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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Bromo-4-methoxy-5-benzyloxybenzoic acid Manufacturer/High quality/Best price/In stock

Cas:24958-42-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-4-Methoxy-5-Benzyloxybenzoic Acid supplier in China

Cas:24958-42-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

TIANFU 24958-42-7 2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 24958-42-7 with competitive price

Cas:24958-42-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 2-Bromo-4-methoxy-5-benzyloxybenzoic acid Synonyms: 3-BROMO-4-METHOXY-5-BENZYLOXYBENZOIC ACID;5-BENZYLOXY-2-BROMO-4-METHOXY-BENZOIC ACID;2-BROMO-5-BENZYLOXY-4-METHOXYBENZOIC ACID;2-BROMO-4-MET

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Benzyloxy-2-Bromo-4-Methoxybenzoic Acid

Cas:24958-42-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-BROMO-4-METHOXY-5-(BENZYLOXY)BENZOIC ACID

Cas:24958-42-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoic acid,2-bromo-4-methoxy-5-(phenylmethoxy)-

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2-Bromo-4-Methyoxy-5-(Benzyloxy)benzoic Acid CAS No.: 24958-42-7 Molecule Formula:C15H13BrO4 Molecule Weight:337.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price 2-Bromo-4-Methyoxy-5-(Benzyloxy)benzoic Acid

Cas:24958-42-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Bromo-4-methoxy-5-benzyloxybenzoic acid Basic information Product Name: 2-Bromo-4-methoxy-5-benzyloxybenzoic acid Synonyms: 3-BROMO-4-METHOXY-5-BENZYLOXYBENZOIC ACID;5-BENZYLOXY-2-BROMO-4-METHOXY-BENZOIC ACID;5-Benzyloxy-2-Bromo-4-Methoxyb;2

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Naphthalenesulfonyl chloride Cas no.24958-42-7 98%

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-BroMo-4-Methoxy-5-(benzyloxy)benzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Bromo-4-Methoxy-5-Benzyloxybenzoic Acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

5-Benzyloxy-2-broMo-4-Methoxybenzoic Acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2-Bromo-4-methoxy-5-benzyloxybenzoic acid cas 24958-42-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-Bromo-4-methoxy-5-benzyloxybenzoic acid cas 24958-42-7

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Other

inquiry

Wuhan ZeShanCheng Biomedical Technology Co., Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highl

5-Benzyloxy-2-Bromo-4-Methoxybenzoic Acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

24958-42-7 Application:intermediate

2-bromo-4-methoxy-5-(benzyloxy)benzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Bromo-4-methoxy-5-benzyloxybenzoic acid 24958-42-7

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Bromo-4-methoxy-5-benzyloxybenzoic acid 24958-42-7

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

2-Bromo-4-methoxy-5-(benzyloxy)benzoic acid

Cas:24958-42-7

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

5-benzoyloxy-2-bromo-4-methoxybenzoic acid

Cas:24958-42-7

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

2-Bromo-4-methoxy-5-benzyloxybenzoic acid Basic information Product Name: 2-Bromo-4-methoxy-5-benzyloxybenzoic acid Synonyms:

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai AngewChem Co., Ltd.

Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Com

Benzoic acid,2-bromo-4-methoxy-5-(phenylmethoxy)

Cas:24958-42-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

2-Bromo-4-methoxy-5-benzyloxybenzoic acid

Cas:24958-42-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-benzyloxy-2-bromo-4-methoxybenzaldehyde
6451-86-1

5-benzyloxy-2-bromo-4-methoxybenzaldehyde

2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

Conditions
ConditionsYield
With potassium permanganate In methanol; water at 50 - 55℃;70%
Stage #1: 5-benzyloxy-2-bromo-4-methoxybenzaldehyde With hydrogenchloride; potassium permanganate In acetone
Stage #2: With potassium hydroxide In acetone
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

[2-(4-benzyloxy-phenyl)-ethyl]methylamine
38961-21-6

[2-(4-benzyloxy-phenyl)-ethyl]methylamine

5-benzyloxy-N-[2-(4-benzyloxy-phenyl)-ethyl]-2-bromo-4-methoxy-N-methylbenzamide
24958-43-8

5-benzyloxy-N-[2-(4-benzyloxy-phenyl)-ethyl]-2-bromo-4-methoxy-N-methylbenzamide

Conditions
ConditionsYield
With phenylboronic acid In toluene at 110℃; for 30h;93%
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

recorcinol
108-46-3

recorcinol

8-(benzyloxy)-3-hydroxy-9-methoxy-6H-benzo[c]chromen-6-one

8-(benzyloxy)-3-hydroxy-9-methoxy-6H-benzo[c]chromen-6-one

Conditions
ConditionsYield
Stage #1: 2-bromo-4-methoxy-5-benzyloxy-benzoic acid; recorcinol With sodium hydroxide In water at 120℃; for 0.75h;
Stage #2: With copper(II) sulfate In water for 0.25h; Reflux;
52%
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

5-Benzyloxy-2-bromo-4-methoxybenzoylchlorid
27240-64-8

5-Benzyloxy-2-bromo-4-methoxybenzoylchlorid

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide at 20℃; for 12h; Chlorination;
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane Substitution;
With thionyl chloride In chloroform for 3h; Heating / reflux;
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 30 - 35℃; for 0.5h;
With thionyl chloride; N,N-dimethyl-formamide In toluene at 68℃; for 2h;
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide
206002-18-8

N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2; DMF / CH2Cl2
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride; dimethylformamide / 12 h / 20 °C
2: Et3N / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

6-benzyloxy-5-methoxy-2-(4-methoxy-benzyl)-2,3-dihydro-isoindol-1-one

6-benzyloxy-5-methoxy-2-(4-methoxy-benzyl)-2,3-dihydro-isoindol-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: SOCl2; DMF / CH2Cl2
3.1: KHMDS / toluene; tetrahydrofuran / 2.5 h / -78 - 20 °C
3.2: 67 percent / NaOH; H2O / toluene; tetrahydrofuran / 3 h / Heating
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

6-(benzyloxy)-3-[(2-bromo-6-methoxyphenyl)methylene]-2,3-dihydro-5-methoxy-2-[(4-methoxyphenyl)methyl]-1H-isoindol-1-one

6-(benzyloxy)-3-[(2-bromo-6-methoxyphenyl)methylene]-2,3-dihydro-5-methoxy-2-[(4-methoxyphenyl)methyl]-1H-isoindol-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride; dimethylformamide / 12 h / 20 °C
2.1: Et3N / CH2Cl2 / 2 h / 0 - 20 °C
3.1: KHMDS / toluene; tetrahydrofuran / 3.5 h / -78 - -30 °C
3.2: 81 percent / toluene; tetrahydrofuran / 0.5 h / -30 - 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

5-benzyloxy-2-bromo-4-methoxy benzoic acid benzotriazole-1-yl ester
873195-14-3

5-benzyloxy-2-bromo-4-methoxy benzoic acid benzotriazole-1-yl ester

Conditions
ConditionsYield
Stage #1: 2-bromo-4-methoxy-5-benzyloxy-benzoic acid; benzotriazol-1-ol In dichloromethane at 25 - 35℃; for 0.25h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 25 - 45℃; for 3 - 6h; Product distribution / selectivity;
3-methoxycarbonylindole
942-24-5

3-methoxycarbonylindole

2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

5-(benzyloxy)-4-methoxy-2-[3-(methoxycarbonyl)-1H-indol-1-yl]benzoic acid

5-(benzyloxy)-4-methoxy-2-[3-(methoxycarbonyl)-1H-indol-1-yl]benzoic acid

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 16h; Inert atmosphere;
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 16h; Inert atmosphere;
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

N-[4-(benzyloxy)phenyl]-N-phenyl-1H-indole-3-carboxamide

N-[4-(benzyloxy)phenyl]-N-phenyl-1H-indole-3-carboxamide

5-(benzyloxy)-2-(3-{[4-(benzyloxy)phenyl](phenyl)carbamoyl}-1H-indol-1-yl)-4-methoxybenzoic acid

5-(benzyloxy)-2-(3-{[4-(benzyloxy)phenyl](phenyl)carbamoyl}-1H-indol-1-yl)-4-methoxybenzoic acid

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-[4-(benzyloxy)phenyl]-N-phenyl-1H-indole-3-carboxamide

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-[4-(benzyloxy)phenyl]-N-phenyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(4-hydroxyphenyl)-N-phenyl-1H-indole-3-carboxamide

1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(4-hydroxyphenyl)-N-phenyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
3: palladium 10% on activated carbon; ammonium formate / 2.5 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
3: palladium 10% on activated carbon; ammonium formate / methanol / 2.5 h / Inert atmosphere; Reflux
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylic acid methyl ester

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

sodium 1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylate

sodium 1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: methanol; sodium hydroxide / tetrahydrofuran / 7 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: sodium hydroxide; water / methanol; tetrahydrofuran / 7 h / 50 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carbonyl chloride

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carbonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: methanol; sodium hydroxide / tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: sodium hydroxide; water / methanol; tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-cyclohexyl-N-phenyl-1H-indole-3-carboxamide

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-cyclohexyl-N-phenyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: methanol; sodium hydroxide / tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
5: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: sodium hydroxide; water / methanol; tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
5: pyridine / dichloromethane / 0 - 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

N-cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)-methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-phenyl-1H-indole-3-carboxamide

N-cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)-methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-phenyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: methanol; sodium hydroxide / tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
5: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
6: palladium 10% on activated carbon; ammonium formate / methanol / 1 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 6 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: sodium hydroxide; water / methanol; tetrahydrofuran / 7 h / 50 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C / Inert atmosphere
5: pyridine / dichloromethane / 0 - 20 °C
6: palladium 10% on activated carbon; ammonium formate / methanol / 1 h / Reflux
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

lithium 1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylate

lithium 1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-{4-[(tert-butyldimethylsilyl)oxy]phenyl}-N-cyclohexyl-1H-indole-3-carboxamide

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-{4-[(tert-butyldimethylsilyl)oxy]phenyl}-N-cyclohexyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-cyclohexyl-N-(4-hydroxyphenyl)-1H-indole-3-carboxamide

1-[4-(benzyloxy)-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl]-N-cyclohexyl-N-(4-hydroxyphenyl)-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
5.1: potassium hydroxide; methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
5.1: water; potassium hydroxide / methanol / 3 h / 20 °C
View Scheme
2-bromo-4-methoxy-5-benzyloxy-benzoic acid
24958-42-7

2-bromo-4-methoxy-5-benzyloxy-benzoic acid

N-cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)-methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(4-hydroxyphenyl)-1H-indole-3-carboxamide

N-cyclohexyl-1-{4-hydroxy-5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)-methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(4-hydroxyphenyl)-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
5.1: potassium hydroxide; methanol / 3 h / 20 °C
6.1: palladium 10% on activated carbon; ammonium formate / methanol / 48 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 72 h / 20 °C
3.1: lithium hydroxide / 1,4-dioxane / 32 h / Reflux
4.1: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
5.1: water; potassium hydroxide / methanol / 3 h / 20 °C
6.1: palladium 10% on activated carbon; ammonium formate / methanol / 48 h / Inert atmosphere; Reflux
View Scheme

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