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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Bromo-5-fluoro-2-nitrotoluene Manufacturer/High quality/Best price/In stock

Cas:224185-19-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-5-Fluoro-2-Nitrotoluene

Cas:224185-19-7

Min.Order:1

Negotiable

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Bromo-5-fluoro-2-nitrotoluene CAS:224185-19-7

Cas:224185-19-7

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 224185-19-7 with fast shipping

Cas:224185-19-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:224185-19-7

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Bromo-5-Fluoro-2-Nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

1-Bromo-2-fluoro-4-methyl-5-nitrobenzene

Cas:224185-19-7

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:In Room Temperature Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Transportation:as your request Port:Shanghai, Ningb

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-Bromo-5-fluoro-2-nitrotoluene Basic information Product Name: 4-Bromo-5-fluoro-2-nitrotoluene Synonyms: 4-BROMO-3-FLUORO-6-NITROTOLUENE;4-BROMO-5-FLUORO-2-NITROTOLUENE;4-Bromo-5-fluoro-2-nitortoluene;2-Nitro-4-Bromo-5-Fluorotoluene;1-Bromo-2-fluor

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-5-fluoro-2-nitrotoluene cas no. 224185-19-7 98%

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-BroMo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

4-Bromo-5-Fluoro-2-Nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chemsigma International Co.,Ltd.

bulk productiongoods in stockswe have the best competitive price in the marketmeantime,we are committed to service to our every customer Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Fandachem Co.,Ltd

4-Bromo-5-fluoro-2-nitrotoluene cas 224185-19-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

4-Bromo-5-fluoro-2-nitrotoluene cas 224185-19-7

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

4-BROMO-2-CHLORO-5-FLUOROPYRIDINE

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

224185-19-7 Application:intermediate

1-bromo-2-fluoro-4-methyl-5-nitrobenzene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

4-Bromo-5-fluoro-2-nitrotoluene 224185-19-7

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:White powder Storage:keep sealed and keep from direct light Package:According client's requirements Application:pharmaceutica

4-Bromo-5-fluoro-2-nitrotoluene manufacturer

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-Bromo-5-fluoro-2-nitrotoluene

Cas:224185-19-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

4-bromo-3-fluorotoluene
452-74-4

4-bromo-3-fluorotoluene

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate at 0 - 20℃;100%
With sulfuric acid; potassium nitrate at 0℃;100%
With sulfuric acid; nitric acid at 0℃;92%
2-fluoro-4-methyl-5-nitro-phenylamine
259860-00-9

2-fluoro-4-methyl-5-nitro-phenylamine

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

Conditions
ConditionsYield
Stage #1: 2-fluoro-4-methyl-5-nitro-phenylamine With hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 0.25h;
Stage #2: With copper(I) oxide; hydrogen bromide In water at 0℃;
91%
3-fluoro-6-nitrotoluene
446-33-3

3-fluoro-6-nitrotoluene

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

Conditions
ConditionsYield
With sulfuric acid; bromine; silver nitrate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate83%
copper(I) bromide
7787-70-4

copper(I) bromide

2-fluoro-4-methyl-5-nitro-phenylamine
259860-00-9

2-fluoro-4-methyl-5-nitro-phenylamine

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

Conditions
ConditionsYield
With sodium nitrite In water; hydrogen bromide50%
sodium ethanolate
141-52-6

sodium ethanolate

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

1-bromo-2-ethoxy-4-methyl-5-nitrobenzene
1226903-38-3

1-bromo-2-ethoxy-4-methyl-5-nitrobenzene

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 20℃; for 1h;99%
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one
1002309-52-5

1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

5-(2-fluoro-4-methyl-5-nitrophenyl)-1-methylpyridin-2(1H)-one

5-(2-fluoro-4-methyl-5-nitrophenyl)-1-methylpyridin-2(1H)-one

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Microwave irradiation;99%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Inert atmosphere; Microwave irradiation;99%
2,4-difluorophenol
367-27-1

2,4-difluorophenol

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

1-bromo-2-(2,4-difluorophenoxy)-4-methyl-5-nitrobenzene

1-bromo-2-(2,4-difluorophenoxy)-4-methyl-5-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20℃;99%
With caesium carbonate In dimethyl sulfoxide at 100℃; for 3h;3.8 g
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

5-bromo-4-fluoro-2-methylaniline
627871-16-3

5-bromo-4-fluoro-2-methylaniline

Conditions
ConditionsYield
With 2,3-dimethyl-2,3-butane diol; [MoO2Cl2(dmf)2] In o-xylene at 130℃; for 3h; chemoselective reaction;95%
With iron; ammonium chloride In water for 48.5h; Heating / reflux;72%
With ammonium chloride; iron In water for 48h; Heating / reflux;72%
bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

2-(2-fluoro-4-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1510828-68-8

2-(2-fluoro-4-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; potassium acetate In 1,4-dioxane at 100℃; for 1h; Suzuki Coupling; Inert atmosphere; Sealed tube;91%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 90℃; for 15h; Inert atmosphere;
methanol
67-56-1

methanol

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

1-bromo-2-methoxy-4-methyl-5-nitrobenzene
861076-28-0

1-bromo-2-methoxy-4-methyl-5-nitrobenzene

Conditions
ConditionsYield
Stage #1: methanol With sodium at 0℃; for 0.5h;
Stage #2: 3-bromo-4-fluoro-6-methylnitrobenzene at 30℃; for 2h;
87.8%
With sodium at 40℃; for 2h; Cooling with ice;
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

N-(5-bromo-4-fluoro-2-methylphenyl)iminodiacetic acid diethyl ester
1190892-54-6

N-(5-bromo-4-fluoro-2-methylphenyl)iminodiacetic acid diethyl ester

Conditions
ConditionsYield
85%
N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

[2-(4-bromo-5-fluoro-2-nitro-phenyl)-vinyl]-dimethyl-amine
1034894-73-9

[2-(4-bromo-5-fluoro-2-nitro-phenyl)-vinyl]-dimethyl-amine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 125℃; for 3h;83%
morpholine
110-91-8

morpholine

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

4-(2-bromo-5-methyl-4-nitrophenyl)morpholine
1192471-65-0

4-(2-bromo-5-methyl-4-nitrophenyl)morpholine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 3h;77%
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.5h;5.7 g
2-amino-phenol
95-55-6

2-amino-phenol

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

3-methyl-2-nitro-10H-phenoxazine

3-methyl-2-nitro-10H-phenoxazine

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;62%
2-Hydroxy-4-methylanilin
2835-98-5

2-Hydroxy-4-methylanilin

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

C14H12N2O3

C14H12N2O3

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;60%
3-amino-4-hydroxytoluene
95-84-1

3-amino-4-hydroxytoluene

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

C14H12N2O3

C14H12N2O3

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;57%
2-hydroxy-5-chloro-aniline
95-85-2

2-hydroxy-5-chloro-aniline

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

C13H9ClN2O3

C13H9ClN2O3

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;52%
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

C7H4Br2FNO2

C7H4Br2FNO2

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 16h; Reflux;50%
o-(N-methylamino)phenol
611-24-5

o-(N-methylamino)phenol

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

C14H12N2O3

C14H12N2O3

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 24h;48%
tert-butyl 2-((2S,6R)-4-(2-hydroxyethyl)-2,6-dimethylpiperazin-1-yl)acetate

tert-butyl 2-((2S,6R)-4-(2-hydroxyethyl)-2,6-dimethylpiperazin-1-yl)acetate

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

tert-butyl 2-((2S,6R)-4-(2-(2-bromo-5-methyl-4-nitrophenoxy)ethyl)-2,6-dimethylpiperazin-1-yl)acetate

tert-butyl 2-((2S,6R)-4-(2-(2-bromo-5-methyl-4-nitrophenoxy)ethyl)-2,6-dimethylpiperazin-1-yl)acetate

Conditions
ConditionsYield
Stage #1: tert-butyl 2-((2S,6R)-4-(2-hydroxyethyl)-2,6-dimethylpiperazin-1-yl)acetate With sodium t-butanolate In tetrahydrofuran at 0℃; for 1h;
Stage #2: 3-bromo-4-fluoro-6-methylnitrobenzene In tetrahydrofuran at 15℃; for 1h; Temperature;
44.4%
cyclohexanol
108-93-0

cyclohexanol

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

1-bromo-2-(cyclohexyloxy)-4-methyl-5-nitrobenzene
1351812-80-0

1-bromo-2-(cyclohexyloxy)-4-methyl-5-nitrobenzene

Conditions
ConditionsYield
With potassium hydroxide In acetonitrile at 0 - 20℃; for 22h; Suzuki Coupling;36%
aluminum nickel

aluminum nickel

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

6-bromo-5-fluoro-1H-indole
259860-08-7

6-bromo-5-fluoro-1H-indole

Conditions
ConditionsYield
With hydrazine hydrate In tetrahydrofuran; methanol; N,N-dimethyl-formamide16%
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

5-bromo-4-fluoro-2-methylbenzenethiol
873922-26-0

5-bromo-4-fluoro-2-methylbenzenethiol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-one
873922-28-2

4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
5.1: SOCl2 / 90 °C
6.1: AlCl3 / chlorobenzene
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetyl chloride

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
5.1: SOCl2 / 90 °C
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetic acid
873922-27-1

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

2-(4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-yl)-ethanol
845746-23-8

2-(4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-yl)-ethanol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
5.1: SOCl2 / 90 °C
6.1: AlCl3 / chlorobenzene
7.1: 39 percent / toluene / 120 °C
8.1: 83 percent / LiAlH4 / tetrahydrofuran / 0 °C
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester

(5-bromo-4-fluoro-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

(4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-yl)-acetic acid ethyl ester
873922-29-3

(4-bromo-5-fluoro-7-methyl-benzo[b]thiophen-3-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
5.1: SOCl2 / 90 °C
6.1: AlCl3 / chlorobenzene
7.1: 39 percent / toluene / 120 °C
View Scheme
3-bromo-4-fluoro-6-methylnitrobenzene
224185-19-7

3-bromo-4-fluoro-6-methylnitrobenzene

(5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-[1]benzothieno[2,3-c]pyran-1-yl)acetic acid
845746-06-7

(5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-[1]benzothieno[2,3-c]pyran-1-yl)acetic acid

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 63 percent / SnCl2 / ethyl acetate
2.1: NaNO2; aq. HCl
2.2: potassium ethyl xanthogenate
2.3: 92 percent / KOH / ethanol
3.1: pyridine / 0 °C
4.1: TFA / CH2Cl2
5.1: SOCl2 / 90 °C
6.1: AlCl3 / chlorobenzene
7.1: 39 percent / toluene / 120 °C
8.1: 83 percent / LiAlH4 / tetrahydrofuran / 0 °C
9.1: 75 percent / BF3-Et2O / CH2Cl2
10.1: NMP / 0.25 h / 220 °C / microwave irradiation
11.1: aq. NaOH / ethanol; tetrahydrofuran
View Scheme

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