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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3,5-DICHLORO-4-FLUOROANILINE

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

High quality 3,5-dichloro-4-fluoroaniline Cas 2729-34-2 with low price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fee

High quality 3,5-dichloro-4-fluoroaniline Cas 2729-34-2 with low price

Cas:2729-34-2

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 2729-34-2 with competitive price

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3,5-dichloro-4-fluoroaniline Synonyms: 3,5-dichloro-4-fluoroaniline;3,5-Dichloro-4-fluorobenzenamine;(3,5-dichloro-4-fluoro-phenyl)amine;3,5-Dichloro-4-fluoroaniline 98%;,5-Dichloro-4-fluoroaniline;Benzenamine, 3,5-dichloro-4-fluo

3,5-dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,5-dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3,5-Dichloro-4-Fluoroaniline CAS No.: 2729-34-2 Molecule Formula:C6H4Cl2FN Molecule Weight:180.01 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard

Lower Price 3,5-Dichloro-4-Fluoroaniline

Cas:2729-34-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

3,5-dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3,5-dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 15.0

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,5-Dichloro-4-fluoroaniline cas no. 2729-34-2 98%

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Boiling point 393.8 °C at 760 mmHg Melting point 67 °C Density 1.094 g/cm3 Storage

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

3,5-dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzenamine,3,5-dichloro-4-fluoro-

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

2729-34-2 supplier in China Application:2729-34-2 supplier in China

2729-34-2 supplier in China

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

3,5-Dichloro-4-fluoroaniline

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

2729-34-2

Cas:2729-34-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

3,5-dichloro-4-fluoro-nitrobenzene
3107-19-5

3,5-dichloro-4-fluoro-nitrobenzene

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Conditions
ConditionsYield
With hydrogen In methanol Inert atmosphere;90%
With hydrogenchloride; tin(ll) chloride
With ammonium formate; zinc In methanol; water for 1.33333h;
3,4,5-trichloronitrobenzen
20098-48-0

3,4,5-trichloronitrobenzen

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide; potassium fluoride / 150 °C
2: SnCl2; aqueous HCl
View Scheme
Multi-step reaction with 2 steps
1: potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride / 11 h / 140 - 175 °C
2: hydrogen / methanol / Inert atmosphere
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1,3-dichloro-2-fluorobenzene
2268-05-5

1,3-dichloro-2-fluorobenzene

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With nitrosylsulfuric acid at 10 - 15℃; for 6h;
Stage #2: With copper(I) oxide; sodium hypophosphite; sulfuric acid; water for 1h;
86%
2-amino-6-methyl-4-chloropyrimidine
5600-21-5

2-amino-6-methyl-4-chloropyrimidine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine

N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;81%
2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-(morpholinosulfonyl)benzamide

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-(morpholinosulfonyl)benzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;76%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

2,4-dichloro-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoyl chloride

2,4-dichloro-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoyl chloride

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-((4-methylpiperazin-1-yl)sulfonyl)benzamide

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-((4-methylpiperazin-1-yl)sulfonyl)benzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;64%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

O-ehyl (3,5-dichloro-4-fluorophenyl)sulfanylmethanethioate

O-ehyl (3,5-dichloro-4-fluorophenyl)sulfanylmethanethioate

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at -5℃;
Stage #2: potassium ethyl xanthogenate In water at 50℃; for 3h;
60%
With hydrogenchloride; sodium nitrite In water at 0 - 70℃; for 2h;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl (3,5-dichloro-4-fluorophenyl)carbamate

phenyl (3,5-dichloro-4-fluorophenyl)carbamate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;55%
With sodium hydrogencarbonate In water; ethyl acetate
4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(3,5-dichloro-4-fluorophenyl)-[1-(4-methoxybenzyl)-5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl]amine

(3,5-dichloro-4-fluorophenyl)-[1-(4-methoxybenzyl)-5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl]amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 20 - 85℃; for 15.0833h; Inert atmosphere;53%
1-benzyl-5-bromo-1H-[1,2,4]triazole

1-benzyl-5-bromo-1H-[1,2,4]triazole

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(2-benzyl-2H-[1,2,4]triazol-3-yl)(3,5-dichloro-4-fluorophenyl)amine

(2-benzyl-2H-[1,2,4]triazol-3-yl)(3,5-dichloro-4-fluorophenyl)amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 18h; Inert atmosphere;15%
2-acetylpropanoic acid ethyl ester
609-14-3

2-acetylpropanoic acid ethyl ester

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

ethyl (2Z)-2-[2-(3,5-dichloro-4-fluorophenyl)hydrazin-1-ylidene]propanoate

ethyl (2Z)-2-[2-(3,5-dichloro-4-fluorophenyl)hydrazin-1-ylidene]propanoate

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In ethanol; water at 0℃; for 0.0833333h;
Stage #2: 2-acetylpropanoic acid ethyl ester In ethanol; water at -10℃; for 0.05h;
14.7%
1-benzyl-3-bromo-1H-[1,2,4]triazole

1-benzyl-3-bromo-1H-[1,2,4]triazole

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(1-benzyl-1H-[1,2,4]triazol-3-yl)-(3,5-dichloro-4-fluorophenyl)amine

(1-benzyl-1H-[1,2,4]triazol-3-yl)-(3,5-dichloro-4-fluorophenyl)amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 19h; Inert atmosphere;7%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

ethyl cyanoacetimidate hydrochloride
55244-11-6

ethyl cyanoacetimidate hydrochloride

N5-(3,5-dichloro-4-fluoro-phenyl)-1H-pyrazole-3,5-diamine

N5-(3,5-dichloro-4-fluoro-phenyl)-1H-pyrazole-3,5-diamine

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine; ethyl cyanoacetimidate hydrochloride In ethanol at 20℃; under 760.051 Torr; Inert atmosphere;
Stage #2: With hydrazine In ethanol; water under 760.051 Torr; for 4.5h; Inert atmosphere; Heating;
5%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

3,5-dichloro-4-fluorophenol
2995-04-2

3,5-dichloro-4-fluorophenol

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; sodium nitrite In water at 0℃; for 0.166667h;
Stage #2: With sulfuric acid; water; sodium sulfate at 90 - 120℃; for 2.5h; Enzymatic reaction;
5%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
1159735-51-9

[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h;
Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at 20℃; for 20h;
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - 20℃;
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h;
Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at -15 - 20℃;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Kalium-ethyl-adipat
24356-36-3

Kalium-ethyl-adipat

C14H15Cl2FN2O4
1570075-05-6

C14H15Cl2FN2O4

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at 0 - 8℃; for 0.333333h;
Stage #2: Kalium-ethyl-adipat In water at 0 - 40℃; for 1h; Japp-Klingemann Hydrazone Synthesis;
4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(3,5-dichloro-4-fluorophenyl)-(5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl)amine

(3,5-dichloro-4-fluorophenyl)-(5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl)amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / toluene / 15.08 h / 20 - 85 °C / Inert atmosphere
2: trifluoroacetic acid / 2 h / 65 °C
View Scheme
4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride

4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride

5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride

Conditions
ConditionsYield
In toluene for 2h; Reflux;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-cyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-cyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C
8.1: trifluoroacetic acid / 2 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-2-fluorocyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-2-fluorocyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-2-fluorocyclopropanecarbohydrazide

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-2-fluorocyclopropanecarbohydrazide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C
8.1: trifluoroacetic acid / 2 h / 20 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl 2,2-difluorocyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl 2,2-difluorocyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h / 50 - 70 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-isovaleryl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-isovaleryl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-2-butenoyl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-2-butenoyl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-3-hydroxy-butanoyl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-3-hydroxy-butanoyl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one
1190865-44-1

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1,3-dichloro-2-fluoro-5-iodo-benzene

1,3-dichloro-2-fluoro-5-iodo-benzene

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; acetic acid; sodium nitrite at 20℃; for 4h; Cooling with ice;
Stage #2: With potassium iodide at 70℃; for 1h; Cooling with ice;
29.7 g
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
View Scheme

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