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Shanghai Biobond Pharmaceutical Co.,Ltd

High quality Purity(GC)>90%; e.e%>99% This product can be produced with dozens of kg per bacth Appearance:Colorless to light yellow liquid Storage:2-8 ℃ Application:It is key intermediate for synthesizing treprostinil Transportation:Be ca

2-(((S)-Dec-1-yn-5-yl)oxy)tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(S)-5-[(Tetrahydropyranyl)oxy]-1-decyne

Cas:223734-62-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 223734-62-1 with competitive price

Cas:223734-62-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-[(5S)-dec-1-yn-5-yloxy]oxane

Cas:223734-62-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2H-Pyran, 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-

Cas:223734-62-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-[[(1S)-1-(3-Butyn-1-yl)hexyl]oxy]tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-[[(1S)-1-(3-Butyn-1-yl)hexyl]oxy]tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-[[(1S)-1-(3-Butyn-1-yl)hexyl]oxy]tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2H-Pyran, 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-

Cas:223734-62-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(S)-5-[(Tetrahydropyranyl)oxy]-1-decyne cas no. 223734-62-1 98%

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

2H-Pyran, 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk productionChemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine chem

2-[[(1S)-1-(3-Butynyl)hexyl]oxy]tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-(((S)-Dec-1-yn-5-yl)oxy)tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-[[(1S)-1-(3-Butyn-1-yl)hexyl]oxy]tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2-((S)-Dec-1-yn-5-yloxy)tetrahydro-2H-pyran

Cas:223734-62-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

2-[(5S)-dec-1-yn-5-yloxy]oxane

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

nanjing bam biomedical technology co.,ltd

It is composed of professionals with senior industry background and rich market experience. More than 90% of the personnel have chemistry, chemical, pharmaceutical or related professional knowledge. They are all rigorously trained and evaluated, and

2-[(5S)-dec-1-yn-5-yloxy]oxane

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Reply quotation within 2 hours.Guarantee the time of delivery. Update the progress of customization Weekly.High purity& High product customization success rate.Inquiries for other compounds are acceptable. Storage:refrigeration Package:1g,5g,10g,100g

2-[(5S)-dec-1-yn-5-yloxy]oxane

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Genriver Pharmaceutical Co., Ltd.

Our Quality systemWe has a sound quality management system and documents, equipped with SHIMADZU HPLC, GC chromatography and other series of testing equipment, in order to meet the quality priority principle. Quality management department is independ

Alchemist-pharm chemical Technology Co. Ltd.

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

223734-62-1

Cas:223734-62-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-(trimethylsilyl)-O-tetrahydropyran-2-yl-1-decyn-5-(S)-ol
678992-52-4

1-(trimethylsilyl)-O-tetrahydropyran-2-yl-1-decyn-5-(S)-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 20h;
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

(+-)-4-hydroxy-3-methyl-butan-2-one

(+-)-4-hydroxy-3-methyl-butan-2-one

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TsOH*pyridine / CH2Cl2 / 15 h / 20 °C
2: BuLi / tetrahydrofuran; hexane / 15 h / 0 - 20 °C
3: NaOH / ethanol / 20 h / 20 °C
View Scheme
(S)-1-chloroheptane-2-ol
81007-64-9

(S)-1-chloroheptane-2-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TsOH*pyridine / CH2Cl2 / 15 h / 20 °C
2: BuLi / tetrahydrofuran; hexane / 15 h / 0 - 20 °C
3: NaOH / ethanol / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tert-butyl methyl ether / 18 h / 25 °C
2.1: magnesium; iodine; mercury dichloride / diethyl ether / 0 - 36 °C / Inert atmosphere
2.2: 0.5 h
3.1: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide / tert-butyl methyl ether / 18 h / 25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -50 - -35 °C / Inert atmosphere
2.2: 2.5 h / -40 - -20 °C
3.1: sodium hydroxide; ethanol / 2 h / 25 °C
4.1: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydroxide / tert-butyl methyl ether / 18 h / 25 °C
2: copper(l) iodide / tetrahydrofuran / 3 h / 0 - 5 °C / Inert atmosphere
3: pyridinium p-toluenesulfonate / dichloromethane / 25 °C
4: pyridine; pyridinium perbromide hydrobromide / dichloromethane / 3 h / 0 - 5 °C
5: sodium amide / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
View Scheme
(S)-1-chloro-O-tetrahydropyran-2-yl-heptan-2-ol
678992-51-3

(S)-1-chloro-O-tetrahydropyran-2-yl-heptan-2-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: BuLi / tetrahydrofuran; hexane / 15 h / 0 - 20 °C
2: NaOH / ethanol / 20 h / 20 °C
View Scheme
(S)-2-pentyloxirane
61229-03-6

(S)-2-pentyloxirane

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium; iodine; mercury dichloride / diethyl ether / 0 - 36 °C / Inert atmosphere
1.2: 0.5 h
2.1: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -50 - -35 °C / Inert atmosphere
1.2: 2.5 h / -40 - -20 °C
2.1: sodium hydroxide; ethanol / 2 h / 25 °C
3.1: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: copper(l) iodide / tetrahydrofuran / 3 h / 0 - 5 °C / Inert atmosphere
2: pyridinium p-toluenesulfonate / dichloromethane / 25 °C
3: pyridine; pyridinium perbromide hydrobromide / dichloromethane / 3 h / 0 - 5 °C
4: sodium amide / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
View Scheme
(5S)-dec-1-en-5-ol
1374332-11-2

(5S)-dec-1-en-5-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridinium p-toluenesulfonate / dichloromethane / 25 °C
2: pyridine; pyridinium perbromide hydrobromide / dichloromethane / 3 h / 0 - 5 °C
3: sodium amide / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
View Scheme
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 0 - 25℃; for 24h; Temperature;65.1 g
C15H28O2

C15H28O2

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; pyridinium perbromide hydrobromide / dichloromethane / 3 h / 0 - 5 °C
2: sodium amide / tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene / Inert atmosphere; Reflux
View Scheme
C15H28Br2O2

C15H28Br2O2

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
With sodium amide In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene Inert atmosphere; Reflux;
C13H26OSi

C13H26OSi

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; ethanol / 2 h / 25 °C
2: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
View Scheme
2-allyl-3-methoxybenzaldehyde
94956-98-6

2-allyl-3-methoxybenzaldehyde

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol
223734-56-3

3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Conditions
ConditionsYield
With ethylmagnesium bromide In tetrahydrofuran; diethyl ether at 0 - 20℃;92%
2-allyl-3-methoxybenzaldehyde
94956-98-6

2-allyl-3-methoxybenzaldehyde

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(αS)-3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol
223734-58-5

(αS)-3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Conditions
ConditionsYield
Stage #1: 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 0.25h;
Stage #2: 2-allyl-3-methoxybenzaldehyde In toluene for 3h;
87%
2-allyl-3-(carbomethoxy)benzyloxybenzaldehyde
1351472-15-5

2-allyl-3-(carbomethoxy)benzyloxybenzaldehyde

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C34H44O6
1351472-16-6

C34H44O6

Conditions
ConditionsYield
Stage #1: 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine In toluene at 20℃;
Stage #2: 2-allyl-3-(carbomethoxy)benzyloxybenzaldehyde In toluene at 20℃; for 2h;
84%
2-allyl-3-benzyloxy-N-methoxy-N-methyl-benzamide

2-allyl-3-benzyloxy-N-methoxy-N-methyl-benzamide

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(6S)-1-(2-allyl-3-(benzyloxy)phenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one

(6S)-1-(2-allyl-3-(benzyloxy)phenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one

Conditions
ConditionsYield
Stage #1: 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran With ethylmagnesium bromide In tetrahydrofuran; diethyl ether at 35 - 40℃;
Stage #2: 2-allyl-3-benzyloxy-N-methoxy-N-methyl-benzamide In tetrahydrofuran; diethyl ether at 25℃; for 1h; Reflux;
77.9%
2-allyl-3-[(carbomethoxy)methoxy]benzaldehyde
1292809-43-8

2-allyl-3-[(carbomethoxy)methoxy]benzaldehyde

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C28H40O6
1351472-11-1

C28H40O6

Conditions
ConditionsYield
Stage #1: 2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine In toluene at 20℃;
Stage #2: 2-allyl-3-[(carbomethoxy)methoxy]benzaldehyde In toluene at 20℃; for 16h;
70%
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

treprostinil
81846-19-7

treprostinil

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
7: NaBH4; aq. NaOH / ethanol / 6 h / -10 °C
8: 2162 g / TsOH / methanol / 15 h / 0 - 20 °C
9: 80 percent / Ph2PH; n-BuLi / tetrahydrofuran; hexane / 20 h / Heating
10: 100 percent / K2CO3; tetrabutylammonium bromide / acetone / 8 h / Heating
11: 83 percent / aq. KOH / methanol / 3 h / Heating
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(1R,2R,3aS,9aS)-1-[(3S)-3-hydroxyoctyl]-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol
101692-01-7

(1R,2R,3aS,9aS)-1-[(3S)-3-hydroxyoctyl]-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
7: NaBH4; aq. NaOH / ethanol / 6 h / -10 °C
8: 2162 g / TsOH / methanol / 15 h / 0 - 20 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol
101692-02-8

(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
7: NaBH4; aq. NaOH / ethanol / 6 h / -10 °C
8: 2162 g / TsOH / methanol / 15 h / 0 - 20 °C
9: 80 percent / Ph2PH; n-BuLi / tetrahydrofuran; hexane / 20 h / Heating
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

2-((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalen-5-yloxy)acetonitrile
101692-03-9

2-((1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalen-5-yloxy)acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
7: NaBH4; aq. NaOH / ethanol / 6 h / -10 °C
8: 2162 g / TsOH / methanol / 15 h / 0 - 20 °C
9: 80 percent / Ph2PH; n-BuLi / tetrahydrofuran; hexane / 20 h / Heating
10: 100 percent / K2CO3; tetrabutylammonium bromide / acetone / 8 h / Heating
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecyn-1-one
223734-57-4

(6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecyn-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(αS)-3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol
223734-58-5

(αS)-3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

1,3,3a,4,9,9a-hexahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-2H-benz[f]inden-2-one
223734-61-0

1,3,3a,4,9,9a-hexahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-2H-benz[f]inden-2-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-1H-benz[f]inden-2-ol
101758-87-6

(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-1H-benz[f]inden-2-ol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
6: H2; K2CO3 / Pd/C / ethanol / 20 °C / 4654.33 Torr
7: NaBH4; aq. NaOH / ethanol / 6 h / -10 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(1,1-dimethylethyl)[[(1S,6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecynyl]oxy]dimethylsilane
223734-59-6

(1,1-dimethylethyl)[[(1S,6S)-1-[3-methoxy-2-(2-propenyl)phenyl]-6-[(tetrahydro-2H-pyran-2-yl)oxy]-2-undecynyl]oxy]dimethylsilane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

(3aS,9aS)-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-2H-benz[f]inden-2-one
223734-60-9

(3aS,9aS)-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-2H-benz[f]inden-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C
2: 75 percent / PCC / CH2Cl2 / 15 h / 0 - 20 °C
3: BH3; Me2S; (R)-methyloxazaborolidine / toluene; tetrahydrofuran / 1 h / -30 °C
4: 92 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide; CH2Cl2 / 15 h / 20 °C
5: CH2Cl2 / 2 h / 20 °C
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C38H56O4Si

C38H56O4Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: zinc trifluoromethanesulfonate; triethylamine; (1S,2R)-(+)-N-methylephedrine
2: 1H-imidazole / dichloromethane
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C39H56O5Si

C39H56O5Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc trifluoromethanesulfonate; triethylamine; (1S,2R)-(+)-N-methylephedrine
2: 1H-imidazole / dichloromethane
3: Co(CO)8 / 1,2-dimethoxyethane / 3620.13 Torr
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C26H38O4

C26H38O4

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: zinc trifluoromethanesulfonate; triethylamine; (1S,2R)-(+)-N-methylephedrine
2: 1H-imidazole / dichloromethane
3: Co(CO)8 / 1,2-dimethoxyethane / 3620.13 Torr
4: palladium on activated charcoal; hydrogen; potassium carbonate / ethanol / 4137.29 Torr
View Scheme
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C26H40O4

C26H40O4

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: zinc trifluoromethanesulfonate; triethylamine; (1S,2R)-(+)-N-methylephedrine
2: 1H-imidazole / dichloromethane
3: Co(CO)8 / 1,2-dimethoxyethane / 3620.13 Torr
4: palladium on activated charcoal; hydrogen; potassium carbonate / ethanol / 4137.29 Torr
5: sodium hydroxide; sodium tetrahydroborate
View Scheme
3-benzyloxy-2-allylbenzaldehyde

3-benzyloxy-2-allylbenzaldehyde

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

C32H42O4

C32H42O4

Conditions
ConditionsYield
With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine

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