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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

7-AMCA Manufacturer/High quality/Best price/In stock

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 7-amino 3-methyloxymethyl-3-cephem 4-carboxylic acid(NA) supplier in China

Cas:24701-69-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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EAST CHEMSOURCES LIMITED

7-AMCA English name: 7-AMCA Chemical name: 7-Amino-3-methyl-3-cephem-4-carboxylic acid; 7-Amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Category involve

7-AMCA

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 7-AMCA 24701-69-7 GMP Manufacturer

Cas:24701-69-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Amino-3-(methyloxymethyl)-3-cephem-4-carboxylic acid

Cas:24701-69-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

7-AMCA CAS:24701-69-7

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 24701-69-7 with best quality

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid Synonyms: 7-AMCA CAS:24701-69-7 MF:C9H12N2O4S Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Organic synthesis Trans

7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

7-AMCA cas no 24701-69-7

Cas:24701-69-7

Min.Order:1 Kilogram

Negotiable

Type:Other

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply 7-AMINO-3-METHOXYMETHYL-3-CEPHEM-4-CARBOXYLIC ACID CAS 24701-69-7

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:24701-69-7

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

7-AMCA

Cas:24701-69-7

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7-AMINO-3-METHOXYMETHYL-3-CEPHEM-4-CARBOXYLIC ACID

Cas:24701-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

7-AMCA

Cas:24701-69-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Off-White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Intermediates Transporta

7-Amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cas:24701-69-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

7-AMCA

Cas:24701-69-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-3-(methoxymethyl)-8-oxo-, (6R,7R)-

Cas:24701-69-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

7-AMCA Basic information Product Name: 7-AMCA Synonyms: 7-AMINO-3-METHOXYMETHYL-3-CEPHEM-4-CARBOXYLIC ACID;7-ami

24701-69-7 C9H12N2O4S 7-AMCA

Cas:24701-69-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity 7-AMCA

Cas:24701-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 7-AMCA CAS No.:24701-69-7 Molecule Formula:C9H12N2O4S Molecule Weight:244.27 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITE

Best Quality 7-AMCA

Cas:24701-69-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

7-Amino-3-methoxy-3-cephem-4-carboxylicacid

Cas:24701-69-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

7-AMCA

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

7-AMCA Cas no.24701-69-7 98%

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-3-(methoxymethyl)-8-oxo-, (6R,7R)-

Cas:24701-69-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

7-Amino-3-Methoxymethyl-3-Cephem-4-Carboxylicacid

Cas:24701-69-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

7-AMCA

Cas:24701-69-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (R)-1-(2,2-dimethyl-propionyloxy)-ethyl ester; hydrochloride

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (R)-1-(2,2-dimethyl-propionyloxy)-ethyl ester; hydrochloride

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol at 25 - 30℃; for 5h; immobilized enzyme, pH 6.8;81%
Trimethyl borate
121-43-7

Trimethyl borate

methyl bisulfate
75-93-4

methyl bisulfate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 0 - 20℃; for 5h;66.88%
methanol
67-56-1

methanol

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

A

6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione
184696-69-3

6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione

B

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid; trifluorormethanesulfonic acid at 13 - 14℃; for 0.75h; Yield given. Yields of byproduct given;
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

A

6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione
184696-69-3

6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione

B

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid; trifluorormethanesulfonic acid In methanol at 13 - 14℃; for 0.75h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
methanol
67-56-1

methanol

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: methanol; 7-Aminocephalosporanic acid; boron trifluoride In sulfolane
Stage #2: With triethylamine In sulfolane; methanol; water
With methanesulfonic acid at 5 - 12℃; Reagent/catalyst; Temperature;
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

trimethyl orthoformate
149-73-5

trimethyl orthoformate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid In acetonitrile at 5 - 40℃; Reagent/catalyst; Solvent;
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In acetonitrile at -20 - 25℃; for 0.916667h;
Stage #2: (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid In acetonitrile at 25℃; Temperature;
Trimethyl borate
121-43-7

Trimethyl borate

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid at 5 - 40℃;
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid at 5 - 40℃;
Methyl formate
107-31-3

Methyl formate

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid at 5 - 40℃;
Dimethoxymethane
109-87-5

Dimethoxymethane

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid at 5 - 40℃;
Trimethyl borate
121-43-7

Trimethyl borate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With 1H-imidazole; 1,1,1,3,3,3-hexamethyl-disilazane In dimethyl sulfoxide at 30 - 35℃; for 1h; Inert atmosphere;
Stage #2: Trimethyl borate With methanesulfonic acid In methanol; dimethyl sulfoxide at 0 - 5℃; Concentration; Solvent; Reagent/catalyst;
43 g
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
80756-85-0

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefpodoxime
80210-62-4

cefpodoxime

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at -5 - 5℃; for 2h;82.86%
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol at 8 - 12℃;
Stage #2: With sulfuric acid In methanol; water at 0 - 20℃; pH=2.4 - 2.5; Product distribution / selectivity;
With triethylamine In methanol; water at 15 - 20℃;81 mg
C13H7(2)H3N4O2S3

C13H7(2)H3N4O2S3

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefpodoxime-d3

cefpodoxime-d3

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water at 20℃; for 2h; Cooling with ice;69%
1-iodoethyl 2,2-dimethylpropionate
80195-78-4

1-iodoethyl 2,2-dimethylpropionate

C35H33N3O6S2
77934-90-8

C35H33N3O6S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

cefdaloxime

cefdaloxime

B

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

C

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

D

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(E)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(E)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

Conditions
ConditionsYield
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
1-iodoethyl 2,2-dimethylpropionate
80195-78-4

1-iodoethyl 2,2-dimethylpropionate

C35H33N3O6S2
77934-90-8

C35H33N3O6S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

2,2-Dimethyl-propionic acid 1-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetoxy}-ethyl ester

2,2-Dimethyl-propionic acid 1-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetoxy}-ethyl ester

B

(6R,7R)-7-{2-[(Z)-Hydroxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-[(Z)-Hydroxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

C

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

D

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine 1.) CH2Cl2, 15 deg C, 30 min; acetone, 0-5 deg C, 30 min, 2.) acetone, 20 deg C, 10 min; 20 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine 1.) CH2Cl2, 15 deg C, 30 min; acetone, 0-5 deg C, 30 min, 2.) acetone, 20 deg C, 10 min; 20 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
C35H33N3O6S2
77934-90-8

C35H33N3O6S2

2,2-dimethyl-propionic acid (RS)-1-bromo-ethyl ester
55419-51-7

2,2-dimethyl-propionic acid (RS)-1-bromo-ethyl ester

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

B

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine 1.) CH2Cl2, 15 deg C, 30 min; acetone, 0-5 deg C, 30 min, 2.) acetone, 20 deg C, 27 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine 1.) CH2Cl2, 15 deg C, 30 min; acetone, 0-5 deg C, 30 min, 2.) acetone, 20 deg C, 27 h; Yield given. Multistep reaction. Yields of byproduct given;
C35H33N3O6S2
77934-90-8

C35H33N3O6S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

cefdaloxime

cefdaloxime

B

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

C

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

D

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(E)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(E)-hydroxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(2,2-dimethyl-propionyloxy)-ethyl ester

Conditions
ConditionsYield
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
C35H33N3O6S2
77934-90-8

C35H33N3O6S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-Methoxymethyl-7-{2-[(Z)-1-methoxy-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

B

[(Z)-1-Methoxy-1-methyl-ethoxyimino]-[2-(trityl-amino)-thiazol-4-yl]-acetic acid; compound with triethyl-amine

[(Z)-1-Methoxy-1-methyl-ethoxyimino]-[2-(trityl-amino)-thiazol-4-yl]-acetic acid; compound with triethyl-amine

C

(Z)-2-Hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)-acetic acid
68672-45-7

(Z)-2-Hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)-acetic acid

Conditions
ConditionsYield
With triethylamine 1.) CH2Cl2, 15 deg C, 30 min, 2.) acetone, 0-5 deg C, 30 min; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
2,2-dimethyl-propionic acid (RS)-1-bromo-ethyl ester
55419-51-7

2,2-dimethyl-propionic acid (RS)-1-bromo-ethyl ester

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

A

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (S)-1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (S)-1-(2,2-dimethyl-propionyloxy)-ethyl ester

B

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (R)-1-(2,2-dimethyl-propionyloxy)-ethyl ester

(6R,7R)-7-Amino-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (R)-1-(2,2-dimethyl-propionyloxy)-ethyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone 1.) r.t., 15 min, 2.) r.t., 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone 1.) r.t., 15 min, 2.) r.t., 4 h; Yield given. Yields of byproduct given;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C15H28N2O4SSi2

C15H28N2O4SSi2

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane for 3h; Heating;
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-[2-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-propionylamino]-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-[2-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-propionylamino]-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,1,1,3,3,3-hexamethyldisilazane / CH2Cl2 / 3 h / Heating
2: 28 percent / CH2Cl2 / 2 h / -25 - -20 °C
View Scheme
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[2-(2,8-Bis-trifluoromethyl-quinolin-4-yloxy)-acetylamino]-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[2-(2,8-Bis-trifluoromethyl-quinolin-4-yloxy)-acetylamino]-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,1,1,3,3,3-hexamethyldisilazane / CH2Cl2 / 3 h / Heating
2: 64 percent / CH2Cl2 / 2 h / -25 - -20 °C
View Scheme
2-(2-aminothiazol-4-yl)-2(Z)-(methoxyimino)mercaptobenzothiazolyl acetate

2-(2-aminothiazol-4-yl)-2(Z)-(methoxyimino)mercaptobenzothiazolyl acetate

1-iodoethyl isopropyl carbonate
84089-73-6, 91508-00-8

1-iodoethyl isopropyl carbonate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

vantin

vantin

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; ethyl acetate
1-iodoethyl isopropyl carbonate
84089-73-6, 91508-00-8

1-iodoethyl isopropyl carbonate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

1-(Isopropoxycarbonyloxy)ethyl (6R,7R)-7-amino-3-methoxymethyl-3-cephem-4-carboxylate p-toluenesulfonate
148893-80-5

1-(Isopropoxycarbonyloxy)ethyl (6R,7R)-7-amino-3-methoxymethyl-3-cephem-4-carboxylate p-toluenesulfonate

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; di-isopropyl ether; ethyl acetate
(benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate

(benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefpodoxime
80210-62-4

cefpodoxime

Conditions
ConditionsYield
Stage #1: (benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol; water at 15 - 20℃;
Stage #2: With sulfuric acid In methanol; water
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one
94088-75-2

2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefpodoxime
80210-62-4

cefpodoxime

Conditions
ConditionsYield
With triethylamine In dichloromethane at 5 - 25℃; pH=8 - 9; Temperature;
C12H14N6O5S2

C12H14N6O5S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C21H22N8O8S3

C21H22N8O8S3

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; dichloromethane at 20 - 25℃; for 5h;16.2 g
C13H13N3O5S2

C13H13N3O5S2

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
24701-69-7

(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefpodoxime
80210-62-4

cefpodoxime

Conditions
ConditionsYield
With triethylamine In methanol at -30 - 0℃; for 0.5h; Solvent;

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