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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Thiophene Carboxylic Acid supplier in China

Cas:88-13-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Appearance:white powder Storage:dry condition Package:According to the demand of customer Application:intermediate Transportation:By sea or by Air Port:Shanghai Port

88-13-1 3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1000 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Thiophenecarboxylic acid

Cas:88-13-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 3-Thiophenecarboxylic acid CAS No. 8

3-Thiophenecarboxylic acid

Cas:88-13-1

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Thiophenecarboxylic acid

Cas:88-13-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 88-13-1 with best price

Cas:88-13-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Thiophenezoic acid 88-13-1

Cas:88-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Organic synthesis reagent, 3-Thiophenezoic acid CAS:88-13-1

Cas:88-13-1

Min.Order:1 Kilogram

FOB Price: $57.5 / 63.4

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Thiophenezoic acid CAS: 88-13-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

3-Thiophenezoic acid CAS: 88-13-1

Cas:88-13-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:88-13-1

Cas:88-13-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Thiophene Carboxylic Acid

Cas:88-13-1

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Thiophenecarboxylic acid

Cas:88-13-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Thiophenecarboxylic acid

Cas:88-13-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Thiophenecarboxylic acid/High quality/Best price

Cas:88-13-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-Thiophene Carboxylic Acid

Cas:88-13-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:white to light yellow crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermedia

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

3-Thiophenezoic acid Chemical Properties Melting point 136-141 °C(lit.) storage temp. Refrigerated. solubility wa

88-13-1 3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

CAS:88-13-1 EINECS:201-802-5 MW:128.15 MF:C5H4O2S Melting point:136-141 °C(lit.) Appearance:White needle crystal Package:25kg/drum Transportation:by sea/air/courier Port:Shanghai

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Thiophenezoic acid MF: C5H4O2S MW: 128.15 EINECS: 201-802-5 Mol File: 88-13-1.mol 3-Thiophenezoic acid Structure 3-Thiophenezoic acid Chemical Properties Melting point 136-141 °C (lit.) Boiling point 260&d

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

88-13-1 CAS NO.88-13-1

Cas:88-13-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Name: 3-Thiophenezoicacid. Synonym:3-Carboxythiophene;Thiophene-3-carboxylicacid,99%;3-Thenoylicacid;3-Thiophenecarboxylicacid,99%;3-Carboxythiophene,3-Thenoicacid;3-Thiophenecarboxylicacid,99%1GR;3-ThiophenecarboxylicAcid3-ThiophenicAcid;3-thiop

3-Thiophenezoicacid

Cas:88-13-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

3-Thiophenezoic acid

Cas:88-13-1

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Synthetic route

3-Bromothiophene
872-31-1

3-Bromothiophene

carbon dioxide
124-38-9

carbon dioxide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique;
Stage #2: 3-Bromothiophene With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 7h; Schlenk technique; Sealed tube;
94%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 60℃; for 0.416667h; Schlenk technique;
Stage #2: 3-Bromothiophene With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 7h; Schlenk technique;
94%
With manganese; 2.9-dimethyl-1,10-phenanthroline; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;65%
3-thienyl iodide
10486-61-0

3-thienyl iodide

formic acid
64-18-6

formic acid

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;90%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 100℃; for 20h; Inert atmosphere; Sealed tube;46%
2-(thiophen-3-yl)-5,5-dimethyl-1,3,2-dioxaborinane
905966-46-3

2-(thiophen-3-yl)-5,5-dimethyl-1,3,2-dioxaborinane

carbon dioxide
124-38-9

carbon dioxide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
Stage #1: 5,5-dimethyl-2-(thiophen-3-yl)-1,3,2-dioxaborinane; carbon dioxide With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃;
88%
Stage #1: 5,5-dimethyl-2-(thiophen-3-yl)-1,3,2-dioxaborinane; carbon dioxide With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave;
Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere;
83%
With 1,3-bis-(diphenylphosphino)propane; cesium fluoride; [Rh(OH)(cod)]2 In 1,4-dioxane at 60℃;64%
3-hydroxymethyl-thiophene
71637-34-8

3-hydroxymethyl-thiophene

A

3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With sodium hypochlorite; C8H18NPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;A 87.5%
B 0.1%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; Schlenk technique;A 18 %Spectr.
B 65%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;A 52.3%
B 2.3%
3-ethynylthiophene
67237-53-0

3-ethynylthiophene

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With oxone; sodium hydrogencarbonate In water; acetonitrile at 20℃; for 8h;86%
With carbon tetrabromide; water; oxygen In ethyl acetate for 20h; Irradiation;16%
3-thienyl iodide
10486-61-0

3-thienyl iodide

carbon dioxide
124-38-9

carbon dioxide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h;85%
3-thienyl iodide
10486-61-0

3-thienyl iodide

carbon monoxide
201230-82-2

carbon monoxide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 12h;84%
3-hydroxymethyl-thiophene
71637-34-8

3-hydroxymethyl-thiophene

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With hydrogen bromide; oxygen In acetonitrile for 10h; Irradiation;83%
With carbon tetrabromide; oxygen; triphenylphosphine In acetonitrile for 10h; fluorescent irradiation;80%
With dichloro(1,5-cyclooctadiene)ruthenium(II); C30H30N3P2(1+)*Cl(1-); potassium hydroxide In toluene at 120℃; for 24h; Inert atmosphere; Schlenk technique;76%
3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With water; chromium(VI) oxide In diethyl ether80%
With chromic acid In diethyl ether at 0℃; for 3h;80%
With sodium hydroxide; silver(l) oxide
3-Bromothiophene
872-31-1

3-Bromothiophene

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

A

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With CoCRACO; sodium tert-pentoxide; sodium hydride In tetrahydrofuran for 14h; Irradiation;A 80%
B 12.5%
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 14h; Irradiation;A 80%
B 12.5%
3-Bromothiophene
872-31-1

3-Bromothiophene

carbon monoxide
201230-82-2

carbon monoxide

A

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 14h; Irradiation;A 80%
B 12.5%
3-chlorothiophene
17249-80-8

3-chlorothiophene

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

A

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 17h; Irradiation;A 77.5%
B 8.5%
3-chlorothiophene
17249-80-8

3-chlorothiophene

carbon monoxide
201230-82-2

carbon monoxide

A

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 17h; Irradiation;A 77.5%
B 8.5%
3-Methylthiophene
616-44-4

3-Methylthiophene

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
at 30℃; for 16h; Pseudomonas putida ATCC 33015;70%
With sodium dichromate In water at 250℃; for 16h;60%
With oxygen; cobalt(II) acetate; sodium bromide In acetic acid at 100℃; for 1.5h; Kinetics; Rate constant;
1-(thiophen-3-yl)butane-1,3-dione

1-(thiophen-3-yl)butane-1,3-dione

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With 2-chloroanthracene-9,10-dione; oxygen; caesium carbonate In acetone for 48h; Irradiation;70%
With iodine; oxygen In ethyl acetate for 10h; Mercury lamp irradiation;57%
C21H22O2SSi

C21H22O2SSi

A

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

B

2-(tert-Butyl-diphenyl-silanyl)-thiophene-3-carboxylic acid

2-(tert-Butyl-diphenyl-silanyl)-thiophene-3-carboxylic acid

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -78℃; for 0.25h;A n/a
B 64%
thiophen-3-yl-acetic acid
6964-21-2

thiophen-3-yl-acetic acid

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With iodine; dimethyl sulfoxide at 120℃; for 26h; Sealed tube; Green chemistry;62%
C14H24O2SSi

C14H24O2SSi

A

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

B

2-Triisopropylsilanyl-thiophene-3-carboxylic acid

2-Triisopropylsilanyl-thiophene-3-carboxylic acid

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -78℃; for 0.25h;A n/a
B 57%
3-chlorothiophene
17249-80-8

3-chlorothiophene

carbon dioxide
124-38-9

carbon dioxide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With manganese; 2,9-dibutyl-4,7-dimethyl-1,10-phenanthroline; tetraethylammonium iodide; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 100℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;51%
C11H18O2SSi

C11H18O2SSi

A

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

B

2-(tert-Butyl-dimethyl-silanyl)-thiophene-3-carboxylic acid

2-(tert-Butyl-dimethyl-silanyl)-thiophene-3-carboxylic acid

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -78℃; for 0.25h;A n/a
B 47%
thiophene
188290-36-0

thiophene

carbon monoxide
201230-82-2

carbon monoxide

A

β-thiophen carboxylic anhydride
13191-43-0

β-thiophen carboxylic anhydride

B

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With palladium diacetate; ethylene dibromide at 100℃; under 11400 Torr; for 20h;A 35%
B 42%
3-thienyl iodide
10486-61-0

3-thienyl iodide

malononitrile
109-77-3

malononitrile

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-thienyl iodide; malononitrile With copper(l) iodide; caesium carbonate; L-proline In dimethyl sulfoxide at 130℃; for 24h; Ullmann type reaction; Inert atmosphere;
Stage #2: In dimethyl sulfoxide at 140℃; for 12h;
Stage #3: With hydrogenchloride In water pH=2 - 3;
37%
Thien-3-ylboronic acid
6165-69-1

Thien-3-ylboronic acid

ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere;27%
3-Bromothiophene
872-31-1

3-Bromothiophene

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

diethyl ether
60-29-7

diethyl ether

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
at -70℃; anschliessend mit festem Kohlendioxid;
3-Bromothiophene
872-31-1

3-Bromothiophene

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

benzene
71-43-2

benzene

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
anschliessenden Behandeln mit Kohlendioxid;
3-Bromothiophene
872-31-1

3-Bromothiophene

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With ethyl bromide; diethyl ether; magnesium Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
With n-butyllithium; diethyl ether at -70℃; Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
3-thienyl iodide
10486-61-0

3-thienyl iodide

potassium cyanide
151-50-8

potassium cyanide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With ethanol; copper(l) cyanide at 180℃;
3-thienyl iodide
10486-61-0

3-thienyl iodide

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With ethyl bromide; diethyl ether; magnesium anschliessend Behandeln mit Kohlendioxid;
3-thiophenecarbonitrile
1641-09-4

3-thiophenecarbonitrile

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

Conditions
ConditionsYield
In diethyl ether100%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

acetaldehyde
75-07-0

acetaldehyde

2-(1-hydroxy-ethyl)-thiophene-3-carboxylic acid
329351-95-3

2-(1-hydroxy-ethyl)-thiophene-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃;
Stage #2: acetaldehyde In tetrahydrofuran; pentane at -78 - 20℃;
100%
Stage #1: 3-Thiophene carboxylic acid With lithium hexamethyldisilazane In tetrahydrofuran at -80 - -50℃; for 1h;
Stage #2: acetaldehyde In tetrahydrofuran at -80 - -20℃; for 0.5h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 20℃;
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

2-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-5-amine

2-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-5-amine

N-(2-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-5-yl)thiophene-3-carboxamide

N-(2-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-5-yl)thiophene-3-carboxamide

Conditions
ConditionsYield
With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 16h;100%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

β-thiophen carboxylic anhydride
13191-43-0

β-thiophen carboxylic anhydride

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃;
Stage #2: With bis(trichloromethyl) carbonate In tetrahydrofuran at 0 - 20℃;
99%
With acetic anhydride; toluene
With 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate In tetrahydrofuran for 0.0166667h;
Multi-step reaction with 2 steps
1.1: potassium hydroxide / water / 0.5 h / 20 °C
2.1: trichloroisocyanuric acid; triphenylphosphine / dichloromethane / 0 - 20 °C
2.2: 2 h / 20 °C
View Scheme
dichloromethane
75-09-2

dichloromethane

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

C11H8O4S2

C11H8O4S2

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 130℃; for 5h;99%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-formylthiophene-3-carboxylic acid
19991-69-6

2-formylthiophene-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; for 0.166667h;
Stage #2: With n-butyllithium In tetrahydrofuran for 1h;
Stage #3: N,N-dimethyl-formamide In tetrahydrofuran for 0.5h;
98.3%
Stage #1: 3-Thiophene carboxylic acid With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere;
Stage #2: With n-butyllithium In tetrahydrofuran for 1h;
Stage #3: N,N-dimethyl-formamide In tetrahydrofuran for 0.5h;
98.3%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

2-bromothiophene-4-carboxylic acid
100523-84-0

2-bromothiophene-4-carboxylic acid

Conditions
ConditionsYield
With bromine; acetic acid at 20℃;98%
With bromine In acetic acid74%
With bromine In acetic acid70%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

7,13-O,O-diacetyl-2-O-debenzoylbaccatin III
329318-51-6

7,13-O,O-diacetyl-2-O-debenzoylbaccatin III

7,13-O,O-diacetyl-2-O-debenzoyl-2-O-(3-thiophenecarbonyl)baccatin III
1215640-85-9

7,13-O,O-diacetyl-2-O-debenzoyl-2-O-(3-thiophenecarbonyl)baccatin III

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran; toluene at 80℃; for 36h; Inert atmosphere;98%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

(S)-allyl 2-(allyloxy)-4-(2-(allyloxy)-4-(4-(2-(4-aminobenzamido)-3-cyanopropanamido)benzamido)-3-methoxybenzamido)-3-methoxybenzoate

(S)-allyl 2-(allyloxy)-4-(2-(allyloxy)-4-(4-(2-(4-aminobenzamido)-3-cyanopropanamido)benzamido)-3-methoxybenzamido)-3-methoxybenzoate

C48H44N6O11S

C48H44N6O11S

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: (S)-allyl 2-(allyloxy)-4-(2-(allyloxy)-4-(4-(2-(4-aminobenzamido)-3-cyanopropanamido)benzamido)-3-methoxybenzamido)-3-methoxybenzoate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 12h;
98%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

3-thiophene carboxylic acid chloride
41507-35-1

3-thiophene carboxylic acid chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 1.91667h; Inert atmosphere; Reflux;97%
With oxalyl dichloride In dichloromethane at 0 - 20℃;91%
With oxalyl dichloride In dichloromethane at 0℃; for 12h;78%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

L-proline methyl ester monohydrochloride
2133-40-6

L-proline methyl ester monohydrochloride

methyl (2S)-N-(3-thiophenecarbonyl)pyrrolidin-2-carboxylate
849795-61-5

methyl (2S)-N-(3-thiophenecarbonyl)pyrrolidin-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;97%
potassium thiophene-3-carboxylate

potassium thiophene-3-carboxylate

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

β-thiophen carboxylic anhydride
13191-43-0

β-thiophen carboxylic anhydride

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With trichloroisocyanuric acid; triphenylphosphine In dichloromethane at 0 - 20℃;
Stage #2: potassium thiophene-3-carboxylate In dichloromethane at 20℃; for 2h;
97%
benzoxazole
273-53-0

benzoxazole

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

2-(thiophen-3-yl)benzo[d]oxazole
638213-72-6

2-(thiophen-3-yl)benzo[d]oxazole

Conditions
ConditionsYield
With dmap; copper (II)-fluoride; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane In 1,4-dioxane at 160℃; for 15h; Schlenk technique; Inert atmosphere; chemoselective reaction;97%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

2,5-dibromothiophene-3-carboxylic acid
7311-70-8

2,5-dibromothiophene-3-carboxylic acid

Conditions
ConditionsYield
With N-Bromosuccinimide In N,N-dimethyl-formamide Inert atmosphere; Darkness;95%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 50℃; for 28h; Darkness; Inert atmosphere;92%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 50℃; for 18h; Darkness;88%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(thiophen-3-yl)-1H-benzo[d]imidazole
3878-21-5

2-(thiophen-3-yl)-1H-benzo[d]imidazole

Conditions
ConditionsYield
With PPA at 180℃; for 1.5h;95%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

dimethyl dicarbonate
4525-33-1

dimethyl dicarbonate

methyl thiophene-3-carboxylate
22913-26-4

methyl thiophene-3-carboxylate

Conditions
ConditionsYield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;95%
1,4-dioxane
123-91-1

1,4-dioxane

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

1,4-dioxan-2-yl thiophene-3-carboxylate
1597710-78-5

1,4-dioxan-2-yl thiophene-3-carboxylate

Conditions
ConditionsYield
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique;95%
1-phenyl-1-butyne
622-76-4

1-phenyl-1-butyne

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

A

7-ethyl-6-phenyl-4H-thieno[3,2-c]pyran-4-one

7-ethyl-6-phenyl-4H-thieno[3,2-c]pyran-4-one

B

6-ethyl-7-phenyl-4H-thieno[3,2-c]pyran-4-one

6-ethyl-7-phenyl-4H-thieno[3,2-c]pyran-4-one

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; oxygen; sodium acetate In methanol at 45℃; under 760.051 Torr; for 18h; Schlenk technique; regioselective reaction;A 95%
B 2%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

aminoguanidine bicarbonate
2582-30-1

aminoguanidine bicarbonate

amino(hydrazinyl)methaniminium thiophene-3-carboxylate

amino(hydrazinyl)methaniminium thiophene-3-carboxylate

Conditions
ConditionsYield
In methanol at 50℃;94%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

5,6-dimethoxy-2-(N-propylamino)indan
162751-96-4

5,6-dimethoxy-2-(N-propylamino)indan

thiophene-3-carboxylic acid (5,6-dimethoxy-indan-2-yl)-propyl-amide
745060-12-2

thiophene-3-carboxylic acid (5,6-dimethoxy-indan-2-yl)-propyl-amide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In dichloromethane at 20℃; for 24h;93%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

tert-butyl thiophene-3-carboxylate
125294-45-3

tert-butyl thiophene-3-carboxylate

Conditions
ConditionsYield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;93%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

dibenzyl dicarbonate
31139-36-3

dibenzyl dicarbonate

benzyl thiophene-3-carboxylate
14597-48-9

benzyl thiophene-3-carboxylate

Conditions
ConditionsYield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;93%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

4-cyclohexyl-thiosemicarbazide
21198-18-5

4-cyclohexyl-thiosemicarbazide

cyclohexyl-(5-thiophen-3-yl-[1,3,4]thiadiazol-2-yl)-amine

cyclohexyl-(5-thiophen-3-yl-[1,3,4]thiadiazol-2-yl)-amine

Conditions
ConditionsYield
With trichlorophosphate In 1,4-dioxane at 60 - 95℃; for 5h;93%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

thiosemicarbazide
79-19-6

thiosemicarbazide

cyclohexyl-(5-thiophen-3-yl-[1,3,4]thiadiazol-2-yl)-amine

cyclohexyl-(5-thiophen-3-yl-[1,3,4]thiadiazol-2-yl)-amine

Conditions
ConditionsYield
With sodium hydrogencarbonate; trichlorophosphate In 1,4-dioxane93%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

diphenyl acetylene
501-65-5

diphenyl acetylene

6,7-diphenyl-4H-thieno[3,2-c]pyran-4-one
1147304-41-3

6,7-diphenyl-4H-thieno[3,2-c]pyran-4-one

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; oxygen; sodium acetate In methanol at 45℃; under 760.051 Torr; for 18h; Schlenk technique; regioselective reaction;93%
With dichloro[1,3-di(ethoxycarbonyl)-2,4,5-trimethylcyclopentadienyl]rhodium(III) dimer; copper(II) acetate monohydrate; silver(I) triflimide In dichloromethane at 20℃; for 24h; Sealed tube;74%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate In N,N-dimethyl-formamide at 120℃; for 2h;60%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate In water at 120℃; for 0.5h; Microwave irradiation; Green chemistry;45%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

4-iodobenzonitrile
3058-39-7

4-iodobenzonitrile

4-cyanophenyl thiophene-3-carboxylate

4-cyanophenyl thiophene-3-carboxylate

Conditions
ConditionsYield
With potassium phosphate; 1-(2,2-diphenyl-2λ4,3λ4-[1,3,2]diazaborolo[4,5,1-ij]quinolin-1(2H)-yl)-3-phenylpropan-1-one; 4,4'-di-tert-butyl-2,2'-bipyridine; nickel dibromide In dimethyl sulfoxide at 25℃; for 22h; Irradiation;93%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

2-iodophenylamine
615-43-0

2-iodophenylamine

N-(2-iodophenyl)thiophene-3-carboxamide
136341-16-7

N-(2-iodophenyl)thiophene-3-carboxamide

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With thionyl chloride In toluene at 70℃; for 2.5h;
Stage #2: 2-iodophenylamine With TEA In dichloromethane at 20℃; for 5h;
92%
1-(3-dimethylaminopropyl)-3-ethylcabodiimide hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcabodiimide hydrochloride

3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

thiophene-3-(N-methoxy-N-methyl)carboxamide
357405-56-2

thiophene-3-(N-methoxy-N-methyl)carboxamide

Conditions
ConditionsYield
With 4-methyl-morpholine; dmap In dichloromethane92%
3-Thiophene carboxylic acid
88-13-1

3-Thiophene carboxylic acid

4-[(2S',6S')-6'-(4-((6-aminohexyl)oxy)butyl)tetrahydropyran-2-yl]-1-[(2S'',6S'')-6''-(4-hydroxybutyltetrahydropyran-2-yl)methyl]-1H-1,2,3-triazole

4-[(2S',6S')-6'-(4-((6-aminohexyl)oxy)butyl)tetrahydropyran-2-yl]-1-[(2S'',6S'')-6''-(4-hydroxybutyltetrahydropyran-2-yl)methyl]-1H-1,2,3-triazole

N-(6-(4-((2S,6S)-6-((4-((2S,6S)-6-(4-(benzyloxy)butyl)tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-1-yl)methyl)tetrahydro-2H-pyran-2-yl)butoxy)hexyl)thiophene-3-carboxamide

N-(6-(4-((2S,6S)-6-((4-((2S,6S)-6-(4-(benzyloxy)butyl)tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-1-yl)methyl)tetrahydro-2H-pyran-2-yl)butoxy)hexyl)thiophene-3-carboxamide

Conditions
ConditionsYield
Stage #1: 3-Thiophene carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.166667h;
Stage #2: 4-[(2S',6S')-6'-(4-((6-aminohexyl)oxy)butyl)tetrahydropyran-2-yl]-1-[(2S'',6S'')-6''-(4-hydroxybutyltetrahydropyran-2-yl)methyl]-1H-1,2,3-triazole In dichloromethane at 20℃;
92%

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