As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:80210-62-4
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
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inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:80210-62-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:80210-62-4
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inquiryCefpodoxime CAS:80210-62-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:80210-62-4
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:80210-62-4
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inquiryCefpodoximeAppearance:white powder Storage:Store in a cool dry place and keep away from strong light Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: Cefpodoxime CAS No.: 80210-62-4 Molecule Formula:C15H17N5O6S2 Molecule Weight:427.46 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at -5 - 5℃; for 2h; | 82.86% |
With triethylamine In tetrahydrofuran at 0 - 5℃; for 2h; | 82.86% |
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol at 8 - 12℃; Stage #2: With sulfuric acid In methanol; water at 0 - 20℃; pH=2.4 - 2.5; Product distribution / selectivity; | |
With triethylamine In methanol; water at 15 - 20℃; | 81 mg |
sodium methylate
2-(2-amino-4-thiazolyl)-2-(Z)-methoxyiminoacetyl chloride
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: sodium methylate; 7-amino-3-chloromethyl-3-cephem-4-carboxylic acid With benzyltrihexylammonium chloride; potassium iodide In dimethyl sulfoxide at 15℃; for 8h; Stage #2: 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyiminoacetyl chloride In dimethyl sulfoxide at 10℃; for 4h; Temperature; Solvent; Reagent/catalyst; | 82.2% |
(6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester
A
(2R,6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid
B
cefpodoxime
C
(2R,6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester
Conditions | Yield |
---|---|
With water In N,N-dimethyl-formamide at 37℃; Rate constant; phosphate buffer, var. pH, add of bovin serum albumin (as protein); |
7-Aminocephalosporanic acid
cefpodoxime
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 12 °C 2: triethylamine / water; methanol / 15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: methyl bisulfate / N,N-dimethyl-formamide; methanol / 5 h / 0 - 20 °C 2: triethylamine / tetrahydrofuran / 2 h / 0 - 5 °C View Scheme |
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanesulfonic acid / acetonitrile / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: methanesulfonic acid / 5 - 40 °C 2: triethylamine / methanol; water / 15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: boron trifluoride diethyl etherate / acetonitrile / 0.92 h / -20 - 25 °C 1.2: 25 °C 2.1: triethylamine / dichloromethane / 5 - 25 °C / pH 8 - 9 View Scheme |
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: (benzothiazol-2-yl)-2-(2-aminothiazol-4-yl)-Z-2-methoxyimino-thioacetate; (6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In methanol; water at 15 - 20℃; Stage #2: With sulfuric acid In methanol; water |
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 5 - 25℃; pH=8 - 9; Temperature; |
cefotaxime
cefpodoxime
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N,N-dimethyl acetamide / 0.08 h 1.2: 1.5 h / -11 - 15 °C 2.1: triethylamine / methanol / 0.5 h / -30 - 0 °C View Scheme |
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
Conditions | Yield |
---|---|
With triethylamine In methanol at -30 - 0℃; for 0.5h; Solvent; |
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
trimethyl orthoformate
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: trimethyl orthoformate With boron trifluoride diethyl etherate In acetonitrile at -30℃; for 1.58333h; Stage #2: (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid In acetonitrile at 25℃; for 0.25h; Stage #3: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate With triethylamine In dichloromethane at 0℃; pH=8 - 9; |
1-iodoethyl isopropyl carbonate
cefpodoxime
cefpodoxime proxetil
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1-butyl-3-methylimidazolium hydroxide; potassium carbonate In N,N-dimethyl-formamide at -18 - -15℃; for 0.333333h; Inert atmosphere; Stage #2: 1-iodoethyl isopropyl carbonate In N,N-dimethyl-formamide for 0.5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; | 94.5% |
Stage #1: cefpodoxime With sodium acetate In water; N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 1-iodoethyl isopropyl carbonate In water; N,N-dimethyl-formamide at 3℃; for 2h; | 73% |
Stage #1: cefpodoxime With N,N,N',N'-tetramethylguanidine In ISOPROPYLAMIDE at -12 - -4℃; for 1h; Stage #2: 1-iodoethyl isopropyl carbonate In ISOPROPYLAMIDE at -15 - -8℃; for 0.5 - 1.5h; Product distribution / selectivity; |
1-iodoethyl isopropyl carbonate
cefpodoxime
A
cefpodoxime proxetil
Conditions | Yield |
---|---|
With disodium hydrogenphosphate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -10 - -5℃; for 2.16667h; | A 80.5% B 0.5% |
1-iodoethyl isopropyl carbonate
cefpodoxime
A
(R)-1-(isopropoxycarbonyloxy)ethyl-(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-iodoethyl isopropyl carbonate; cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE; water at -15 - -6℃; for 0.5 - 0.75h; Stage #2: With hydrogenchloride Product distribution / selectivity; |
1-iodoethyl isopropyl carbonate
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -10 - -6℃; Stage #2: 1-iodoethyl isopropyl carbonate In ISOPROPYLAMIDE at -10 - -6℃; for 0.5 - 0.75h; |
methanesulfonic acid
1-iodoethyl isopropyl carbonate
cefpodoxime
A
(R)-1-(isopropoxycarbonyloxy)ethyl-(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-iodoethyl isopropyl carbonate; cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In ISOPROPYLAMIDE at -15 - 6℃; for 0.666667h; Stage #2: With hydrogenchloride Stage #3: methanesulfonic acid With sodium hydrogencarbonate Product distribution / selectivity; more than 3 stages; |
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodoethyl methyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h; | 20.5 g |
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodopropyl isopropyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h; | 52 g |
1-iodoethyl propyl carbonate
cefpodoxime
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: 1-iodoethyl propyl carbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h; | 20.5 g |
cefpodoxime
ethyl 1-iodoethylcarbonate
Conditions | Yield |
---|---|
Stage #1: cefpodoxime With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 0.5h; Stage #2: ethyl 1-iodoethylcarbonate In N,N-dimethyl acetamide; toluene at -20 - -15℃; for 2.5h; | 20 g |
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