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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(5S)-1-Decyn-5-ol

Cas:848609-05-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(5S)-1-Decyn-5-ol

Cas:848609-05-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1-Decyn-5-ol,(5S)- 848609-05-2

Cas:848609-05-2

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 848609-05-2 with best quality

Cas:848609-05-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

1-Decyn-5-ol,(5S)-CAS848609-05-2

Cas:848609-05-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 25.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

1-Decyn-5-ol

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Decyn-5-ol, (5S)- 848609-05-2

Cas:848609-05-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1-Decyn-5-ol,(5S)- CAS:848609-05-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

1-Decyn-5-ol,(5S)- CAS:848609-05-2

Cas:848609-05-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Decyn-5-ol, (5S)-

Cas:848609-05-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Decyn-5-ol, (5S)-

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-Decyn-5-ol,(5S)-

Cas:848609-05-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-Decyn-5-ol

Cas:848609-05-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1-Decyn-5-ol;(5S)-

Cas:848609-05-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

848609-05-2 CAS NO.848609-05-2

Cas:848609-05-2

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(5S)-1-Decyn-5-ol

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(5S)-dec-1-yn-5-ol cas no. 848609-05-2 98%

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

1-Decyn-5-Ol,(5S)-

Cas:848609-05-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

(5S)-dec-1-yn-5-ol supplier in China

Cas:848609-05-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-Decyn-5-ol, (5S)-

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

1-Decyn-5-ol;(5S)- CAS No.848609-05-2

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

848609-05-2

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-Decyn-5-ol,(5S)-

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

848609-05-2

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(5S)-dec-1-yn-5-ol

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

1-Decyn-5-Ol

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-Decyn-5-ol,(5S)-

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

1-Decyn-5-ol

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(5S)-1-Decyn-5-ol

Cas:848609-05-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

Zhengzhou Kingorgchem Chemical Technology Co., Ltd. was founded on the basis of Organophosphorus Chemistry Lab of Institute of Chemistry Henan Academy of Sciences in 2015. The laboratory covers 600 m2 and the pilot plant covers 2000 m2. Kingorgchem i

National Research Platform ISO 9001 848609-05-2

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

848609-05-2 CAS NO.848609-05-2

Cas:848609-05-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(S)-dec-2-yn-5-ol

(S)-dec-2-yn-5-ol

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

Conditions
ConditionsYield
Stage #1: (S)-dec-2-yn-5-ol With potassium tert-butylate; lithium; Trimethylenediamine In diethyl ether at 20 - 70℃; for 2.33333h;
Stage #2: With water In diethyl ether at 0℃;
n/a
(S)-1-chloroheptane-2-ol
81007-64-9

(S)-1-chloroheptane-2-ol

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tert-butyl methyl ether / 18 h / 25 °C
2.1: magnesium; iodine; mercury dichloride / diethyl ether / 0 - 36 °C / Inert atmosphere
2.2: 0.5 h
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tert-butyl methyl ether / 18 h / 25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -50 - -35 °C / Inert atmosphere
2.2: 2.5 h / -40 - -20 °C
3.1: sodium hydroxide; ethanol / 2 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide / dichloromethane / 3 h / 20 °C / Cooling with ice
2.1: mercury dichloride; magnesium; iodine / diethyl ether / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
View Scheme
(S)-2-pentyloxirane
61229-03-6

(S)-2-pentyloxirane

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -50 - -35 °C / Inert atmosphere
1.2: 2.5 h / -40 - -20 °C
2.1: sodium hydroxide; ethanol / 2 h / 25 °C
View Scheme
(S)-2-pentyloxirane
61229-03-6

(S)-2-pentyloxirane

propargyl bromide
106-96-7

propargyl bromide

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

Conditions
ConditionsYield
Stage #1: propargyl bromide With iodine; magnesium; mercury dichloride In diethyl ether at 0 - 36℃; Inert atmosphere;
Stage #2: (S)-2-pentyloxirane In diethyl ether for 0.5h;
62.9 g
Stage #1: propargyl bromide With iodine; magnesium; mercury dichloride In diethyl ether Inert atmosphere;
Stage #2: (S)-2-pentyloxirane In diethyl ether at 20℃; for 2h; Inert atmosphere;
10.2 g
C13H26OSi

C13H26OSi

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

Conditions
ConditionsYield
With ethanol; sodium hydroxide at 25℃; for 2h;73.9 g
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(S)-tert-butyl(dec-1-yn-5-yloxy)diphenylsilane

(S)-tert-butyl(dec-1-yn-5-yloxy)diphenylsilane

Conditions
ConditionsYield
Stage #1: (S)-Dec-1-yn-5-ol With dmap In dichloromethane; N,N-dimethyl-formamide at 20 - 250℃; for 0.333333h;
Stage #2: tert-butylchlorodiphenylsilane In dichloromethane; N,N-dimethyl-d6-formamide at 20℃; for 12h;
89%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran
223734-62-1

2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In dichloromethane at 0 - 25℃; for 24h; Temperature;65.1 g
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

(6S)-1-(2-allyl-3-(benzyloxy)phenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one

(6S)-1-(2-allyl-3-(benzyloxy)phenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 24 h / 0 - 25 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 35 - 40 °C
2.2: 1 h / 25 °C / Reflux
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl 2-(2-allyl-3-((6S)-6-((tert-butyldiphenylsilyl)oxy)-1-hydroxyundec-2-yn-1-yl)phenoxy)acetate

tert-butyl 2-(2-allyl-3-((6S)-6-((tert-butyldiphenylsilyl)oxy)-1-hydroxyundec-2-yn-1-yl)phenoxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl (S)-2-(2-allyl-3-(6-((tert-butyldiphenylsilyl)oxy)undec-2-ynoyl)phenoxy)acetate

tert-butyl (S)-2-(2-allyl-3-(6-((tert-butyldiphenylsilyl)oxy)undec-2-ynoyl)phenoxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl 2-(2-allyl-3-((1S,6S)-6-((tert-butyldiphenylsilyl)oxy)-1-hydroxyundec-2-yn-1-yl)phenoxy)acetate

tert-butyl 2-(2-allyl-3-((1S,6S)-6-((tert-butyldiphenylsilyl)oxy)-1-hydroxyundec-2-yn-1-yl)phenoxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl 2-(2-allyl-3-((1S,6S)-6-tert-butyldiphenylsilyloxy-1-tert-butyldimethylsilyloxyundec-2-yn-1-yl)phenoxy)acetate

tert-butyl 2-(2-allyl-3-((1S,6S)-6-tert-butyldiphenylsilyloxy-1-tert-butyldimethylsilyloxyundec-2-yn-1-yl)phenoxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
5.1: dmap; 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl 2-(((4R,9aS)-4-((tert-butyldimethylsilyl)oxy)-3-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-oxo-2,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-8-yl)oxy)acetate

tert-butyl 2-(((4R,9aS)-4-((tert-butyldimethylsilyl)oxy)-3-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-oxo-2,4,9,9a-tetrahydro-1H-cyclopenta[b]naphthalen-8-yl)oxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
5.1: dmap; 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere
6.1: dicobalt octacarbonyl / toluene / 170 °C / 15001.5 Torr / Flow reactor
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

tert-butyl 2-(((3aS,9aS)-1-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-oxo-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate

tert-butyl 2-(((3aS,9aS)-1-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-oxo-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
5.1: dmap; 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere
6.1: dicobalt octacarbonyl / toluene / 170 °C / 15001.5 Torr / Flow reactor
7.1: potassium carbonate; palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 2250.23 Torr
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

2-(((1R,2R,3aS,9aS)-1-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-hydroxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid

2-(((1R,2R,3aS,9aS)-1-((S)-3-((tert-butyldiphenylsilyl)oxy)octyl)-2-hydroxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
5.1: dmap; 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere
6.1: dicobalt octacarbonyl / toluene / 170 °C / 15001.5 Torr / Flow reactor
7.1: potassium carbonate; palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 2250.23 Torr
8.1: sodium hydroxide / ethanol; water / 0.5 h / -10 °C
8.2: 13 h / -10 - 0 °C
View Scheme
(S)-Dec-1-yn-5-ol
848609-05-2

(S)-Dec-1-yn-5-ol

treprostinil
81846-19-7

treprostinil

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: dmap / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 - 250 °C
1.2: 12 h / 20 °C
2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere; Reflux
2.2: 12 h / 0 - 20 °C / Inert atmosphere
3.1: manganese(IV) oxide / acetone / 24 h / 0 - 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
5.1: dmap; 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere
6.1: dicobalt octacarbonyl / toluene / 170 °C / 15001.5 Torr / Flow reactor
7.1: potassium carbonate; palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 2250.23 Torr
8.1: sodium hydroxide / ethanol; water / 0.5 h / -10 °C
8.2: 13 h / -10 - 0 °C
9.1: pyridine; pyridine hydrogenfluoride / 15 h / 20 °C / Cooling
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