreous carbon; further reagents; |
2,3,5-tribromothiophene
A
3-Bromothiophene
B
2,3-dibromothiophen
C
2,4-dibromothiophene
Conditions | Yield |
---|---|
With sodium tetrahydroborate In dimethyl sulfoxide at 26℃; for 4h; Product distribution; Mechanism; other catalysts, var. solvent; | |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran for 6h; Reagent/catalyst; Time; Reflux; Inert atmosphere; regioselective reaction; |
Conditions | Yield |
---|---|
at 700 - 750℃; |
Tetrabromothiophene
acetic acid
A
3-Bromothiophene
B
3,4-dibromothiophene
3-Bromothiophene
N,N-dimethyl-formamide
3-bromo-2-thiophenecarboxaldehyde
Conditions | Yield |
---|---|
Stage #1: 3-Bromothiophene With lithium diisopropyl amide In tetrahydrofuran at 0 - 5℃; for 0.5h; Inert atmosphere; Large scale; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0 - 5℃; for 3h; Inert atmosphere; Large scale; | 100% |
Stage #1: 3-Bromothiophene With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 3h; | 100% |
Stage #1: 3-Bromothiophene With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0 - 20℃; for 4h; | 94% |
Conditions | Yield |
---|---|
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In acetonitrile at 60℃; for 16h; Sonogashira coupling; | 100% |
With 1,4-diaza-bicyclo[2.2.2]octane; bis(η3-allyl-μ-chloropalladium(II)); tri-tert-butyl phosphine In hexane; acetonitrile at 20℃; for 16h; Sonogashira coupling; | 96% |
With pyrrolidine; bis(η3-allyl-μ-chloropalladium(II)); triphenylphosphine; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 4h; Heck alkynylation; Inert atmosphere; | 95% |
3-Bromothiophene
1-t-Butoxycarbonylpiperazine
Conditions | Yield |
---|---|
Stage #1: 3-Bromothiophene; 1-t-Butoxycarbonylpiperazine With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In xylene at 50℃; Stage #2: With macroporous polymer-supported isocyanate In xylene at 50℃; for 24h; | 100% |
Conditions | Yield |
---|---|
With C50H64Cl2N12Pd2(6+)*6F6P(1-); sodium acetate In N,N-dimethyl-formamide at 140℃; for 4h; Reagent/catalyst; Heck Reaction; | 100% |
With sodium acetate In water at 20℃; for 0.5h; Heck Reaction; Green chemistry; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 5h; Catalytic behavior; | 88% |
3-Bromothiophene
o-fluorophenylboronic acid
3-(2-fluorophenyl)thiophene
Conditions | Yield |
---|---|
With potassium fluoride; palladium diacetate In tetrahydrofuran at 20℃; for 1h; Schlenk technique; Inert atmosphere; | 100% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 85℃; for 4h; Inert atmosphere; | 99% |
3-Bromothiophene
3-pyridylboronic acid
butan-1-ol
3-(thiophen-3-yl)pyridine
Conditions | Yield |
---|---|
In water | 100% |
Conditions | Yield |
---|---|
Stage #1: 3-Bromothiophene With n-butyllithium In diethyl ether; hexane at -68℃; for 2.5h; Inert atmosphere; Stage #2: di-n-heptadecyl ketone In diethyl ether; hexane at -78 - 25℃; for 5.16667h; | 100% |
Stage #1: 3-Bromothiophene With n-butyllithium In diethyl ether; hexane at -68℃; for 2.5h; Inert atmosphere; Stage #2: di-n-heptadecyl ketone In diethyl ether; hexane at -78 - 20℃; for 15h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With n-butyllithium In diethyl ether; hexane at -40℃; for 3h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With N-Bromosuccinimide; perchloric acid In tetrachloromethane for 24h; Ambient temperature; | 99% |
With bromine In acetic acid | 89% |
Stage #1: 3-Bromothiophene With N-Bromosuccinimide; perchloric acid In hexane; water at 20℃; for 24h; Stage #2: With potassium carbonate In hexane; water | 89% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine at 110℃; | 99% |
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃; for 24h; | 99% |
Conditions | Yield |
---|---|
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Green chemistry; | 99% |
With [Pd(N,N'-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2-ylidene)(acetylacetonate)Cl]; lithium hexamethyldisilazane In 1,4-dioxane at 110℃; for 3h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube; | 89% |
With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In xylene at 120℃; for 24h; | 80% |
Conditions | Yield |
---|---|
With palladium diacetate; sodium t-butanolate; ruphos In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Green chemistry; | 99% |
With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 20℃; for 16h; | 93% |
With Pd(π-crotyl)(QPhos)Cl; sodium t-butanolate In toluene at 100℃; for 3h; Buchwald-Hartwig coupling reaction; Inert atmosphere; | 90% |
With [(1,3-(2,6-diisopropylphenyl)imidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride]; potassium tert-butylate In toluene at 100℃; Buchwald-Hartwig amination; Inert atmosphere; | 73% |
3-Bromothiophene
(R)-(3-thienyl)[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]methanol
Conditions | Yield |
---|---|
With tert.-butyl lithium In diethyl ether at -78℃; | 99% |
Conditions | Yield |
---|---|
With copper(l) iodide; N-((4-nitro-1-oxy-pyridin-2-yl)methyl)oxalamic acid; tetrabutylammomium bromide; potassium hydroxide In water at 100℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube; | 99% |
With copper(l) iodide; potassium carbonate; heptakis(6-amino-6-deoxy)-β-cyclodextrin In dimethyl sulfoxide at 110℃; for 24h; Sealed tube; | 97% |
With [bmim]BF4; potassium carbonate; L-proline; copper(l) iodide at 110℃; for 36h; | 72% |
3-Bromothiophene
1-(2-diethylaminoethyl)-4-bromoisatin
1-(2-Diethylaminoethyl)-3-hydroxy-3-(3-thienyl)-4-bromooxindole
Conditions | Yield |
---|---|
With tert.-butyl lithium In tetrahydrofuran; methanol; chloroform; pentane | 99% |
3-Bromothiophene
2-phenylpyridine
2-di[2-(3-thiophenyl)]phenylpyridine
Conditions | Yield |
---|---|
With potassium carbonate; triphenylphosphine; RuCl2(η6-C6H6) In 1-methyl-pyrrolidin-2-one at 120℃; for 20h; | 99% |
3-Bromothiophene
(3-(morpholinosulfonyl)phenyl)boronic acid
4-(3-thiophen-3-yl-benzenesulfonyl)-morpholine
Conditions | Yield |
---|---|
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 180℃; for 0.333333h; Microwave irradiation; | 99% |
3-Bromothiophene
5-methoxy-7-methylbicyclo[4.2.0]octa-1,3,5-trien-7-ol
1-[3-methoxy-2-(thiophen-3-yl)phenyl]propan-2-one
Conditions | Yield |
---|---|
Stage #1: 5-methoxy-7-methylbicyclo[4.2.0]octa-1,3,5-trien-7-ol With tris-(dibenzylideneacetone)dipalladium(0); silver carbonate; DavePhos In toluene for 0.0833333h; Inert atmosphere; Stage #2: 3-Bromothiophene In toluene at 65℃; Inert atmosphere; | 99% |
3-Bromothiophene
(1,5-anhydro-2-deoxy-4,6-O-bis(tert-butylsilylidene)-3-O-triisopropylsilyl-D-arabino-hex-1-enitol)boronic acid pinacol ester
3-(1,5-anhydro-2-deoxy-4,6-O-di(tert-butyl)silanediyl-3-O-triisopropylsilyl-D-arabino-hex-1-enitolyl)thiophene
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water for 4h; Reflux; | 99% |
Conditions | Yield |
---|---|
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; tetrabutylammomium bromide; sodium hydrogencarbonate In water for 1h; Catalytic behavior; Suzuki-Miyaura Coupling; Reflux; | 99% |
3-Bromothiophene
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
3-phenylthiophene
Conditions | Yield |
---|---|
With potassium carbonate In water at 20℃; for 6h; Suzuki-Miyaura Coupling; | 99% |
3-Bromothiophene
1-methyl-4-((phenylethynyl)sulfonyl)benzene
1-phenyl-2-(3-thienyl)ethyne
Conditions | Yield |
---|---|
Stage #1: 3-Bromothiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: 1-methyl-4-((phenylethynyl)sulfonyl)benzene In tetrahydrofuran for 0.25h; Reagent/catalyst; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With [(di-tert-butylneopentylphosphine)PdCl2]2; sodium carbonate In water; acetonitrile at 23℃; for 18h; Reagent/catalyst; Suzuki-Miyaura Coupling; Sealed tube; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With C30H32Cl3N4Ni2(1+)*Cl(1-); potassium hydroxide In 1,4-dioxane at 40℃; for 6h; Reagent/catalyst; | 99% |
Conditions | Yield |
---|---|
With bismuth(lll) trifluoromethanesulfonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 2-methyltetrahydrofuran; water at 20 - 110℃; for 13h; Reagent/catalyst; Temperature; Solvent; | 98.6% |
Conditions | Yield |
---|---|
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 0 - 5℃; for 0.25h; Kumada Cross-Coupling; Inert atmosphere; | 98.2% |
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran for 15h; Kumada Cross-Coupling; Reflux; | 86% |
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 20℃; for 12h; | 78% |
Conditions | Yield |
---|---|
Stage #1: acetyl chloride With aluminium trichloride In dichloromethane cooling; Stage #2: 3-Bromothiophene In dichloromethane at 0 - 20℃; for 1.66667h; Friedel-Crafts acylation; | 98% |
Stage #1: acetyl chloride With aluminum (III) chloride In dichloromethane at 0℃; for 0.666667h; Inert atmosphere; Stage #2: 3-Bromothiophene In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere; | 98% |
With tin(IV) chloride | 90% |
Conditions | Yield |
---|---|
With [(t-Bu)3PH]BF4; palladium diacetate; sodium hydroxide In water; butan-1-ol at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Glovebox; | 98% |
With potassium carbonate In water; N,N-dimethyl-formamide at 85℃; for 0.05h; Suzuki Coupling; Microwave irradiation; | 97% |
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); tri-tert-butyl phosphine In 1,1,1,2,3,3,3-Heptafluoropropane; ethanol; 1,1,1,3,3-pentafluorobutane at 20℃; for 24h; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere; | 96% |
3-Bromothiophene
trimethylsilylacetylene
3-(trimethylsilylethynyl)thiophene
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine at 80℃; | 98% |
Stage #1: 3-Bromothiophene In diisopropylamine for 0.5h; Sonogashira coupling; Inert atmosphere; Stage #2: trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In diisopropylamine at 60℃; for 8h; Sonogashira coupling; Inert atmosphere; | 81% |
Stage #1: 3-Bromothiophene With copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 0.05h; Stage #2: trimethylsilylacetylene; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 140℃; for 0.25h; Microwave irradiation; | 66% |
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