Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(3R,4R)-N-CBZ-3,4-DIFLUOROPYRROLIDINE

Cas:263769-22-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester CAS 263769-22-8

Cas:263769-22-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3-Piperidinecarboxylicacid, 4-(4-chlorophenyl)-1-methyl-, methyl ester, (3R,4S)-

Cas:263769-22-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Piperidinecarboxylicacid, 4-(4-chlorophenyl)-1-methyl-, methyl ester, (3R,4S)-

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

(3R,4R)-N-CBZ-3,4-DIFLUOROPYRROLIDINEAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:An important raw material and intermediate used in Organic Synthesis, Pharmaceuticals Transpor

(3R,4R)-N-CBZ-3,4-DIFLUOROPYRROLIDINE

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

best price good quality Storage:Room Temperature Application:For pharmacy chemiacals Transportation:By sea air

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:intermediate

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(3R, 4S)-4-(4-Chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl esterAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea,

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

home-produced Application:medicine

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylic acid methyl ester

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(3R,4S)-methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate

Cas:263769-22-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

(3R,4R)-N-CBZ-3,4-DIFLUOROPYRROLIDINE CAS NO.263769-22-8

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

methyl (3R,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate

Cas:263769-22-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate
214335-16-7

(-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
With sodium methylate In methanol epimerization; Heating;100%
With sodium methylate In methanol for 24h; Heating;86%
With sodium methylate In methanol at 60℃; for 6h;
arecoline
63-75-2

arecoline

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Stage #1: arecoline; (4-chlorphenyl)magnesium bromide In diethyl ether at -10℃; Addition;
Stage #2: With O,O'-dibenzoyl-L-tartaric acid Racemate resolution; Further stages.;
arecoline
63-75-2

arecoline

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 56 percent / diethyl ether / 0.5 h / -10 °C
3: 86 percent / NaOMe / methanol / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: tert-butyl methyl ether; diethyl ether / 3 h / -20 - -5 °C / Inert atmosphere
2: O,O'-dibenzoyl-L-tartaric acid / methanol / 0.5 h / 60 - 65 °C
3: sodium methylate / methanol / 6 h / 60 °C
View Scheme
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(+-)-2-hydroxy-1-phenyl-propan-1-one

(+-)-2-hydroxy-1-phenyl-propan-1-one

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 56 percent / diethyl ether / 0.5 h / -10 °C
3: 86 percent / NaOMe / methanol / 24 h / Heating
View Scheme
(±)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

(±)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 86 percent / NaOMe / methanol / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: O,O'-dibenzoyl-L-tartaric acid / methanol / 0.5 h / 60 - 65 °C
2: sodium methylate / methanol / 6 h / 60 °C
View Scheme
methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate

methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
2: O,O'-dibenzoyl-L-tartaric acid / methanol / 0.5 h / 60 - 65 °C
3: sodium methylate / methanol / 6 h / 60 °C
View Scheme
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tert-butyl methyl ether; diethyl ether / 3 h / -20 - -5 °C / Inert atmosphere
2: O,O'-dibenzoyl-L-tartaric acid / methanol / 0.5 h / 60 - 65 °C
3: sodium methylate / methanol / 6 h / 60 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-4β-(4-Chlorophenyl)-3α-(hydroxymethyl)-1-methylpiperidine
263769-24-0

(+)-4β-(4-Chlorophenyl)-3α-(hydroxymethyl)-1-methylpiperidine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;92%
With lithium aluminium tetrahydride In tetrahydrofuran92%
Stage #1: (+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With water; ammonium chloride In tetrahydrofuran
92%
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Ambient temperature;84%
With lithium aluminium tetrahydride In tetrahydrofuran
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-piperidine

(3R,4S)-4-(4-Chloro-phenyl)-1-methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-piperidine

Conditions
ConditionsYield
With molecular sieve; sodium hydride In tetrahydrofuran Heating;74%
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(3R,4S)-4-(4-chlorophenyl)piperidine-3-carboxylic acid methyl ester

(3R,4S)-4-(4-chlorophenyl)piperidine-3-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: (+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane for 1.5h; Heating;
Stage #2: In methanol for 1h; Heating; Further stages.;
67%
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-4β-(4-Chlorophenyl)-1-methylpiperidine-3α-carboxylic Acid
263769-44-4

(+)-4β-(4-Chlorophenyl)-1-methylpiperidine-3α-carboxylic Acid

Conditions
ConditionsYield
With hydrogenchloride Hydrolysis; Heating;
With hydrogenchloride Heating;
With hydrogenchloride Hydrolysis; Heating;
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

2-[(3R,4S)-4-(4-Chloro-phenyl)-piperidin-3-ylmethylsulfanyl]-ethanol
896710-05-7

2-[(3R,4S)-4-(4-Chloro-phenyl)-piperidin-3-ylmethylsulfanyl]-ethanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
4: 80 percent / 1-chloroethyl chloroformate; proton sponge / CH2Cl2
5: 56 percent / LiAlH4 / tetrahydrofuran
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

2-[(3R,4S)-4-(4-Chloro-phenyl)-piperidin-3-ylmethylsulfanyl]-1-piperidin-1-yl-ethanone
896710-06-8

2-[(3R,4S)-4-(4-Chloro-phenyl)-piperidin-3-ylmethylsulfanyl]-1-piperidin-1-yl-ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
4: 80 percent / 1-chloroethyl chloroformate; proton sponge / CH2Cl2
5: methanol
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-(3R,4S)-4-(4-chlorophenyl)-3-(iodomethyl)-1-methylpiperidine
807342-01-4

(+)-(3R,4S)-4-(4-chlorophenyl)-3-(iodomethyl)-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
View Scheme
Multi-step reaction with 2 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]acetic acid methyl ester
807342-02-5

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]ethanol
807342-04-7

(+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]ethanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
4: 56 percent / LiAlH4 / tetrahydrofuran
View Scheme
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methylsulfanyl]acetic acid methyl ester
807342-26-3

(+)-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methylsulfanyl]acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
4: 80 percent / 1-chloroethyl chloroformate; proton sponge / CH2Cl2
View Scheme
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 80 percent / 1,8-bis(dimethylamino)naphthalene; α-chloroethyl chloroformate / CH2Cl2 / 2.5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2.5 h / Heating / reflux
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-1-(piperidin-1-yl)ethanone
807342-17-2

(+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-1-(piperidin-1-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran
2: 86 percent / Ph3P; I2; imidazole
3: 88 percent / Cs2CO3
4: methanol
View Scheme
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 92 percent / methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: methanol / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-(3R,4S)-4-(4-chlorophenyl)-3-[(2-methoxyethylsulfanyl)methyl]-1-methylpiperidine
807342-06-9

(+)-(3R,4S)-4-(4-chlorophenyl)-3-[(2-methoxyethylsulfanyl)methyl]-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2.1: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3.1: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4.1: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
5.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
5.2: 65 percent / tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3.1: caesium carbonate / acetonitrile / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 0 °C
5.2: 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]ethanol

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]ethanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
5: 69 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-methylacetamide
807342-14-9

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-methylacetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 72 percent / methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: methanol / 24 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-(3R,4S)-4-(4-chlorophenyl)-3-[(2-methoxyethylsulfinyl)methyl]-1-methylpiperidine

(+)-(3R,4S)-4-(4-chlorophenyl)-3-[(2-methoxyethylsulfinyl)methyl]-1-methylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2.1: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3.1: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4.1: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
5.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
5.2: 65 percent / tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C
6.1: 61 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3.1: caesium carbonate / acetonitrile / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 0 °C
5.2: 20 °C
6.1: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methylsulfanyl]acetamide
807342-27-4

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methylsulfanyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 90 percent / NH3(gas) / 2-methyl-propan-2-ol / 72 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2.5 h / Heating / reflux
5: ammonia / tert-butyl alcohol / 72 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]acetamide
807342-12-7

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 95 percent / NH3 (gas) / 2-methyl-propan-2-ol / 72 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: ammonia / tert-butyl alcohol / 72 h / 20 °C / Sealed tube
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N,N-dimethylacetamide
807342-15-0

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N,N-dimethylacetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 91 percent / methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: methanol / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]acetic acid methyl ester

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 80 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide
807342-13-8

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 76 percent / hydroxylamine hydrochloride; KOH / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: potassium hydroxide; hydroxylamine hydrochloride / methanol / 2 h / 5 - 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methanesulfinyl]acetamide

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)piperidin-3-yl]methanesulfinyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 90 percent / NH3(gas) / 2-methyl-propan-2-ol / 72 h / 20 °C
5: 73 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 2.5 h / Heating / reflux
5: ammonia / tert-butyl alcohol / 72 h / 20 °C
6: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-acetic acid 2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]ethyl ester
807342-08-1

(+)-acetic acid 2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
5: 70 percent / 4-(dimethylamino)pyridine; pyridine / 2 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5: pyridine / dmap / 2 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]acetamide
807342-18-3

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 95 percent / NH3 (gas) / 2-methyl-propan-2-ol / 72 h / 20 °C
5: 69 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: ammonia / tert-butyl alcohol / 72 h / 20 °C / Sealed tube
5: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]-N-methylacetamide

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]-N-methylacetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 72 percent / methanol / 24 h / 20 °C
5: 80 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: methanol / 24 h / 20 °C
5: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-(3R,4S)-[[4-(4-chlorophenyl)-1-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]methyl]piperidine
807342-24-1

(+)-(3R,4S)-[[4-(4-chlorophenyl)-1-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]methyl]piperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2.1: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3.1: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4.1: NaH / tetrahydrofuran / 2.5 h / Heating
4.2: 79 percent / 4A molecular sieves / tetrahydrofuran / 16 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3.1: caesium carbonate / acetonitrile / 20 °C
4.1: sodium hydride / tetrahydrofuran / 2.5 h / Heating / reflux
4.2: 16 h / Heating / reflux; Molecular sieve
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-acetic acid 2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]ethyl ester

(+)-acetic acid 2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 82 percent / LiAlH4 / tetrahydrofuran / 20 °C
5: 70 percent / 4-(dimethylamino)pyridine; pyridine / 2 h / 20 °C
6: 82 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5: pyridine / dmap / 2 h / 20 °C
6: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate
263769-22-8

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]-N,N-dimethylacetamide

(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methanesulfinyl]-N,N-dimethylacetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 20 °C
2: 86 percent / PPh3; I2; imidazole / CH2Cl2 / 2.5 h / Heating
3: 88 percent / Cs2CO3 / acetonitrile / 20 °C
4: 91 percent / methanol / 20 °C
5: 87 percent / aq. H2O2; CH3COOH / 2.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / Heating / reflux
3: caesium carbonate / acetonitrile / 20 °C
4: methanol / 20 °C
5: dihydrogen peroxide / water; acetic acid / 2.5 h / 20 °C
View Scheme

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View