Product Name: Daunorubicin hydrochloride CAS No.: 23541-50-6 Chemical formula: C27H30ClNO10 Molecular weight: 563.98 Appearance An orange-red crytalline hygroscopic powder. Lightly soluble in water or methanol, slightly so
Cas:23541-50-6
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:23541-50-6
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:23541-50-6
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:23541-50-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:23541-50-6
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Type:Manufacturers
inquiryDaunorubicin hydrochloride CAS 23541-50-6 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals i
Cas:23541-50-6
Min.Order:10 Kilogram
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Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:23541-50-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:23541-50-6
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:23541-50-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiry1. Direct manufacturer 2. Stock available 3. Stable and fine quality 4. Premium service Appearance:white solid Storage:?20°C Package:bag/bottle/drum Application:anti neoplastic Transportation:common transportation Port
Cas:23541-50-6
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:23541-50-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:23541-50-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:23541-50-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:23541-50-6
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:23541-50-6
Min.Order:1 Kilogram
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inquiryChemical Name Benzoicacid hydrazide,3-hydrazone with daunorubicin CAS Number 23541-50-6 Molecular Formula C27H29NO10.HCl
Cas:23541-50-6
Min.Order:5 Metric Ton
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Type:Other
inquiryDescription Orange-red crystalline powder, hygroscopic Lightly soluble in water or methanol, slightly soluble in ethanol, practically insoluble in acetone. Identification A. The retention time of the major peak of the chromatogram obtained with
Cas:23541-50-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:23541-50-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hu
Cas:23541-50-6
Min.Order:1 Gram
FOB Price: $600.0 / 800.0
Type:Trading Company
inquiry1.More than 8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized in APIs, chemical interme
Cas:23541-50-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:23541-50-6
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:23541-50-6
Min.Order:1 Kilogram
FOB Price: $295.0 / 330.0
Type:Trading Company
inquiryDaunorubicin hydrochloride CAS:23541-50-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
Cas:23541-50-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:23541-50-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:23541-50-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:According to the COA Storage:According to the COA Package:As your request Application:intermediate Transportation:Store with seal at regular temperature Port:Shanghai,Qingdao,Tianjing,Others
Cas:23541-50-6
Min.Order:1 Kilogram
FOB Price: $0.05 / 0.1
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:23541-50-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:23541-50-6
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryBenzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
daunomycin hydrochloride
B
benzoic acid hydrazide
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
Nicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
Nicotinic acid hydrazide
B
daunomycin hydrochloride
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer; |
Isonicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
isoniazid
B
daunomycin hydrochloride
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer; |
4-Amino-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
daunomycin hydrochloride
B
4-aminobenzohydrazide
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
4-Hydroxy-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
daunomycin hydrochloride
B
4-hydroxybenzoic acid hydrazide
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride
A
daunomycin hydrochloride
B
ethyl m-hydrazinecarbonyl benzoate
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
4-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride
A
4-hydrazinocarbonyl-benzoic acid ethyl ester
B
daunomycin hydrochloride
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
daunoform
daunomycin hydrochloride
Conditions | Yield |
---|---|
Stage #1: daunoform In dimethylsulfoxide-d6; water-d2 for 24h; Stage #2: With hydrogenchloride In dimethylsulfoxide-d6; water-d2 |
daunomycin hydrochloride
trifluoroacetic anhydride
3'-N,4'-O-di-trifluoroacetyldaunomycin
Conditions | Yield |
---|---|
In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere; | 100% |
In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere; | 100% |
In dichloromethane at 0℃; for 1.5h; |
daunomycin hydrochloride
Conditions | Yield |
---|---|
In aq. acetate buffer at 20℃; for 24h; pH=5.2; | 100% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
In aq. acetate buffer at 20℃; for 24h; pH=5.2; | 100% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
In aq. acetate buffer at 20℃; for 24h; pH=5.2; | 100% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
In aq. acetate buffer at 20℃; for 24h; pH=5.2; | 100% |
daunomycin hydrochloride
trifluoroacetic anhydride
3'-N-trifluoroacetyldaunorubicin
Conditions | Yield |
---|---|
With pyridine In diethyl ether at -20℃; for 0.166667h; | 99% |
With pyridine at -20℃; for 0.5h; | 95% |
With pyridine at -20℃; | 95% |
daunomycin hydrochloride
(+)-Daunomycinone
Conditions | Yield |
---|---|
With hydrogenchloride at 90 - 95℃; for 3.5h; | 98% |
With hydrogenchloride at 90℃; for 1h; Hydrolysis; | 93% |
With hydrogenchloride at 90℃; for 1h; | 92% |
daunomycin hydrochloride
Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate
C61H70N6O19
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one; triethylamine for 16h; Substitution; | 97% |
daunomycin hydrochloride
N-2-biphenyl-2'-carboxylic acid O-(methyl 2,3,4-tri-O-acetyl β-D-glucuronyl) carbamate
A
6(5H)-phenanthridinone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane | A n/a B 95% |
Conditions | Yield |
---|---|
With pyridine at -20℃; for 0.25h; | 95% |
ethyl trifluoroacetate,
daunomycin hydrochloride
3'-N-trifluoroacetyldaunorubicin
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 4h; | 95% |
daunomycin hydrochloride
(E)-4-pentachlorophenyl 5,6-bis<4-(tert-butyldimethylsiloxy)phenyl>-5-octenoate
(E)-5,6-Bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-oct-5-enoic acid [(2S,3S,4S,6R)-6-((1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-pyran-4-yl]-amide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran for 17h; Ambient temperature; | 94% |
Conditions | Yield |
---|---|
With pyridine; dmap for 120h; | 92% |
daunomycin hydrochloride
(S)-2-[4-(4-Nitro-phenoxycarbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide for 3.5h; Ambient temperature; | 92% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 92% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 10h; | 92% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 90% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 90% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 90% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 90% |
isoniazid
daunomycin hydrochloride
Isonicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
Conditions | Yield |
---|---|
In methanol Heating; | 89% |
daunomycin hydrochloride
14-bromodaunorubicin hydrochloride
Conditions | Yield |
---|---|
Stage #1: daunomycin hydrochloride With trimethyl orthoformate In 1,4-dioxane; methanol at 20℃; for 0.333333h; Stage #2: With bromine In 1,4-dioxane; methanol; chloroform at 20℃; for 0.666667h; pH=7; | 89% |
Stage #1: daunomycin hydrochloride With trimethyl orthoformate In 1,4-dioxane; methanol at 20℃; for 0.333333h; Stage #2: With bromine In 1,4-dioxane; methanol; chloroform at 30℃; for 0.666667h; | 84% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With bromine; trimethyl orthoformate In 1,4-dioxane; methanol; chloroform at 20℃; for 1h; | 89% |
daunomycin hydrochloride
14-bromodaunorubicin
Conditions | Yield |
---|---|
With bromine In 1,4-dioxane; methanol; chloroform for 2h; Ambient temperature; | 88% |
Multi-step reaction with 2 steps 1: bromine; hydrogen bromide / methanol; 1,4-dioxane / 2 - 6 °C / Inert atmosphere 2: hydrogen bromide / acetone; water / 6 h / 15 - 20 °C / pH 3 View Scheme |
daunomycin hydrochloride
A
(2R)-2-acetyl-1,2,3,4-tetrahydro-2,11-dihydroxy-7-methoxy-5,12-naphthacenedione
B
(2R)-2-acetyl-1,2,3,4-tetrahydro-2,6-dihydroxy-7-methoxy-5,12-naphthacenedione
Conditions | Yield |
---|---|
Stage #1: daunomycin hydrochloride With hydrogen; Pd-BaSO4 In methanol at 20℃; for 5.5h; Catalytic hydrogenation; Stage #2: With air In methanol Oxidation; | A 88% B 8% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 88% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 10h; | 88% |
daunomycin hydrochloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Condensation; | 84% |
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; N,N-dimethyl-formamide at 20℃; | A 15% B 81% |
succinic acid anhydride
daunomycin hydrochloride
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 72h; Inert atmosphere; Darkness; | 80.8% |
With triethylamine In N,N-dimethyl-formamide at 20℃; for 72h; Inert atmosphere; Darkness; | 80.8% |
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